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article

Prostaglandin-mediated control of rat brain kynurenic acid synthesis – opposite actions by COX-1 and COX-2 isoforms

L. Schwieler, S. Erhardt, C. Erhardt, G. Engberg

Journal of Neural Transmission > 2005 > 112 > 7 > 863-872

. Here, we analyze whether cyclooxygenase (COX)-1 or COX-2 modulate the levels of rat brain KYNA. The non-selective COX-inhibitor diclofenac (50 mg/kg, i.p.) or indomethacin (50 mg/kg, i.p.), a non-selective inhibitor with a preferential selectivity for COX-1, produced an elevation in brain KYNA. In contrast, the COX-2

article

Crystallization of recombinant cyclo-oxygenase-2

Journal of Crystal Growth > 1999 > 196 > 2-4 > 350-355

The integral membrane protein, prostaglandin H ₂ synthase, or cyclo-oxygenase (COX), catalyses the first step in the conversion of arachidonic acid to prostaglandins (PGs) and is the target of nonsteroidal anti-inflammatory drugs (NSAIDs). Two isoforms are known. The constitutive enzyme, COX-1, is

article

Exacerbation of inflammatory bowel diseases associated with the use of nonsteroidal anti-inflammatory drugs: myth or reality?

Helenie Kefalakes, Theodoros J. Stylianides, George Amanakis, George Kolios

European Journal of Clinical Pharmacology > 2009 > 65 > 10 > 963-970

papers, controlled trials, case reports, reviews, and editorials published in English at the PubMed, Scopus Database, and Science Direct database, searching with the following keywords: nonsteroidal anti-inflammatory drugs (NSAIDs), COX-2 inhibitors, Coxibs, inflammatory bowel diseases (IBD), ulcerative colitis (UC), Crohn

article

Assaying the efficacy of dual-antiplatelet therapy: use of a controlled-shear-rate microfluidic device with a well-defined collagen surface to track dynamic platelet adhesion

Margaret B Lucitt, Sinead O’Brien, Jonathan Cowman, Gerardene Meade, more

Analytical and Bioanalytical Chemistry > 2013 > 405 > 14 > 4823-4834

We report the development and demonstration of an assay that distinguishes the pharmacological effects of two widely used antiplatelet therapies, aspirin (COX-1 inhibitor) and clopidogrel (P2Y₁₂ inhibitor). Whole blood is perfused through a low-volume microfluidic device in contact with a well

article

Prostaglandins in Health and Disease: An Overview

Stephen B. Miller

Seminars in Arthritis and Rheumatism > 2006 > 36 > 1 > 37-49

normal and abnormal clinical states. The critical therapeutic implications of the use of nonsteroidal antiinflammatory drugs in altering organ homeostasis are also examined. References were taken from Medline, Embase, and Index Medicus from 1966 to September 2005. A search was done with keywords, including prostaglandins

article

Current view on nasal polyps management in Samter's triad patients

Katarzyna Mrówka-Kata, Eugeniusz Czecior, Dariusz Kata, Grzegorz Namysłowski, more

Otolaryngologia Polska > 2012 > 66 > 6 > 373-378

The nasal polyps associated with Samter's triad are often very extensive, difficult to treat, with great tendency to recurrence. In this paper the current opinion on nasal polyps management in aspirin triad patients was presented. Pathogenesis: Opinions on pathogenesis of these disease was remembered as well as its epidemiology. Diagnostic methods: The available diagnostic methods were presented....

article

The diet-induced proinflammatory state:

David R. Seaman

Journal of Manipulative and Physiological Therapeutics > 2002 > 25 > 3 > 168-179

Background: It is the rare physician who includes diet therapy and nutritional supplements in patient care. Perhaps this is because chiropractic and medical schools devote very few classroom hours to nutrition. It is also possible that physicians are under the misconception that a detailed biochemical understanding of each individual disease is required before nutritional interventions can be used...

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Keywords

INFLAMMATION (2)
PROSTAGLANDINS (2)
PROSTAGLANDIN H 2 SYNTHASE (1)
ANTIOXIDANTS (1)
ANTIPLATELET THERAPY (1)
ARACHIDONIC ACID (1)
COLLAGEN–PLATELET INTERACTIONS (1)
COX - 1 (1)
COX - 2 (1)
COX-1 (1)
COX-2 (1)
COX-2 INHIBITORS (1)
COXIBS (1)
CRYSTALLIZATION (1)
CYCLO-OXYGENASE (1)
DEGENERATIVE DISEASE (1)
DIET (1)
INFLAMMATORY BOWEL DISEASES (1)
KEYWORDS (1)
KEYWORDS: KYNURENINE, NOCICEPTION, PSYCHOSES, SCHIZOPHRENIA, NSAID, INDOMETHACIN, DICLOFENAC, PARACETAMOL, KETOROLAC, PARECOXIB, MELOXICAM, MISOPROSTOL. (1)
MEMBRANE PROTEIN (1)
MICROFLUIDICS (1)
NASAL POLYPS (1)
NONSTEROIDAL ANTIINFLAMMATORY DRUGS (1)
NSAID (NONSTEROIDAL ANTI-INFLAMMATORY DRUG) (1)
NSAIDS (1)
PAIN (1)
PARALLEL-PLATE FLOW CHAMBER (1)
SAMTER'S TRIAD (1)
THROMBOSIS (1)
TREATMENT (1)
[UNCONTROLLED KEYWORD (DEFAULT)] 87.15.-V (1)
[UNCONTROLLED KEYWORD (DEFAULT)] 87.15.BY (1)
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Elsevier (4)
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Search results

Prostaglandin-mediated control of rat brain kynurenic acid synthesis – opposite actions by COX-1 and COX-2 isoforms

Crystallization of recombinant cyclo-oxygenase-2

Exacerbation of inflammatory bowel diseases associated with the use of nonsteroidal anti-inflammatory drugs: myth or reality?

Assaying the efficacy of dual-antiplatelet therapy: use of a controlled-shear-rate microfluidic device with a well-defined collagen surface to track dynamic platelet adhesion

Prostaglandins in Health and Disease: An Overview

Current view on nasal polyps management in Samter's triad patients

The diet-induced proinflammatory state:

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