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article

Translational and clinical pharmacology considerations in drug repurposing for X‐linked adrenoleukodystrophy—A rare peroxisomal disorder

Julianne H. Tieu, Siddhee A. Sahasrabudhe, Paul J. Orchard, James C. Cloyd, more

British Journal of Clinical Pharmacology > 88 > 6 > 2552 - 2563

X‐linked adrenoleukodystrophy (X‐ALD) is an inherited, neurodegenerative rare disease that can result in devastating symptoms of blindness, gait disturbances and spastic quadriparesis due to progressive demyelination. Typically, the disease progresses rapidly, causing death within the first decade of life. With limited treatments available, efforts to determine an effective therapy that can alter...

article

Network‐Based Approaches for Drug Repositioning

Tao Song, Gan Wang, Mao Ding, Alfonso Rodriguez‐Paton, more

Molecular Informatics > 41 > 5 > n/a - n/a

With deep learning creeping up into the ranks of big data, new models based on deep learning and massive data have made great leaps forward rapidly in the field of drug repositioning. However, there is no relevant review to summarize the transformations and development process of models and their data in the field of drug repositioning. Among all the computational methods, network‐based methods play...

article

Repurposing topical triclosan for cutaneous leishmaniasis: Preclinical efficacy in a murine Leishmania (L.) amazonensis model

Juliana Tonini Mesquita, Maiara Maria Romanelli, Cristiana de Melo Trinconi Trinconi CM, Juliana Mariotti Guerra, more

Drug Development Research > 83 > 2 > 285 - 295

Leishmaniasis remains an important neglected tropical infection caused by the protozoan Leishmania and affects 12 million people in 98 countries. The treatment is limited with severe adverse effects. In the search for new therapies, the drug repositioning and combination therapy have been successfully applied to neglected diseases. The aim of the present study was to evaluate the in vitro and in vivo...

article

Improvement of the performance of anticancer peptides using a drug repositioning pipeline

Elyas Mohammadi, Mojtaba Tahmoorespur, Rui Benfeitas, Ozlem Altay, more

Biotechnology Journal > 17 > 1 > n/a - n/a

The use of anticancer peptides (ACPs) as an alternative/complementary strategy to conventional chemotherapy treatments has been shown to decrease drug resistance and/or severe side effects. However, the efficacy of the positively‐charged ACP is inhibited by elevated levels of negatively‐charged cell‐surface components which trap the peptides and prevent their contact with the cell membrane. Consequently,...

article

Pharmacovigilance‐based drug repurposing: The search for inverse signals via OpenVigil identifies putative drugs against viral respiratory infections

Ruwen Böhm, Claudia Bulin, Vicki Waetzig, Ingolf Cascorbi, more

British Journal of Clinical Pharmacology > 87 > 11 > 4421 - 4431

article

Disproportionality analysis in VigiBase as a drug repositioning method for the discovery of potentially useful drugs in Alzheimer's disease

Basile Chrétien, Jean‐Pierre Jourdan, Audrey Davis, Sophie Fedrizzi, more

British Journal of Clinical Pharmacology > 87 > 7 > 2830 - 2837

Drug repositioning aims to propose new indications for marketed drugs. Although several methods exist, the utility of pharmacovigilance databases for this purpose is unclear. We conducted a disproportionality analysis in the World Health Organization pharmacovigilance database VigiBase to identify potential anticholinesterase drug candidates for repositioning in Alzheimer's disease (AD). Methods...

article

COVID‐19 drug repurposing: Summary statistics on current clinical trials and promising untested candidates

J. Wes Ulm, Stanley F. Nelson

Transboundary and Emerging Diseases > 68 > 2 > 313 - 317

Repurposing of existing anti‐viral drugs, immunological modulators and supportive therapies represents a promising path towards rapidly developing new control strategies to mitigate the devastating public health consequences of the COVID‐19 pandemic. A comprehensive text‐mining and manual curation approach was used to comb and summarize the most pertinent information from existing clinical trials...

article

Redirecting drug repositioning to discover innovative cosmeceuticals

Georgia Sotiropoulou, Eleni Zingkou, Georgios Pampalakis

Experimental Dermatology > 30 > 5 > 628 - 644

Skin appearance is essential for self‐esteem and quality of life; consequently, skin care products represent a huge market. In particular, cosmeceuticals constitute a hybrid category of skin care formulations, at the interphase of cosmetics and pharmaceuticals, rationally designed to target (patho) physiological mechanisms aiming to enhance skin health and appearance. Cosmeceuticals are marketed as...

article

Impact of metformin therapy on health‐related quality of life outcomes in tuberculosis patients with diabetes mellitus in India: A prospective study

Ritu Mishra, Shri Krishan, Ali Nasir Siddiqui, Prem Kapur, more

International Journal of Clinical Practice > 75 > 4 > n/a - n/a

Objective To assess the impact of metformin use on health‐related quality of life (HRQoL) in tuberculosis (TB) patients who are presented with type 2 diabetes mellitus (T2DM). Methodology In this community‐based prospective study, TB patients attending Hakeem Abdul Hameed Centenary Hospital, New Delhi (India) and had comorbidity of T2DM between April 2018 and July 2019 were enrolled. Patients were...

article

Comparative analysis of antiviral efficacy of FDA‐approved drugs against SARS‐CoV‐2 in human lung cells

Meehyun Ko, Sangeun Jeon, Wang‐Shick Ryu, Seungtaek Kim

Journal of Medical Virology > 93 > 3 > 1403 - 1408

Drug repositioning represents an effective way to control the current COVID‐19 pandemic. Previously, we identified 24 FDA‐approved drugs which exhibited substantial antiviral effect against severe acute respiratory syndrome coronavirus 2 in Vero cells. Since antiviral efficacy could be altered in different cell lines, we developed an antiviral screening assay with human lung cells, which is more appropriate...

article

Repurposing current therapeutics for treating COVID‐19: A vital role of prescription records data mining

David Gurwitz

Drug Development Research > 81 > 7 > 777 - 781

Since its outbreak in late 2019, the SARS‐Cov‐2 pandemic already infected over 3.7 million people and claimed more than 250,000 lives globally. At least 1 year may take for an approved vaccine to be in place, and meanwhile millions more could be infected, some with fatal outcome. Over thousand clinical trials with COVID‐19 patients are already listed in ClinicalTrials.com, some of them for assessing...

article

In Silico Analysis of FDA Drugs as P2X4 Modulators for the Treatment of Alcohol Use Disorder

Francisco Reyes‐Espinosa, María G. Nieto‐Pescador, Virgilio Bocanegra‐García, Eduardo Lozano‐Guzmán, more

Molecular Informatics > 39 > 9 > n/a - n/a

Recent studies have shown the potential application of ivermectins in the treatment of alcohol use disorder (AUD). Ivermectin is a positive allosteric modulator (PAM) of P2X4R and this molecule exerts its action in the transmembrane region (known as the TM region) of trimeric channel structure (the pocket formed by Asp331, Met336, Trp46, Trp50, and Tyr42). The aim of this study is to identify FDA...

article

Identifying drugs with disease‐modifying potential in Parkinson's disease using artificial intelligence and pharmacoepidemiology

Laura C. Maclagan, Naomi P. Visanji, Yi Cheng, Mina Tadrous, more

Pharmacoepidemiology and Drug Safety > 29 > 8 > 864 - 872

Purpose The aim of the study was to assess the feasibility of an approach combining computational methods and pharmacoepidemiology to identify potentially disease‐modifying drugs in Parkinson's disease (PD). Methods We used a two‐step approach; (a) computational method using artificial intelligence to rank 620 drugs in the Ontario Drug Benefit formulary based on their predicted ability to inhibit...

article

Metro‐SMHOP 01: Metronomics combination with cyclophosphamide‐etoposide and valproic acid for refractory and relapsing pediatric malignancies

Maria El kababri, Sarra Benmiloud, Siham Cherkaoui, Jamila El houdzi, more

Pediatric Blood & Cancer > 67 > 9 > n/a - n/a

Background In low‐ and middle‐income countries, therapeutic options for advanced, refractory, or relapsing malignancies are limited due to local constraints such as cost of drugs, distance from oncology centers, and lack of availability of new anticancer drugs. Metronomics, which combines metronomic chemotherapy (MC) and drug repositioning, allows for the provision of new therapeutic options for...

article

Mycophenolic acid is a drug with the potential to be repurposed for suppressing tumor growth and metastasis in osteosarcoma treatment

Jeerawan Klangjorhor, Parunya Chaiyawat, Pimpisa Teeyakasem, Nutnicha Sirikaew, more

International Journal of Cancer > 146 > 12 > 3397 - 3409

Our previous review of proteomics data showed that in osteosarcoma, some overexpressed proteins were targets of FDA‐approved immunosuppressive and anti‐arrhythmic drugs, including mycophenolate mofetil (MMF), ribavirin, leflunomide, azathioprine and digoxin. Here, these drugs were screened for growth inhibitory effects in human osteosarcoma cell lines, including MNNG/HOS, U2OS, SaOS‐2, MG‐63 and 143B...

article

Identify old drugs as selective bacterial β‐GUS inhibitors by structural‐based virtual screening and bio‐evaluations

Zhou Chen, Xiaoshuang Xu, Lianhua Piao, Shan Chang, more

Chemical Biology & Drug Design > 95 > 3 > 368 - 379

Irinotecan (CPT‐11) is a cytotoxic drug that has wide applicability and usage in cancer treatment. Despite its success, patients suffer dose‐dependent diarrhea, limiting the drug's efficacy. No effective therapy is available for this unmet medical need. The bacterial β‐glucuronidase (β‐GUS) plays pivotal role in CPT‐11‐induced diarrhea (CID) via activating the non‐toxic SN‐38G to toxic SN‐38 inside...

article

Old drugs in new therapeutic indications - the case of chloroquine

Bartosz A. Grzybowski, Grzegorz Grynkiewicz

Polish Technical Review > 2020 > No. 1 > 5--10

Drug reposition is a viable strategy of pharmaceutical R & D, considerably reducing risk, cost and time needed for drug registration and implementation. Chloroquine, designed already in 1930 as a synthetic replacement for scarcely available alkaloid quinine, a traditional malaria treatment, was recently proposed as an antiviral substance, with putative efficacy in some cases of SARS COVID infections...

article

A botanical drug composed of three herbal materials attenuates the sensorimotor gating deficit and cognitive impairment induced by MK‐801 in mice

Bokyung Koo, Ho Jung Bae, Nayeon Goo, Jaehoon Kim, more

Journal of Pharmacy and Pharmacology > 72 > 1 > 149 - 160

Objectives A botanical drug derived from the ethanolic extract composed of Clematis chinensis Osbeck (Ranunculaceae), Trichosanthes kirilowii Maximowicz (Cucurbitaceae) and Prunella vulgaris Linné (Lamiaceae) has been used to ameliorate rheumatoid arthritis as an ethical drug in Korea. In our study, we investigated the effect of this herbal complex extract (HCE) on schizophrenia‐like behaviours induced...

article

In silico drug repositioning: from large-scale transcriptome data to therapeutics

Ok-Seon Kwon, Wankyu Kim, Hyuk-Jin Cha, Haeseung Lee

Archives of Pharmacal Research > 2019 > 42 > 10 > 879-889

Drug repositioning is an attractive alternative to conventional drug development when new beneficial effects of old drugs are clinically validated because pharmacokinetic and safety profiles are generally already available. Since ~ 30% of drugs newly approved by the US food and drug administration (FDA) are developed through drug repositioning, identifying novel usage for existing drugs is an emerging...

article

Influence of batch effect correction methods on drug induced differential gene expression profiles

Wei Zhou, Karel K. M. Koudijs, Stefan Böhringer

BMC Bioinformatics > 2019 > 20 > 1 > 1-14

Background Batch effects were not accounted for in most of the studies of computational drug repositioning based on gene expression signatures. It is unknown how batch effect removal methods impact the results of signature-based drug repositioning. Herein, we conducted differential analyses on the Connectivity Map (CMAP) database using several batch effect correction methods to evaluate the influence...

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Search results

Translational and clinical pharmacology considerations in drug repurposing for X‐linked adrenoleukodystrophy—A rare peroxisomal disorder

Network‐Based Approaches for Drug Repositioning

Repurposing topical triclosan for cutaneous leishmaniasis: Preclinical efficacy in a murine Leishmania (L.) amazonensis model

Improvement of the performance of anticancer peptides using a drug repositioning pipeline

Pharmacovigilance‐based drug repurposing: The search for inverse signals via OpenVigil identifies putative drugs against viral respiratory infections

Disproportionality analysis in VigiBase as a drug repositioning method for the discovery of potentially useful drugs in Alzheimer's disease

COVID‐19 drug repurposing: Summary statistics on current clinical trials and promising untested candidates

Redirecting drug repositioning to discover innovative cosmeceuticals

Impact of metformin therapy on health‐related quality of life outcomes in tuberculosis patients with diabetes mellitus in India: A prospective study

Comparative analysis of antiviral efficacy of FDA‐approved drugs against SARS‐CoV‐2 in human lung cells

Repurposing current therapeutics for treating COVID‐19: A vital role of prescription records data mining

In Silico Analysis of FDA Drugs as P2X4 Modulators for the Treatment of Alcohol Use Disorder

Identifying drugs with disease‐modifying potential in Parkinson's disease using artificial intelligence and pharmacoepidemiology

Metro‐SMHOP 01: Metronomics combination with cyclophosphamide‐etoposide and valproic acid for refractory and relapsing pediatric malignancies

Mycophenolic acid is a drug with the potential to be repurposed for suppressing tumor growth and metastasis in osteosarcoma treatment

Identify old drugs as selective bacterial β‐GUS inhibitors by structural‐based virtual screening and bio‐evaluations

Old drugs in new therapeutic indications - the case of chloroquine

A botanical drug composed of three herbal materials attenuates the sensorimotor gating deficit and cognitive impairment induced by MK‐801 in mice

In silico drug repositioning: from large-scale transcriptome data to therapeutics

Influence of batch effect correction methods on drug induced differential gene expression profiles

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