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Items from 1 to 20 out of 36 results

article

BACH1 encourages ferroptosis by activating KDM4C‐mediated COX2 demethylation after cerebral ischemia–reperfusion injury

Tianqi Zhang, Meimei Yang, Chi Ma, Xinya Wei, more

European Journal of Neuroscience > 58 > 1 > 2194 - 2214

It has been confirmed that BTB domain and CNC homologue 1 (BACH1) are involved in ferroptosis‐related diseases. However, the function of BACH1 in cerebral ischemia–reperfusion injury (CIRI)‐induced ferroptosis remains to be largely unrevealed. First, analysis of differentially expressed genes in CIRI based on the GEO dataset GSE119121 revealed that BACH1 was upregulated in CIRI. BACH1 level was prominently...

article

Ferroptosis: regulation by competition between NRF2 and BACH1 and propagation of the death signal

Hironari Nishizawa, Mie Yamanaka, Kazuhiko Igarashi

The FEBS Journal > 290 > 7 > 1688 - 1704

Ferroptosis is triggered by a chain of intracellular labile iron‐dependent peroxidation of cell membrane phospholipids. Ferroptosis is important not only as a cause of ischaemic and neurodegenerative diseases but also as a mechanism of cancer suppression, and a better understanding of its regulatory mechanism is required. It has become clear that ferroptosis is finely controlled by two oxidative stress‐responsive...

article

BACH1 regulates erythrophagocytosis and iron‐recycling in β‐thalassemia

Tipparat Penglong, Apisara Saensuwanna, Nuttanan Pholngam, Natta Tansila, more

Genes to Cells > 28 > 3 > 211 - 225

Macrophages play essential roles in erythrophagocytosis and iron recycling. β‐thalassemia is characterized by a genetic defect in hemoglobin synthesis, which increases the rate of iron recycling. We previously showed that reduced expression of the BTB and CNC homolog 1 (BACH1) gene leads to increased phagocytosis of abnormal RBCs by activated monocytes. However, the mechanisms underlying this abnormal...

article

Heme oxygenase promotes B‐Raf‐dependent melanosphere formation

Kimberly J. Jasmer, Jie Hou, Philip Mannino, Jianlin Cheng, more

Pigment Cell & Melanoma Research > 33 > 6 > 850 - 868

Biosynthesis and degradation of heme, an iron‐bound protoporphyrin molecule utilized by a wide variety of metabolic processes, are tightly regulated. Two closely related enzymes, heme oxygenase 1 (HMOX1) and heme oxygenase 2 (HMOX2), degrade free heme to produce carbon monoxide, Fe²⁺, and biliverdin. HMOX1 expression is controlled via the transcriptional activator, NFE2L2, and the transcriptional...

article

HMGA2 and Bach‐1 cooperate to promote breast cancer cell malignancy

Behzad Mansoori, Ali Mohammadi, Zahra Asadzadeh, Solmaz Shirjang, more

Journal of Cellular Physiology > 234 > 10 > 17714 - 17726

During breast cancer progression, tumor cells acquire multiple malignant features. The transcription factors and cell cycle regulators high mobility group A2 (HMGA2) and BTB and CNC homology 1 (Bach‐1) are overexpressed in several cancers, but the mechanistic understanding of how HMGA2 and Bach‐1 promote cancer development has been limited. We found that HMGA2 and Bach‐1 are overexpressed in breast...

article

MicroRNA‐let‐7c suppresses hepatitis C virus replication by targeting Bach1 for induction of haem oxygenase‐1 expression

Wei‐Chun Chen, Chih‐Ku Wei, Jin‐Ching Lee

Journal of Viral Hepatitis > 26 > 6 > 655 - 665

MicroRNAs are small noncoding RNAs that are central factors between hepatitis C virus (HCV) and host cellular factors for viral replication and liver disease progression, including liver fibrosis, cirrhosis and hepatocellular carcinoma. In the present study, we found that overexpressing miR‐let‐7c markedly reduced HCV replication because it induced haem oxygenase‐1 (HO‐1) expression by targeting HO‐1...

article

Dysregulated heme oxygenase-1^low M2-like macrophages augment lupus nephritis via Bach1 induced by type I interferons

Daiga Kishimoto, Yohei Kirino, Maasa Tamura, Mitsuhiro Takeno, more

Arthritis Research & Therapy > 2018 > 20 > 1 > 1-11

Background Innate immunity including macrophages (Mϕ) in lupus nephritis (LN) has been gaining attention, but roles of Mϕ in LN remain uncertain. Methods Immunohistochemical staining was performed to determine CD68, CD163, heme oxygenase (HO)-1 (a stress-inducible heme-degrading enzyme with anti-inflammatory property), pSTAT1, and CMAF-expressing Mϕ in the glomeruli of patients with LN. Effects...

article

The electrophilic character of quinones is essential for the suppression of Bach1

Chuanyang Su, Zixuan Liu, Yawen Wang, Yuxin Wang, more

Toxicology > 2017 > 387 > C > 17-26

The activation of nuclear factor erythroid 2-related factor 2 (Nrf2) is the most important cellular defense mechanisms against oxidative attack. BTB and CNC homology-1 (Bach1), like Kelch-like ECH-associated protein 1 (Keap1), is one of a negative regulator of Nrf2 that control antioxidant response elements (ARE)-dependent gene expressions. In the current study, we found that quinones show greater...

article

Potential role of heme metabolism in the inducible expression of heme oxygenase-1

Taka-aki Takeda, Machiko Sasai, Yuka Adachi, Keiko Ohnishi, more

Biochimica et Biophysica Acta (BBA) - General Subjects > 2017 > 1861 > 7 > 1813-1824

The degradation of heme significantly contributes to cytoprotective effects against oxidative stress and inflammation. The enzyme heme oxygenase-1 (HO-1), involved in the degradation of heme, forms carbon monoxide (CO), ferrous iron, and bilirubin in conjunction with biliverdin reductase, and is induced by various stimuli including oxidative stress and heavy metals. We examined the involvement of...

article

Differentiation modifies Bach1 dependent regulation of HO-1 expression and increases sensitivity to oxidative stress in neuroblastoma cells

Sabrina Piras, Lorenzo Brondolo, Anna Lisa Furfaro, Mario Passalacqua, more

Free Radical Biology and Medicine > 2017 > 108 > S1 > S80

Neuronal adaptation to oxidative stress is crucial to prevent degenerative diseases. The role of the Nrf2/HO-1 system in cell response to hydrogen peroxide (H₂O₂) has been investigated using SH-SY5Y neuroblastoma cells as undifferentiated or after differentiation with all-trans retinoic acid (ATRA). We showed that undifferentiated cells resisted to oxidative stimulus and up-regulated HO-1 which was...

article

Therapeutic effects of bach1 siRNA on human breast adenocarcinoma cell line

Mansoor Aletaha, Behzad Mansoori, Ali Mohammadi, Mehdi Fazeli, more

Biomedicine & Pharmacotherapy > 2017 > 88 > C > 34-42

Despite the great improvements in clinical and therapeutic techniques in recent years, many advanced breast cancer patients still died of the postoperative recurrence and metastasis of disease. Bach1 plays a role in the development of the invasive phenotypes of cancer, cell division and apoptosis in tumor cells. The aim of this study was to investigate the effect of specific bach1 siRNAs, on the proliferation,...

article

BACH1 silencing by siRNA inhibits migration of HT-29 colon cancer cells through reduction of metastasis-related genes

Sadaf Davudian, Neda Shajari, Tohid Kazemi, Behzad Mansoori, more

Biomedicine & Pharmacotherapy > 2016 > 84 > C > 191-198

Metastasis to distant organs is a hallmark of many tumor cells. BACH1 (BTB and CNC homology 1) is a transcriptional factor which promotes the migration and invasion of breast cancer cells. BACH1 expression and its target genes are intimately associated with the metastasis possibility of clinical samples, and BACH1 reduction leads to meaningful depletion in metastasis. The evaluation of BACH1 role...

article

BACH1, the master regulator gene: A novel candidate target for cancer therapy

Sadaf Davudian, Behzad Mansoori, Neda Shajari, Ali Mohammadi, more

Gene > 2016 > 588 > 1 > 30-37

BACH1 (BTB and CNC homology 1, basic leucine zipper transcription factor 1) is a transcriptional factor and a member of cap ‘n’ collar (CNC) and basic region leucine zipper factor family. In contrast to other bZIP family members, BACH1 appeared as a comparatively specific transcription factor. It acts as transcription regulator and is recognized as a recently hypoxia regulator and functions as an...

article

Tetrachlorobenzoquinone induces Nrf2 activation via rapid Bach1 nuclear export/ubiquitination and JNK-P62 signaling

Chuanyang Su, Qiong Shi, Xiufang Song, Juanli Fu, more

Toxicology > 2016 > 363-364 > C > 48-57

Our previous studies demonstrated that tetrachlorobenzoquinone (TCBQ), an active metabolite of pentachlorophenol, has effects on the generation of reactive oxygen species (ROS) and oxidative stress in vitro and in vivo. Nuclear factor erythroid-derived 2-like 2 (Nrf2) is a cellular sensor of electrophilic or oxidative stress that regulates the expression of antioxidant enzymes and defensive proteins...

article

Bach1 differentially regulates distinct Nrf2-dependent genes in human venous and coronary artery endothelial cells adapted to physiological oxygen levels

Sarah J. Chapple, Thomas P. Keeley, Daniela Mastronicola, Matthew Arno, more

Free Radical Biology and Medicine > 2016 > 92 > C > 152-162

The effects of physiological oxygen tension on Nuclear Factor-E2-Related Factor 2 (Nrf2)-regulated redox signaling remain poorly understood. We report the first study of Nrf2-regulated signaling in human primary endothelial cells (EC) adapted long-term to physiological O₂ (5%). Adaptation of EC to 5% O₂ had minimal effects on cell ultrastructure, viability, basal redox status or HIF1-α expression...

article

The Bach Family of Transcription Factors: A Comprehensive Review

Yin Zhou, Haijing Wu, Ming Zhao, Christopher Chang, more

Clinical Reviews in Allergy & Immunology > 2016 > 50 > 3 > 345-356

The transcription factors Bach1 and Bach2, which belong to a basic region-leucine zipper (bZip) family, repress target gene expression by forming heterodimers with small Maf proteins. With the ability to bind to heme, Bach1 and Bach2 are important in maintaining heme homeostasis in response to oxidative stress, which is characterized by high levels of reactive oxygen species (ROS) in cells and thereby...

article

FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice

Xianfei Sun, Miguel A. Brieño-Enríquez, Alyssa Cornelius, Andrew J. Modzelewski, more

Chromosoma > 2016 > 125 > 2 > 237-252

Fancj, the gene associated with Fanconi anemia (FA) Complementation Group J, encodes a DNA helicase involved in homologous recombination repair and the cellular response to replication stress. FANCJ functions in part through its interaction with key DNA repair proteins, including MutL homolog-1 (MLH1), Breast Cancer Associated gene-1 (BRCA1), and Bloom syndrome helicase (BLM). All three...

article

Dual regulation of skin sensitizer-induced HMOX1 expression by Bach1 and Nrf2: Comparison to regulation of the AKR1C2-ARE element in the KeratinoSens cell line

Roger Emter, Andreas Natsch

Toxicology and Applied Pharmacology > 2015 > 288 > 3 > 281-288

Heme oxygenase (decycling) 1 (HMOX1) is the most consistently found genetic marker induced by skin sensitizers. HMOX1 is often referred to as typical gene regulated by nuclear factor erythroid 2-related factor 2 (Nrf2), however, it is also regulated by other DNA-binding factors, including BTB and CNC homolog 1 (Bach1). The KeratinoSens™ assay is the first validated in vitro assay for sensitizers that...

article

Cell-type-specific downregulation of heme oxygenase-1 by lipopolysaccharide via Bach1 in primary human mononuclear cells

Mirrin J. Dorresteijn, Ananta Paine, Eva Zilian, Maaike G.E. Fenten, more

Free Radical Biology and Medicine > 2015 > 78 > Complete > 224-232

Heme oxygenase (HO)-1 is the inducible isoform of the heme-degrading enzyme HO, which is upregulated by multiple stress stimuli. HO-1 has major immunomodulatory and anti-inflammatory effects via its cell-type-specific functions in mononuclear cells. Contradictory findings have been reported on HO-1 regulation by the Toll-like receptor (TLR) 4 ligand lipopolysaccharide (LPS) in these cells. Therefore,...

article

Hemopexin-dependent heme uptake via endocytosis regulates the Bach1 transcription repressor and heme oxygenase gene activation

Hiroshi Hada, Takuma Shiraki, Miki Watanabe-Matsui, Kazuhiko Igarashi

BBA - General Subjects > 2014 > 1840 > 7 > 2351-2360

Intracellular heme plays versatile roles in a variety of physiological processes including mitochondrial respiration. Heme also induces the expression of genes such as heme oxygenase-1 (HO-1) by inactivating the transcription repressor Bach1 through direct binding. However, the source of heme for the regulation of the Bach1–HO-1 axis has been unclear. Considering that extracellular heme exists as...

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BACH1 (36)
NRF2 (9)
HO-1 (7)
OXIDATIVE STRESS (7)
HEME (6)
FREE RADICALS (5)
HEME OXYGENASE-1 (5)
HEME OXYGENASE 1 (4)
BREAST CANCER (3)
KEAP1 (3)
SIRNA (3)
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ANTIOXIDANT RESPONSE ELEMENT (2)
BACH2 (2)
CANCER (2)
ENDOTHELIAL (2)
FERROPTOSIS (2)
HMOX1 (2)
REACTIVE OXYGEN SPECIES (2)
REDOX SIGNALING (2)
UVA (2)
IN SILICO ANALYSIS (1)
5-AMINOLEVULINIC ACID (ALA) (1)
AGING (1)
ANGIOGENESIS (1)
ANTIOXIDANT (1)
APOPTOSIS (1)
ARSENIC (1)
BRAIN (1)
BRCA1 (1)
BRCT REPEAT (1)
BRIP1 (1)
BRONCHOALVEOLAR LAVAGE (1)
CANCER PREDISPOSITION (1)
CANCER STEM CELL (1)
CARDIOVASCULAR DISEASE (1)
CELL DEATH (1)
CEREBRAL ISCHEMIA–REPERFUSION (1)
CHROMATIN IMMUNOPRECIPITATION ANALYSIS (1)
COLD INJURY MODEL (1)
COLON (1)
CORM3 (1)
CORONARY ARTERY (1)
COX2 (1)
CREB‐BINDING PROTEIN (1)
DAMAGE‐ASSOCIATED MOLECULAR PATTERNS (DAMPS) (1)
DICER (1)
DIFFERENTIATION (1)
DJ-1 (1)
DNA SEQUENCING (1)
DOCKING (1)
DROSHA (1)
EMT (1)
ENDOCYTOSIS (1)
ENDOTHELIAL CELLS (1)
ERYTHROPHAGOCYTOSIS (1)
EXON 20 (1)
EXPORTIN-5 (1)
EXTRACELLULAR MATRIX PROTEINS (1)
FANCONI ANEMIA (1)
GAMETOGENESIS (1)
GCL (1)
GENE EXPRESSION (1)
GLUTAMATE CYSTEINE LIGASE CATALYTIC SUBUNIT (1)
GLUTATHIONE (1)
GLUTATHIONE REDUCTASE GR (1)
H3K9ME3 (1)
HAEM OXYGENASE‐1 (1)
HEME METABOLISM (1)
HEME OXYGENASE (1)
HEME OXYGENASE-1 (HO-1) (1)
HEME OXYGENASE1 (1)
HEME OXYGENASE‐1 (1)
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KNOCKDOWN (1)
LET-7 (1)
LIPID PEROXIDATION (1)
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MEIOTIC PROPHASE I (1)
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Search results

BACH1 encourages ferroptosis by activating KDM4C‐mediated COX2 demethylation after cerebral ischemia–reperfusion injury

Ferroptosis: regulation by competition between NRF2 and BACH1 and propagation of the death signal

BACH1 regulates erythrophagocytosis and iron‐recycling in β‐thalassemia

Heme oxygenase promotes B‐Raf‐dependent melanosphere formation

HMGA2 and Bach‐1 cooperate to promote breast cancer cell malignancy

MicroRNA‐let‐7c suppresses hepatitis C virus replication by targeting Bach1 for induction of haem oxygenase‐1 expression

Dysregulated heme oxygenase-1^low M2-like macrophages augment lupus nephritis via Bach1 induced by type I interferons

The electrophilic character of quinones is essential for the suppression of Bach1

Potential role of heme metabolism in the inducible expression of heme oxygenase-1

Differentiation modifies Bach1 dependent regulation of HO-1 expression and increases sensitivity to oxidative stress in neuroblastoma cells

Therapeutic effects of bach1 siRNA on human breast adenocarcinoma cell line

BACH1 silencing by siRNA inhibits migration of HT-29 colon cancer cells through reduction of metastasis-related genes

BACH1, the master regulator gene: A novel candidate target for cancer therapy

Tetrachlorobenzoquinone induces Nrf2 activation via rapid Bach1 nuclear export/ubiquitination and JNK-P62 signaling

Bach1 differentially regulates distinct Nrf2-dependent genes in human venous and coronary artery endothelial cells adapted to physiological oxygen levels

The Bach Family of Transcription Factors: A Comprehensive Review

FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice

Dual regulation of skin sensitizer-induced HMOX1 expression by Bach1 and Nrf2: Comparison to regulation of the AKR1C2-ARE element in the KeratinoSens cell line

Cell-type-specific downregulation of heme oxygenase-1 by lipopolysaccharide via Bach1 in primary human mononuclear cells

Hemopexin-dependent heme uptake via endocytosis regulates the Bach1 transcription repressor and heme oxygenase gene activation

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