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article

High circulating osteoprotegerin levels are associated with non-zero blood groups

Elod Erno Nagy, Timea Varga-Fekete, Attila Puskas, Piroska Kelemen, more

BMC Cardiovascular Disorders > 2016 > 16 > 1 > 1-8

Background Osteoprotegerin (OPG) and von Willebrand factor (VWF) form complex within endothelial cells and following secretion. The nature of blood group antigens strongly influences the levels of circulating VWF, but there is no available data concerning its ascendancy on OPG levels. We aimed to assess the relationship of AB0 blood groups with OPG, VWF levels (VWF: Ag) and collagen binding activity...

article

High‐methionine diets accelerate atherosclerosis by HHcy‐mediated FABP4 gene demethylation pathway via DNMT1 in ApoE^−/− mice

An-Ning Yang, Hui-Ping Zhang, Yue Sun, Xiao-Ling Yang, more

FEBS Letters > 589 > 24PartB > 3998 - 4009

Homocysteine (Hcy) is an independent risk factor for atherosclerosis, but the underlying molecular mechanisms are not known. We investigated the effects of Hcy on fatty acid‐binding protein 4 (FABP4), and tested our hypothesis that Hcy‐induced atherosclerosis is mediated by increased FABP4 expression and decreased methylation. The FABP4 expression and DNA methylation was assessed in the aorta of ApoE...

article

New Aspects on the Metabolic role of Intestinal Microbiota in the Development of Atherosclerosis

Ioannis Drosos, Anna Tavridou, George Kolios, I. Drosos, more

Metabolism > 2015 > 64 > 4 > 476-481

Gut microbiota remains a very interesting, yet largely unexplored ecosystem inside the human organism. The importance of this ecosystem for the physiology and the pathophysiology of the organism is being slowly unraveled. Recent studies reveal a connection between intestinal microbiota and atherosclerosis development. It seems that alterations in the function and composition of this bacterial population...

article

Variants in ALOX5, ALOX5AP and LTA4H are not associated with atherosclerotic plaque phenotypes: The Athero-Express Genomics Study

Sander W. van der Laan, Hassan Foroughi Asl, Pleunie van den Borne, Jessica van Setten, more

Atherosclerosis > 2015 > 239 > 2 > 528-538

Background: The eicosanoid genes ALOX5, ALOX5AP and LTA4H have been implicated in atherosclerosis. We assessed the impact of common variants in these genes on gene expression, circulating protein levels, and atherosclerotic plaque phenotypes. Methods: We included patients from the Stockholm Atherosclerosis Gene Expression study (STAGE, N = 109), and the Athero-Express Biobank Study (AE, N = 1443)...

article

Macrovascular disease: pathogenesis and risk assessment

Sandro Vella, John R. Petrie, S. Vella, J.R. Petrie

Medicine > 2015 > 43 > 1 > 1-6

Type 2 diabetes mellitus is characterized by obesity and insulin resistance (IR). Macrovascular (cardiovascular) disease (CVD) encompasses myocardial infarction, stroke and peripheral artery disease. It is caused by atherosclerosis, a complex pathological process that is accelerated in people with diabetes and therefore accounts for a higher proportion of total mortality. Risk is modified by established...

article

Bifurcation analysis of a model for atherosclerotic plaque evolution

M.A.K. Bulelzai, J.L.A. Dubbeldam, H.G.E. Meijer, M.A.K. Bulelzai, more

Physica D: Nonlinear Phenomena > 2014 > 278-279 > Complete > 31-43

We analyze two ordinary differential equation (ODE) models for atherosclerosis. The ODE models describe long time evolution of plaques in arteries. We show how the dynamics of the first atherosclerosis model (model A) can be understood using codimension-two bifurcation analysis. The Low-Density Lipoprotein (LDL) intake parameter (d) is the first control parameter and the second control parameter is...

article

The influence of computational strategy on prediction of mechanical stress in carotid atherosclerotic plaques: Comparison of 2D structure-only, 3D structure-only, one-way and fully coupled fluid-structure interaction analyses

Yuan Huang, Zhongzhao Teng, Umar Sadat, Martin J. Graves, more

Journal of Biomechanics > 2014 > 47 > 6 > 1465-1471

Background: Compositional and morphological features of carotid atherosclerotic plaques provide complementary information to luminal stenosis in predicting clinical presentations. However, they alone cannot predict cerebrovascular risk. Mechanical stress within the plaque induced by cyclical changes in blood pressure has potential to assess plaque vulnerability. Various modeling strategies have been...

article

Cardiovascular disease in autoimmune rheumatic diseases

Ivana Hollan, Pier Luigi Meroni, Joseph M. Ahearn, J.W. Cohen Tervaert, more

Autoimmunity Reviews > 2013 > 12 > 10 > 1004-1015

Various autoimmune rheumatic diseases (ARDs), including rheumatoid arthritis, spondyloarthritis, vasculitis and systemic lupus erythematosus, are associated with premature atherosclerosis. However, premature atherosclerosis has not been uniformly observed in systemic sclerosis. Furthermore, although experimental models of atherosclerosis support the role of antiphospholipid antibodies in atherosclerosis,...

article

Allogeneic bone marrow mesenchymal stem cells transplantation for stabilizing and repairing of atherosclerotic ruptured plaque

Shun-Miao Fang, Da-Yong Du, Yun-Tian Li, Xing-Li Ge, more

Thrombosis Research > 2013 > 131 > 6 > e253-e257

Introduction: There have been no satisfactory therapies on stabilizing and repairing ruptured plagues nowadays, which are the fundamental causes of acute coronary syndrome (ACS) and stroke. The aim of this study was to investigate the therapeutic potential of bone marrow mesenchymal stem cells (MSCs) in stabilizing and repairing ruptured plaques. Materials and Methods: 28 male New Zealand rabbits...

article

Vulnerabilidad a la aterosclerosis en pacientes con psoriasis y artritis psoriásica, según las determinaciones de la velocidad de la onda de pulso carótido-femoral (aórtica)

Mehmet Soy, Mustafa Yildiz, Mehmet Sevki Uyanik, Nuran Karaka, more

Revista Espanola de Cardiologia (English Edition) > 2009 > 62 > 1 > 96-99

In this study we analyzed the susceptibility to atherosclerosis of patients with psoriasis and psoriatic arthritis (PsA) by determining the femoral-carotid pulse wave velocity (PWV), which is a measure of the viscoelastic properties of blood vessels.The study included 25 patients with psoriasis (age 18-63 years, 13 male), of whom 9 had arthritis, as well as 39 sex- and age–matched healthy control...

article

Systemic lupus erythematosus and “lupus dyslipoproteinemia”

Jozélio Freire de Carvalho, Eloísa Bonfá, Eduardo Ferreira Borba

Autoimmunity Reviews > 2008 > 7 > 3 > 246-250

A growing body of evidences reinforces the close link between systemic lupus erythematosus (SLE) and atherosclerosis which is due to traditional and nontraditional risk factors for cardiovascular diseases. It is now recognized that SLE has a particular pattern of dyslipoproteinemia characterized by low HDL levels and increased triglycerides, which is aggravated by flares. Multiple mechanisms can induce...

article

Edge‐Type Hyperintense Intracranial Artery Plaque: A Potential MRI Biomarker of Stroke Recurrence

Hongxia Li, Sui Chen, Jia Liu, Yingle Li, more

Journal of Magnetic Resonance Imaging > 60 > 5 > 2030 - 2039

Background Identifying patients at high risk of stroke recurrence is important for stroke prevention and treatment. Purpose To explore the characteristics of T1 hyperintense plaques (HIP) and their relationship with stroke recurrence in patients with symptomatic intracranial atherosclerotic stenosis (sICAS). Study Type Retrospective. Population One hundred fifty‐seven patients with moderate‐to‐severe...

article

Puerarin alleviates acrolein‐induced atherosclerosis by activating the MYH9‐mediated SIRT1/Nrf2 cascade to inhibit the activation of inflammasome

XiaoNing Li, YeTing Li, HuiHui Jiao, AiTing Wang, more

Biotechnology and Applied Biochemistry > 71 > 5 > 1129 - 1138

Puerarin (Pue) has significant antioxidant and anti‐inflammatory properties. This work was designed to clarify and investigate the potential mechanisms of Pue in atherosclerosis (AS) progression. In vivo, acrolein (Acr) was inhaled through drinking water to construct AS model. In vitro, CCK‐8 assay and lactate dehydrogenase (LDH) assay kit were used to detect cell viability. Apoptosis was detected...

article

Codelivery of Dual Gases with Metal‐Organic Supramolecular Cage‐Based Microenvironment‐Responsive Nanomedicine for Atherosclerosis Therapy

Dongye Li, Jingjing Chen, Yulin Lu, Xinyu Yan, more

Small > 20 > 40 > n/a - n/a

Atherosclerosis (AS) is a common cause of coronary heart disease and stroke. The delivery of exogenous H₂S and in situ production of O₂ within atherosclerotic plaques can help suppress inflammatory cell infiltration and alleviate disease progression. However, the uncontrolled release of gas donors hinders achieving effective drug concentrations and causes toxic effects. Herein, diallyl trisulfide...

article

Cholesterol transport and beyond: Illuminating the versatile functions of HDL apolipoproteins through structural insights and functional implications

Aishwarya Sudam Bhale, Olivier Meilhac, Christian Lefebvre d'Hellencourt, Mookambeswaran A. Vijayalakshmi, more

BioFactors > 50 > 5 > 922 - 956

High‐density lipoproteins (HDLs) play a vital role in lipid metabolism and cardiovascular health, as they are intricately involved in cholesterol transport and inflammation modulation. The proteome of HDL particles is indeed complex and distinct from other components in the bloodstream. Proteomics studies have identified nearly 285 different proteins associated with HDL; however, this review focuses...

article

Emerging clinical role of proprotein convertase subtilisin/kexin type 9 inhibition—Part one: Pleiotropic pro‐atherosclerotic effects of PCSK9

Alexander M. Cao Zhang, Efthymios Ziogos, Tarek Harb, Gary Gerstenblith, more

European Journal of Clinical Investigation > 54 > 10 > n/a - n/a

Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is primarily recognized for its role in lipid metabolism, but recent evidence suggests that it may have broader implications due to its diverse tissue expression. Objective This review aims to explore the multifaceted functions of PCSK9, highlighting its pro‐atherosclerotic effects, including its impact on circulating lipoprotein...

article

T‐cell senescence was correlated with early atherosclerosis in patients with systemic lupus erythematosus

Mirza Zaka Pratama, Cesarius Singgih Wahono, Ahmad Bayhaqi Nasir Aslam, Syahrul Chilmi, more

International Journal of Rheumatic Diseases > 27 > 9 > n/a - n/a

Aim To investigate the correlation between T‐cell senescence with the atherosclerosis markers in patients with systemic lupus erythematosus (SLE). Methods The study participants were 40 female SLE patients aged 18–45 years who met the 2019 EULAR/ACR criteria and 40 healthy individuals. The atherosclerosis markers were investigated using the Doppler ultrasonography examinations to measure the cIMT...

article

Increased prevalence of high‐risk coronary plaques in metabolic dysfunction associated steatotic liver disease patients: A meta‐analysis

Ovidio De Filippo, Gianluca Di Pietro, Marco Nebiolo, Davide Giuseppe Ribaldone, more

European Journal of Clinical Investigation > 54 > 9 > n/a - n/a

Background Metabolic dysfunction associated steatotic liver disease (MASLD) is associated with an increased risk of coronary artery disease. Computed Tomography Coronary Angiography (CTCA) can assess both the extent and the features of coronary plaques. We aimed to gather evidence about the prevalence and features of coronary plaques among MASLD patients. Methods PubMed, Scopus, and Google Scholar...

article

Gut microbiota and its relationship with early vascular ageing in a Spanish population (MIVAS study)

Rita Salvado, Sandra Santos‐Minguez, Cristina Lugones‐Sánchez, Susana Gonzalez‐Sánchez, more

European Journal of Clinical Investigation > 54 > 9 > n/a - n/a

Background Gut microbiota and its by‐products are increasingly recognized as having a decisive role in cardiovascular diseases. The aim is to study the relationship between gut microbiota and early vascular ageing (EVA). Methods A cross‐sectional study was developed in Salamanca (Spain) in which 180 subjects aged 45–74 years were recruited. EVA was defined by the presence of at least one of the...

article

Role of osteokines in atherosclerosis

Yi‐Fan Liu, Yuan Tian, Xiao‐Fang Chen, Chi Zhang, more

Cell Biochemistry and Function > 42 > 6 > n/a - n/a

Despite their diverse physiologies and roles, the heart, skeletal muscles, and smooth muscles all derive from a common embryonic source as bones. Moreover, bone tissue, skeletal and smooth muscles, and the heart share conserved signaling pathways. The maintenance of skeletal health is precisely regulated by osteocytes, osteoblasts, and osteoclasts through coordinated secretion of bone‐derived factors...

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Search results

High circulating osteoprotegerin levels are associated with non-zero blood groups

High‐methionine diets accelerate atherosclerosis by HHcy‐mediated FABP4 gene demethylation pathway via DNMT1 in ApoE^−/− mice

New Aspects on the Metabolic role of Intestinal Microbiota in the Development of Atherosclerosis

Variants in ALOX5, ALOX5AP and LTA4H are not associated with atherosclerotic plaque phenotypes: The Athero-Express Genomics Study

Macrovascular disease: pathogenesis and risk assessment

Bifurcation analysis of a model for atherosclerotic plaque evolution

The influence of computational strategy on prediction of mechanical stress in carotid atherosclerotic plaques: Comparison of 2D structure-only, 3D structure-only, one-way and fully coupled fluid-structure interaction analyses

Cardiovascular disease in autoimmune rheumatic diseases

Allogeneic bone marrow mesenchymal stem cells transplantation for stabilizing and repairing of atherosclerotic ruptured plaque

Vulnerabilidad a la aterosclerosis en pacientes con psoriasis y artritis psoriásica, según las determinaciones de la velocidad de la onda de pulso carótido-femoral (aórtica)

Systemic lupus erythematosus and “lupus dyslipoproteinemia”

Edge‐Type Hyperintense Intracranial Artery Plaque: A Potential MRI Biomarker of Stroke Recurrence

Puerarin alleviates acrolein‐induced atherosclerosis by activating the MYH9‐mediated SIRT1/Nrf2 cascade to inhibit the activation of inflammasome

Codelivery of Dual Gases with Metal‐Organic Supramolecular Cage‐Based Microenvironment‐Responsive Nanomedicine for Atherosclerosis Therapy

Cholesterol transport and beyond: Illuminating the versatile functions of HDL apolipoproteins through structural insights and functional implications

Emerging clinical role of proprotein convertase subtilisin/kexin type 9 inhibition—Part one: Pleiotropic pro‐atherosclerotic effects of PCSK9

T‐cell senescence was correlated with early atherosclerosis in patients with systemic lupus erythematosus

Increased prevalence of high‐risk coronary plaques in metabolic dysfunction associated steatotic liver disease patients: A meta‐analysis

Gut microbiota and its relationship with early vascular ageing in a Spanish population (MIVAS study)

Role of osteokines in atherosclerosis

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