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ON CICERO’S FABIUS ARGUMENT

Vladimír Marko

Filozofia (Philosophy) > 2020 > 75 > 8 > 677 – 692

This article aims to show that it is impossible to put Cicero’s testimonies regarding The Fabius Argument in a consistent inferential order. Either we must suppose that additional premises are tacitly assumed in the text or we must compare it with other sources, which leads to inconsistencies in the proof’s reconstruction. Cicero’s reconstruction of the progression of the argument has formal shortcomings,...

article

Generation of a novel mouse strain with conditional, cell‐type specific, expression of DND1

Lisa Nunez, Sharada Mokkapati, Chengtai Yu, Jian M. Deng, more

genesis > 57 > 11-12 > n/a - n/a

Dead‐End 1 (DND1) encodes an RNA binding protein critical for viable primordial germ cells in vertebrates. When introduced into cancer cell lines, DND1 suppresses cell proliferation and enhances apoptosis. However, the molecular function of mammalian wild‐type DND1 has mostly been studied in cell lines and not verified in the organism. To facilitate study of wild‐type DND1 function in mammalian systems,...

article

Compilation of static and evolving conditional knowledge bases for computing induced nonmonotonic inference relations

Christoph Beierle, Steven Kutsch, Kai Sauerwald

Annals of Mathematics and Artificial Intelligence > 2019 > 87 > 1-2 > 5-41

Several different semantics have been proposed for conditional knowledge bases R $\mathcal {R}$ containing qualitative conditionals of the form “If A, then usually B”, leading to different nonmonotonic inference relations induced by R $\mathcal {R}$ . For the notion of c-representations which are a subclass of all ranking functions accepting R $\mathcal {R}$ , a skeptical inference relation,...

article

Dynamic organelle localization and cytoskeletal reorganization during preimplantation mouse embryo development revealed by live imaging of genetically encoded fluorescent fusion proteins

Hiroshi Kiyonari, Mari Kaneko, Takaya Abe, Go Shioi, more

genesis > 57 > 2 > n/a - n/a

Live imaging is one of the most powerful technologies for studying the behaviors of cells and molecules in living embryos. Previously, we established a series of reporter mouse lines in which specific organelles are labeled with various fluorescent proteins. In this study, we examined the localizations of fluorescent signals during preimplantation development of these mouse lines, as well as a newly...

article

Cover Image, Volume 57, Issue 2

Hiroshi Kiyonari, Mari Kaneko, Takaya Abe, Go Shioi, more

genesis > 57 > 2 > n/a - n/a

The cover image is based on the Research Article Dynamic organelle localization and cytoskeletal reorganization during preimplantation mouse embryo development revealed by live imaging of genetically encoded fluorescent fusion proteins by Hiroshi Kiyonari et al., DOI: 10.1002/dvg.23277.

article

Implications for BACE1 Inhibitor Clinical Trials: Adult Conditional BACE1 Knockout Mice Exhibit Axonal Organization Defects in the Hippocampus

R. Vassar

The Journal of Prevention of Alzheimer's Disease > 2019 > 6 > 2 > 78-84

BACE1 is the rate-limiting enzyme for the production of the Aβ peptide that forms amyloid plaques in Alzheimer’s disease (AD). Small molecule inhibitors of BACE1 are being tested in clinical trials for AD, but the safety and efficacy of BACE1 inhibition has yet to be fully explored. Knockout of the Bace1 gene in the germline of mice causes multiple neurological phenotypes, suggesting that BACE1 inhibition...

article

Application of long single-stranded DNA donors in genome editing: generation and validation of mouse mutants

Gemma F. Codner, Joffrey Mianné, Adam Caulder, Jorik Loeffler, more

BMC Biology > 2018 > 16 > 1 > 1-16

Background Recent advances in clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) genome editing have led to the use of long single-stranded DNA (lssDNA) molecules for generating conditional mutations. However, there is still limited available data on the efficiency and reliability of this method. Results We generated conditional mouse alleles using...

article

Properties of skeptical c-inference for conditional knowledge bases and its realization as a constraint satisfaction problem

Christoph Beierle, Christian Eichhorn, Gabriele Kern-Isberner, Steven Kutsch

Annals of Mathematics and Artificial Intelligence > 2018 > 83 > 3-4 > 247-275

While the axiomatic system P is an important standard for plausible, nonmonotonic inferences from conditional knowledge bases, it is known to be too weak to solve benchmark problems like Irrelevance or Subclass Inheritance. Ordinal conditional functions provide a semantic base for system P and have often been used to design stronger inference relations, like Pearl’s system Z, or c-representations...

article

Moral Sentimentalism in Counterfactual Contexts: Moral Properties Are Response-Enabled

Daniel Dohrn

Philosophia > 2018 > 46 > 1 > 69-82

According to moral sentimentalism, there are close connections between moral truths and moral emotions. Emotions largely form our moral attitudes. They contribute to our answerability to moral obligations. We take them as authoritative in guiding moral judgement. This role is difficult to understand if one accepts a full-blown moral realism, according to which moral truths are completely independent...

article

On the Use of the Expected ARL Metric for Control Charts Based on Estimated Parameters

Marit Schoonhoven

Quality and Reliability Engineering International > 33 > 4 > 745 - 749

At the origination of the Shewhart control chart, it was assumed that the process parameters were known. The in‐control Average Run Length (ARL) and the probability of having a false alarm (P) were introduced as metrics to indicate the in‐control performance. These two metrics are related when the process data are i.i.d. normally distributed: the ARL equals 1/P. When the process parameters are unknown...

article

Adaptive regression model for synthesizing anthropometric population data

Erik Brolin, Dan Högberg, Lars Hanson, Roland Örtengren

International Journal of Industrial Ergonomics > 2017 > 59 > C > 46-53

This paper presents the development of an adaptive linear regression model for synthesizing of missing anthropometric population data based on a flexible set of known predictive data. The method is based on a conditional regression model and includes use of principal component analysis, to reduce effects of multicollinearity between selected predictive measurements, and incorporation of a stochastic...

article

The (Non-)classicality of (Non-)classical Mathematics

Luis Estrada-González

Journal of Indian Council of Philosophical Research > 2017 > 34 > 2 > 365-377

Purpose Graham Priest has recently argued that the distinctive trait of classical mathematics is that the conditional of its underlying logic—that is, classical logic—is extensional. In this article, I aim to present an alternate explanation of the specificity of classical mathematics (and actually for L-mathematics, for a significative amount of instances of 'L'). Method I examine Priest's argument...

article

Thought experiments without possible worlds

Daniel Dohrn

Philosophical Studies > 2018 > 175 > 2 > 363-384

The method of thought experiments or possible cases is widespread in philosophy and elsewhere. Thought experiments come with variegated theoretical commitments. These commitments are risky. They may turn out to be false or at least controversial. Other things being equal, it seems preferable to do with minimal commitments. I explore exemplary ways of minimising commitments, focusing on modal ones...

article

A Systems Approach Reveals MAVS Signaling in Myeloid Cells as Critical for Resistance to Ebola Virus in Murine Models of Infection

Mukta Dutta, Shelly J. Robertson, Atsushi Okumura, Dana P. Scott, more

Cell Reports > 2017 > 18 > 3 > 816-829

The unprecedented 2013–2016 outbreak of Ebola virus (EBOV) resulted in over 11,300 human deaths. Host resistance to RNA viruses requires RIG-I-like receptor (RLR) signaling through the adaptor protein, mitochondrial antiviral signaling protein (MAVS), but the role of RLR-MAVS in orchestrating anti-EBOV responses in vivo is not known. Here we apply a systems approach to MAVS^−/− mice infected with either...

chapter

Conditional subscription and notification in information centric networks

Lijun Dong, Guoqiang Wang

2017 14th IEEE Annual Consumer Communications & Networking Conference (CCNC) > 473 - 479

2017 14th IEEE Annual Consumer Communications & Networking Conference (CCNC)

This paper proposes mechanisms to support basic, as well as conditional subscription/notification communication pattern in the Information Centric Networks (ICN), which still leverage and build on the ICN architecture and fundamental design principles with minimum change to the protocols. The proposed new interest message integrates content retrieve request, subscription and notification functions,...

article

Focus, scales, and concessive conditionals in German

Jörg Bücker

Language Sciences > 2016 > 58 > C > 163-177

Based on examples from spoken talk-in-interaction, this paper deals with German auch/selbst/sogar wenn constructions. It aims to show that two auch/selbst/sogar wenn patterns have to be distinguished. The first pattern – auch/selbst/sogar wenn as an expression of conditional sufficiency – is characterized by a free and compositional relationship between the focus particle (i.e., auch, selbst, or sogar),...

chapter

The Completion of the Emergence of Modern Logic from Boole’s The Mathematical Analysis of Logic to Frege’s Begriffsschrift

Priyedarshi Jetli

Lecture Notes in Computer Science > Logic and Its Applications > 105-123

Modern logic begins with Boole’s The Mathematical Analysis of Logic when the algebra of logic was developed so that classical logic syllogisms were proven as algebraic equations and the turn from the logic of classes to propositional logic was suggested. The emergence was incomplete as Boole algebraised classical logic. Frege in Begriffsschrift replaced Aristotelian subject–predicate propositions...

article

Generation of a mouse model for a conditional inactivation of Gtf2i allele

Badam Enkhmandakh, Chris Stoddard, Kris Mack, Wei He, more

genesis > 54 > 7 > 407 - 412

The multifunctional transcription factor TFII‐I encoded by the Gtf2i gene is expressed at the two‐cell stage, inner cell mass, trophectoderm, and early gastrula stages of the mouse embryo. In embryonic stem cells, TFII‐I colocalizes with bivalent domains and depletion of Gtf2i causes embryonic lethality, neural tube closure, and craniofacial defects. To gain insight into the function of TFII‐I during...

chapter

Steroid Receptors

E. F. Greiner, T. Wintermantel, G. Schütz

Handbook of Experimental Pharmacology > Transgenic Models in Pharmacology > Endocrinology > 575-606

Steroids are lipophilic hormones and regulate multiple functions in development, physiology, and reproduction by binding to their cognate receptors. Steroid receptors are intracellular proteins that transduce biological signals into direct transcriptional responses. Because of both the lipophilic nature of the steroid signal and the immediacy of the signal transmission, steroid receptors make ideal...

chapter

Transgenic and Knockout Models in NPY Research

H. Herzog

Handbook of Experimental Pharmacology > Neuropeptide Y and Related Peptides > 447-478

The neuropeptide Y system consists of three peptide precursor genes encoding neuropeptide Y (NPY), peptide YY (PYY) and pancreatic polypeptide (PP) and at least five receptor genes encoding the Y₁, Y₂, Y₄, Y₅ and y₆ receptor making it complex to work with. In the past, delineating the function of the NPY system relied mainly on pharmacological approaches using modified peptide ligands and a few synthetic...

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ON CICERO’S FABIUS ARGUMENT

Generation of a novel mouse strain with conditional, cell‐type specific, expression of DND1

Compilation of static and evolving conditional knowledge bases for computing induced nonmonotonic inference relations

Dynamic organelle localization and cytoskeletal reorganization during preimplantation mouse embryo development revealed by live imaging of genetically encoded fluorescent fusion proteins

Cover Image, Volume 57, Issue 2

Implications for BACE1 Inhibitor Clinical Trials: Adult Conditional BACE1 Knockout Mice Exhibit Axonal Organization Defects in the Hippocampus

Application of long single-stranded DNA donors in genome editing: generation and validation of mouse mutants

Properties of skeptical c-inference for conditional knowledge bases and its realization as a constraint satisfaction problem

Moral Sentimentalism in Counterfactual Contexts: Moral Properties Are Response-Enabled

On the Use of the Expected ARL Metric for Control Charts Based on Estimated Parameters

Adaptive regression model for synthesizing anthropometric population data

The (Non-)classicality of (Non-)classical Mathematics

Thought experiments without possible worlds

A Systems Approach Reveals MAVS Signaling in Myeloid Cells as Critical for Resistance to Ebola Virus in Murine Models of Infection

Conditional subscription and notification in information centric networks

Focus, scales, and concessive conditionals in German

The Completion of the Emergence of Modern Logic from Boole’s The Mathematical Analysis of Logic to Frege’s Begriffsschrift

Generation of a mouse model for a conditional inactivation of Gtf2i allele

Steroid Receptors

Transgenic and Knockout Models in NPY Research

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