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Items from 1 to 20 out of 3,042 results

article

Distribution of water-soluble inorganic ions in the soils of Cyprus

Andreas M. Zissimos, Irene C. Christoforou, Eleni Morisseau, David R. Cohen, more

Journal of Geochemical Exploration > 2014 > 146 > Complete > 1-8

The water-soluble anion content of soils reflects variable input of geogenic and anthropogenic influences, and is an important indicator of soil fertility, the existence or risk of salinization and effects of other pollutants. A rapid ion chromatography method has been used to determine the concentration of water-soluble F ⁻ , Cl ⁻ , NO ₃ ⁻ and SO ₄ ²⁻ on a...

article

Teflon-HPLC: A novel chromatographic system for application to isotope geochemistry and other industries

T.J. Ireland, F.L.H. Tissot, R. Yokochi, N. Dauphas, more

Chemical Geology > 2013 > 357 > Complete > 203-214

Traditional column chromatography techniques are restricted by several factors, including limitations on column length, resin grain size, elution time, and a general inability to slowly ramp up or down reagent concentrations along a gradient. Likewise, most existing high-performance liquid chromatography (HPLC) systems are not amenable to certain column chromatography techniques that require highly...

article

Chiral initiator-induces self-disproportionation of enantiomers via achiral chromatography: application to enantiomer separation of racemate

Kaori Tateishi, Shiori Tsukagoshi, Tsuyoshi Nakamura, Shotaro Watanabe, more

Tetrahedron Letters > 2013 > 54 > 38 > 5220-5223

We report here the theoretical design and proof of principle of the first example of a conceptually new approach for the preparation of enantiomerically pure compounds from the racemates by chiral initiator-induced Self-Disproportionation of Enantiomers (SDE) via achiral chromatography.

article

Coupled affinity and sizing chromatography: A novel in-process analytical tool to measure titer and trend Fc-protein aggregation

Martin Lemmerer, Anne Serdakowski London, Alexandra Panicucci, Cristina Gutierrez-Vargas, more

Journal of Immunological Methods > 2013 > 393 > 1-2 > 81-85

The expanding use of monoclonal antibodies in the biopharmaceuticals industry has brought the need for new analytical tools. We have developed a coupled affinity and gel-filtration high-performance liquid chromatography method to simultaneously analyze titer and quality of monoclonal antibodies. Before this assay, available analytical methods for protein aggregation required highly purified proteins...

chapter

Antifungal efficacy of pyocyanin produced from bioindicators of nosocomial hazards

T. Sudhakar, S. Karpagam

International Conference on Green technology and environmental Conservation (GTEC-2011) > 224 - 229

2011 International Conference on Green Technology and Environmental Conservation (GTEC 2011)

Pseudomonas, a common bacterium is found in soil, water, skin flora and in most of the man made environments such as Hospital, Industry, Effluent treatment plant. Pseudomonas aeruginosa one of the most important opportunistic pathogen which causes nosocomial infections to the patient in Intensive care unit has become a major threat in the medical care. It also exhibits multidrug resistance which has...

article

Phytochemical Characterization of Cannabis sativa L. Roots from Northeastern Brazil

Janaine Almeida Neto, Daniel Amando Nery, Katia Simoni Bezerra Lima, Maria Eduarda Gomes da Cruz Silva, more

Chemistry & Biodiversity > 20 > 3 > n/a - n/a

This article describes the phytochemical study of Cannabis sativa roots from northeastern Brazil. The dried plant material was pulverized and subjected to exhaustive maceration with ethanol at room temperature, obtaining the crude ethanolic extract (Cs‐EEBR). The volatile compounds were analyzed by gas chromatography coupled with mass spectrometry (GC/MS), which allowed to identify 22 compounds by...

article

PlasmaCap EBA: An innovative method of isolating plasma proteins from human plasma

David Miller, Gillian Vanderlee, Olivier Vaute, Mark Krause

Vox Sanguinis > 118 > 2 > 128 - 137

Background and Objectives The growing demand for immunoglobulin (IG) requires development of improved plasma fractionation methods to provide higher yields in a cost effective, scalable manner without compromising product purity and efficacy. A novel protein extraction method, utilizing expanded bed adsorption (EBA) chromatography, has been developed. PlasmaCap IG (10% liquid formulation intravenous...

article

Increasing yield of in vitro transcription reaction with at‐line high pressure liquid chromatography monitoring

Domen Pregeljc, Janja Skok, Tina Vodopivec, Nina Mencin, more

Biotechnology and Bioengineering > 120 > 3 > 737 - 747

The COVID‐19 pandemic triggered an unprecedented rate of development of messenger ribonucleic acid (mRNA) vaccines, which are produced by in vitro transcription reactions. The latter has been the focus of intense development to increase productivity and decrease cost. Optimization of in vitro transcription (IVT) depends on understanding the impact of individual reagents on the kinetics of mRNA production...

article

Comprehensive studies on building a scalable downstream process for mRNAs to enable mRNA therapeutics

Tingting Cui, Kareem Fakhfakh, Hannah Turney, Gülin Güler‐Gane, more

Biotechnology Progress > 39 > 1 > n/a - n/a

In recent years, mRNA‐based therapeutics have been a fast‐growing new class of biologics that can, in principle, encode any protein(s) directly in patients to treat various diseases. mRNA vaccines have been proven to work efficiently, have high potency, and can be rapidly developed and deployed, which is critical for a quick responses in the case of a pandemic. Such agile development is enabled by...

article

Evaluation of the Amazonian fruit Ambelania acida: Chemical and nutritional studies

Pollyane Gomes Corrêa, Leonardo Gomes Sanders Moura, Ana Claudia Fernandes Amaral, Maíra Martins H. de Almeida, more

Journal of Food Science > 88 > 2 > 757 - 771

Ambelania acida is native to the Amazon region, with few published studies of its fruits. We examined the proximate composition of its fruits, including minerals, fatty acids, volatile organic compounds (VOCs), as well as its antioxidant capacity. The protein contents (2.61%) of the pulp and seeds (13.6%) were higher than observed in other taxa of the family or in other tropical fruits. Peel and pulp...

article

Recent advances in top‐down proteome sample processing ahead of MS analysis

Jessica L. Nickerson, Venus Baghalabadi, Subin R. C. K. Rajendran, Philip J. Jakubec, more

Mass Spectrometry Reviews > 42 > 2 > 457 - 495

Top‐down proteomics is emerging as a preferred approach to investigate biological systems, with objectives ranging from the detailed assessment of a single protein therapeutic, to the complete characterization of every possible protein including their modifications, which define the human proteoform. Given the controlling influence of protein modifications on their biological function, understanding...

article

A Novel, Laser‐Based Microsampling Technique for Texturally Controlled, Combined and Complementary Sr and Nd Isotope Measurements in Silicate Minerals

Andrew S. Logue, Grant M. Bybee, Michael J. Tappa, Ethan Baxter, more

Geostandards and Geoanalytical Research > 46 > 4 > 789 - 809

The limitations of many in situ microsampling techniques, especially when applied to isotopic analyses, may result in lower measurement precision and limit the ability to compare different isotope systems within the same phase or the same isotope system between phases. High‐precision, combined and complementary isotopic measurements are typically limited to whole‐rock samples or mineral separates...

article

Gram‐Scale mRNA Production Using a 250‐mL Single‐Use Bioreactor

Janja Skok, Polona Megušar, Tina Vodopivec, Domen Pregeljc, more

Chemie Ingenieur Technik > 94 > 12 > 1928 - 1935

The COVID‐19 pandemic triggered an unprecedented surge in development of mRNA‐based vaccines. Despite the need to increase process productivity and thus decrease the cost of mRNA vaccines, limited scientific literature is available on strategies to increase the yield of in vitro transcription (IVT) reaction, the unit operation with highest cost of goods, which has traditionally been performed as a...

article

White wine phenolics: current methods of analysis

Sarah Clarke, Gurthwin Bosman, Wessel Toit, Jose Luis Aleixandre‐Tudo

Journal of the Science of Food and Agriculture > 103 > 1 > 7 - 25

White wine phenolic analyses are less common in the literature than analyses of red wine phenolics. Analytical techniques for white wine phenolic analyses using spectrophotometric, chromatographic, spectroscopic, and electrochemical methods are reported. The interest of research in this area combined with the advances in technology aimed at the winemaking industry are promoting the establishment of...

article

Dual‐Gradient Unified Chromatography: A New Paradigm for Versatility in Simultaneous Multicomponent Analysis

Gioacchino Luca Losacco, Raffeal Bennett, Imad A. Haidar Ahmad, Rodell C. Barrientos, more

Angewandte Chemie International Edition > 61 > 45 > n/a - n/a

Generality in analytical chemistry can be manifested in impactful platforms that can streamline modern organic synthesis and biopharmaceutical processes. We herein introduce a hybrid separation technique named Dual‐Gradient Unified Chromatography (DGUC), which is built upon an automated dynamic modulation of CO₂, organic modifier, and water blends with various buffers. This concept enables simultaneous...

article

Dual‐Gradient Unified Chromatography: A New Paradigm for Versatility in Simultaneous Multicomponent Analysis

Gioacchino Luca Losacco, Raffeal Bennett, Imad A. Haidar Ahmad, Rodell C. Barrientos, more

Angewandte Chemie > 134 > 45 > n/a - n/a

article

Application crude multienzyme extract from Aspergillus niger as a pretreatment for the extraction of essential oil from Croton argyrophyllus leaves

Matheus Andrade Rocha Costa, Simone Andrade Gualberto, Polyany Cabral Oliveira, Iasnaia Maria de Carvalho Tavares, more

Biotechnology and Applied Biochemistry > 69 > 5 > 1843 - 1856

Leaves of Croton argyrophyllus contain essential oil with promising active components for the development of drugs and botanical insecticides. In this study, we evaluated the enzymatic pretreatment process to increase the extraction of essential oil from fresh and dried leaves of C. argyrophyllus. Pretreatment was carried out using a crude multienzymatic extract obtained via solid‐state fermentation...

article

Big (Bio)Chemical Data Mining Using Chemometric Methods: A Need for Chemists

Hadi Parastar, Roma Tauler

Angewandte Chemie International Edition > 61 > 44 > n/a - n/a

This Review summarizes how big (bio)chemical data (BBCD) can be analyzed with multivariate chemometric methods and highlights some of the important challenges faced by modern analytical researches. Here, the potential of chemometric methods to solve BBCD problems that are being encountered in chromatographic, spectroscopic and hyperspectral imaging measurements will be discussed, with an emphasis...

article

Big (Bio)Chemical Data Mining Using Chemometric Methods: A Need for Chemists

Hadi Parastar, Roma Tauler

Angewandte Chemie > 134 > 44 > n/a - n/a

article

Determination of the geographic origin of 52 honey samples based on the assessment of anionic content profiling with a new algorithm using monolithic column‐based micellar nano‐liquid chromatography

Hakiye Aslan, Zeynep Günyel, Turan Sarıkaya, Sedat Golgiyaz, more

Journal of Food Science > 87 > 10 > 4636 - 4648

Abstract In the present study, a new micellar nano LC‐UV was, for the first time, reported for the separation and determination of five anions (chloride, nitrite, bromide, sulfate and nitrate) in 52 honey samples. Based on this approach, a graphene oxide‐based monolithic column was prepared and applied for the samples. Various amounts of hexadecyltrimethyl‐ammonium bromide (HTAB) in the mobile phase...

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Search results

Distribution of water-soluble inorganic ions in the soils of Cyprus

Teflon-HPLC: A novel chromatographic system for application to isotope geochemistry and other industries

Chiral initiator-induces self-disproportionation of enantiomers via achiral chromatography: application to enantiomer separation of racemate

Coupled affinity and sizing chromatography: A novel in-process analytical tool to measure titer and trend Fc-protein aggregation

Antifungal efficacy of pyocyanin produced from bioindicators of nosocomial hazards

Phytochemical Characterization of Cannabis sativa L. Roots from Northeastern Brazil

PlasmaCap EBA: An innovative method of isolating plasma proteins from human plasma

Increasing yield of in vitro transcription reaction with at‐line high pressure liquid chromatography monitoring

Comprehensive studies on building a scalable downstream process for mRNAs to enable mRNA therapeutics

Evaluation of the Amazonian fruit Ambelania acida: Chemical and nutritional studies

Recent advances in top‐down proteome sample processing ahead of MS analysis

A Novel, Laser‐Based Microsampling Technique for Texturally Controlled, Combined and Complementary Sr and Nd Isotope Measurements in Silicate Minerals

Gram‐Scale mRNA Production Using a 250‐mL Single‐Use Bioreactor

White wine phenolics: current methods of analysis

Dual‐Gradient Unified Chromatography: A New Paradigm for Versatility in Simultaneous Multicomponent Analysis

Dual‐Gradient Unified Chromatography: A New Paradigm for Versatility in Simultaneous Multicomponent Analysis

Application crude multienzyme extract from Aspergillus niger as a pretreatment for the extraction of essential oil from Croton argyrophyllus leaves

Big (Bio)Chemical Data Mining Using Chemometric Methods: A Need for Chemists

Big (Bio)Chemical Data Mining Using Chemometric Methods: A Need for Chemists

Determination of the geographic origin of 52 honey samples based on the assessment of anionic content profiling with a new algorithm using monolithic column‐based micellar nano‐liquid chromatography

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