Search results

article

Interoceptive conditioning in rats: Effects of using a single training dose or a set of 5 different doses of nicotine

Steven T. Pittenger, Rick A. Bevins, S.T. Pittenger, R.A. Bevins

Pharmacology, Biochemistry and Behavior > 2013 > 114-115 > Complete > 82-89

Interoceptive conditioning contributes to the tenacity of nicotine dependence. Previous research investigating nicotine as an interoceptive stimulus has typically employed administration of a single training dose of nicotine over an extended time. This approach has allowed for careful study of the nicotine stimulus. In humans, the nicotine stimulus is unlikely to be fixed across learning episodes...

article

Drug discrimination and neurochemical studies in α7 null mutant mice: tests for the role of nicotinic α7 receptors in dopamine release

Davide Quarta, Christopher G. Naylor, Jacques Barik, Cathy Fernandes, more

Psychopharmacology > 2009 > 203 > 2 > 399-410

Rationale The nicotine discriminative stimulus has been linked to β2-containing (β2*) nicotinic receptors, with little evidence of a role for α7 nicotinic receptors, because nicotine discrimination was very weak in β2 null mutant mice but normal in α7 mutants. Objectives As both α7 and β2* nicotinic receptors have been implicated in nicotine-stimulated dopamine overflow, this study focused on the...

article

Tailoring Electrode Surface Charge to Achieve Discrimination and Quantification of Chemically Similar Small Molecules with Electrochemical Aptamers

Vladimir Kesler, Kaiyu Fu, Yihang Chen, Chan Ho Park, more

Advanced Functional Materials > 33 > 1 > n/a - n/a

Electrochemical biosensors based on structure‐switching aptamers offer many advantages because they can operate directly in complex samples and offer the potential to integrate with miniaturized electronics. Unfortunately, these biosensors often suffer from cross‐reactivity problems when measuring a target in samples containing other chemically similar molecules, such as precursors or metabolites...

article

Tailoring Electrode Surface Charge to Achieve Discrimination and Quantification of Chemically Similar Small Molecules with Electrochemical Aptamers (Adv. Funct. Mater. 1/2023)

Vladimir Kesler, Kaiyu Fu, Yihang Chen, Chan Ho Park, more

Advanced Functional Materials > 33 > 1 > n/a - n/a

Electrochemical Aptamer Biosensors In article number 2208534, Fu, Soh, and co‐workers report an electrochemical biosensor to distinguish molecules with a minuscule difference in chemical composition by tuning the charge state of the surface on which the aptamer probes are immobilized. As an exemplar, it is shown that the strategy can distinguish between doxorubicin and many structurally similar analytes,...

article

2‐Fluorodeschloroketamine has similar abuse potential as ketamine

Feng Li, Han Du, Bo Wu, Jiayun Wei, more

Addiction Biology > 27 > 3 > n/a - n/a

2‐Fluorodeschloroketamine (2‐FDCK) as a substitute for ketamine has emerged among drug abusers in recent years. However, 2‐FDCK has not been controlled or regulated in many countries, which may be partly related to the lack of evidence on its abuse potential. In this study, we evaluated the abuse potential of 2‐FDCK via the tests of the conditioned place preference (CPP), locomotor sensitization,...

article

Behavioral effects of four novel synthetic cathinone analogs in rodents

Michael B. Gatch, Ritu A. Shetty, Nathalie Sumien, Michael J. Forster

Addiction Biology > 26 > 4 > n/a - n/a

A new generation of novel cathinone compounds has been developed as stimulant substitutes to avoid drug control laws and detection of use by blood tests. Dipentylone, N‐ethylhexedrone, 4‐chloroethcathinone (4‐CEC), and 4′‐methyl‐α‐pyrrolidinohexiophenone (MPHP) were tested for in vivo psychostimulant‐like effects to assess their abuse liability. Locomotor activity was assessed in an open‐field assay...

article

Low‐dose alcohol: Interoceptive and molecular effects and the role of dentate gyrus in rats

Patrick A. Randall, Dennis F. Lovelock, Kalynn VanVoorhies, Verda E. Agan, more

Addiction Biology > 26 > 3 > n/a - n/a

Alcohol abuse and dependence are world‐wide health problems. Most research on alcohol use focuses on the consequences of moderate to high levels of alcohol. However, even at low concentrations, alcohol is capable of producing effects in the brain that can ultimately affect behavior. The current studies seek to understand the effects of low‐dose alcohol (blood alcohol levels of ≤10mM). To do so, these...

article

Discriminative Stimulus Effects and Metabolism of Ethanol in Rhesus Monkeys

Daicia C. Allen, Kathleen A. Grant

Alcoholism: Clinical and Experimental Research > 43 > 9 > 1909 - 1917

Background Animal models are an essential feature of drug and pharmacotherapy development for treating alcohol use disorders (AUDs). The rhesus macaque is a robust animal model for many aspects of AUDs particularly in exploiting individual differences in oral self‐administration of ethanol (EtOH), endocrine orchestration of stress response, and menstrual cycle characteristics. However, the clearance...

article

GABA_A Receptor Subtypes and the Abuse‐Related Effects of Ethanol in Rhesus Monkeys: Experiments with Selective Positive Allosteric Modulators

Lais F. Berro, Daniela Rüedi‐Bettschen, Jemma E. Cook, Lalit K. Golani, more

Alcoholism: Clinical and Experimental Research > 43 > 5 > 791 - 802

Background Previous studies have investigated α1GABA_A and α5GABA_A receptor mechanisms in the behavioral effects of ethanol (EtOH) in monkeys. However, genetic studies in humans and preclinical studies with mutant mice suggest a role for α2GABA_A and/or α3GABA_A receptors in the effects of EtOH. The development of novel positive allosteric modulators (PAMs) with functional selectivity (i.e., selective...

article

Effects of dopaminergic and serotonergic compounds in rats trained to discriminate a high and a low training dose of the synthetic cathinone mephedrone

Iman Saber, Andrew Milewski, Allen B. Reitz, Scott M. Rawls, more

Psychopharmacology > 2019 > 236 > 3 > 1015-1029

Rationale The underlying pharmacological mechanisms of mephedrone, especially as related to interactions with different neurotransmitter systems, are a critical area of study as mephedrone continues to be abused. Objective Direct-acting 5-HT_2A/2C receptor agonists and antagonists and D_1–3 receptor antagonists were examined in two groups of rats trained to discriminate mephedrone. A high dose of...

article

Contribution of monoaminergic mechanisms to the discriminative stimulus effects of 3,4-methylenedioxypyrovalerone (MDPV) in Sprague-Dawley rats

Harmony I. Risca, Lisa E. Baker

Psychopharmacology > 2019 > 236 > 3 > 963-971

Rationale 3,4-Methylenedioxypyrovalerone (MDPV) is a popular synthetic cathinone reported to have a high abuse potential. Recent preclinical research indicates the psychopharmacology of MDPV is comparable to cocaine. Despite a recent influx of research on the psychopharmacology of MDPV, few studies have employed preclinical drug discrimination methods to discern the neurochemical mechanisms involved...

article

Effects of cocaine on the discriminative stimulus and reinforcing effects of mephedrone in male rats

Laura L. Erwin, Mark R. Nilges, Zachary B. Bondy, Peter J. Winsauer

Psychopharmacology > 2019 > 236 > 3 > 1043-1056

Rationale Abuse of cathinones has been a worldwide health concern for some time. Their chemical structures and wide variation in pharmacodynamic effects have led to clinical and preclinical effects that can be both similar to and different from other psychoactive substances such as methylenedioxymethamphetamine (MDMA), methamphetamine, and cocaine. Objective The present study examined the discriminative...

article

Evaluation of samidorphan, a μ‐opioid antagonist, in a drug discrimination assay in rats

Mario P. Sgro, Deah L. Modlin, Daniel R. Deaver, Mary J. Kallman, more

Drug Development Research > 79 > 5 > 234 - 238

Background: Samidorphan, a μ‐opioid receptor antagonist, is in clinical development for central nervous system related diseases. The discriminative stimulus effects of samidorphan were assessed in rats trained to discriminate the effects of a known morphinan of abuse, morphine, from that of saline. Methods: Escalating doses of samidorphan were substituted for morphine and rats were allowed to respond...

article

Functional role for suppression of the insular–striatal circuit in modulating interoceptive effects of alcohol

Anel A. Jaramillo, Verda E. Agan, Viren H. Makhijani, Stephen Pedroza, more

Addiction Biology > 23 > 5 > 1020 - 1031

The insular cortex (IC) is a region proposed to modulate, in part, interoceptive states and motivated behavior. Interestingly, IC dysfunction and deficits in interoceptive processing are often found among individuals with substance‐use disorders. Furthermore, the IC projects to the nucleus accumbens core (AcbC), a region known to modulate the discriminative stimulus/interoceptive effects of alcohol...

article

Nicotine drug discrimination and nicotinic acetylcholine receptors in differentially reared rats

Charles S. Bockman, Wanyun Zeng, Jamie Hall, Beth Mittelstet, more

Psychopharmacology > 2018 > 235 > 5 > 1415-1426

Rationale Individuals vary in sensitivity to the behavioral effects of nicotine, resulting in differences in vulnerability to nicotine addiction. The role of rearing environment in determining individual sensitivity to nicotine is unclear. The neuropharmacological mechanisms mediating the effect of rearing environment on the behavioral actions of nicotine are also poorly understood. Objectives The...

article

Mu-opioid peptide (MOP) and nociceptin/orphanin FQ peptide (NOP) receptor activation both contribute to the discriminative stimulus properties of cebranopadol in the rat

Thomas M. Tzschentke, Kris Rutten

Neuropharmacology > 2018 > 129 > C > 100-108

The novel potent analgesic cebranopadol is an agonist at nociceptin/orphanin FQ peptide (NOP) and classical opioid receptors, with the highest in-vitro activity at NOP and mu-opioid peptide (MOP) receptors, and somewhat lower activity at kappa-opioid peptide (KOP) and delta-opioid peptide (DOP) receptors. We addressed the question of which of these pharmacological activities contribute to the stimulus...

article

Δ⁹-Tetrahydrocannabinol-like discriminative stimulus effects of five novel synthetic cannabinoids in rats

Michael B. Gatch, Michael J. Forster

Psychopharmacology > 2018 > 235 > 3 > 673-680

Rationale and objectives Novel synthetic cannabinoid compounds continue to appear in the market advertised as legal alternatives to marijuana and the older synthetic cannabinoid compounds which are now controlled substances. Most of these newer compounds have been found to act at CB1 receptors, so the purpose of this study was to study the abuse liability of these compounds. Methods Five of these...

article

Discriminative stimulus and locomotor effects of para-substituted and benzofuran analogs of amphetamine

Sean B. Dolan, Michael J. Forster, Michael B. Gatch

Drug and Alcohol Dependence > 2017 > 180 > C > 39-45

Novel psychoactive substances have maintained a prominent role in the global drug culture, despite increased regulation by governing bodies. Novel compounds continue to become available on the market, often in “Ecstasy” or “Molly” formulations in lieu of MDMA, at a much faster rate than they can be properly characterized. The current study aimed to investigate the discriminative stimulus and locomotor...

article

Imidazoline I2 receptors: An update

Jun-Xu Li

Pharmacology & Therapeutics > 2017 > 178 > C > 48-56

Since first introduced more than two decades ago, the research in imidazoline I₂ receptors has been steadily increasing. This review provides an update on the current status of I₂ receptor pharmacology. Imidazoline I₂ receptors or I₂ binding sites refer to several (at least four) different proteins that bind to [³H]-idazoxan and [³H]-2-BFI with high affinity. The molecular identities of the proteins...

article

Inhibition of the endocannabinoid-regulating enzyme monoacylglycerol lipase elicits a CB1 receptor-mediated discriminative stimulus in mice

Robert A. Owens, Mohammed A. Mustafa, Bogna M. Ignatowska-Jankowska, M. Imad Damaj, more

Neuropharmacology > 2017 > 125 > C > 80-86

Substantial challenges exist for investigating the cannabinoid receptor type 1 (CB₁)-mediated discriminative stimulus effects of the endocannabinoids, 2-arachidonoylglycerol (2-AG) and N-arachidonoylethanolamine (anandamide; AEA), compared with exogenous CB₁ receptor agonists, such as Δ⁹-tetrahydrocannabinol (THC) and the synthetic cannabinoid CP55,940. Specifically, each endocannabinoid is rapidly...

INFONA - science communication portal

Search results

Interoceptive conditioning in rats: Effects of using a single training dose or a set of 5 different doses of nicotine

Drug discrimination and neurochemical studies in α7 null mutant mice: tests for the role of nicotinic α7 receptors in dopamine release

Tailoring Electrode Surface Charge to Achieve Discrimination and Quantification of Chemically Similar Small Molecules with Electrochemical Aptamers

Tailoring Electrode Surface Charge to Achieve Discrimination and Quantification of Chemically Similar Small Molecules with Electrochemical Aptamers (Adv. Funct. Mater. 1/2023)

2‐Fluorodeschloroketamine has similar abuse potential as ketamine

Behavioral effects of four novel synthetic cathinone analogs in rodents

Low‐dose alcohol: Interoceptive and molecular effects and the role of dentate gyrus in rats

Discriminative Stimulus Effects and Metabolism of Ethanol in Rhesus Monkeys

GABA_A Receptor Subtypes and the Abuse‐Related Effects of Ethanol in Rhesus Monkeys: Experiments with Selective Positive Allosteric Modulators

Effects of dopaminergic and serotonergic compounds in rats trained to discriminate a high and a low training dose of the synthetic cathinone mephedrone

Contribution of monoaminergic mechanisms to the discriminative stimulus effects of 3,4-methylenedioxypyrovalerone (MDPV) in Sprague-Dawley rats

Effects of cocaine on the discriminative stimulus and reinforcing effects of mephedrone in male rats

Evaluation of samidorphan, a μ‐opioid antagonist, in a drug discrimination assay in rats

Functional role for suppression of the insular–striatal circuit in modulating interoceptive effects of alcohol

Nicotine drug discrimination and nicotinic acetylcholine receptors in differentially reared rats

Mu-opioid peptide (MOP) and nociceptin/orphanin FQ peptide (NOP) receptor activation both contribute to the discriminative stimulus properties of cebranopadol in the rat

Δ⁹-Tetrahydrocannabinol-like discriminative stimulus effects of five novel synthetic cannabinoids in rats

Discriminative stimulus and locomotor effects of para-substituted and benzofuran analogs of amphetamine

Imidazoline I2 receptors: An update

Inhibition of the endocannabinoid-regulating enzyme monoacylglycerol lipase elicits a CB1 receptor-mediated discriminative stimulus in mice

Filter options

Publication date

Content availability

Publication type

Publication language

Keywords

Data set

INFONA - science communication portal

Search results

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Content availability

Publication type

Publication language

Keywords

Data set

Reporting an error / abuse

Sending the report failed

Accessibility options