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article

A multimodal neuroimaging study of a case of crossed nonfluent/agrammatic primary progressive aphasia

Edoardo G. Spinelli, Francesca Caso, Federica Agosta, Giuseppe Gambina, more

Journal of Neurology > 2015 > 262 > 10 > 2336-2345

Crossed aphasia has been reported mainly as post-stroke aphasia resulting from brain damage ipsilateral to the dominant right hand. Here, we described a case of a crossed nonfluent/agrammatic primary progressive aphasia (nfvPPA), who developed a corticobasal syndrome (CBS). We collected clinical, cognitive, and neuroimaging data for four consecutive years from a 55-year-old right-handed lady (JV)...

article

Diagnosis and Treatment of Corticobasal Degeneration

Melissa J. Armstrong

Current Treatment Options in Neurology > 2014 > 16 > 3 > 1-12

Opinion statement Corticobasal degeneration is a pathologic entity. Presenting clinical phenotypes include corticobasal syndrome (CBS), frontal behavioral spatial syndrome, aphasia, progressive supranuclear palsy-like syndrome (PSPS), and a predominantly cognitive phenotype often mistaken for Alzheimer’s disease (AD). Treatment of CBD is symptomatic, particularly given recently negative neuroprotective...

article

Could a structural damage mimic a Parkinson plus syndrome?

Athanasia Alexoudi, Ioannis Zalonis, Pantelis Stathis

Open Medicine > 2013 > 8 > 4 > 450-454

Corticobasal syndrome (CBS) is a progressive disease that includes a heterogeneous neuropathological spectrum. In the majority of cases, corticobasal degeneration (CBD) is the underlying disease. Clinical heterogeneity is reflected in the clinical presentation of the syndrome and consequently misdiagnosis is common. Our case is of interest because the symptoms, the poor response to L-dopa and the...

article

Could a structural damage mimic a Parkinson plus syndrome?

Athanasia Alexoudi, Ioannis Zalonis, Pantelis Stathis

Open Medicine > 2013 > 8 > 4 > 450-454

article

Screening for C9orf72 repeat expansions in parkinsonian syndromes

Tu-Hsueh Yeh, Szu-Chia Lai, Yi-Hsin Weng, Hung-Chou Kuo, more

Neurobiology of Aging > 2013 > 34 > 4 > 1311.e3-1311.e4

Parkinsonism might precede, coincide, or follow the behavioral or language-predominant cognitive impairments characteristic of frontotemporal dementia (FTD). In this study, we analyze the hexanucleotide repeat expansions within C9orf72 gene in various parkinsonian syndromes because it is a recently identified important genetic cause of FTD. The expanded hexanucleotide repeat is only identified in...

article

Could a structural damage mimic a Parkinson plus syndrome?

Athanasia Alexoudi, Ioannis Zalonis, Pantelis Stathis

Central European Journal of Medicine > 2013 > 8 > 4 > 450-454

article

Symmetrical Corticobasal Syndrome Caused by a Novel c.314dup Progranulin Mutation

Elise G. P. Dopper, Harro Seelaar, Wang Zheng Chiu, Inge Koning, more

Journal of Molecular Neuroscience > 2011 > 45 > 3 > 354-358

Corticobasal syndrome (CBS) is characterised by asymmetrical parkinsonism and cognitive impairment. The underlying pathology varies between corticobasal degeneration, progressive supranuclear palsy, Alzheimer’s disease, Creutzfeldt–Jakob disease and frontotemporal lobar degeneration sometimes in association with GRN mutations. A 61-year-old male underwent neurological examination, neuropsychological...

article

The many faces of corticobasal degeneration

Pettarusp M. Wadia, Anthony E. Lang

Parkinsonism and Related Disorders > 2007 > 13 > Supplement 3 > S336-S340

Corticobasal degeneration (CBD) has characteristic neuropathological features, but is a clinically heterogeneous disorder. It can present with various clinical syndromes. The corticobasal syndrome (CBS) is the best recognized and over the course of the illness may be the most common manifestation. Dementia, progressive non-fluent aphasia, speech apraxia, progressive supranuclear palsy (PSP)-like syndrome...

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Keywords

CORTICOBASAL SYNDROME (CBS) (8)
CORTICIBASAL DEGENERATION (CBD) (3)
I123 IOFLUPANE CIT SPECT (DAT-SCAN) (3)
VASCULAR DEMENTIA (3)
CORTICOBASAL DEGENERATION (CBD) (2)
FRONTOTEMPORAL DEMENTIA (FTD) (2)
PROGRANULIN (GRN) (1)
18-FLUORODEOXYGLUCOSE POSITRON EMISSION TOMOGRAPHY (18F-FDG PET) (1)
ATYPICAL PARKINSONISM (1)
BEHAVIORAL SYMPTOMS (1)
C9ORF72 (1)
COGNITIVE SYMPTOMS (1)
CROSSED APHASIA (1)
DEMENTIA (1)
DEMENTIA WITH LEWY BODIES (DLB) (1)
DIAGNOSTIC CRITERIA (1)
DIFFUSION TENSOR TRACTOGRAPHY (1)
FRONTOTEMPORAL LOBAR DEGENERATION (FTLD) (1)
FUNCTIONAL MRI (1)
GGGGCC HEXANUCLEOTIDE REPEAT EXPANSION (1)
MOTOR SYMPTOMS (1)
NEURODEGENERATIVE DISEASE (1)
NONFLUENT/AGRAMMATIC PRIMARY PROGRESSIVE APHASIA (NFVPPA) (1)
PARKINSON'S DISEASE WITH DEMENTIA (PDD) (1)
PROGRESSIVE CORTICAL ATROPHY SYNDROME (1)
PROGRESSIVE NON-FLUENT APHASIA (1)
PROGRESSIVE SUPRANUCLEAR PALSY (PSP) (1)
SPEECH APRAXIA (1)
TAU (1)
TAUOPATHY (1)
TDP-43 (1)
TREATMENT (1)
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Springer (4)
Elsevier (2)
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