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article

Antibiotic use during pregnancy in Sweden: A nationwide utilization study covering 2007–2019

Aya Olivia Nakitanda, Ingvild Odsbu, Björn Pasternak, Pär Karlsson, more

Acta Obstetricia et Gynecologica Scandinavica > 103 > 3 > 531 - 539

Introduction Antibiotics are often prescribed during pregnancy. Assessing the current state of prenatal antibiotic use is therefore imperative for optimizing prescribing and identifying emerging research priorities. The study aimed to describe recent trends and patterns in antibiotic use during pregnancy among women who gave birth in Sweden, including user characteristics. Material and methods...

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ZIF‐8 Based Active Wound Dressing for pH Modulation and pH‐Responsive Delivery of Curcumin and Zn²⁺: Effect of Acidity on the Drug Release for Antibacterial and Antioxidant Efficacy

Seojin Jung, Seokhee Chang, Na‐Eun Kim, Yoon‐Jae Song, more

Macromolecular Materials and Engineering > 308 > 11 > n/a - n/a

A wound evolves with variable pHs depending on the healing stage, and the maintenance of mild acidic condition can help healing by deterring the formation of a biofilm. Herein, a dual‐layer wound dressing with an acid‐responsive zeolitic imidazolate framework–8 (ZIF‐8) layer and an acid‐modulating layer is designed to control the acid‐dependent release of therapeutic agents for the improved healing...

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Bacterial Outer Membrane‐Based Biomimetic Immune Adaptors: Mild Immunomodulatory and Bacterial Targeted Delivery Strategy Against Implant‐Related Infections

Cheng Ding, Renke He, Tao Cheng, Jinxia Wang, more

Advanced Functional Materials > 33 > 42 > n/a - n/a

Implant‐related infections (IRIs) are difficult to manage and are a major cause of surgical failure. The formation of biofilms with a solid barrier on the surface of implants and concomitant suppression of the local immune response constitute major challenges for treating IRIs. This study develops a multifunctional biomimetic immune adaptor (Hybrid Membrane@Levo@SiO₂; HMLS) generated by loading the...

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An Ultrastable Self‐Assembled Antibacterial Nanospears Made of Protein

Christian K. O. Dzuvor, Bhuvana K. Shanbhag, Hsin‐Hui Shen, Victoria S. Haritos, more

Advanced Materials > 35 > 30 > n/a - n/a

Protein‐based nanomaterials have broad applications in the biomedical and bionanotechnological sectors owing to their outstanding properties such as high biocompatibility and biodegradability, structural stability, sophisticated functional versatility, and being environmentally benign. They have gained considerable attention in drug delivery, cancer therapeutics, vaccines, immunotherapies, biosensing,...

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Trends in anti‐infective use during pregnancy in France between 2010 and 2019: a nationwide population‐based study

Sarah Tubiana, Jeanne Sibiude, Philippe Herlemont, Jérôme Drouin, more

British Journal of Clinical Pharmacology > 89 > 5 > 1629 - 1639

Aims To describe the trends in anti‐infective use during pregnancy between 2010 and 2019 and determine whether they were prescribed according to drug foetal safety international classification systems. Methods We conducted a population‐based, nationwide study using the French national health data system including all pregnancies ended between 2010 and 2019. Anti‐infective agents were considered...

article

Siderophore‐Linked Ruthenium Catalysts for Targeted Allyl Ester Prodrug Activation within Bacterial Cells

James W. Southwell, Reyme Herman, Daniel J. Raines, Justin E. Clarke, more

Chemistry – A European Journal > 29 > 8 > n/a - n/a

Due to rising resistance, new antibacterial strategies are needed, including methods for targeted antibiotic release. As targeting vectors, chelating molecules called siderophores that are released by bacteria to acquire iron have been investigated for conjugation to antibacterials, leading to the clinically approved drug cefiderocol. The use of small‐molecule catalysts for prodrug activation within...

article

Amino‐Terminated Hyperbranched Polymer‐Based Recyclable Elastic Fibers for a Breathable and Antibacterial Triboelectric Nanogenerator

Pan Jia, Li Wang, Xuefeng Yao, Desuo Zhang, more

Macromolecular Materials and Engineering > 307 > 9 > n/a - n/a

Realizing recyclable triboelectric active materials with commendable elasticity, breathability, and durable antibacterial performance is significant for the sustainable development of wearables and bioelectronics. A spinnable elastic polymer (MPVA) is developed by modifying polyvinyl alcohol (PVA) with amino‐terminated hyperbranched polymers (HBP‐NH₂), demonstrating a junction‐reinforced electrospun...

article

Solution‐Phase Synthesis of Backbone‐Constrained Cationic Peptoid Hexamers with Antibacterial and Anti‐Biofilm Activities

Radhe Shyam, Christiane Forestier, Nicolas Charbonnel, Olivier Roy, more

European Journal of Organic Chemistry > 2021 > 42 > 5813 - 5822

Abstract: Submonomer synthesis in solution and block‐coupling protocols were combined to prepare amphiphilic peptoid hexamers. The amphipathic character arises from the use of hydrophobic aliphatic tert‐butyl side‐chains imposing the cis‐amide backbone conformation and various cationic side‐chains periodically introduced each three residues. Evaluation of the effect on Gram‐positive and Gram‐negative...

article

Congener‐Induced Sulfur‐Related Metabolism Interference Therapy Promoted by Photothermal Sensitization for Combating Bacteria

Renke He, Cheng Ding, Yao Luo, Geyong Guo, more

Advanced Materials > 33 > 44 > n/a - n/a

Metabolic homeostasis is vital for individual cells to keep alive. Stronger metabolic homeostasis allows bacteria to survive in vivo and do persistent harm to hosts, which is especially typical in implant‐associated infection (IAI) with biofilm intervention. Herein, based on the competitive role of selenium (Se) and sulfur (S) in bacteria metabolism as congeners, a congener‐induced sulfur‐related...

article

Antibiotic–cell‐penetrating peptide conjugates targeting challenging drug‐resistant and intracellular pathogenic bacteria

Samantha M. Zeiders, Jean Chmielewski

Chemical Biology & Drug Design > 98 > 5 > 762 - 778

The failure to treat everyday bacterial infections is a current threat as pathogens are finding new ways to thwart antibiotics through mechanisms of resistance and intracellular refuge, thus rendering current antibiotic strategies ineffective. Cell‐penetrating peptides (CPPs) are providing a means to improve antibiotics that are already approved for use. Through coadministration and conjugation of...

article

The future of antibiotics begins with discovering new combinations

Meilin Zhu, Megan W. Tse, Juliane Weller, Julie Chen, more

Annals of the New York Academy of Sciences > 1496 > 1 > 82 - 96

Antibiotic resistance is a worldwide and growing clinical problem. With limited drug development in the antibacterial space, combination therapy has emerged as a promising strategy to combat multidrug‐resistant bacteria. Antibacterial combinations can improve antibiotic efficacy and suppress antibacterial resistance through independent, synergistic, or even antagonistic activities. Combination therapies...

article

Best therapeutic practices for the use of antibacterial agents in finfish aquaculture: a particular view on European seabass (Dicentrarchus labrax) and gilthead seabream (Sparus aurata) in Mediterranean aquaculture

George Rigos, Dimitra Kogiannou, Francesc Padrós, Carles Cristòfol, more

Reviews in Aquaculture > 13 > 3 > 1285 - 1323

Antibacterial therapy is still in many cases the only way to control bacterial disease outbreaks, with relevant economic issues. Nevertheless, this necessity should also be well balanced with other relevant aspects such as suitability, efficacy and refinement of the treatments but also with consumer and environmental welfare. With this aim, the literature pertaining to the use of antibacterials (i...

article

Antibacterial activity of a new class of tris homoleptic Ru (II)‐complexes with alkyl‐tetrazoles as diimine‐type ligands

Nicola Monti, Stefano Zacchini, Massimiliano Massi, Alejandro Hochkoeppler, more

Applied Organometallic Chemistry > 34 > 9 > n/a - n/a

Herein, we describe a new family of tris chelate homoleptic Ru (II) complexes, [Ru(N^N)₃]²⁺, where the role of the diimine‐type ligands (N^N) was fulfilled by 2‐pyridyl (PTZ) or 2‐quinolyl tetrazole (QTZ) derivatives decorated with various alkyl substituents at the N‐2 position of the tetrazole ring. The new Ru (II) complexes with general formula [Ru (PTZ‐R)₃]²⁺ and [Ru (QTZ‐R)₃]²⁺, were obtained...

article

Antibacterial activity of free or encapsulated selected phenylpropanoids against Escherichia coli and Staphylococcus epidermidis

L. Auezova, A. Najjar, M. Kfoury, S. Fourmentin, more

Journal of Applied Microbiology > 128 > 3 > 710 - 720

Aims Antibacterial activities of phenylpropenes (PPs) (eugenol, isoeugenol, estragole and trans‐anethole) and hydroxycinnamic acids (HCAs) (p‐coumaric, caffeic and ferulic acids) were assessed against Escherichia coli and Staphylococcus epidermidis. Effect of cyclodextrin and liposome encapsulation on the PPs activity was also evaluated. Methods and Results All PPs inhibited the bacterial growth...

article

Prevalence, predictors, and consequences of inappropriate empiric antimicrobial therapy for complicated urinary tract and intra-abdominal infections in Winnipeg hospitals

Christiaan H. Righolt, Philippe Lagace-Wiens, Salaheddin M. Mahmud

Diagnostic Microbiology and Infectious Disease > 2020 > 96 > 1

Information on inappropriate empiric antimicrobial therapy (ET) in Canadian hospitals is scarce. All Manitobans 18 years of age and over who were admitted to a hospital in Winnipeg with a complicated urinary tract infection (cUTI) or complicated intra-abdominal infection (cIAI) from January 2006 to December 2014 were eligible for inclusion in this cohort study. The prevalence of inappropriate ET was...

article

CRISPR-cas system: biological function in microbes and its use to treat antimicrobial resistant pathogens

Muhammad Abu Bakr Shabbir, Muhammad Zubair Shabbir, Qin Wu, Sammina Mahmood, more

Annals of Clinical Microbiology and Antimicrobials > 2019 > 18 > 1 > 1-9

The development of antibiotic resistance in bacteria is a major public health threat. Infection rates of resistant pathogens continue to rise against nearly all antimicrobials, which has led to development of different strategies to combat the antimicrobial resistance. In this review, we discuss how the newly popular CRISPR-cas system has been applied to combat antibiotic resistance in both extracellular...

article

Biologically active metabolite(s) from haemolymph of red-headed centipede Scolopendra subspinipes possess broad spectrum antibacterial activity

Salwa Mansur Ali, Naveed Ahmed Khan, K. Sagathevan, Ayaz Anwar, more

AMB Express > 2019 > 9 > 1 > 1-17

The discovery of novel antimicrobials from animal species under pollution is an area untapped. Chinese red-headed centipede is one of the hardiest arthropod species commonly known for its therapeutic value in traditional Chinese medicine. Here we determined the antibacterial activity of haemolymph and tissue extracts of red-headed centipede, Scolopendra subspinipes against a panel of Gram-positive...

article

Is antibacterial treatment intensity lower in elderly patients? A retrospective cohort study in a German surgical intensive care unit

Dominik Beier, Christel Weiß, Michael Hagmann, Ümniye Balaban, more

BMC Health Services Research > 2019 > 19 > 1 > 1-9

Background Demographic change concurrent with medical progress leads to an increasing number of elderly patients in intensive care units (ICUs). Antibacterial treatment is an important, often life-saving, aspect of intensive care but burdened by the associated antimicrobial resistance risk. Elderly patients are simultaneously at greater risk of infections and may be more restrictively treated because,...

article

Potential drug interactions with antibacterials in long-term care facilities analyzed by two interaction checkers

Matej Štuhec, Ines Potočin, Dora Stepan, Lea Ušaj, more

International Journal of Clinical Pharmacy > 2019 > 41 > 4 > 932-938

Background Residents in long-term care facilities take many medications concomitantly, including antibacterials, which increases the risk of drug–drug interactions. Objectives The aims of the study were to investigate the prevalence of severe potential interactions between antibacterials and other medications in Slovenian long-term care facilities and to compare the performance of two different drug–drug...

article

Cross‐national comparison of paediatric antibiotic use in Norway, Portugal and Hungary

Ria Benko, Maria Matuz, Ana Silva, Joaquina Ferreira, more

Basic & Clinical Pharmacology & Toxicology > 124 > 6 > 722 - 729

A cross‐national comparison was performed on paediatric (0‐19 years) antibiotic use in Hungary, Norway and Portugal to explore and compare the scale and pattern of paediatric antibiotic use in these three European countries. Ambulatory care systemic antibiotic use (ATC: J01) was retrieved from national databases for year 2014. The main outcome measure was number of antibacterial packages per child...

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Search results

Antibiotic use during pregnancy in Sweden: A nationwide utilization study covering 2007–2019

ZIF‐8 Based Active Wound Dressing for pH Modulation and pH‐Responsive Delivery of Curcumin and Zn²⁺: Effect of Acidity on the Drug Release for Antibacterial and Antioxidant Efficacy

Bacterial Outer Membrane‐Based Biomimetic Immune Adaptors: Mild Immunomodulatory and Bacterial Targeted Delivery Strategy Against Implant‐Related Infections

An Ultrastable Self‐Assembled Antibacterial Nanospears Made of Protein

Trends in anti‐infective use during pregnancy in France between 2010 and 2019: a nationwide population‐based study

Siderophore‐Linked Ruthenium Catalysts for Targeted Allyl Ester Prodrug Activation within Bacterial Cells

Amino‐Terminated Hyperbranched Polymer‐Based Recyclable Elastic Fibers for a Breathable and Antibacterial Triboelectric Nanogenerator

Solution‐Phase Synthesis of Backbone‐Constrained Cationic Peptoid Hexamers with Antibacterial and Anti‐Biofilm Activities

Congener‐Induced Sulfur‐Related Metabolism Interference Therapy Promoted by Photothermal Sensitization for Combating Bacteria

Antibiotic–cell‐penetrating peptide conjugates targeting challenging drug‐resistant and intracellular pathogenic bacteria

The future of antibiotics begins with discovering new combinations

Best therapeutic practices for the use of antibacterial agents in finfish aquaculture: a particular view on European seabass (Dicentrarchus labrax) and gilthead seabream (Sparus aurata) in Mediterranean aquaculture

Antibacterial activity of a new class of tris homoleptic Ru (II)‐complexes with alkyl‐tetrazoles as diimine‐type ligands

Antibacterial activity of free or encapsulated selected phenylpropanoids against Escherichia coli and Staphylococcus epidermidis

Prevalence, predictors, and consequences of inappropriate empiric antimicrobial therapy for complicated urinary tract and intra-abdominal infections in Winnipeg hospitals

CRISPR-cas system: biological function in microbes and its use to treat antimicrobial resistant pathogens

Biologically active metabolite(s) from haemolymph of red-headed centipede Scolopendra subspinipes possess broad spectrum antibacterial activity

Is antibacterial treatment intensity lower in elderly patients? A retrospective cohort study in a German surgical intensive care unit

Potential drug interactions with antibacterials in long-term care facilities analyzed by two interaction checkers

Cross‐national comparison of paediatric antibiotic use in Norway, Portugal and Hungary

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