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article

Serum level of IL‐4 predicts response to topical immunotherapy with diphenylcyclopropenone in alopecia areata

Yugang Gong, Ying Zhao, Xiaoting Zhang, Shiling Qi, more

Experimental Dermatology > 29 > 3 > 231 - 238

Background This study investigated predictors of response to topical diphenylyclopropenone (DPCP) immunotherapy in patients with alopecia areata (AA). Objective To identify predictors of response, or resistance, to treatment for AA through clinical observations and serum tests. Methods Eighty four AA patients were treated with DPCP. Serum cytokine levels were measured in 33 AA patients pre‐ and...

article

Effect of heavy metals on fish larvae deformities: A review

D.G. Sfakianakis, E. Renieri, M. Kentouri, A.M. Tsatsakis, more

Environmental Research > 2015 > 137 > Complete > 246-255

Heavy metals have been associated with many fish deformities in natural populations and in laboratory produced specimens as well. Deformities in general have devastating effects on fish populations since they affect the survival, the growth rates, the welfare and their external image. Although the embryonic stage in respect to heavy metal exposure has been extensively studied, there is not much information...

article

Comment on the Kaiho et al., paper “A forest fire and soil erosion event during the Late Devonian mass extinction” [Palaeogeography, Palaeoclimatology, Palaeoecology 392 (2013): 272–280]

Leszek Marynowski, Grzegorz Racki, L. Marynowski, G. Racki

Palaeogeography, Palaeoclimatology, Palaeoecology > 2015 > 417 > Complete > 569-572

Kaiho et al. (2013, Palaeogeography, Palaeoclimatology, Palaeoecology 392 (2013): 272–280) interpreted the occurrence of elevated concentrations of high molecular weight polycyclic aromatic hydrocarbons and dibenzofuran as indicators of wildfires and enhanced run-off near the Frasnian–Famennian (F–F) boundary. We argue that other processes, including weathering or hydrothermal oxidation (not discussed...

article

Hydrous pyrolysis of different kerogen types of source rock at high temperature-bulk results and biomarkers

Mingliang Liang, Zuodong Wang, Jianjing Zheng, Xiaoguang Li, more

Journal of Petroleum Science and Engineering > 2015 > 125 > Complete > 209-217

Hydrous pyrolysis experiments were conducted on immature petroleum source rocks containing different types of kerogen (I and II) at a temperature range of 250–550°C to investigate the role of kerogen type in petroleum formation at high temperature. At temperatures less than 350°C, the bulk results and biomarker compositions were quite similar and show negligible variations for different kerogen types...

article

Molecular composition of fossil charcoal and relationship with incomplete combustion of wood

Leszek Marynowski, Rafał Kubik, Dieter Uhl, Bernd R.T. Simoneit, more

Organic Geochemistry > 2014 > 77 > Complete > 22-31

Upper Triassic charcoal extracts were studied using gas chromatography–mass spectrometry (GC–MS) to recognize their molecular composition. Extractable compounds were divided into: (i) biomarkers, i.e. diagenetically changed primary wood components and (ii) products of combustion. Major compounds in the first group were: 1,2,5-trimethylnaphthalene and 1,2,5,6-tetramethylnaphthalene, cadalene, dehydroabietane,...

article

Evidence of accelerated aging among African Americans and its implications for mortality

M.E. Levine, E.M. Crimmins, M.E. Levine, E.M. Crimmins

Social Science & Medicine > 2014 > 118 > Complete > 27-32

Blacks experience morbidity and mortality earlier in the life course compared to whites. Such premature declines in health may be indicative of an acceleration of the aging process. The current study uses data on 7644 black and white participants, ages 30 and above, from the third National Health and Nutrition Examination Survey, to compare the biological ages of blacks and whites as indicated from...

article

Cardiovascular disease detection using bio-sensing techniques

Zeynep Altintas, Wellington M. Fakanya, Ibtisam E. Tothill, Z. Altintas, more

Talanta > 2014 > 128 > Complete > 177-186

Universally, cardiovascular disease (CVD) is recognised as the prime cause of death with estimates exceeding 20 million by 2015 due to heart disease and stroke. Facts regarding the disease, its classification and diagnosis are still lacking. Hence, understanding the issues involved in its initiation, its symptoms and early detection will reduce the high risk of sudden death associated with it. Biosensors...

article

Organic facies variability in the Posidonia Black Shale from Luxembourg: Implications for thermal maturation and depositional environment

Jinli Song, Ralf Littke, Robert Maquil, Philipp Weniger, more

Palaeogeography, Palaeoclimatology, Palaeoecology > 2014 > 410 > Complete > 316-336

Posidonia Shale (Lias ε, Lower Toarcian, ''Schiste bitumineux'') samples were obtained from a well in southern Luxembourg (Esch-sur-Alzette). Elemental composition and organic facies were studied along the cores, and accordingly the thermal maturity and depositional environment were evaluated. The organic matter content is high with an average of 7.2%, ranging between 2.8% and 13.5%. The average vitrinite...

article

Health status assessment through an integrative biomarker approach in mussels of different ages with a different history of exposure to the Prestige oil spill

U. Izagirre, L. Garmendia, M. Soto, N. Etxebarria, more

Science of the Total Environment > 2014 > 493 > Complete > 65-78

A battery of cell and tissue-level biomarkers was applied in mussels of 6 size-classes collected from Galicia and the Basque coast in summer 2007 in an attempt to examine the health status of individuals affected as adults (mature before 2003), affected during their developmental or juvenile stages (2003–2004 offspring), or not directly affected by the Prestige oil spill (POS) exposure (presumably...

article

Tau protein, beta-amyloid1–42 and clusterin CSF levels in the differential diagnosis of Parkinsonian syndrome with dementia

Hana Přikrylová Vranová, Eva Hényková, Michaela Kaiserová, Kateřina Menšíková, more

Journal of the Neurological Sciences > 2014 > 343 > 1-2 > 120-124

Background: Parkinson's disease (PD), PD with dementia (PDD) and Lewy body dementia (DLB) are synucleinopathies. PDD and DLB are sometimes considered a transition between PD and Alzheimer dementia (AD). Finding in vivo markers or their combination could help in the differential diagnosis of these neurodegenerative (ND) diseases. Objective: The aim of this study was to assess cerebrospinal fluid (CSF)...

article

Multi-proxy study of soil organic matter dynamics in permafrost peat deposits reveal vulnerability to climate change in the European Russian Arctic

Joyanto Routh, Gustaf Hugelius, Peter Kuhry, Timothy Filley, more

Chemical Geology > 2014 > 368 > Complete > 104-117

Soil organic carbon (SOC) in permafrost terrain is vulnerable to climate change. Perennially frozen peat deposits store large amounts of SOC, but we know little about its chemical composition and lability. We used plant macrofossil and biomarker analyses to reconstruct the Holocene paleovegetation and paleoenvironmental changes in two peat plateau profiles from the European Russian Arctic. Peat plateaus...

article

Limitations of metallothioneins in common cockles (Cerastoderma edule) and sponges (Haliclona oculata) as biomarkers of metal contamination in a semi-enclosed coastal area

W. Aly, I.D. Williams, M.D. Hudson, W. Aly, more

Science of the Total Environment > 2014 > 473-474 > Complete > 391-397

Poole Harbour is typical of many heavily anthropologically impacted semi-enclosed estuarine coastal areas under pressure from metal pollution across the world. This study examined the physiological significance of metal burdens within that sensitive area, and assessed the potential use of metallothionein (MT) concentrations in two organisms: the common cockle (Cerastoderma edule) and the Mermaid's...

article

Metabolomics in diabetes

Ai-hua Zhang, Shi Qiu, Hong-ying Xu, Hui Sun, more

Clinica Chimica Acta > 2014 > 429 > Complete > 106-110

Characterization of metabolic changes is key to early detection, treatment, and understanding molecular mechanisms of diabetes. Diabetes represents one of the most important global health problems. Approximately 90% of diabetics have type 2 diabetes. Identification of effective screening markers is critical for early treatment and intervention that can delay and/or prevent complications associated...

article

Equatorial Indian Ocean productivity during the last 33kyr and possible linkage to Westerly Jet variability

Vikesano R. Punyu, Virupaxa K. Banakar, Anita Garg, V.R. Punyu, more

Marine Geology > 2014 > 348 > Complete > 44-51

The top 1m radiocarbon dated section of a 5.6m long sediment core retrieved from the Equatorial Indian Ocean is studied for productivity changes in response to climate variability that have taken place during the last ~33kyr. The robust indicators of marine productivity such as phytol and brassicasterol exhibit distinctly higher contents (av. 5.8ng/g and 4.8ng/g respectively) during the LGM (25-17kyBP)...

article

A review of peripheral biomarkers in major depression: The potential of inflammatory and oxidative stress biomarkers

Adrian L. Lopresti, Garth L. Maker, Sean D. Hood, Peter D. Drummond, more

Progress in Neuropsychopharmacology & Biological Psychiatry > 2014 > 48 > Complete > 102-111

Biomarkers are regularly used in medicine to provide objective indicators of normal biological processes, pathogenic processes or pharmacological responses to therapeutic interventions, and have proved invaluable in expanding our understanding and treatment of medical diseases. In the field of psychiatry, assessment and treatment has, however, primarily relied on patient interviews and questionnaires...

article

A review of airborne polycyclic aromatic hydrocarbons (PAHs) and their human health effects

Ki-Hyun Kim, Shamin Ara Jahan, Ehsanul Kabir, Richard J.C. Brown, more

Environment International > 2013 > 60 > Complete > 71-80

Polycyclic aromatic hydrocarbons (PAHs) are a large group of organic compounds comprised of two or more fused benzene rings arranged in various configurations. PAHs are widespread environmental contaminants formed as a result of incomplete combustion of organic materials such as fossil fuels. The occurrence of PAHs in ambient air is an increasing concern because of their carcinogenicity and mutagenicity...

article

Inflammatory biomarkers for predicting cardiovascular disease

Lee Stoner, Adam A. Lucero, Barry R. Palmer, Lynnette M. Jones, more

Clinical Biochemistry > 2013 > 46 > 15 > 1353-1371

The pathology of cardiovascular disease (CVD) is complex; multiple biological pathways have been implicated, including, but not limited to, inflammation and oxidative stress. Biomarkers of inflammation and oxidative stress may serve to help identify patients at risk for CVD, to monitor the efficacy of treatments, and to develop new pharmacological tools. However, due to the complexities of CVD pathogenesis...

article

Organic geochemistry and petroleum potential of Jurassic and Cretaceous deposits of the Yenisei–Khatanga regional trough

N.S. Kim, A.P. Rodchenko, N.S. Kim, A.P. Rodchenko

Russian Geology and Geophysics > 2013 > 54 > 8 > 966-979

We present results of geochemical studies of organic matter of the Jurassic–Cretaceous deposits in the west of the Yenisei–Khatanga regional trough. The studies were carried out on a representative set of well cores by a complex of modern organic-geochemistry methods (determination of organic-carbon content in rocks, pyrolysis, estimation of the carbon isotope composition in the kerogen of rocks,...

article

Clonal haematopoiesis of indeterminate potential: associations with heart failure incidence, clinical parameters and biomarkers

Canxia Shi, Joseph Pierre Aboumsallem, Navin Suthahar, Aniek O. Graaf, more

European Journal of Heart Failure > 25 > 1 > 4 - 13

Aim We aimed to analyse the association of clonal haematopoiesis of indeterminate potential (CHIP) with incident heart failure (HF) in a European population cohort. Methods and results From the prospective Prevention of Renal and Vascular End‐stage Disease (PREVEND) cohort, we included all 374 participants with incident HF and selected 1:1 age‐ and sex‐matched control subjects. Peripheral blood...

article

Characterisation of key biomarkers in diabetic ulcers via systems bioinformatics

Zhan Zhang, Ying Zhang, Dan Yang, Yue Luo, more

International Wound Journal > 20 > 2 > 529 - 542

Diabetic ulcers (DUs) are characterised by a high incidence and disability rate. However, its pathogenesis remains elusive. Thus, a deep understanding of the underlying mechanisms for the pathogenesis of DUs has vital implications. The weighted gene co‐expression network analysis was performed on the main data from the Gene Expression Omnibus database. Gene Ontology (GO) terms, Kyoto Encyclopedia...

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Search results

Serum level of IL‐4 predicts response to topical immunotherapy with diphenylcyclopropenone in alopecia areata

Effect of heavy metals on fish larvae deformities: A review

Comment on the Kaiho et al., paper “A forest fire and soil erosion event during the Late Devonian mass extinction” [Palaeogeography, Palaeoclimatology, Palaeoecology 392 (2013): 272–280]

Hydrous pyrolysis of different kerogen types of source rock at high temperature-bulk results and biomarkers

Molecular composition of fossil charcoal and relationship with incomplete combustion of wood

Evidence of accelerated aging among African Americans and its implications for mortality

Cardiovascular disease detection using bio-sensing techniques

Organic facies variability in the Posidonia Black Shale from Luxembourg: Implications for thermal maturation and depositional environment

Health status assessment through an integrative biomarker approach in mussels of different ages with a different history of exposure to the Prestige oil spill

Tau protein, beta-amyloid1–42 and clusterin CSF levels in the differential diagnosis of Parkinsonian syndrome with dementia

Multi-proxy study of soil organic matter dynamics in permafrost peat deposits reveal vulnerability to climate change in the European Russian Arctic

Limitations of metallothioneins in common cockles (Cerastoderma edule) and sponges (Haliclona oculata) as biomarkers of metal contamination in a semi-enclosed coastal area

Metabolomics in diabetes

Equatorial Indian Ocean productivity during the last 33kyr and possible linkage to Westerly Jet variability

A review of peripheral biomarkers in major depression: The potential of inflammatory and oxidative stress biomarkers

A review of airborne polycyclic aromatic hydrocarbons (PAHs) and their human health effects

Inflammatory biomarkers for predicting cardiovascular disease

Organic geochemistry and petroleum potential of Jurassic and Cretaceous deposits of the Yenisei–Khatanga regional trough

Clonal haematopoiesis of indeterminate potential: associations with heart failure incidence, clinical parameters and biomarkers

Characterisation of key biomarkers in diabetic ulcers via systems bioinformatics

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