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article

Successful treatment of cutaneous protothecosis with fluconazole: A case report and epidemiology study of Prototheca infection in China

Chandi Xu, Chaolan Pan, Chengan Xu, Wei Zheng, more

Journal of Cosmetic Dermatology > 23 > 6 > 2190 - 2198

Background Protothecosis is an infection of humans and animals caused by a rare conditionally pathogenic fungus (prototheca). It can occur in immunocompromised or normal patients. Aims To describe the epidemiology of prototheca infection in China. Methods We report a case of successful treatment of cutaneous protothecosis with fluconazole and analyzed the epidemiological characteristics, risk...

article

Insights into the anti‐Candida albicans properties of natural phytochemicals: An in vitro and in vivo investigation

Daifan Yue, Dongming Zheng, Yuxin Bai, Linlan Yang, more

Phytotherapy Research > 38 > 5 > 2518 - 2538

Invasive candidiasis, attributed to Candida albicans, has long been a formidable threat to human health. Despite the advent of effective therapeutics in recent decades, the mortality rate in affected patient populations remains discouraging. This is exacerbated by the emergence of multidrug resistance, significantly limiting the utility of conventional antifungals. Consequently, researchers are compelled...

article

Characterization of the Fusarium circinatum biofilm environmental response role

Francinah M. Ratsoma, Nthabiseng Z. Mokoena, Quentin C. Santana, Brenda D. Wingfield, more

Journal of Basic Microbiology > 64 > 4 > n/a - n/a

The capacity to form biofilms is a common trait among many microorganisms present on Earth. In this study, we demonstrate for the first time that the fatal pine pitch canker agent, Fusarium circinatum, can lead a biofilm‐like lifestyle with aggregated hyphal bundles wrapped in extracellular matrix (ECM). Our research shows F. circinatum's ability to adapt to environmental changes by assuming a biofilm‐like...

article

Reshaping Echinocandin Antifungal Drugs To Circumvent Glucan Synthase Point‐Mutation‐Mediated Resistance

Moriah Jospe‐Kaufman, Efrat Ben‐Zeev, Austin Mottola, Anna Dukhovny, more

Angewandte Chemie > 136 > 9 > n/a - n/a

Echinocandins are a class of antifungal drugs that inhibit the activity of the β‐(1,3)‐glucan synthase complex, which synthesizes fungal cell wall β‐(1,3)‐glucan. Echinocandin resistance is linked to mutations in the FKS gene, which encodes the catalytic subunit of the glucan synthase complex. We present a molecular‐docking‐based model that provides insight into how echinocandins interact with the...

article

Reshaping Echinocandin Antifungal Drugs To Circumvent Glucan Synthase Point‐Mutation‐Mediated Resistance

Moriah Jospe‐Kaufman, Efrat Ben‐Zeev, Austin Mottola, Anna Dukhovny, more

Angewandte Chemie International Edition > 63 > 9 > n/a - n/a

Echinocandins are a class of antifungal drugs that inhibit the activity of the β‐(1,3)‐glucan synthase complex, which synthesizes fungal cell wall β‐(1,3)‐glucan. Echinocandin resistance is linked to mutations in the FKS gene, which encodes the catalytic subunit of the glucan synthase complex. We present a molecular‐docking‐based model that provides insight into how echinocandins interact with the...

article

Our current clinical understanding of Candida biofilms: where are we two decades on?

Gordon Ramage, Elisa Borghi, Célia Fortuna Rodrigues, Ryan Kean, more

APMIS > 131 > 11 > 636 - 653

Clinically we have been aware of the concept of Candida biofilms for many decades, though perhaps without the formal designation. Just over 20 years ago the subject emerged on the back of progress made from the bacterial biofilms, and academic progress pace has continued to mirror the bacterial biofilm community, albeit at a decreased volume. It is apparent that Candida species have a considerable...

article

Trends in anti‐infective use during pregnancy in France between 2010 and 2019: a nationwide population‐based study

Sarah Tubiana, Jeanne Sibiude, Philippe Herlemont, Jérôme Drouin, more

British Journal of Clinical Pharmacology > 89 > 5 > 1629 - 1639

Aims To describe the trends in anti‐infective use during pregnancy between 2010 and 2019 and determine whether they were prescribed according to drug foetal safety international classification systems. Methods We conducted a population‐based, nationwide study using the French national health data system including all pregnancies ended between 2010 and 2019. Anti‐infective agents were considered...

article

Antifungal Activity, Antibiofilm and Association Studies with O‐Alkylamidoximes against Cryptococcus spp.

Anna Paula Castro Teixeira, Gustavo Fernandes Queiroga Moraes, Romário Jonas Oliveira, Cosme Silva Santos, more

Chemistry & Biodiversity > 20 > 3 > n/a - n/a

This is the first study that describes the antifungal and anti‐biofilm potential of O‐alkylamidoximes against strains of Cryptococcus neoformans and Cryptococcus gattii. In vitro tests have shown that O‐alkylamidoximes are capable of inhibiting fungal growth and biofilm formation of the C. neoformans and C. gattii strains, suggesting, from molecular docking, the potential for interaction with the...

article

Voriconazole‐induced severe skin allergy and neurological adverse event in a liver failure patient: A case report

Yun Lu, Wen‐jing Li, Su‐yu Gao, Xuan‐xuan Wang, more

Journal of Clinical Pharmacy and Therapeutics > 47 > 10 > 1725 - 1728

What Is Known and Objective Triazole antifungal‐associated severe skin allergy has received little attention. Here we report a case of an acute‐on‐chronic liver failure (ACLF) patient with diffused skin allergy pervading from the chest, abdomen, back, knees to perineum, with red colour and partially desquamation as well as a neurological adverse (insomnia) event after voriconazole treatment. Case...

article

Cirrhosis and fungal infections‐a cocktail for catastrophe: A systematic review and meta‐analysis with machine learning

Nipun Verma, Shreya Singh, Akash Roy, Arun Valsan, more

Mycoses > 65 > 9 > 844 - 858

Objectives We evaluated the magnitude and factors contributing to poor outcomes among cirrhosis patients with fungal infections (FIs). Methods We searched PubMed, Embase, Ovid and WOS and included articles reporting mortality in cirrhosis with FIs. We pooled the point and relative‐risk (RR) estimates of mortality on random‐effects meta‐analysis and explored their heterogeneity (I ²) on subgroups,...

article

Evaluation of the effect of conventional and natural antifungals on motility and kinetics of cooled stallion semen

Alexandra Usuga, Víctor Gutiérrez, María Elisa López, Luisa Fernanda Pérez, more

Reproduction in Domestic Animals > 57 > 7 > 701 - 710

Microbial growth in semen may cause a decline of sperm quality and fertility; however, the addition of antifungals to semen extender has been shown to impair the overall fertility of the sperm. The aim of this study was to evaluate the antifungal activity of conventional and natural compounds, and their effect on the motility and kinetics of cooled stallion semen. A total of 15 ejaculates from five...

article

Antimicrobial resistance

Alessandra Silva Dantas

Molecular Microbiology > 117 > 5 > 959 - 960

article

Systemic antifungal therapy with isavuconazonium sulfate or other agents in adults with invasive mucormycosis or invasive aspergillosis (non‐fumigatus): A multicentre, non‐interventional registry study

George R. Thompson, Julia Garcia‐Diaz, Marisa H. Miceli, M. Hong Nguyen, more

Mycoses > 65 > 2 > 186 - 198

Background Isavuconazole, administered as isavuconazonium sulfate (ISAVUSULF), is a broad‐spectrum triazole agent for the treatment of invasive fungal disease. In phase 3 studies, ISAVUSULF showed comparable efficacy to voriconazole and amphotericin B for the treatment of invasive aspergillosis (IA) and invasive mucormycosis (IM), respectively. Objectives The objective of this study is to determine...

article

Hyperpolarization of common antifungal agents with SABRE

Keilian MacCulloch, Patrick Tomhon, Austin Browning, Evan Akeroyd, more

Magnetic Resonance in Chemistry > 59 > 12 > 1225 - 1235

Signal amplification by reversible exchange (SABRE) is a robust and inexpensive hyperpolarization (HP) technique to enhance nuclear magnetic resonance (NMR) spectroscopy and magnetic resonance imaging (MRI) signals using parahydrogen (pH₂). The substrate scope of SABRE is continually expanding. Here, we present the polarization of three antifungal drugs (voriconazole, clotrimazole, and fluconazole)...

article

Therapeutic drug monitoring of flucytosine in a cardiac transplant patient receiving continuous veno‐venous hemofiltration and intermittent hemodialysis: A case report

Kelsey N. Williams, Monique R. Bidell, Meagan L. Adamsick, Ramy H. Elshaboury, more

Transplant Infectious Disease > 23 > 4 > n/a - n/a

Invasive candidiasis is one of the common infections in solid organ transplant recipients. Guidelines recommend echinocandins or liposomal amphotericin with consideration of flucytosine (5‐fluorocytosine; 5‐FC) as synergistic therapy for treatment of select deep‐seated Candida infections, including complex endovascular infections. Flucytosine undergoes extensive renal elimination; however, optimal...

article

The efficacy of 8‐hydroxyquinoline derivatives in controlling the fungus Ilyonectria liriodendri, the causative agent of black foot disease in grapevines

L.M. Souza, M.A. Chaves, A.R. Joaquim, M.P. Gionbelli, more

Journal of Applied Microbiology > 131 > 3 > 1440 - 1451

Aim The purpose of this study was to evaluate the in vitro and in vivo efficiency of derivatives of 8‐Hydroxyquinoline (8HQ) in controlling the fungus Ilyonectria liriodendri. Methods and Results The in vitro tests consisted of assessing its susceptibility to the minimal inhibitory concentration (MIC) and the inhibition of mycelial growth. While the in vivo tests consisted of applying and assessing...

article

Genotyping, antifungal susceptibility, enzymatic activity, and phenotypic variation in Candida albicans from esophageal candidiasis

Hadis Jafarian, Maral Gharaghani, Seyed Saeed Seyedian, Ali Zarei Mahmoudabadi

Journal of Clinical Laboratory Analysis > 35 > 7 > n/a - n/a

Background Esophageal candidiasis is the most frequent form of esophagitis. The pathogenicity of Candida spp. is related to a combination of microbial factors, hydrolytic enzyme secretion and phenotypic switching. This study was designed to investigate esophageal candidiasis, antifungal activity, enzymatic activity patterns, phenotyping, and genotyping profiles of Candida albicans species. Methods...

article

Bioactivity‐guided separation of antifungal compounds by preparative high‐performance liquid chromatography

Zhidong Li, Zhuoshun Dai, Dasen Jiang, Yingping Dai, more

Journal of Separation Science > 44 > 12 > 2382 - 2390

Bioactivity‐guided chromatographic methods are of great significance for the isolation of the active compounds in complex samples. In this study, four anti‐fungal compounds were located by activity screening and successfully isolated from a microbial fermentation sample by preparative high‐performance liquid chromatography. Separation performance of columns including C18, positively charged C18, negatively...

article

Combatting the evolution of antifungal resistance in Cryptococcus neoformans

Arianne Bermas, Jennifer Geddes‐McAlister

Molecular Microbiology > 114 > 5 > 721 - 734

Fungal infections are a global concern and the evolution of intrinsic resistance to current antifungals presents an alarming problem. For Cryptococcus neoformans, a human fungal pathogen of primarily immunocompromised individuals, resistance toward treatment strategies demands alternative approaches. Given the prevalence of virulence factor production during cryptococcal infection, an emerging and...

article

Successful challenge of voriconazole in a patient with posaconazole‐associated minor drug eruption: A case report

Benjabhorn Weeraphon, Jakapat Vanichanan, Sang Usayaporn

Journal of Clinical Pharmacy and Therapeutics > 45 > 6 > 1486 - 1488

What is known and objective Triazole antifungal‐associated skin rash is rare. Data on cross‐reaction triazole antifungals remain inconclusive and poorly defined. We report successful voriconazole challenge in a patient allergic to posaconazole. Case summary A 38‐year‐old female diagnosed with acute myeloid leukaemia and receiving chemotherapy treatment in our institution developed a maculopapular...

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Search results

Successful treatment of cutaneous protothecosis with fluconazole: A case report and epidemiology study of Prototheca infection in China

Insights into the anti‐Candida albicans properties of natural phytochemicals: An in vitro and in vivo investigation

Characterization of the Fusarium circinatum biofilm environmental response role

Reshaping Echinocandin Antifungal Drugs To Circumvent Glucan Synthase Point‐Mutation‐Mediated Resistance

Reshaping Echinocandin Antifungal Drugs To Circumvent Glucan Synthase Point‐Mutation‐Mediated Resistance

Our current clinical understanding of Candida biofilms: where are we two decades on?

Trends in anti‐infective use during pregnancy in France between 2010 and 2019: a nationwide population‐based study

Antifungal Activity, Antibiofilm and Association Studies with O‐Alkylamidoximes against Cryptococcus spp.

Voriconazole‐induced severe skin allergy and neurological adverse event in a liver failure patient: A case report

Cirrhosis and fungal infections‐a cocktail for catastrophe: A systematic review and meta‐analysis with machine learning

Evaluation of the effect of conventional and natural antifungals on motility and kinetics of cooled stallion semen

Antimicrobial resistance

Systemic antifungal therapy with isavuconazonium sulfate or other agents in adults with invasive mucormycosis or invasive aspergillosis (non‐fumigatus): A multicentre, non‐interventional registry study

Hyperpolarization of common antifungal agents with SABRE

Therapeutic drug monitoring of flucytosine in a cardiac transplant patient receiving continuous veno‐venous hemofiltration and intermittent hemodialysis: A case report

The efficacy of 8‐hydroxyquinoline derivatives in controlling the fungus Ilyonectria liriodendri, the causative agent of black foot disease in grapevines

Genotyping, antifungal susceptibility, enzymatic activity, and phenotypic variation in Candida albicans from esophageal candidiasis

Bioactivity‐guided separation of antifungal compounds by preparative high‐performance liquid chromatography

Combatting the evolution of antifungal resistance in Cryptococcus neoformans

Successful challenge of voriconazole in a patient with posaconazole‐associated minor drug eruption: A case report

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