Search results

article

New fluorinated quinazolinone derivatives as anticonvulsant agents

Mohamed F. Zayed, M.F. Zayed

Journal of Taibah University Medical Sciences > 2014 > 9 > 2 > 104-109

Objectives: The aim of the present work was to synthesize some novel fluorinated quinazolinones and to evaluate them for anticonvulsant activity and neurotoxicity. Methods: Eight compounds were synthesized. Their anticonvulsant activity was evaluated from maximal electroshock-induced seizures in eight groups of six Swiss mice given the test compounds (100mg/kg intraperitoneally), one control group...

article

What treatment works best for restless legs syndrome? Meta-analyses of dopaminergic and non-dopaminergic medications

Magdolna Hornyak, Hanna Scholz, Ralf Kohnen, Juergen Bengel, more

Sleep Medicine Reviews > 2014 > 18 > 2 > 153-164

Background: At the time of writing only dopamine agonists are licensed for the treatment of restless legs syndrome (RLS) in various countries, but randomized controlled trials (RCTs) have been performed with other treatments. We performed comprehensive meta-analyses and indirect comparisons of RCTs for all currently recommended treatments of RLS. Methods: We searched the Central, Medline, Embase,...

article

Cyclization of the semicarbazone template of aryl semicarbazones: synthesis and anticonvulsant activity of 4,5-diphenyl-2H-1,2,4-triazol-3(4H)-one

M. Shalini, P. Yogeeswari, D. Sriram, J.P. Stables

Biomedicine & Pharmacotherapy > 2009 > 63 > 3 > 187-193

A new series of 4,5-diphenyl-2H-1,2,4-triazol-3(4H)-one were synthesized to study the effect of cyclization of the semicarbazone moiety of aryl semicarbazones on the anticonvulsant activity. Structures of the synthesized compounds were confirmed by the use of their spectral data besides elemental analysis. All compounds were evaluated for their anticonvulsant activity in four animal models of seizures,...

article

A Simulation‐Based Assessment of Levetiracetam Concentrations Following Fixed and Weight‐Based Loading Doses: A Meta‐Regression and Pharmacokinetic Modeling Analysis

Anthony Lau, Hans Haag, Anil Maharaj

The Journal of Clinical Pharmacology > 64 > 9 > 1173 - 1180

Current recommendations for refractory status epilepticus (SE) unresponsive to benzodiazepines suggest a loading dose of levetiracetam (LEV) of 60 mg/kg to a maximum of 4500 mg. LEV therapeutic drug monitoring can help guide therapy and is garnering increasing attention. The objective of this study is to simulate the probability of target attainment (PTA) of fixed dose and weight‐based loading doses...

article

Network Pharmacology Approach to Identify the Calotropis Phytoconstituents’ Potential Epileptic Targets and Evaluation of Molecular Docking, MD Simulation, and MM‐PBSA Performance

Punam Salaria, Amarendar Reddy M

Chemistry & Biodiversity > 21 > 5 > n/a - n/a

Epilepsy originates from unusual electrical rhythm within brain cells, causes seizures. Calotropis species have been utilized to treat a wide spectrum of ailments since antiquity. Despite chemical and biological investigations, there have been minimal studies on their anticonvulsant activity, and the molecular targets of this plant constituents are unexplored. This study aimed to investigate the plausible...

article

Comparative anticonvulsant activity of the GABAkine KRM‐II‐81 and a deuterated analog

Xingjie Ping, Michelle J. Meyer, Nicolas M. Zahn, Lalit K. Golani, more

Drug Development Research > 84 > 3 > 601 - 605

A series of imidazodiazepines has been developed that possess reduced sedative liabilities but retain efficacy in anticonvulsant screening models. The latest of these compounds, (5‐(8‐ethynyl‐6‐(pyridin‐2‐yl)‐4H‐benzo[f]imidazole[1,5‐α][1,4]diazepin‐3‐yl) oxazole known as KRM‐II‐81) is currently awaiting advancement into the clinic. A deuterated structural analog (D5‐KRM‐II‐81) was made as a potential...

article

Prognostic interictal electroencephalographic biomarkers and models to assess antiseizure medication efficacy for clinical practice: A scoping review

Ashley Reynolds, Michaela Vranic‐Peters, Alan Lai, David B. Grayden, more

Epilepsia > 64 > 5 > 1125 - 1174

Antiseizure medication (ASM) is the primary treatment for epilepsy. In clinical practice, methods to assess ASM efficacy (predict seizure freedom or seizure reduction), during any phase of the drug treatment lifecycle, are limited. This scoping review identifies and appraises prognostic electroencephalographic (EEG) biomarkers and prognostic models that use EEG features, which are associated with...

article

Novel spiro[indene‐1,2′‐quinazolin]‐4′(3′H)‐one derivatives as potent anticonvulsant agents: One‐pot synthesis, in vivo biological evaluation, and molecular docking studies

Ali Asghar Mohammadi, Salman Taheri, Sanaz Shisheboran, Reza Ahdenov, more

Journal of Biochemical and Molecular Toxicology > 37 > 1 > n/a - n/a

A new series of spiro[indene‐1,2′‐quinazolin]‐4′(3′H)‐one derivatives 4a–m were synthesized via a one‐pot method and evaluated for anticonvulsant activities using pentylenetetrazole (PTZ) and maximal electroshock (MES)‐induced seizures. Obtained results demonstrated that these compounds have not anticonvulsant activity in PTZ test while are active in the MES test. Among the synthesized compounds,...

article

Presumed zonisamide‐induced blood dyscrasias in four dogs

Maria Brandifino, Virginia Sinnott‐Stutzman, Allen Sisson, Megan Whelan

Journal of Veterinary Emergency and Critical Care > 32 > 6 > 805 - 811

Objective To describe 4 canine cases of presumed zonisamide‐induced blood dyscrasias. Case summary From 2007 to 2018 at Angell Animal Medical Center and from 2014 to 2019 at the Cummings School of Veterinary Medicine at Tufts University, 4 dogs presented with febrile neutropenia while being administered zonisamide. No septic focus was found on workup for any of the dogs, and the clinical signs...

article

HPLC and GC–MS–based metabolic profiles and in vivo anticonvulsant, sedative, and antinociceptive potentials of truffles Tirmania nivea and Tirmania pinoyi hydromethanolic extracts in mice

Mona E. Aboutabl, Waill A. Elkhateeb, Marwa A. Masoud, Ghoson M. Daba, more

Biomedical Chromatography > 36 > 12 > n/a - n/a

GC–MS and HPLC analyses of the hydromethanolic extracts of the truffles Tirmania nivea (TN) and Tirmania pinoyi (TP) revealed the presence of 18 metabolites and 11 polyphenols, respectively. In vivo, TP extract protected against subcutaneous pentylenetetrazole (scPTZ) and maximal electric shock (MES)‐induced convulsions faster than TN extract. TP extract (100 and 300 mg/kg) showed 100% protection...

article

Presumptive renal tubular acidosis secondary to topiramate administration in a cat

Steven J. Centola, Gregory Kaiman, Kaila Rizzo, Yekaterina Buriko, more

Journal of Veterinary Emergency and Critical Care > 32 > 3 > 420 - 425

Objective To describe renal tubular acidosis (RTA) and secondary acquired hyperaldosteronism in a cat as an adverse effect of topiramate therapy. Case Summary An 8‐year‐old neutered female cat on chronic oral topiramate therapy at a recommended dose (11.9 mg/kg q 8 h) for seizure control was presented with severe metabolic acidosis and hypokalemia. Plasma electrolyte and acid–base analysis identified...

article

Cardioprotective effects of amiodarone in a rat model of epilepsy‐induced cardiac dysfunction

Inas A. Harb, Hend Ashour, Abeer Mostafa, Hala M. El Hanbuli, more

Clinical and Experimental Pharmacology and Physiology > 49 > 3 > 406 - 418

Cardiac dysfunction is one of the leading causes of death in epilepsy. The anti‐arrhythmic drug, amiodarone, is under investigation for its therapeutic effects in epilepsy. We aimed to evaluate the possible effects of amiodarone on cardiac injury during status epilepticus, as it can cause prolongation of the QT interval. Five rat groups were enrolled in the study; three control groups (1) Control,...

article

Childhood maltreatment and clinical response to mood stabilizers in patients with bipolar disorder

Giammarco Cascino, Giulia D'Agostino, Alessio Maria Monteleone, Francesca Marciello, more

Human Psychopharmacology: Clinical and Experimental > 36 > 4 > n/a - n/a

Objective The association between childhood maltreatment (CM) and clinical response to mood stabilizers has been scarcely investigated in bipolar disorder (BD). Therefore, we assessed whether CM affects the response to lithium or anticonvulsant treatments in BD patients. Methods A retrospective assessment of clinical response to mood stabilizers was conducted in 97 euthymic patients with BD by...

article

In vivo‐ and in silico‐driven identification of novel synthetic quinoxalines as anticonvulsants and AMPA inhibitors

Hamada S. Abulkhair, Salwa Elmeligie, Adel Ghiaty, Ahmed El‐Morsy, more

Archiv der Pharmazie > 354 > 5 > n/a - n/a

The lack of effective therapies for epileptic patients and the potentially harmful consequences of untreated seizure incidents have made epileptic disorders in humans a major health concern. Therefore, new and more potent anticonvulsant drugs are continually sought after, to combat epilepsy. On the basis of the pharmacophoric structural specifications of effective α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic...

article

Synthesis and Evaluation of Anticonvulsant Activity of Some Schiff Bases of 7‐Amino‐1,3‐dihydro‐2H‐1,4‐benzodiazepin‐2‐one

Pankaj R. Nilkanth, Sujit K. Ghorai, Arulmozhi Sathiyanarayanan, Kiran Dhawale, more

Chemistry & Biodiversity > 17 > 9 > n/a - n/a

A variety of 1,3‐dihydro‐2H‐1,4‐benzodiazepin‐2‐one azomethines and 1,3‐dihydro‐2H‐1,4‐benzodiazepin‐2‐one benzamide were prepared, characterized and evaluated for the anticonvulsant activity in the rat using picrotoxin‐induced seizure model. The prepared 1,3‐dihydro‐2H‐1,4‐benzodiazepin‐2‐one azomethine derivatives emerged potentially anticonvulsant molecular scaffolds exemplified by compounds, 7‐{(...

article

Treatment of refractory and superrefractory status epilepticus with topiramate: A cohort study of 106 patients and a review of the literature

Anne Fechner, Kristina Hubert, Kolja Jahnke, Susanne Knake, more

Epilepsia > 60 > 12 > 2448 - 2458

Objective Novel treatments are needed to control treatment‐resistant status epilepticus (SE). We present a summary of clinical cases where oral topiramate (TPM) was used in refractory SE (RSE) and superrefractory SE (SRSE). Methods A review of medical records was carried out to detect TPM administration in SE patients treated in Frankfurt and Marburg between 2011 and 2016. The primary outcome question...

article

Neuropharmacological effects of d‐pinitol and its possible mechanisms of action

Angel Josabad Alonso‐Castro, Clara Alba‐Betancourt, Erik Rocha‐González, Alberto Ruiz‐Arredondo, more

Journal of Food Biochemistry > 43 > 12 > n/a - n/a

The aim was to evaluate the diuretic and neuropharmacological actions of d‐pinitol and describe a possible mechanism of action. The diuretic effects of d‐pinitol were evaluated using mice placed in metabolic cages. The sedative, anxiolytic‐like, antidepressant‐like, and anticonvulsant effects of 1–100 mg/kg d‐pinitol were assessed. The possible mechanisms of action of the anxiolytic‐like, antidepressant‐like,...

article

Cyclooxygenase-2 (COX-2) inhibitors: future therapeutic strategies for epilepsy management

Chitra Rawat, Samiksha Kukal, Ujjwal Ranjan Dahiya, Ritushree Kukreti

Journal of Neuroinflammation > 2019 > 16 > 1 > 1-15

Epilepsy, a common multifactorial neurological disease, affects about 69 million people worldwide constituting nearly 1% of the world population. Despite decades of extensive research on understanding its underlying mechanism and developing the pharmacological treatment, very little is known about the biological alterations leading to epileptogenesis. Due to this gap, the currently available antiepileptic...

article

Synthesis and evaluation of anticonvulsant activities of 7‐phenyl‐4,5,6,7‐tetrahydrothieno[3,2‐b ]pyridine derivatives

Shiben Wang, Hui Liu, Xuekun Wang, Kang Lei, more

Archiv der Pharmazie > 352 > 10 > n/a - n/a

A series of 7‐phenyl‐4,5,6,7‐tetrahydrothieno[3,2‐b]pyridine derivatives containing triazole and other heterocycle substituents (methyltriazole, tetrazole, and triazolone) is described. Two experimental methods, maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ), were used to evaluate the anticonvulsant activity of the target compounds. Moreover, the neurotoxicity (NT) was tested...

article

Anticonvulsant and Neuroprotective Effects of Paeonol in Epileptic Rats

Dong-Hai Liu, Elvis Agbo, Shu-Hong Zhang, Jin-Ling Zhu

Neurochemical Research > 2019 > 44 > 11 > 2556-2565

Paeonol is the main active compound in the root bark extract of the peony tree, and it has antioxidative and anti-inflammatory effects. Recent studies have reported the neuroprotective effects of paeonol including its capacity in improving impaired memory. However, the effect of paeonol on epilepsy is yet to be demystified. We aimed to investigate the therapeutic effect of paeonol in epilepsy and...

INFONA - science communication portal

Search results

New fluorinated quinazolinone derivatives as anticonvulsant agents

What treatment works best for restless legs syndrome? Meta-analyses of dopaminergic and non-dopaminergic medications

Cyclization of the semicarbazone template of aryl semicarbazones: synthesis and anticonvulsant activity of 4,5-diphenyl-2H-1,2,4-triazol-3(4H)-one

A Simulation‐Based Assessment of Levetiracetam Concentrations Following Fixed and Weight‐Based Loading Doses: A Meta‐Regression and Pharmacokinetic Modeling Analysis

Network Pharmacology Approach to Identify the Calotropis Phytoconstituents’ Potential Epileptic Targets and Evaluation of Molecular Docking, MD Simulation, and MM‐PBSA Performance

Comparative anticonvulsant activity of the GABAkine KRM‐II‐81 and a deuterated analog

Prognostic interictal electroencephalographic biomarkers and models to assess antiseizure medication efficacy for clinical practice: A scoping review

Novel spiro[indene‐1,2′‐quinazolin]‐4′(3′H)‐one derivatives as potent anticonvulsant agents: One‐pot synthesis, in vivo biological evaluation, and molecular docking studies

Presumed zonisamide‐induced blood dyscrasias in four dogs

HPLC and GC–MS–based metabolic profiles and in vivo anticonvulsant, sedative, and antinociceptive potentials of truffles Tirmania nivea and Tirmania pinoyi hydromethanolic extracts in mice

Presumptive renal tubular acidosis secondary to topiramate administration in a cat

Cardioprotective effects of amiodarone in a rat model of epilepsy‐induced cardiac dysfunction

Childhood maltreatment and clinical response to mood stabilizers in patients with bipolar disorder

In vivo‐ and in silico‐driven identification of novel synthetic quinoxalines as anticonvulsants and AMPA inhibitors

Synthesis and Evaluation of Anticonvulsant Activity of Some Schiff Bases of 7‐Amino‐1,3‐dihydro‐2H‐1,4‐benzodiazepin‐2‐one

Treatment of refractory and superrefractory status epilepticus with topiramate: A cohort study of 106 patients and a review of the literature

Neuropharmacological effects of d‐pinitol and its possible mechanisms of action

Cyclooxygenase-2 (COX-2) inhibitors: future therapeutic strategies for epilepsy management

Synthesis and evaluation of anticonvulsant activities of 7‐phenyl‐4,5,6,7‐tetrahydrothieno[3,2‐b ]pyridine derivatives

Anticonvulsant and Neuroprotective Effects of Paeonol in Epileptic Rats

Filter options

Publication date

Content availability

Publication type

Publication language

Keywords

Data set

INFONA - science communication portal

Search results

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Content availability

Publication type

Publication language

Keywords

Data set

Reporting an error / abuse

Sending the report failed

Accessibility options