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Items from 1 to 20 out of 216 results

article

Cytochrome 1A1 and 1B1 gene diversity in the Zanzibar islands

I. Cavaco, R. Piedade, M. I. Msellem, A. Bjorkman, more

Tropical Medicine & International Health > 17 > 7 > 854 - 857

Amodiaquine (AQ) is a 4‐aminoquinoline widely used in the treatment of malaria as part of the artemisinin combination therapy (ACT). AQ is metabolised towards its main metabolite desethylamodiaquine mainly by cytochrome P450 2C8 (CYP2C8). CYP1A1 and CYP1B1 play a minor role in the metabolism but they seem to be significantly involved in the formation of the short‐lived quinine‐imine. To complete the...

article

First evidence of SOX2 mutations in Peters' anomaly: Lessons from molecular screening of 95 patients

Bertrand Chesneau, Marion Aubert‐Mucca, Félix Fremont, Jacmine Pechmeja, more

Clinical Genetics > 101 > 5-6 > 494 - 506

Peters' anomaly (PA) is a rare anterior segment dysgenesis characterized by central corneal opacity and irido‐lenticulo‐corneal adhesions. Several genes are involved in syndromic or isolated PA (B3GLCT, PAX6, PITX3, FOXE3, CYP1B1). Some copy number variations (CNVs) have also been occasionally reported. Despite this genetic heterogeneity, most of patients remain without genetic diagnosis. We retrieved...

article

Quinazolinone derivative BNUA‐3 ameliorated [NDEA+2‐AAF]‐induced liver carcinogenesis in SD rats by modulating AhR‐CYP1B1‐Nrf2‐Keap1 pathway

Pritha Bose, Mohd. Usman M. Siddique, Reetuparna Acharya, Venkatesan Jayaprakash, more

Clinical and Experimental Pharmacology and Physiology > 47 > 1 > 143 - 157

Cytochrome P450 1B1, considered as one of the novel chemotherapeutic targets involved in cancer prevention and therapy is also associated with the conversion of procarcinogens into their active metabolites. The aryl hydrocarbon receptor (AhR) is responsible for mediating different biological responses to a wide variety of environmental pollutants and also causes transcriptional activation of cytochrome...

article

Mutational analysis of the CYP1B1 gene in Pakistani primary congenital glaucoma patients: Identification of four known and a novel causative variant at the 3′ splice acceptor site of intron 2

Rabia Afzal, Sabika Firasat, Haiba Kaul, Bashir Ahmed, more

Congenital Anomalies > 59 > 5 > 152 - 161

Primary congenital glaucoma (PCG) causes blindness in early age. It has an autosomal recessive pattern of inheritance, hence is more prevalent in populations with frequent consanguineous marriages that occur in the Pakistani population. Mutations in the CYP1B1 gene are commonly associated with PCG. The aim of the present study was to identify genetic mutations in the CYP1B1 gene in PCG cases belonging...

article

Protective roles of FICZ and aryl hydrocarbon receptor axis on alveolar bone loss and inflammation in experimental periodontitis

Jing Huang, Xinjie Cai, Yanjing Ou, Le Fan, more

Journal of Clinical Periodontology > 46 > 9 > 882 - 893

Aim The aryl hydrocarbon receptor (AhR)‐ligand axis has been shown to be involved in inflammatory diseases and bone homeostasis. However, the activation of AhR signalling pathway and the possible functions of AhR ligands in periodontitis are underexplored. This study investigated the expression of the AhR target gene cytochrome P450 subfamily B member 1 (CYP1B1) and the functions and mechanisms of...

article

AHR and GPER mediate the stimulatory effects induced by 3-methylcholanthrene in breast cancer cells and cancer-associated fibroblasts (CAFs)

Francesca Cirillo, Rosamaria Lappano, Leonardo Bruno, Bruno Rizzuti, more

Journal of Experimental & Clinical Cancer Research > 2019 > 38 > 1 > 1-18

Background The chemical carcinogen 3-methylcholanthrene (3MC) binds to the aryl hydrocarbon receptor (AHR) that regulates the expression of cytochrome P450 (CYP) enzymes as CYP1B1, which is involved in the oncogenic activation of environmental pollutants as well as in the estrogen biosynthesis and metabolism. 3MC was shown to induce estrogenic responses binding to the estrogen receptor (ER) α and...

article

A combined epigenome- and transcriptome-wide association study of the oral masticatory mucosa assigns CYP1B1 a central role for epithelial health in smokers

Gesa M. Richter, Jochen Kruppa, Matthias Munz, Ricarda Wiehe, more

Clinical Epigenetics > 2019 > 11 > 1 > 1-18

Background The oral mucosa has an important role in maintaining barrier integrity at the gateway to the gastrointestinal and respiratory tracts. Smoking is a strong environmental risk factor for the common oral inflammatory disease periodontitis and oral cancer. Cigarette smoke affects gene methylation and expression in various tissues. This is the first epigenome-wide association study (EWAS) that...

article

Expression of CYP1A1, CYP1B1 and IL-1β in PBMCs and skin samples of PCB exposed individuals

Marike M. Leijs, André Esser, Philipp M. Amann, Thomas Schettgen, more

Science of The Total Environment > 2018 > 642 > C > 1429-1438

Polychlorinated biphenyls (PCBs) are well- known man-made persistent environmental pollutants and endocrine disruptors. As a result of mass production in the past, background levels of these compounds can be measured in human blood worldwide.In 2010 high internal levels of PCBs were discovered in workers of a transformer-recycling company in Germany. Our aim was to measure, whether the expression...

article

Mitochondrial cytochrome P450 (CYP) 1B1 is responsible for melatonin‐induced apoptosis in neural cancer cells

Zhenlong Yu, Xiangge Tian, Yuling Peng, Zheng Sun, more

Journal of Pineal Research > 65 > 1 > n/a - n/a

Melatonin is an endogenous indoleamine with a wide range of biological functions in the various organisms from bacteria to mammals. Evidence indicates that melatonin facilitates apoptosis in cancer cells and enhances the antitumor activity of chemotherapy in animals and clinical studies. However, the melatonin metabolism and the key metabolic targets in cancer cells still remain unknown. In this study,...

article

In the search for reliable biomarkers for the early diagnosis of autism spectrum disorder: the role of vitamin D

Afaf El-Ansary, John J. Cannell, Geir Bjørklund, Ramesa Shafi Bhat, more

Metabolic Brain Disease > 2018 > 33 > 3 > 917-931

Autism spectrum disorder (ASD) affects about 1% of the world’s population. Vitamin D is thought to be essential for normal brain development and modulation of the immune system. Worldwide about 1 billion people are affected by vitamin D deficiency. High-sensitivity C-reactive protein (hs-CRP), cytochrome P450 2E1 (CYP2E1) and 8-hydroxy-2′-deoxyguanosine (8-OH-dG) are biomarkers related to inflammation...

article

Cancer chemoprevention revisited: Cytochrome P450 family 1B1 as a target in the tumor and the microenvironment

Gabriele D'Uva, Denisa Baci, Adriana Albini, Douglas M. Noonan

Cancer Treatment Reviews > 2018 > 63 > C > 1-18

Cancer chemoprevention is the use of synthetic, natural or biological agents to prevent or delay the development or progression of malignancies. Intriguingly, many phytochemicals with anti-inflammatory and anti-angiogenic effects, recently proposed as chemoprevention strategies, are inhibitors of Cytochrome P450 family 1B1 (CYP1B1), an enzyme overexpressed in a wide variety of tumors and associated...

article

The effect of mechanical stress on the proliferation, adipogenic differentiation and gene expression of human adipose‐derived stem cells

Nora E. Paul, Bernd Denecke, Bong‐Sung Kim, Alice Dreser, more

Journal of Tissue Engineering and Regenerative Medicine > 12 > 1 > 276 - 284

To allow for a better implementation of external volume expansion to clinical applications for soft tissue regeneration, it is necessary to comprehensively understand the underlying mechanisms. As human adipose‐derived stem cells (hASCs) play a crucial role in soft tissue enlargement, we investigated the impact of cyclic stretch on gene expression, proliferation rate and adipogenic differentiation...

article

Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts

Laziyan Mahemuti, Qixuan Chen, Melanie C. Coughlan, Cunye Qiao, more

Archives of Toxicology > 2018 > 92 > 4 > 1453-1469

Experimental and/or epidemiological studies suggest that prenatal exposure to bisphenol A (BPA) may delay fetal lung development and maturation and increase the susceptibility to childhood respiratory disease. However, the underlying mechanisms remain to be elucidated. In our previous study with cultured human fetal lung fibroblasts (HFLF), we demonstrated that 24-h exposure to 1 and 100 µM BPA increased...

article

Glycyrrhiza glabra extract and quercetin reverses cisplatin resistance in triple-negative MDA-MB-468 breast cancer cells via inhibition of cytochrome P450 1B1 enzyme

Rajni Sharma, Linda Gatchie, Ibidapo S. Williams, Shreyans K. Jain, more

Bioorganic & Medicinal Chemistry Letters > 2017 > 27 > 24 > 5400-5403

The development of multi-drug resistance to existing anticancer drugs is one of the major challenges in cancer treatment. The over-expression of cytochrome P450 1B1 enzyme has been reported to cause resistance to cisplatin. With an objective to discover cisplatin-resistance reversal agents, herein, we report the evaluation of Glycyrrhiza glabra (licorice) extracts and its twelve chemical constituents...

article

Evaluation of the effect of the new methoxy-stilbenes on expression of receptors and enzymes involved in estrogen synthesis in cancer breast cells

Barbara Licznerska, Hanna Szaefer, Marcin Wierzchowski, Renata Mikstacka, more

Molecular and Cellular Biochemistry > 2018 > 444 > 1-2 > 53-62

Our previous study showed that the new synthetic methoxy-stilbenes, 3,4,2′-trimethoxy-trans-stilbene (3MS), 3,4,2′,4′-tetramethoxy-trans-stilbene (4MS), and 3,4,2′,4′,6′-pentamethoxy-trans-stilbene (5MS), modulate the constitutive expression of enzymes and receptors involved in estrogen metabolism in breast immortalized epithelial MCF10 cells. In this study, we evaluated the effect of 3MS, 4MS, and...

article

Role of CYP1B1, p.E229K and p.R368H mutations among 120 families with sporadic juvenile onset open-angle glaucoma

Viney Gupta, Bindu I. Somarajan, Gagandeep Kaur Walia, Jasbir Kaur, more

Graefe's Archive for Clinical and Experimental Ophthalmology > 2018 > 256 > 2 > 355-362

Background To determine the frequency of CYP1B1 p.E229K and p.R368H, gene mutations in a cohort of sporadic juvenile onset open-angle glaucoma (JOAG) patients and to evaluate their genotype/phenotype correlation. Methods Unrelated JOAG patients whose first-degree relatives had been examined and found to be unaffected were included in the study. The patients and their parents were screened for p...

article

Elimination of dysfunctional mitochondria through mitophagy suppresses benzo[a]pyrene-induced apoptosis

Durgesh Nandini Das, Prajna Paramita Naik, Subhadip Mukhopadhyay, Prashanta Kumar Panda, more

Free Radical Biology and Medicine > 2017 > 112 > C > 452-463

Mitophagy, a special type of autophagy, plays an important role in the mitochondria quality control and cellular homeostasis. In this study, we examined the molecular mechanism of mitophagy induction with benzo[a]pyrene (B[a]P), a ubiquitous polycyclic aromatic hydrocarbon, which acts as a prosurvival response against apoptotic cell death. Our study showed that B[a]P displayed higher cytotoxicity...

article

Decreased expression of cytochrome p450 1B1 in non-small cell lung cancer

Bartosz Kazimierz Słowikowski, Bartłomiej Gałęcki, Wojciech Dyszkiewicz, Paweł Piotr Jagodziński

Biomedicine & Pharmacotherapy > 2017 > 95 > C > 339-345

Recent studies have associated oestrogen metabolism and cigarette smoking with their carcinogenic impact on the lungs. Compounds commonly found in tobacco smoke induce the activity of CYP1B1, the enzyme responsible for the synthesis of catecholic derivatives of oestrogens. During their redox transformations, these structures can release large amounts of reactive oxygen species or can form DNA adducts,...

article

Potential role of CYP1B1 in the development and treatment of metabolic diseases

Fei Li, Weifeng Zhu, Frank J. Gonzalez

Pharmacology & Therapeutics > 2017 > 178 > C > 18-30

Cytochrome P450 1B1 (CYP1B1), a member of CYP superfamily, is expressed in liver and extrahepatic tissues carries out the metabolism of numerous xenobiotics, including metabolic activation of polycyclic aromatic hydrocarbons. Surprisingly, CYP1B1 was also shown to be important in regulating endogenous metabolic pathways, including the metabolism of steroid hormones, fatty acids, melatonin, and vitamins...

article

Synthesis and biological evaluation of pyrrole-based chalcones as CYP1 enzyme inhibitors, for possible prevention of cancer and overcoming cisplatin resistance

Ibidapo S. Williams, Prashant Joshi, Linda Gatchie, Mohit Sharma, more

Bioorganic & Medicinal Chemistry Letters > 2017 > 27 > 16 > 3683-3687

Inhibitors of CYP1 enzymes may play vital roles in the prevention of cancer and overcoming chemo-resistance to anticancer drugs. In this letter, we report synthesis of twenty-three pyrrole based heterocyclic chalcones which were screened for inhibition of CYP1 isoforms. Compound 3n potently inhibited CYP1B1 with an IC₅₀ of ∼0.2μM in Sacchrosomes™ and CYP1B1-expressing live human cells. However, compound...

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Cytochrome 1A1 and 1B1 gene diversity in the Zanzibar islands

First evidence of SOX2 mutations in Peters' anomaly: Lessons from molecular screening of 95 patients

Quinazolinone derivative BNUA‐3 ameliorated [NDEA+2‐AAF]‐induced liver carcinogenesis in SD rats by modulating AhR‐CYP1B1‐Nrf2‐Keap1 pathway

Mutational analysis of the CYP1B1 gene in Pakistani primary congenital glaucoma patients: Identification of four known and a novel causative variant at the 3′ splice acceptor site of intron 2

Protective roles of FICZ and aryl hydrocarbon receptor axis on alveolar bone loss and inflammation in experimental periodontitis

AHR and GPER mediate the stimulatory effects induced by 3-methylcholanthrene in breast cancer cells and cancer-associated fibroblasts (CAFs)

A combined epigenome- and transcriptome-wide association study of the oral masticatory mucosa assigns CYP1B1 a central role for epithelial health in smokers

Expression of CYP1A1, CYP1B1 and IL-1β in PBMCs and skin samples of PCB exposed individuals

Mitochondrial cytochrome P450 (CYP) 1B1 is responsible for melatonin‐induced apoptosis in neural cancer cells

In the search for reliable biomarkers for the early diagnosis of autism spectrum disorder: the role of vitamin D

Cancer chemoprevention revisited: Cytochrome P450 family 1B1 as a target in the tumor and the microenvironment

The effect of mechanical stress on the proliferation, adipogenic differentiation and gene expression of human adipose‐derived stem cells

Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts

Glycyrrhiza glabra extract and quercetin reverses cisplatin resistance in triple-negative MDA-MB-468 breast cancer cells via inhibition of cytochrome P450 1B1 enzyme

Evaluation of the effect of the new methoxy-stilbenes on expression of receptors and enzymes involved in estrogen synthesis in cancer breast cells

Role of CYP1B1, p.E229K and p.R368H mutations among 120 families with sporadic juvenile onset open-angle glaucoma

Elimination of dysfunctional mitochondria through mitophagy suppresses benzo[a]pyrene-induced apoptosis

Decreased expression of cytochrome p450 1B1 in non-small cell lung cancer

Potential role of CYP1B1 in the development and treatment of metabolic diseases

Synthesis and biological evaluation of pyrrole-based chalcones as CYP1 enzyme inhibitors, for possible prevention of cancer and overcoming cisplatin resistance

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