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Items from 1 to 20 out of 4,655 results

article

Capillary electrophoresis fingerprinting of 8-aminopyrene-1,3,6-trisulfonate derivatized nitrocellulose after partial acid depolymerization

Elodie Alinat, Nathalie Delaunay, Cédric Przybylski, Régis Daniel, more

Journal of Chromatography A > 2015 > 1387 > Complete > 134-143

Fine characterization of nitrocellulose (NC) remains a challenge, especially in forensic analysis, and a strategy consisting in obtaining representative fingerprints by a separation technique, as for proteins, is of prime interest. In this work, we first established that NCs (especially of high molar mass) cannot be representatively derivatized by 8-aminopyrene-1,3,6-trisulfonic acid (APTS), because...

article

Selective binding of coumarin enantiomers to human α1-acid glycoprotein genetic variants

Eszter Hazai, Júlia Visy, Ilona Fitos, Zsolt Bikádi, more

Bioorganic & Medicinal Chemistry > 2006 > 14 > 6 > 1959-1965

Coumarin-type anticoagulants, warfarin, phenprocoumon and acenocoumarol, were tested for their stereoselective binding to the human orosomucoid (ORM; AGP) genetic variants ORM 1 and ORM 2. Direct binding studies with racemic ligands were carried out by the ultrafiltration method; the concentrations of free enantiomers were determined by capillary electrophoresis. The binding of pure enantiomers was...

article

Mobilization of electroosmotic flow markers in capillary zone electrophoresis

Eva Martínková, Tomáš Křížek, Anna Kubíčková, Pavel Coufal

ELECTROPHORESIS > 42 > 7-8 > 932 - 938

UV‐absorbing neutral substances are commonly used as markers of mean electroosmotic flow in capillary electrophoresis for their zero electrophoretic mobility in an electric field. However, some of these markers can interact with background electrolyte components and migrate at a different velocity than the electroosmotic flow. Thus, we tested 11 markers primarily varying in their degree of methylation...

article

Determination of acidity constants, ionic mobilities, and hydrodynamic radii of carborane‐based inhibitors of carbonic anhydrases by capillary electrophoresis

Veronika Šolínová, Jiří Brynda, Václav Šícha, Josef Holub, more

ELECTROPHORESIS > 42 > 7-8 > 910 - 919

Capillary electrophoresis (CE) has been applied for determination of the thermodynamic acidity constants (pK_a) of the sulfamidoalkyl and sulfonamidoalkyl groups, the actual and limiting ionic mobilities and hydrodynamic radii of important compounds, eight carborane‐based inhibitors of carbonic anhydrases, which are potential new anticancer drugs. Two types of carboranes were investigated, (i) icosahedral...

article

A simple and efficient sequential electrokinetic and hydrodynamic injections in micellar electrokinetic chromatography method for quantification of anticancer drug 5‐fluorouracil and its metabolite in human plasma

Nadhiratul‐Farihin Semail, Siti Salmah Noordin, Aemi Syazwani Abdul Keyon, Maisarah Nasution Waras, more

Biomedical Chromatography > 35 > 5 > n/a - n/a

A simple and sensitive preconcentration strategy using sequential electrokinetic and hydrodynamic injection modes in micellar electrokinetic chromatography with diode array detection was developed and applied for the separation and determination of anticancer agent, 5‐fluorouracil and its metabolite, 5‐fluoro‐2′‐deoxyuridine, in human plasma. Sequential injection modes with increased analyte loading...

article

Developing, optimizing, and assessing a green electrophoretic method for determination of benzbromarone and allopurinol with its active metabolite in biological and pharmaceutical matrices

Hebatallah M. Essam, Heba M. Mohamed

Journal of Separation Science > 44 > 7 > 1461 - 1470

A combination of allopurinol and benzbromarone is a common gout treatment protocol. A suboptimal response to allopurinol in patients is very common due to its pharmacokinetics variability. Moreover, the safe doses of benzbromarone is very crucial in patients with hepatic diseases. This raised the inquisitiveness to develop and optimize a capillary zone electrophoresis method for the determination...

article

Development, validation, and application of capillary zone electrophoresis method for determination of pyrimidine glucosides in seeds of Vicia faba L. var. minor

Mariusz Kowalczyk, Justyna Krzyżanowska‐Kowalczyk, Anna Stochmal

Phytochemical Analysis > 32 > 3 > 375 - 381

Introduction Consumption of fava beans seeds can be harmful to both humans and animals due to the presence of pyrimidine glucosides: vicine and convicine. Therefore, seeds, feed supplements, and protein extracts derived from fava beans should be monitored for the contents of pyrimidine derivatives. Objectives The main objective of this work was the development and validation of an inexpensive,...

article

Characterization of various geometric arrangements of “air‐assisted” flow gating interfaces for capillary electrophoresis

František Opekar, Petr Tůma

ELECTROPHORESIS > 42 > 6 > 749 - 755

For connecting flow‐through analytical methods with capillary electrophoresis, a chip working in the air‐assisted flow gating interface regime is cast from poly(dimethylsiloxane). In the injection space, the exit from the delivery capillary is placed close to the entrance to the separation capillary. Prior to injecting the sample into the separation capillary, the background electrolyte is forced...

article

Determining binding constants for 1:1 and 1:2 inclusion complexes of ester betulin derivatives with (2‐hydroxypropyl)‐β‐cyclodextrin by affinity capillary electrophoresis

Viktoria V. Sursyakova, Vladimir A. Levdansky, Anatoly I. Rubaylo

ELECTROPHORESIS > 42 > 6 > 700 - 707

The complexation of ester betulin derivatives with (2‐hydroxypropyl)‐β‐cyclodextrin (HP‐β‐CD) was studied by mobility shift affinity CE. Electrophoretic mobility for triangular peaks was calculated using the parameter a₁ of the Haarhoff–Van der Linde function instead of the peak top time. Dependences of the viscosity corrected electrophoretic mobility on HP‐β‐CD concentration were not described on...

article

Two capillary approach for a multifunctional nanoflow sheath liquid interface for capillary electrophoresis‐mass spectrometry

Oliver Höcker, Mike Knierman, Jens Meixner, Christian Neusüß

ELECTROPHORESIS > 42 > 4 > 369 - 373

CE hyphenated to ESI‐MS (CE‐ESI‐MS) is a well‐established technique to analyze charged analytes in complex samples. Although various interfaces for CE‐MS coupling are commercially available, the development of alternatives which combine sensitivity, simplicity, and robustness remains a topic of research. In this work, a nanoflow sheath liquid CE‐MS interface with two movable capillaries inside a glass...

article

Application of capillary electrophoresis‐nano‐electrospray ionization‐mass spectrometry for the determination of N‐nitrosodimethylamine in pharmaceuticals

Roman Řemínek, František Foret, Doo Soo Chung

ELECTROPHORESIS > 42 > 4 > 334 - 341

After a presence of highly hepatotoxic and potentially carcinogenic N‐nitrosodimethylamine was detected in certain lots of sartan, ranitidine, metformin, and other pharmaceuticals, local regulatory authorities issued recalls of suspected products, and concerns of the pharmacotherapy safety were widely discussed. Since then, testing of a representative sample of each produced lot of these pharmaceuticals...

article

Improved CE(SDS)‐CZE‐MS method utilizing an 8‐port nanoliter valve

Jennifer Römer, Steffen Kiessig, Bernd Moritz, Christian Neusüß

ELECTROPHORESIS > 42 > 4 > 374 - 380

Capillary sieving electrophoresis utilizing SDS (CE(SDS)) is one of the most applied methods for the analysis of antibody (mAb) size heterogeneity in the biopharmaceutical industry. Inadequate peak identification of observed protein fragments is still a major issue. In a recent publication, we introduced an electrophoretic 2D system, enabling online mass spectrometric detection of generic CE(SDS)...

article

Comparison of separation modes for microchip electrophoresis of proteins

Thushara N. Samarasinghe, Yong Zeng, Carey K. Johnson

Journal of Separation Science > 44 > 3 > 744 - 751

Separation of a set of model proteins was tested on a microchip electrophoresis analytical platform capable of sample injection by two different electrokinetic mechanisms. A range of separation modes—microchip capillary zone electrophoresis, microchip micellar electrokinetic chromatography, and nanoparticle‐based sieving—was tested on glass and polydimethylsiloxane/glass microchips and with silica‐nanoparticle...

article

Recent advances in nanomaterial‐assisted detection coupled with capillary and microchip electrophoresis

Zhao Meng, Junmin Bi, Qianqian Zhang, Hang Ren, more

ELECTROPHORESIS > 42 > 3 > 269 - 278

Nanomaterials have drawn much attention because of their unique properties enabling them to play important roles in various applications in different areas. This review covers literature data in the Web of Science from January 2017 to August 2020, focusing on the applications of nanomaterials (nanoparticles, quantum dots, nanotubes, and graphene) in CE and MCE to achieve enhanced sensitivity of several...

article

Capillary electrophoretic methods for quality control analyses of pharmaceuticals: A review

Roman Řemínek, František Foret

ELECTROPHORESIS > 42 > 1-2 > 19 - 37

Capillary electrophoresis represents a promising technique in the field of pharmaceutical analysis. The presented review provides a summary of capillary electrophoretic methods suitable for routine quality control analyses of small molecule drugs published since 2015. In total, more than 80 discussed methods are sorted into three main sections according to the applied electroseparation modes (capillary...

article

Recent developments in the characterization of nucleic acids by liquid chromatography, capillary electrophoresis, ion mobility, and mass spectrometry (2010–2020)

Inês C. Santos, Jennifer S. Brodbelt

Journal of Separation Science > 44 > 1 > 340 - 372

The development of new strategies for the analysis of nucleic acids has gained momentum due to the increased interest in using these biomolecules as drugs or drug targets. The application of new mass spectrometry ion activation techniques and the optimization of separation methods including liquid chromatography, capillary electrophoresis, and ion mobility have allowed more detailed characterization...

article

Enantioselective analysis of venlafaxine and its active metabolites: A review on the separation methodologies

Gabriel Hancu, Daniela Lupu, Andreea Milan, Monica Budău, more

Biomedical Chromatography > 35 > 1 > n/a - n/a

Venlafaxine (VFX) is a serotonin and norepinephrine reuptake inhibitor chiral drug used in therapy as an antidepressant in the form of a racemate consisting of R‐ and S‐VFX. The two enantiomers of VFX exhibit different pharmacological activities: R‐VFX inhibits both norepinephrine and serotonin synaptic reuptake, whereas S‐VFX inhibits only the serotonin one. R‐ and S‐VFX are metabolized in the liver...

article

A capillary electrophoresis method for the determination of the linagliptin enantiomeric impurity

Xuan‐Lan Mai, Thuy‐Vy Pham, Thi‐Anh‐Tuyet Le, Bao‐Tan Nguyen, more

Journal of Separation Science > 43 > 24 > 4480 - 4487

Linagliptin is a highly specific, long‐acting inhibitor that is used as an orally administrable agent for type‐2 diabetes treatment. Because only the R‐enantiomer is of clinical use, we developed a capillary electrophoresis method for the determination of the enantiomeric impurity of this compound. Carboxymethyl‐β‐cyclodextrin was selected as the chiral selector for the separation of linagliptin enantiomers...

article

Low‐cost automated capillary electrophoresis instrument assembled from commercially available parts

Jasmine S. Furter, Marc‐Aurèle Boillat, Peter C. Hauser

ELECTROPHORESIS > 41 > 24 > 2075 - 2082

A CE instrument that can be assembled from commercially available components with minimal construction effort is described. Except for the electronic control circuitry no specially made parts are required. It is based on a flexible design of microfluidic, electropneumatic, and electronic sections and different configurations can easily be implemented. Automated injection into the capillary is performed...

article

Enantioseparation of ketoconazole and miconazole by capillary electrophoresis and a study on their inclusion interactions with β‐cyclodextrin and derivatives

Nurul Raihana Azhari, Noorfatimah Yahaya, Faiz Bukhari M. Mohd Suah, Samikannu Prabu, more

Chirality > 33 > 1 > 37 - 50

A chiral separation method coupled with capillary electrophoresis (CE) analysis for ketoconazole and miconazole enantiomers using chiral selectors such as β‐cyclodextrin (β‐CD) and hydroxypropyl‐β‐CD (HP‐β‐CD) was developed in this study, which included the optimisation, validation and application of the method on the antifungal cream samples. The formation of inclusion complex between the hosts (β‐CD...

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Search results

Capillary electrophoresis fingerprinting of 8-aminopyrene-1,3,6-trisulfonate derivatized nitrocellulose after partial acid depolymerization

Selective binding of coumarin enantiomers to human α1-acid glycoprotein genetic variants

Mobilization of electroosmotic flow markers in capillary zone electrophoresis

Determination of acidity constants, ionic mobilities, and hydrodynamic radii of carborane‐based inhibitors of carbonic anhydrases by capillary electrophoresis

A simple and efficient sequential electrokinetic and hydrodynamic injections in micellar electrokinetic chromatography method for quantification of anticancer drug 5‐fluorouracil and its metabolite in human plasma

Developing, optimizing, and assessing a green electrophoretic method for determination of benzbromarone and allopurinol with its active metabolite in biological and pharmaceutical matrices

Development, validation, and application of capillary zone electrophoresis method for determination of pyrimidine glucosides in seeds of Vicia faba L. var. minor

Characterization of various geometric arrangements of “air‐assisted” flow gating interfaces for capillary electrophoresis

Determining binding constants for 1:1 and 1:2 inclusion complexes of ester betulin derivatives with (2‐hydroxypropyl)‐β‐cyclodextrin by affinity capillary electrophoresis

Two capillary approach for a multifunctional nanoflow sheath liquid interface for capillary electrophoresis‐mass spectrometry

Application of capillary electrophoresis‐nano‐electrospray ionization‐mass spectrometry for the determination of N‐nitrosodimethylamine in pharmaceuticals

Improved CE(SDS)‐CZE‐MS method utilizing an 8‐port nanoliter valve

Comparison of separation modes for microchip electrophoresis of proteins

Recent advances in nanomaterial‐assisted detection coupled with capillary and microchip electrophoresis

Capillary electrophoretic methods for quality control analyses of pharmaceuticals: A review

Recent developments in the characterization of nucleic acids by liquid chromatography, capillary electrophoresis, ion mobility, and mass spectrometry (2010–2020)

Enantioselective analysis of venlafaxine and its active metabolites: A review on the separation methodologies

A capillary electrophoresis method for the determination of the linagliptin enantiomeric impurity

Low‐cost automated capillary electrophoresis instrument assembled from commercially available parts

Enantioseparation of ketoconazole and miconazole by capillary electrophoresis and a study on their inclusion interactions with β‐cyclodextrin and derivatives

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