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article

Synthesis, characterization and binding interactions of amino acids coupled perylene diimides with colloidal doped and undoped TiO2

E. Kavery, N. Nagarajan, G. Paramaguru, R. Renganathan, more

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy > 2015 > 146 > Complete > 13-23

Two sensitizers based on amino acids coupled with perylene moiety having absorption in the visible region have been designed and their interaction with doped and undoped TiO ₂ for the application of dye sensitized solar cells (DSSCs) has been studied. The synthesized compounds PDI-PA and PDI-AA were characterized using ¹ H and ¹³ C NMR, Mass and FT-IR spectroscopic techniques...

article

Analysis of ionic strength effects on the adsorption of simple amino acids

Damien Sebben, Phillip Pendleton, D. Sebben, P. Pendleton

Journal of Colloid And Interface Science > 2015 > 443 > Complete > 153-161

Hypothesis: Amino acid adsorption by metals and/or oxide surfaces is important in many biomedical and industrial processes, however limited information exists discussing ionic strength influences on the mechanism of adsorption. A comparison of pure water solution and added 1:1 electrolyte should highlight the effects of electrolyte on amount adsorbed. ATR spectroscopy of the adsorbed phase should...

article

Characterization of the salt stress vulnerability of three invasive freshwater plant species using a metabolic profiling approach

Lise Thouvenot, Carole Deleu, Solenne Berardocco, Jacques Haury, more

Journal of Plant Physiology > 2015 > 175 > Complete > 113-121

The effects of salt stress on freshwater plants has been little studied up to now, despite the fact that they are expected to present different levels of salt sensitivity or salt resistance depending on the species. The aim of this work was to assess the effect of NaCl at two concentrations on three invasive freshwater species, Elodea canadensis, Myriophyllum aquaticum and Ludwigia grandiflora, by...

article

Synthesis of novel benzimidazole functionalized chiral thioureas and evaluation of their antibacterial and anticancer activities

Sridhar Madabhushi, Kishore Kumar Reddy Mallu, Venkata Sairam Vangipuram, Srinivas Kurva, more

Bioorganic & Medicinal Chemistry Letters > 2014 > 24 > 20 > 4822-4825

A small library of benzimidazole functionalized chiral thioureas was prepared starting from natural amino acids (S)-alanine, (S)-phenylalanine, (S)-valine and (S)-leucine and also their (R)-isomers and studied their antimicrobial activity against a various Gram-positive and Gram-negative bacterial strains. In this study, compounds 5g and 5j were found to exhibit good antibacterial activity against...

article

Synergistic effects of resistance training and protein intake: Practical aspects

Lucas Guimarães-Ferreira, Jason Michael Cholewa, Marshall Alan Naimo, X.I.A. Zhi, more

Nutrition > 2014 > 30 > 10 > 1097-1103

Resistance training is a potent stimulus to increase skeletal muscle mass. The muscle protein accretion process depends on a robust synergistic action between protein intake and overload. The intake of protein after resistance training increases plasma amino acids, which results in the activation of signaling molecules leading to increased muscle protein synthesis (MPS) and muscle hypertrophy. Although...

article

Extracellular digestion during hyposaline exposure in the Dungeness crab, Cancer magister, and the blue crab, Callinectes sapidus

Daniel L. Curtis, Frank van Breukelen, Iain J. McGaw, D.L. Curtis, more

Comparative Biochemistry and Physiology, Part A > 2013 > 166 > 4 > 564-570

Extracellular digestive processes were examined in the Dungeness crab, Cancer magister and the blue crab, Callinectes sapidus, during hyposaline exposure. Both species are found in estuaries as adults, but vary in their ability to balance the cardiovascular and respiratory demands of concurrent osmoregulation and digestion. The weak osmoregulator, C. magister, is unable to balance the demands of osmoregulation...

article

Anti-tumor activity of a new series of benzoxazepine derivatives in breast cancer

Krishnananda Samanta, Bandana Chakravarti, Jitendra Kumar Mishra, Shailendra Kumar Dhar Dwivedi, more

Bioorganic & Medicinal Chemistry Letters > 2010 > 20 > 1 > 283-287

A series of new benzoxazepine derivatives substituted with different alkoxy and aryloxy group were synthesized comprising synthetic steps of Mitsunobu reaction, lithium aluminum hydride (LAH) reduction, followed by debenzylation and finally intramolecular Mitsunobu cyclization. The new benzoxazepines specifically inhibited growth of breast cancer cell lines, MCF-7 and MDA-MB-231, but lack cytotoxicity...

article

Synthesis, enzymatic activity, and X-ray crystallography of an unusual class of amino acids

Wang Chen, Douglas A. Kuntz, Tamika Hamlet, Lyann Sim, more

Bioorganic & Medicinal Chemistry > 2006 > 14 > 24 > 8332-8340

The synthesis of two novel amino acids, nitrogen analogues of the naturally occurring glycosidase inhibitor, salacinol, containing a carboxylate inner salt are described, along with the crystal structure of one of these analogues in the active site of Drosophila melanogaster Golgi mannosidase II (dGMII). Salacinol, a naturally occurring sulfonium ion, is one of the active principals in the aqueous...

article

Biopharmaceutical applications of calixarenes

E. Da Silva, A.N. Lazar, A.W. Coleman, E. Da Silva, more

Journal of Drug Delivery Science and Technology > 2004 > 14 > 1 > 3-20

During the last 15 years, water soluble calixarenes and especially para-sulphonato-calix[n]arene and amphiphilic calixarenes have been the subject of growing interest in the biological domain. This article provides an overview of the studies, by our group and other research groups, that led to the elucidation of biological and biopharmaceutical activity of these calixarenes. The different studies...

article

Characterization of aroma compounds and effects of amino acids on the release of esters in Laimao baijiu

Yunwei Niu, Wenqi Zhao, Zuobing Xiao, Jiancai Zhu, more

Journal of the Science of Food and Agriculture > 103 > 4 > 1784 - 1799

Background Laimao baijiu is a typical soy‐sauce aroma‐type baijiu in China. Amino acids are non‐volatile compounds in baijiu and are beneficial to human health. Aroma is one of the important indicators that are used to evaluate the quality of baijiu. The interaction between aroma‐active compounds and non‐volatile compounds can also affect the release of aroma compounds. In this study, we identified...

article

Synthesis of Functionalized Proline‐Derived Azabicycloalkane Amino Acids and Their Applications in Drug Discovery: Recent Advances

Massimo Serra, Marco Terreni, Eric Bernardi, Lino Colombo

European Journal of Organic Chemistry > 26 > 5 > n/a - n/a

After the first synthesis reported in 1994, azabicycloalkane amino acids have raised increasing interest, becoming one of the most important classes of constrained dipeptide mimics. Their incorporation into peptidomimetic structures allowed the obtainment of a wide range of biologically active compounds. Over the years, different research groups have worked at the development of synthetic strategies...

article

Nutritional composition of Sacha inchi (Plukenetia volubilis) according to cooking method and its application as an elder‐friendly drink

Dah‐Sol Kim, Fumiko Iida, Nami Joo

International Journal of Food Science & Technology > 58 > 2 > 841 - 850

Sacha inchi (Plukenetia volubilis) can be a great source of nutrition for the elderly since it contains great conditions of bioactive substances such as antioxidants and essential amino acids. Therefore, this study aimed to set up an optimal pretreatment method of Sacha inchi and to develop viscous beverage products for the elderly. As a result, roasting Sacha inchi had a significant effect on improving...

article

Diastereo‐ and Enantioselective Reductive Mannich‐type Reaction of α,β‐Unsaturated Carboxylic Acids to Ketimines: A Direct Entry to Unprotected β^2,3,3‐Amino Acids

Hirotsugu Suzuki, Sora Kondo, Koichiro Yamada, Takanori Matsuda

Chemistry – A European Journal > 29 > 4 > n/a - n/a

Stereoselective construction of unprotected β‐amino acids is a significant challenge owing to the lack of methods for the catalytic generation of highly enantioenriched carboxylic acid enolates. In this study, a novel copper‐catalyzed diastereo‐ and enantioselective reductive Mannich‐type reaction of α,β‐unsaturated carboxylic acids was developed, which provides a direct and scalable synthetic method...

article

Ru₃(CO)₁₂‐Catalyzed Modular Assembly of Hemilabile Ligands by C−H Activation of Phosphines with Isocyanates

Lin Lin, Xue‐jun Zhang, Xinyu Xu, Yue Zhao, more

Angewandte Chemie International Edition > 62 > 5 > n/a - n/a

Hemilabile ligands have been applied extensively in transition metal catalysis, but preparations of these molecules typically require multistep synthesis. Here, modular assembly of diverse phosphine‐amide ligands, including related axially chiral compounds, is first reported through ruthenium‐catalyzed C−H activation of phosphines with isocyanate directed by phosphorus(III) atoms. High reactivity...

article

Ru₃(CO)₁₂‐Catalyzed Modular Assembly of Hemilabile Ligands by C−H Activation of Phosphines with Isocyanates

Lin Lin, Xue‐jun Zhang, Xinyu Xu, Yue Zhao, more

Angewandte Chemie > 135 > 5 > n/a - n/a

Hemilabile ligands have been applied extensively in transition metal catalysis, but preparations of these molecules typically require multistep synthesis. Here, modular assembly of diverse phosphine‐amide ligands, including related axially chiral compounds, is first reported through ruthenium‐catalyzed C−H activation of phosphines with isocyanate directed by phosphorus(III) atoms. High reactivity...

article

Sulfur dioxide‐free Verdejo wines through the use of a pure stilbene extract: exploring possible synergistic effect with glutathione

Rocío Gutiérrez‐Escobar, María José Aliaño‐González, Almudena Marrufo‐Curtido, María Jesús Jiménez‐Hierro, more

Journal of the Science of Food and Agriculture > 103 > 3 > 1152 - 1160

BACKGROUND The search for alternatives to sulfur dioxide (SO₂) in white wine production is a tough challenge for the oenological industry. The current article investigates the effectiveness of several preservatives in protecting Verdejo white wines. The following wines were elaborated: without preservative (CT wines), with SO₂ (SO₂ wines), with stilbene‐enriched extract (ST99 wines), with glutathione...

article

Cellular antioxidant mechanism of mannan‐oligosaccharides involving in enhancing flesh quality in grass carp (Ctenopharyngodon idella)

Zhi‐Yuan Lu, Wei‐Dan Jiang, Pei Wu, Yang Liu, more

Journal of the Science of Food and Agriculture > 103 > 3 > 1172 - 1182

BACKGROUND Deterioration of flesh quality has bad effects on consumer satisfaction. Therefore, effects of safe mannan‐oligosaccharides (MOS) on flesh quality of grass carp (Ctenopharyngodon idella) muscle were studied. A total of 540 healthy fish (215.85 ± 0.30 g) were randomly divided into six groups and fed six separate diets with graded levels of MOS (0, 200, 400, 600, 800 and 1000 mg kg⁻¹) for...

article

Comparative analysis of the variability of the human leukocyte antigen peptide‐binding pockets in patients with acute leukaemia

Wahid Boukouaci, Monica M. Rivera‐Franco, Fernanda Volt, Ching‐Lien Wu, more

British Journal of Haematology > 200 > 2 > 197 - 209

The association between acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML) and the human leukocyte antigens (HLA) has rarely been studied in terms of diversity of peptide‐binding pockets. The objective of this study was to analyse whether motifs of HLA class I and class II peptide‐binding pockets and/or their amino acid positions were differentially associated with ALL and AML....

article

Direct Synthesis of α‐Amino Acid Derivatives by Hydrative Amination of Alkynes

Minghao Feng, Roberto Tinelli, Ricardo Meyrelles, Leticia González, more

Angewandte Chemie International Edition > 62 > 1 > n/a - n/a

α‐Amino acid derivatives are key components of the molecules of life. The synthesis of α‐amino carbonyl/carboxyl compounds is a contemporary challenge in organic synthesis. Herein, we report a practical method for the preparation of α‐amino acid derivatives via direct hydrative amination of activated alkynes under mild conditions, relying on sulfinamides as the nitrogen source. Computational studies...

article

Foliar application of wood distillate boosts plant yield and nutritional parameters of chickpea

Riccardo Fedeli, Andrea Vannini, Silvia Celletti, Viviana Maresca, more

Annals of Applied Biology > 182 > 1 > 57 - 64

In the quest for eco‐friendly products with biostimulant properties, foliar application of wood distillate (WD) was tested on the growth and yield of chickpea (Cicer arietinum L.). WD (pyroligneous acid) is a by‐product of plant biomass pyrolysis and is rich in biologically active substances like polyphenols, alcohols, acids and esters. In this work, chickpea plants were sprayed weekly with 100 ml...

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Search results

Synthesis, characterization and binding interactions of amino acids coupled perylene diimides with colloidal doped and undoped TiO2

Analysis of ionic strength effects on the adsorption of simple amino acids

Characterization of the salt stress vulnerability of three invasive freshwater plant species using a metabolic profiling approach

Synthesis of novel benzimidazole functionalized chiral thioureas and evaluation of their antibacterial and anticancer activities

Synergistic effects of resistance training and protein intake: Practical aspects

Extracellular digestion during hyposaline exposure in the Dungeness crab, Cancer magister, and the blue crab, Callinectes sapidus

Anti-tumor activity of a new series of benzoxazepine derivatives in breast cancer

Synthesis, enzymatic activity, and X-ray crystallography of an unusual class of amino acids

Biopharmaceutical applications of calixarenes

Characterization of aroma compounds and effects of amino acids on the release of esters in Laimao baijiu

Synthesis of Functionalized Proline‐Derived Azabicycloalkane Amino Acids and Their Applications in Drug Discovery: Recent Advances

Nutritional composition of Sacha inchi (Plukenetia volubilis) according to cooking method and its application as an elder‐friendly drink

Diastereo‐ and Enantioselective Reductive Mannich‐type Reaction of α,β‐Unsaturated Carboxylic Acids to Ketimines: A Direct Entry to Unprotected β^2,3,3‐Amino Acids

Ru₃(CO)₁₂‐Catalyzed Modular Assembly of Hemilabile Ligands by C−H Activation of Phosphines with Isocyanates

Ru₃(CO)₁₂‐Catalyzed Modular Assembly of Hemilabile Ligands by C−H Activation of Phosphines with Isocyanates

Sulfur dioxide‐free Verdejo wines through the use of a pure stilbene extract: exploring possible synergistic effect with glutathione

Cellular antioxidant mechanism of mannan‐oligosaccharides involving in enhancing flesh quality in grass carp (Ctenopharyngodon idella)

Comparative analysis of the variability of the human leukocyte antigen peptide‐binding pockets in patients with acute leukaemia

Direct Synthesis of α‐Amino Acid Derivatives by Hydrative Amination of Alkynes

Foliar application of wood distillate boosts plant yield and nutritional parameters of chickpea

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