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Items from 1 to 20 out of 310 results

article

Choriocarcinoma in neonates and infants: A severe but curable disease

Marie Pierre Castex, Joanna Stefanowicz, Laura Clement, Jadwiga Węcławek‐Tompol, more

Pediatric Blood & Cancer > 71 > 8 > n/a - n/a

Choriocarcinoma in neonates and infants (N‐CC) is an extremely rare, but aggressive cancer, frequently observed with concomitant maternal disease. A retrospective, bi‐national study of patients treated in France and Poland for infantile choriocarcinoma analysed eight cases of N‐CC, median age of 6 weeks. All tumours were diffuse. Six patients received a platinum‐based regimen, and five had delayed...

article

Primary mediastinal choriocarcinoma in an 18‐year‐old male with pulmonary and brain metastasis: A case report

Hanlin Wang, Xiu Chen, Renquan Zhang

The Clinical Respiratory Journal > 17 > 10 > 1082 - 1087

Primary mediastinal choriocarcinoma, also known as non‐pregnant choriocarcinoma, is a rare malignancy unrelated to pregnancy, with a higher incidence in males. And primary mediastinal choriocarcinoma is mostly associated with organ and lymph node metastasis, with rapid progression and poor prognosis. Here, we report an extremely rare case of the primary anterior mediastinal choriocarcinoma that occurred...

article

Rolipram suppresses migration and invasion of human choriocarcinoma cells by inhibiting phosphodiesterase 4‐mediated epithelial‐mesenchymal transition

Yaqing Huang, Yanmei Zheng, Qianqian Wang, Caixia Qi

Journal of Biochemical and Molecular Toxicology > 37 > 7 > n/a - n/a

Rolipram is a selective phosphodiesterase‐4 (PDE4) inhibitor. The effect of rolipram on the metastasis of choriocarcinoma is barely known. Here, we evaluated the role of rolipram in the migration and invasion of human choriocarcinoma cells in vitro. Human choriocarcinoma cells lines JEG3 and JAR were used in this study. The expression profile of PDE4 subfamily members in choriocarcinoma cells was...

article

Short tandem repeat polymorphism analysis for primary peritoneal choriocarcinoma: A case report and literature review

Kota Yamauchi, Yukiyasu Sato, Hirokazu Usui, Azusa Sakurai, more

Journal of Obstetrics and Gynaecology Research > 48 > 10 > 2640 - 2646

The peritoneum is an extremely rare site for primary choriocarcinoma development. Primary peritoneal choriocarcinoma could be either gestational or nongestational, whereas it is straightforward to ascribe uterine or tubal choriocarcinoma to the gestational origin. Herein, we report a case of primary peritoneal choriocarcinoma that is genetically diagnosed as a gestational subtype originating from...

article

PD‐L1 in gestational trophoblastic disease: an antibody evaluation

Yvonne M. Hoeijmakers, Michiel Simons, Johan Bulten, Mark A. J. Gorris, more

Acta Obstetricia et Gynecologica Scandinavica > 101 > 9 > 1007 - 1016

Introduction Treatment with antibodies directed against programed‐cell death ligand 1 (PD‐L1) is a novel therapy for patients with gestational trophoblastic disease. Assessment of PD‐L1 expression in tumor tissue is commonly used to identify patients who might benefit from anti‐PD‐L1 treatment. Multiple antibodies are available to detect PD‐L1‐expressing cells, and percentages of PD‐L1‐expressing...

article

Culture strategy as a modulator of target assessments: Functionality of suspension versus hanging drop‐derived choriocarcinoma spheroids as in vitro model of embryo implantation

Mahsa Kazemi, Vahid Jajarmi, Hamid Nazarian, Marefat Ghaffari Novin, more

Journal of Cellular Biochemistry > 122 > 9 > 1192 - 1206

The choriocarcinoma spheroid model has been amply applied to study the underlying molecular mechanism of implantation. Reproducibility and functionality of spheroid tumor models were addressed precisely. To mimic embryo‐endometrium crosstalk, no functional characteristics of spheroids have been provided based on culture strategies. In this study, choriocarcinoma spheroids were provided as suspension...

article

miR‐373‐3p inhibits epithelial–mesenchymal transition via regulation of TGFβR2 in choriocarcinoma

Yanjie Lu, Xiaoru Li, Yanzhen Zuo, Qian Xu, more

Journal of Obstetrics and Gynaecology Research > 47 > 7 > 2417 - 2432

Aim Previous studies have indicated that early metastasis is a major cause of mortality in patients with choriocarcinoma. However, what determines whether early metastasis of choriocarcinoma has occurred is unknown. The emerging role of miRNA in regulating cancer development and progression has been recognized. miR‐373 has been shown to play pivotal roles in tumorigenesis and metastasis. However,...

article

Primary mediastinal choriocarcinoma presenting as cutaneous metastasis with resistance to chemotherapy: case report and literature review

Khaled A. Murshed, Aladdin Kanbour, Mohammed Akhtar, Samir Al Hyassat

Journal of Cutaneous Pathology > 48 > 1 > 81 - 85

Cutaneous metastases of choriocarcinoma are rare. They may indicate poor prognosis and resistance to chemotherapy. In this report, we present a case of a 25‐year‐old man who presented with central pleuritic chest pain and right upper arm mass for about a week. The patient also had significant weight loss during the last 5 months along with an episode of generalized seizure. Chest computed tomography...

article

Demographics, natural history and treatment outcomes of non‐molar gestational choriocarcinoma: a UK population study

P Savage, M Winter, V Parker, V Harding, more

BJOG: An International Journal of Obstetrics & Gynaecology > 127 > 9 > 1102 - 1107

Objective To investigate the demographics, natural history and treatment outcomes of non‐molar gestational choriocarcinoma. Design A retrospective national population‐based study. Setting UK 1995–2015. Population A total of 234 women with a diagnosis of gestational choriocarcinoma, in the absence of a prior molar pregnancy, managed at the UKs two gestational trophoblast centres in London and...

article

Frequent EGFR expression/EGFR amplification and lack of activating mutation in testicular choriocarcinoma

Kosuke Miyai, Keiichi Ito, Susumu Matsukuma, Hitoshi Tsuda

Pathology International > 70 > 5 > 262 - 269

Choriocarcinoma (CC) is the rarest but most aggressive histological component of adult testicular germ cell tumor (TGCT). Although we previously reported a putative role of epidermal growth factor receptor (EGFR) alterations in the progression of CC, little is known about the kinase‐activating mutation status of EGFR, which predicts the response to EGFR‐tyrosine kinase inhibitors. In this study, we...

article

MEG3 is restored by schisandrin A and represses tumor growth in choriocarcinoma cells

Li Ji, Li Ma

Journal of Biochemical and Molecular Toxicology > 34 > 4 > n/a - n/a

Schisandrin A (SchA) has been reported as a multidrug resistance‐reversing agent; however, its antitumor effects have been rarely reported. Consequently, we attempted to explore whether SchA per se possesses an antitumor property in choriocarcinoma JEG‐3 and BeWo cells and its potential mechanisms. JEG‐3, BeWo, and HTR‐8/SVneo cells were stimulated with SchA at different concentrations (10‐100 μM),...

article

Retracted: Long noncoding RNA MEG3 is a tumor suppressor in choriocarcinoma by upregulation of microRNA‐211

Li Ji, Xue Li

Journal of Cellular Physiology > 234 > 12 > 22911 - 22920

Tumor suppressor long noncoding RNA maternally expressed gene 3 (lncRNA MEG3) exists in various cancers. Nonetheless, the functions of lncRNA MEG3 in choriocarcinoma (CC) are still not well studied. We explored the effects of lncRNA MEG3 on human CC JEG‐3 and BeWo cells. lncRNA MEG3 was overexpressed, and the effects of lncRNA MEG3 on cell viability, proliferation, apoptosis, migration, and invasion...

article

Lidocine potentiates the cytotoxicity of 5‐fluorouracil to choriocarcinoma cells by downregulating ABC transport proteins expression

Xue Zhang, Wenwen Pang, Hong Liu, Juan Wang

Journal of Cellular Biochemistry > 120 > 10 > 16533 - 16542

Choriocarcinoma is a gestational trophoblastic cancer, which often occurs in the first 3 months of pregnancy. 5‐Fluorouracil (5‐Fu) is the widely used chemotherapeutic drug for choriocarcinoma but limited by drug resistance. Lidocaine, an aminamide‐type anesthetic, shows potential anticancer and chemosensitization effects in recent years. Herein, we tested the possible chemosensitization activity...

article

Using short tandem repeat analysis for choriocarcinoma diagnosis: a case series

Xiaofei Zhang, Kai Yan, Jianhua Chen, Xing Xie

Diagnostic Pathology > 2019 > 14 > 1 > 1-13

Background Choriocarcinoma is a highly aggressive, malignant trophoblastic neoplasm that can be gestational or non-gestational in origin. Accurate discrimination between these two subtypes, the causative pregnancy type, and the pregnancy-to-treatment interval for gestational choriocarcinoma are vital for clinical management. Methods Fifteen choriocarcinomas were genotyped using multiplex fluorescent...

article

A case of intraplacental gestational choriocarcinoma; characterised by the methylation pattern of the early placenta and an absence of driver mutations

Philip Savage, David Monk, Jose R. Hernandez Mora, Nick Westhuizen, more

BMC Cancer > 2019 > 19 > 1 > 1-10

Background Gestational choriocarcinoma is a rare malignancy believed to arise from the trophoblast cells of the placenta. Despite the frequently aggressive clinical nature, choriocarcinoma has been routinely curable with cytotoxic chemotherapy for over 50 years. To date little is known regarding the route to oncogenesis in this malignancy. Methods In a case of intraplacental choriocarcinoma, we...

article

Primary non‐gestational uterine choriocarcinoma mimicking leiomyoma

Rikiya Sano, Takuya Moriya, Soichiro Suzuki, Wataru Saito, more

Pathology International > 69 > 3 > 160 - 164

Uterine choriocarcinoma is a trophoblastic neoplasm that is most commonly gestational but can also be non‐gestational in origin. However, primary non‐gestational uterine choriocarcinoma is very rare, with only few cases having been reported. We report a case of a premenopausal woman who had initially been diagnosed with myoma delivery but who was discovered to have primary non‐gestational uterine...

article

Oral etoposide for metastatic choriocarcinoma: a case report and review of guidelines

Georg-Peter Breitbach, Panagiotis Sklavounos, Christian Veith, Serban-Dan Costa, more

Archives of Gynecology and Obstetrics > 2019 > 299 > 4 > 1115-1119

Background and purpose Choriocarcinoma (CCA) is a rare form of malignant trophoblastic disease. Systemic polychemotherapy with etoposide, methotrexate, actinomycin D, cyclophosphamide, and vincristine (EMA/CO) is the mainstay of treatment for metastatic disease. Due to the rarity of the condition, however, the evidence basis for this management is small and other chemotherapy regimens may also be...

article

Carvacrol induces mitochondria‐mediated apoptosis via disruption of calcium homeostasis in human choriocarcinoma cells

Whasun Lim, Jiyeon Ham, Fuller W. Bazer, Gwonhwa Song

Journal of Cellular Physiology > 234 > 2 > 1803 - 1815

Carvacrol is a monoterpenoid phenol present in the oils of various plants including Origanum vulgare (oregano) or Origanum majorana (marjoram). For a long time, it has been used as spice in foods because of its antimicrobial properties. Additionally, it appears to have anticancer effects against some cancer but this has not been well studied. Therefore, we conducted various assays to confirm the effects...

article

Gestational trophoblastic neoplasia with brain metastasis at initial presentation: a retrospective study

Déborah Gavanier, Hélène Leport, Jérome Massardier, Fatima Abbas, more

International Journal of Clinical Oncology > 2019 > 24 > 2 > 153-160

Objective To evaluate the survival and functional outcome of patients with brain metastasis due to gestational trophoblastic neoplasia (GTN). Methods A 17-year retrospective study based on case review of women with brain metastasis from GTN identified by the electronic databases held in the French Reference Centre. Primary outcome measure: 5-year overall survival calculated with the Kaplan–Meier...

article

Histopathologie und Klinik der Extrauteringravidität

L.-C. Horn, S. Opitz, R. Handzel, C. E. Brambs

Der Pathologe > 2018 > 39 > 5 > 431-444

Die extrauterine Gravidität (EUG) geht mit einer klinisch relevanten Morbidität und Mortalität im ersten Trimester einher. In der Majorität ist die EUG im ampullären Teil der Tube lokalisiert. Die Häufigkeit steigt im Rahmen einer künstlichen Befruchtung, bei einer Erstschwangerschaft in höherem Alter und bei vorherigen Adnexeingriffen. Es soll ein Überblick über die klinischen Aspekte und die diagnostischen...

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Choriocarcinoma in neonates and infants: A severe but curable disease

Primary mediastinal choriocarcinoma in an 18‐year‐old male with pulmonary and brain metastasis: A case report

Rolipram suppresses migration and invasion of human choriocarcinoma cells by inhibiting phosphodiesterase 4‐mediated epithelial‐mesenchymal transition

Short tandem repeat polymorphism analysis for primary peritoneal choriocarcinoma: A case report and literature review

PD‐L1 in gestational trophoblastic disease: an antibody evaluation

Culture strategy as a modulator of target assessments: Functionality of suspension versus hanging drop‐derived choriocarcinoma spheroids as in vitro model of embryo implantation

miR‐373‐3p inhibits epithelial–mesenchymal transition via regulation of TGFβR2 in choriocarcinoma

Primary mediastinal choriocarcinoma presenting as cutaneous metastasis with resistance to chemotherapy: case report and literature review

Demographics, natural history and treatment outcomes of non‐molar gestational choriocarcinoma: a UK population study

Frequent EGFR expression/EGFR amplification and lack of activating mutation in testicular choriocarcinoma

MEG3 is restored by schisandrin A and represses tumor growth in choriocarcinoma cells

Retracted: Long noncoding RNA MEG3 is a tumor suppressor in choriocarcinoma by upregulation of microRNA‐211

Lidocine potentiates the cytotoxicity of 5‐fluorouracil to choriocarcinoma cells by downregulating ABC transport proteins expression

Using short tandem repeat analysis for choriocarcinoma diagnosis: a case series

A case of intraplacental gestational choriocarcinoma; characterised by the methylation pattern of the early placenta and an absence of driver mutations

Primary non‐gestational uterine choriocarcinoma mimicking leiomyoma

Oral etoposide for metastatic choriocarcinoma: a case report and review of guidelines

Carvacrol induces mitochondria‐mediated apoptosis via disruption of calcium homeostasis in human choriocarcinoma cells

Gestational trophoblastic neoplasia with brain metastasis at initial presentation: a retrospective study

Histopathologie und Klinik der Extrauteringravidität

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