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article

Investigating apical adverse effects of four endocrine active substances in the freshwater gastropod Lymnaea stagnalis

Arnaud Giusti, Laurent Lagadic, Alpar Barsi, Jean-Pierre Thomé, more

Science of the Total Environment > 2014 > 493 > Complete > 147-155

The hermaphroditic gastropod Lymnaea stagnalis is proposed as a candidate species for the development of OECD guidelines for testing of the reprotoxicity of chemicals, including endocrine active substances (EASs). Up to now, only a few putative EASs have been tested for their reproductive toxicity in this species. In this study, we investigate the effects of four EASs with different affinities to...

article

Frank Beach Award Winner: Steroids as neuromodulators of brain circuits and behavior

Luke Remage-Healey, L. Remage-Healey

Hormones and Behavior > 2014 > 66 > 3 > 552-560

Neurons communicate primarily via action potentials that transmit information on the timescale of milliseconds. Neurons also integrate information via alterations in gene transcription and protein translation that are sustained for hours to days after initiation. Positioned between these two signaling timescales are the minute-by-minute actions of neuromodulators. Over the course of minutes, the classical...

article

Synthesis and antimitotic activity of novel 2-methoxyestradiol analogs—Part II

Pemmaraju N. Rao, James W. Cessac, James W. Boyd, Arthur D. Hanson, more

Steroids > 2008 > 73 > 2 > 158-170

The syntheses and antimitotic activity of several novel 18a-homo-analogs of 2-methoxyestradiol are described. Structural modifications of the parent 2-methoxy-18a-homoestradiol include introduction of unsaturation in the D-ring and methylation of the 17-OH. Of seven analogs synthesized, one has demonstrated superior biological activities compared to 2-methoxyestradiol. The relationship between biological...

article

Phase II Study of Low Dose and High Dose Conjugated Estrogen for Androgen Independent Prostate Cancer

Mark Pomerantz, Judith Manola, Mary-Ellen Taplin, Glenn Bubley, more

The Journal of Urology > 2007 > 177 > 6 > 2146-2150

Although estrogens have known antitumor activity in androgen independent prostate cancer, the best studied agent, diethylstilbestrol, is no longer commercially available in the United States. We tested 2 doses of the conjugated estrogen Premarin® in patients with androgen independent prostate cancer to determine the efficacy and safety of this widely available medication.A total of 45 patients with...

article

Pre‐ and peripubertal sex steroids are inversely associated with birth weight in preterm boys

Kjersti Kvernebo Sunnergren, Jovanna Dahlgren, Ann‐Katrine Karlsson, Staffan Nilsson, more

Clinical Endocrinology > 98 > 3 > 342 - 350

Objective The relationship between sex hormone concentrations during childhood and birth weight (BW) is poorly understood. We aimed to investigate this relationship and the associations with anthropometric data at 5, 6, 7, 8, and 10 years of age in preterm boys. Design A prospective longitudinal single‐centre study, including 58 boys with a BW of 1325–3320 g and gestational age (GA) of 32 + 2 to...

article

Estrogens in wastewaters: Can different operating conditions improve their removal in anaerobic conditions?

Vitória L. Louros, Andreia F. C. Sousa, Diana L. D. Lima, Pedro M. P. Santos, more

Water and Environment Journal > 36 > 3 > 399 - 411

The removal of estrone (E1) and 17α‐ethinylestradiol (EE2) from synthetic wastewater under anaerobic conditions, at environmental relevant concentrations (80 and 4 μg L⁻¹, for E1 and EE2, respectively), was here assessed. Results indicated that the increase in temperature favoured E1 removal (complete removal at 25°C, and 34°C after 25 h), while EE2 does not seem to be affected. The lowest mixed liquor...

article

Steroid profiling in brain and plasma of adult zebra finches following traumatic brain injury

Sofia L. Gray, Kiran K. Soma, Kelli A. Duncan

Journal of Neuroendocrinology > 34 > 6 > n/a - n/a

Traumatic brain injury (TBI) is a serious health concern and a leading cause of death. Emerging evidence strongly suggests that steroid hormones (estrogens, androgens, and progesterone) modulate TBI outcomes by regulating inflammation, oxidative stress, free radical production, and extracellular calcium levels. Despite this growing body of evidence on steroid‐mediated neuroprotection, very little...

article

Risk of recurrence in women with venous thromboembolism related to estrogen‐containing contraceptives: Systematic review and meta‐analysis

Hanke M. G. Wiegers, Jannet Knijp, Nick van Es, Michiel Coppens, more

Journal of Thrombosis and Haemostasis > 20 > 5 > 1158 - 1165

Background The risk of recurrence after a venous thromboembolism (VTE) related to estrogen‐containing contraceptives is a key driver to guide anticoagulant treatment decisions. Objective To estimate the incidence rate of recurrent VTE after discontinuation of anticoagulant treatment in women with a first episode of VTE related to estrogen‐containing contraceptives. Methods Embase, MEDLINE, and...

article

Development and validation of a liquid chromatography–tandem mass spectrometry method for the simultaneous analysis of androgens, estrogens, glucocorticoids and progestagens in human serum

Michele Iannone, Anna Pia Dima, Francesca Sciarra, Francesco Botrè, more

Biomedical Chromatography > 36 > 5 > n/a - n/a

We present a liquid chromatography tandem mass spectrometry method for the simultaneous analysis of 16 endogenous steroids (androgens, estrogens, glucocorticoids and progestogens) in human serum. Samples (250 μl of matrix) were extracted with t‐butylmethyl ether prior to LC–MS/MS analysis. The chromatographic separation was achieved on a reversed‐phase column using a methanol–water gradient. The HPLC...

article

Gender‐affirming hormone therapy: An updated literature review with an eye on the future

Laurens D'hoore, Guy T'Sjoen

Journal of Internal Medicine > 291 > 5 > 574 - 592

In line with increasing numbers of transgender (trans) and gender nonbinary people requesting hormone treatment, the body of available research is expanding. More clinical research groups are presenting data, and the numbers of participants in these studies are rising. Many previous review papers have focused on all available data, as these were scarce, but a more recent literature review is timely...

article

Toward Selective Anticancer Agents: Ferrocene‐Steroid Conjugates

Vidak Raičević, Niko Radulović, Marija Sakač

European Journal of Inorganic Chemistry > 2022 > 9 > n/a - n/a

The medicinal chemistry of ferrocene is a diverse and rapidly growing field. In the search for selective and more efficient anticancer drugs, ferrocene‐steroid conjugates were explored in the past as a tool to target hormone‐dependent cancer cells, notably those of breast and prostate cancers. The mechanisms by which ferrocene compounds induce cytotoxicity are first examined, as well as how they can...

article

Use of hormonal contraceptives in perimenopause: A systematic review

Julie Guerin, Alexandra Engelmann, Meena Mattamana, Laura M. Borgelt

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy > 42 > 2 > 154 - 164

Hormonal contraceptives have been used in perimenopausal women to manage a variety of symptoms and prevent unintended pregnancy. However, it is unclear what contraceptive regimen is best for these women. To evaluate hormonal contraceptive methods in women experiencing perimenopause using two prespecified outcomes: perimenopausal symptom management and long‐term effects. A literature search of PubMed...

article

G protein‐coupled estrogen receptor‐1 enhances excitatory synaptic responses in the entorhinal cortex

Ariel A. Batallán Burrowes, Adithi Sundarakrishnan, Camille Bouhour, Clifton Andrew Chapman

Hippocampus > 31 > 11 > 1191 - 1201

Activation of estrogen receptors is thought to modulate cognitive function in the hippocampus, prefrontal cortex, and striatum by affecting both excitatory and inhibitory synaptic transmission. The entorhinal cortex is a major source of cortical sensory and associational input to the hippocampus, but it is unclear whether either estrogens or progestogens may modulate cognitive function through effects...

article

Mechanisms Underlying the Antifibrotic Potential of Estradiol for Vocal Fold Fibrosis

Satomi Ozawa, Shigeyuki Mukudai, Yoichiro Sugiyama, Ryan C. Branski, more

The Laryngoscope > 131 > 10 > 2285 - 2291

Objectives/Hypothesis Vocal fold fibrosis remains a significant clinical challenge. Estrogens, steroid hormones predominantly responsible for secondary sexual characteristics in women, have been shown to alter wound healing and limit fibrosis, but the effects on vocal fold fibrosis are unknown. We sought to elucidate the expression of estrogen receptors and the effects of estrogens on TGF‐β1 signaling...

article

Electroanalytical Determination of Estrone in Seawater Samples Using Functionalized Multiwalled Carbon Nanotubes

Renato Hisashi Okina, Eliana Maíra Agostini Valle, Fabio Ruiz Simões, Lucia Codognoto

Electroanalysis > 33 > 5 > 1264 - 1270

In this work, a glassy carbon electrode (GCE) modified with multiwalled carbon nanotubes functionalized with carboxylic groups (MWCNT−COOH) was used to determine the hormone estrone in seawater samples. Modification of the electrode was optimized using three successive 10‐μL aliquots of the MWCNT−COOH dispersion in ethanol (1 : 5 mL). The cyclic voltammetry results showed an oxidation peak at 0.59...

article

Preparation of porous polymers based on high internal phase emulsion for enrichment of estrogens in urine

Xiangqiong Jiang, Guihua Ruan, Wenjuan Zhang, Yan Zhang, more

Journal of Separation Science > 44 > 6 > 1140 - 1147

In this work, graphene oxide‐hybridized high internal emulsion polymers with crosslinking and open‐cell structure was prepared and applied for separation and enrichment of estrogens. The prepared graphene oxide‐hybridized high internal emulsion polymer monoliths had hydrophobicity, porosity and stability, which were just obtained by one step in‐situ emulsion polymerization of 2‐ethylhexyl acrylate,...

article

Development of Electrochemical Platform Based on Molecularly Imprinted Poly(methacrylic acid) Grafted on Iniferter‐modified Carbon Nanotubes for 17β‐Estradiol Determination in Water Samples

Gabriel Lopes Marques, Luana Rianne Rocha, Maiyara Carolyne Prete, Felipe Augusto Gorla, more

Electroanalysis > 33 > 3 > 568 - 578

This paper describes the development of a new electrochemical sensor for 17β‐estradiol (E2) determination based on glassy carbon electrode (GCE) modified with molecularly imprinted polymer grafted onto iniferter‐multiwall carbon nanotubes surface (MIP‐MWCNT) and dihexadecyl‐hydrogen‐phosphate (DHP). The electrochemical method was based on closed‐circuit preconcentration of E2 in 0.1 mol L⁻¹ phosphate...

article

Optimization and validation of a GC–MS quantitative method for the determination of an extended estrogenic profile in human urine: Variability intervals in a population of healthy women

Eugenio Alladio, Eleonora Amante, Cristina Bozzolino, Sara Vaglio, more

Biomedical Chromatography > 35 > 2 > n/a - n/a

An analytical method based on GC–MS was developed for the determination of a wide panel of urinary estrogens, together with their principal metabolites. Because of the low concentration of estrogens in urine, an efficient sample pre‐treatment was optimized by a design of experiment (DoE) procedure to achieve satisfactory sensitivity. A second DoE was built for the optimization of the chromatographic...

article

Infection by CagA‐Positive Helicobacter pylori Strains and Bone Fragility: A Prospective Cohort Study

Luigi Gennari, Daniela Merlotti, Natale Figura, Christian Mingiano, more

Journal of Bone and Mineral Research > 36 > 1 > 80 - 89

Helicobacter pylori (HP) infection is a common and persistent disorder acting as a major cofactor for the development of upper gastrointestinal diseases and several extraintestinal disorders including osteoporosis. However, no prospective study assessed the effects of HP on bone health and fracture risk. We performed a HP screening in a population‐based cohort of 1149 adults followed prospectively...

article

Estrogen‐dependent sex difference in microglia in the developing brain of Japanese quail (Coturnix japonica)

Charlotte Isabelle Delage, Charlotte Anne Cornil

Developmental Neurobiology > 80 > 7-8 > 239 - 262

Brain sexual differentiation is a developmental process leading to the establishment of stable neural sex differences. In birds and rodents, this process is largely driven by estrogens during a critical period. In rodents, estrogens drive the masculinization of the brain, a process that partly depends on microglia. In contrast, in birds, estrogens produced by females induce demasculinization, but...

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Search results

Investigating apical adverse effects of four endocrine active substances in the freshwater gastropod Lymnaea stagnalis

Frank Beach Award Winner: Steroids as neuromodulators of brain circuits and behavior

Synthesis and antimitotic activity of novel 2-methoxyestradiol analogs—Part II

Phase II Study of Low Dose and High Dose Conjugated Estrogen for Androgen Independent Prostate Cancer

Pre‐ and peripubertal sex steroids are inversely associated with birth weight in preterm boys

Estrogens in wastewaters: Can different operating conditions improve their removal in anaerobic conditions?

Steroid profiling in brain and plasma of adult zebra finches following traumatic brain injury

Risk of recurrence in women with venous thromboembolism related to estrogen‐containing contraceptives: Systematic review and meta‐analysis

Development and validation of a liquid chromatography–tandem mass spectrometry method for the simultaneous analysis of androgens, estrogens, glucocorticoids and progestagens in human serum

Gender‐affirming hormone therapy: An updated literature review with an eye on the future

Toward Selective Anticancer Agents: Ferrocene‐Steroid Conjugates

Use of hormonal contraceptives in perimenopause: A systematic review

G protein‐coupled estrogen receptor‐1 enhances excitatory synaptic responses in the entorhinal cortex

Mechanisms Underlying the Antifibrotic Potential of Estradiol for Vocal Fold Fibrosis

Electroanalytical Determination of Estrone in Seawater Samples Using Functionalized Multiwalled Carbon Nanotubes

Preparation of porous polymers based on high internal phase emulsion for enrichment of estrogens in urine

Development of Electrochemical Platform Based on Molecularly Imprinted Poly(methacrylic acid) Grafted on Iniferter‐modified Carbon Nanotubes for 17β‐Estradiol Determination in Water Samples

Optimization and validation of a GC–MS quantitative method for the determination of an extended estrogenic profile in human urine: Variability intervals in a population of healthy women

Infection by CagA‐Positive Helicobacter pylori Strains and Bone Fragility: A Prospective Cohort Study

Estrogen‐dependent sex difference in microglia in the developing brain of Japanese quail (Coturnix japonica)

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