Search results

article

Targeting urate to reduce oxidative stress in Parkinson disease

Grace F. Crotty, Alberto Ascherio, Michael A. Schwarzschild

Experimental Neurology > 2017 > 298 > PB > 210-224

Oxidative stress has been implicated as a core contributor to the initiation and progression of multiple neurological diseases. Genetic and environmental factors can produce oxidative stress through mitochondrial dysfunction leading to the degeneration of dopaminergic and other neurons underlying Parkinson disease (PD). Although clinical trials of antioxidants have thus far failed to demonstrate slowed...

article

Nettle (Urtica dioica L.) as a source of antioxidant and anti-aging phytochemicals for cosmetic applications

Capucine Bourgeois, Émilie A. Leclerc, Cyrielle Corbin, Joël Doussot, more

Comptes Rendus Chimie > 2016 > 19 > 9 > 1090-1100

Nettle (Urtica dioica L.) is a herbaceous perennial that has been used for centuries in folk medicine. More recently, nettle extracts have also been used in cosmetics because of the many benefits of their topical application for skin health. Their potential anti-aging action is of particular interest and is primarily ascribed to their antioxidant capacity. Here, using an experimental design approach...

article

Use of arbuscular mycorrhizal fungi to improve the drought tolerance of Cupressus atlantica G.

Lamia Zarik, Abdelilah Meddich, Mohamed Hijri, Mohamed Hafidi, more

Comptes Rendus Biologies > 2016 > 339 > 5-6 > 185-196

In this study, we investigated whether indigenous arbuscular mycorrhizal (AM) fungi could improve the tolerance of Cupressus atlantica against water deficit. We tested a gradient of watering regime spanning from 90% to 25% of soil retention capacity of water on mycorhized and non-mycorhized seedlings in pot cultures with sterilized and non-sterilized soils. Our result showed a positive impact of AM...

article

Diosgenin-based thio(seleno)ureas and triazolyl glycoconjugates as hybrid drugs. Antioxidant and antiproliferative profile

Laura L. Romero-Hernández, Penélope Merino-Montiel, Sara Montiel-Smith, Socorro Meza-Reyes, more

European Journal of Medicinal Chemistry > 2015 > 99 > Complete > 67-81

The stereoselective preparation of diosgenin-derived thio(seleno)ureas and glycomimetics bearing a 1,2,3-triazolyl tether on C-3 has been accomplished. The key steps in the synthetic pathway are the incorporation of an amino moiety and its further transformation into thio- and selenoureas, and also a click chemistry reaction involving a propargyl residue and an azido moiety to afford carbohydrate-derived...

article

Characterisation of fatty acid, carotenoid, tocopherol/tocotrienol compositions and antioxidant activities in seeds of three Chenopodium quinoa Willd. genotypes

Yao Tang, Xihong Li, Peter X. Chen, Bing Zhang, more

Food Chemistry > 2015 > 174 > Complete > 502-508

Composition of fatty acids, tocopherols, tocotrienols, and carotenoids, and their contribution to antioxidant activities were investigated in seeds of three coloured quinoa cultivars (white, red and black). The major components and individual compounds were significantly different, and their concentrations were higher in darker seeds (p<0.05). The oil yield was 6.58–7.17% which contained predominantly...

article

Enzymatic production of bioactive docosahexaenoic acid phenolic ester

Mohamed H. Roby, Ahmad Allouche, Layal Dahdou, Vanessa C. De Castro, more

Food Chemistry > 2015 > 171 > Complete > 397-404

Docosahexaenoic acid (DHA) is increasingly considered for its health benefits. However, its use as functional food ingredient is still limited by its instability. In this work, we developed an efficient and solvent-free bioprocess for the synthesis of a phenolic ester of DHA. A fed-batch process catalyzed by Candida antarctica lipase B was optimised, leading to the production of 440g/L vanillyl ester...

article

Curcumin enhances recovery of pancreatic islets from cellular stress induced inflammation and apoptosis in diabetic rats

Kahkashan Rashid, Parames C. Sil, K. Rashid, P.C. Sil

Toxicology and Applied Pharmacology > 2015 > 282 > 3 > 297-310

The phytochemical, curcumin, has been reported to play many beneficial roles. However, under diabetic conditions, the detail mechanism of its beneficial action in the glucose homeostasis regulatory organ, pancreas, is poorly understood. The present study has been designed and carried out to explore the role of curcumin in the pancreatic tissue of STZ induced and cellular stress mediated diabetes in...

article

Effect of Eclipta prostrata on lipid metabolism in hyperlipidemic animals

Yun Zhao, Lu Peng, Wei Lu, Yiqing Wang, more

Experimental Gerontology > 2015 > 62 > Complete > 37-44

Eclipta prostrata (Linn.) Linn. is a traditional Chinese medicine and has previously been reported to have hypolipidemic effects. However, its mechanism of action is not well understood. This study was conducted to identify the active fraction of Eclipta, its toxicity, its effect on hyperlipidemia, and its mechanism of action. The ethanol extract (EP) of Eclipta and fractions EPF1–EPF4, obtained by...

article

Mediterranean semi-arid plant Astragalus armatus as a source of bioactive galactomannan

Zakaria Boual, Guillaume Pierre, Cédric Delattre, Fatima Benaoun, more

Bioactive Carbohydrates and Dietary Fibre > 2015 > 5 > 1 > 10-18

A water-soluble polysaccharide fraction (WSPF) was extracted and purified from Astragalus armatus Lam. (Fabaceae), a spontaneous plant found in North Algerian Sahara. The structural features of WSPF were evaluated by colorimetric assays, Fourier transform infrared (FTIR) spectroscopy, high performance anion exchange chromatography with pulsed amperometric detection (HPAEC-PAD) and gas chromatography...

article

Preventive supplementation with fresh and preserved peach attenuates CCl4-induced oxidative stress, inflammation and tissue damage

Juciano Gasparotto, Nauana Somensi, Rafael Calixto Bortolin, Carolina Saibro Girardi, more

The Journal of Nutritional Biochemistry > 2014 > 25 > 12 > 1282-1295

The present study was elaborated to comparatively evaluate the preventive effect of different peach-derived products obtained from preserved fruits (Syrup and Preserve Pulp Peach [PPP]) and from fresh peels and pulps (Peel and Fresh Pulp Peach [FPP]) in a model of liver/renal toxicity and inflammation induced by carbon tetrachloride (CCl ₄ ) in rats. Tissue damage (carbonyl, thiobarbituric...

article

Design, synthesis and characterization of zinc–morin, a metal flavonol complex and evaluation of its antidiabetic potential in HFD–STZ induced type 2 diabetes in rats

V. Sendrayaperumal, S. Iyyam Pillai, S. Subramanian, V. Sendrayaperumal, more

Chemico-Biological Interactions > 2014 > 219 > Complete > 9-17

The present study deals with the synthesis, characterization of zinc–morin complex and evaluation of its antidiabetic efficacy in High Fat Diet (HFD)-fedStreptozotocin (STZ) induced diabetic rats. Oral administration of zinc–morin complex to diabetic rats (5mg/kg body weight/day) for a period of 30days resulted in the decreased levels of blood glucose and HbA1c. Oral administrations of the zinc–morin...

article

Different concentrations of cysteamine and ergothioneine improve microscopic and oxidative parameters in ram semen frozen with a soybean lecithin extender

Abozar Najafi, Hossein Daghigh Kia, Hossein Mohammadi, Mir Hossein Najafi, more

Cryobiology > 2014 > 69 > 1 > 68-73

The aim of this study was to evaluate the effects of ergothioneine and cysteamine as antioxidant supplements in a soybean lecithin extender for freezing ram semen. Twenty-four ejaculates were collected from four rams and diluted with extenders (1.5% soybean lecithin, 7% glycerol) containing no supplements (control) and cysteamine or ergothioneine (2, 4, 6 or 8mM). Motility by CASA, viability, plasma...

article

Neuroprotective effects of corn silk maysin via inhibition of H2O2-induced apoptotic cell death in SK-N-MC cells

Doo Jin Choi, Sun-Lim Kim, Ji Won Choi, Yong Il Park, more

Life Sciences > 2014 > 109 > 1 > 57-64

Aims: Neuroprotective effects of maysin, which is a flavone glycoside that was isolated from the corn silk (CS, Zea mays L.) of a Korean hybrid corn Kwangpyeongok, against oxidative stress (H ₂ O ₂ )-induced apoptotic cell death of human neuroblastoma SK-N-MC cells were investigated. Main methods: Maysin cytotoxicity was determined by measuring cell viability using MTT and lactate...

article

Thiaflavan scavenges radicals and inhibits DNA oxidation: A story from the ferrocene modification

Hai-Wang Lai, Zai-Qun Liu, H.W. Lai, Z.Q. Liu

European Journal of Medicinal Chemistry > 2014 > 81 > Complete > 227-236

4-Thiaflavan is a sulfur-substituted flavonoid with a benzoxathiin scaffold. The aim of this work is to compare abilities of sulfur and oxygen atom, hydroxyl groups, and ferrocene moiety at different positions of 4-thiaflavan to trap radicals and to inhibit DNA oxidation. It is found that abilities of thiaflavans to trap radicals and to inhibit DNA oxidation are increased in the presence of ferrocene...

article

Antioxidant film development from unrefined extracts of brown seaweeds Laminaria digitata and Ascophyllum nodosum

N. Blanco-Pascual, M.P. Montero, M.C. Gómez-Guillén, N. Blanco-Pascual, more

Food Hydrocolloids > 2014 > 37 > Complete > 100-110

Film-forming carbohydrate-rich extracts from brown seaweeds Laminaria digitata (L) and Ascophyllum nodosum (A) were obtained using Na ₂ CO ₃ (Lc, Ac) or NaOH (Lh, Ah) at different temperatures (21, 50 and 75 °C) and after different acid pre-treatments (H ₂ SO ₄ and HCl). Extracts of L. digitata had higher protein content than of A. nodosum. NaOH extractions were more...

article

Recovery from hypoxia and hypercapnic hypoxia: Impacts on the transcription of key antioxidants in the shrimp Litopenaeus vannamei

Casey D. Kniffin, Louis E. Burnett, Karen G. Burnett, C.D. Kniffin, more

Comparative Biochemistry and Physiology, Part B > 2014 > 170 > Complete > 43-49

Estuarine waters are prone to regular bouts of low oxygen (hypoxia) and high carbon dioxide (hypercapnia). In vertebrates, tissue hypoxia followed by reoxygenation can generate high levels of reactive oxygen species (ROS) that exceed cellular antioxidant capacity, leading to tissue damage. Here we quantified the expression of several antioxidant genes in the hepatopancreas of Pacific whiteleg shrimp,...

article

A comparative study on antioxidant potentials, inhibitory activities against key enzymes related to metabolic syndrome, and anti-inflammatory activity of leaf extract from different Momordica species

Gunasekaran Nagarani, Arumugam Abirami, Perumal Siddhuraju, G. Nagarani, more

Food Science and Human Wellness > 2014 > 3 > 1 > 36-46

Momordica species are vegetable crops widely distributed in warmer regions of the world. In this work, we describe the antioxidant, enzyme inhibitory and anti-inflammatory effects of the leaves from three different species of Momordica. The present investigation was initially carried out to explore the possible link between antioxidant, enzyme inhibitory property of Momordica leaf extract and their...

article

Antioxidative and blood pressure-lowering effects of Scurrula atropurpurea on deoxycorticosterone acetate–salt hypertensive rats

Nour Athiroh, Nur Permatasari, Djanggan Sargowo, M. Aris Widodo, more

Biomarkers and Genomic Medicine > 2014 > 6 > 1 > 32-36

This study aimed to investigate whether a methanolic extract of Scurrula atropurpurea (BL.) Dans. (MESA) was able to reduced oxidative stress and systolic blood pressure (SBP) in deoxycorticosterone acetate–salt hypertensive rats. Twenty-five male Wistar were divided into the control group and four hypertensive groups that received the MESA at a doses of 50 mg/kg, 100 mg/kg, or 200 mg/kg bodyweight,...

article

Polyphenol composition and antioxidant activity of different grass pea (Lathyrus sativus), lentils (Lens culinaris), and chickpea (Cicer arietinum) ecotypes of the Campania region (Southern Italy)

Florinda Fratianni, Federica Cardinale, Autilia Cozzolino, Tiziana Granese, more

Journal of Functional Foods > 2014 > 7 > Complete > 551-557

The phenolic contents and antioxidant activities of grass pea (Lathyrus sativus), lentil (Lens culinaris), and chickpea (Cicer arietinum) cultivars from the Campania region of Southern Italy were investigated. Lentils (cv Colliano and San Gerardo) demonstrated the highest antioxidant activity, (EC ₅₀ not higher than 2.3mg/g), confirming that lentils are an excellent antioxidant food. Grass...

article

Phyto-synthesis of gold nanoparticles using fruit extract of Hovenia dulcis and their biological activities

Nagaraj Basavegowda, Akber Idhayadhulla, Yong Rok Lee, N. Basavegowda, more

Industrial Crops & Products > 2014 > 52 > Complete > 745-751

The authors describe the synthesis of gold nanoparticles (GNPs) at room temperature using an aqueous extract of Hovenia dulcis fruit and the antioxidant and antibacterial activities of the GNPs obtained. The devised method provides a simple, cost-effective aqueous means of producing spherical and hexagonal GNPs of size ∼20nm. The synthesized GNPs were characterized by UV–vis spectrum and obtain a...

INFONA - science communication portal

Search results

Targeting urate to reduce oxidative stress in Parkinson disease

Nettle (Urtica dioica L.) as a source of antioxidant and anti-aging phytochemicals for cosmetic applications

Use of arbuscular mycorrhizal fungi to improve the drought tolerance of Cupressus atlantica G.

Diosgenin-based thio(seleno)ureas and triazolyl glycoconjugates as hybrid drugs. Antioxidant and antiproliferative profile

Characterisation of fatty acid, carotenoid, tocopherol/tocotrienol compositions and antioxidant activities in seeds of three Chenopodium quinoa Willd. genotypes

Enzymatic production of bioactive docosahexaenoic acid phenolic ester

Curcumin enhances recovery of pancreatic islets from cellular stress induced inflammation and apoptosis in diabetic rats

Effect of Eclipta prostrata on lipid metabolism in hyperlipidemic animals

Mediterranean semi-arid plant Astragalus armatus as a source of bioactive galactomannan

Preventive supplementation with fresh and preserved peach attenuates CCl4-induced oxidative stress, inflammation and tissue damage

Design, synthesis and characterization of zinc–morin, a metal flavonol complex and evaluation of its antidiabetic potential in HFD–STZ induced type 2 diabetes in rats

Different concentrations of cysteamine and ergothioneine improve microscopic and oxidative parameters in ram semen frozen with a soybean lecithin extender

Neuroprotective effects of corn silk maysin via inhibition of H2O2-induced apoptotic cell death in SK-N-MC cells

Thiaflavan scavenges radicals and inhibits DNA oxidation: A story from the ferrocene modification

Antioxidant film development from unrefined extracts of brown seaweeds Laminaria digitata and Ascophyllum nodosum

Recovery from hypoxia and hypercapnic hypoxia: Impacts on the transcription of key antioxidants in the shrimp Litopenaeus vannamei

A comparative study on antioxidant potentials, inhibitory activities against key enzymes related to metabolic syndrome, and anti-inflammatory activity of leaf extract from different Momordica species

Antioxidative and blood pressure-lowering effects of Scurrula atropurpurea on deoxycorticosterone acetate–salt hypertensive rats

Polyphenol composition and antioxidant activity of different grass pea (Lathyrus sativus), lentils (Lens culinaris), and chickpea (Cicer arietinum) ecotypes of the Campania region (Southern Italy)

Phyto-synthesis of gold nanoparticles using fruit extract of Hovenia dulcis and their biological activities

Filter options

Publication date

Content availability

Publication type

Publication language

Keywords

Data set

INFONA - science communication portal

Search results

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Content availability

Publication type

Publication language

Keywords

Data set

Reporting an error / abuse

Sending the report failed

Accessibility options