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Items from 1 to 20 out of 544 results

article

Mutagenicity assessment of high‐power 1.6‐THz pulse laser radiation

Midori Shirato, Yuma Takida, Taro Kanno, Hiroshi Matsuura, more

Photochemistry and Photobiology > 100 > 1 > 146 - 158

The effect of terahertz (THz) radiation has been studied in medicine. However, there is a lack of scientific information regarding its possible mutagenicity. Therefore, the present study aimed to assess the mutagenicity of 1.6 THz laser irradiation. The Ames test was conducted using five bacterial tester strains. The bacteria were subjected to (i) 1.6 THz laser irradiation at 3.8 mW/cm² for 60 min...

article

Safety assessment of a solid lipid curcumin particle preparation: In vitro and in vivo genotoxicity studies

Kirt R. Phipps, Victoria Bali, Dhaval Kukadia, Chintan Patel, more

Journal of Applied Toxicology > 43 > 6 > 929 - 939

Curcumin, one of the three principal curcuminoids found within turmeric rhizomes, has long been associated with numerous physiologically beneficial effects; however, its efficacy is limited by its inherently low bioavailability. Several novel formulations of curcumin extracts have been prepared in recent years to increase the systemic availability of curcumin; Longvida®, a solid lipid curcumin particle...

article

Determination of a positive response in the Ames Salmonella mutagenicity assay

Errol Zeiger

Environmental and Molecular Mutagenesis > 64 > 4 > 250 - 258

Genetic toxicology tests are used to categorize substances as genotoxic and potentially carcinogenic. In general, test results are designated as mutagenic, not mutagenic, or inconclusive and, depending on its potential use and applicable regulations, a mutagenic result can restrict or remove a substance from further development, or assign limits to its use. In these tests, mutation responses form...

article

Tools for monitoring toxicological and genotoxicological changes in a drinking water treatment plant in Northeast Italy

Carlotta Alias, Donatella Feretti, Laura Benassi, Ilaria Zerbini, more

Water and Environment Journal > 37 > 1 > 81 - 94

Drinking water quality can be compromised at different stages, from raw water to treated one. This research aimed to evaluate the toxicity and genotoxicity of groundwater contaminated by fluorinated compounds treated in a drinking water treatment plant, through several bioassays. Water samples underwent chemical analyses and were assayed on Daphnia magna, Pseudokirchneriella subcapitata, Allium cepa...

article

In vitro and in vivo assessments of the genotoxic potential of 3‐chloroallyl alcohol

Aisling Redmond, Fagen Zhang, WanYun Cheng, B. Bhaskar Gollapudi

Environmental and Molecular Mutagenesis > 64 > 1 > 26 - 38

3‐Chloroallyl alcohol (3‐CAA) can be found in the environment following the application of plant protection products. 3‐CAA is formed in groundwater following the injection of 1,3‐dichloropropene, a fumigant used to control nematodes. 3‐CAA is also formed, in leafy crops, as a glycoside conjugate following application of the herbicide, clethodim. Human exposure may occur from groundwater used as drinking...

article

Toxicity evaluation of main zopiclone impurities based on quantitative structure–activity relationship models and in vitro tests

Jie Yin, Hairuo Wen, Hua Chen

Journal of Applied Toxicology > 43 > 2 > 230 - 241

Toxicity evaluation of main zopiclone impurities can provide a basis for safety assessment and quality standards of zopiclone. In this study, the impurity profile of zopiclone was analyzed using forced degradation and related substances of zopiclone tablets using high‐performance liquid chromatography (HPLC). Furthermore, various quantitative structure–activity relationship (QSAR) models were used...

article

Development and application of the Ames test using a direct‐exposure module: The assessment of mutagenicity of incense and sidestream cigarette smoke

Po‐Wen Chen, Hung‐Fu Lu, Zhen‐Shu Liu

Indoor Air > 32 > 10 > n/a - n/a

We had previously developed an improved Ames module to directly determine the mutagenicity of gaseous formaldehyde (HCHO) and toluene without liquid extraction. This study further evaluated the suitability and sensitivity of this module on whole and real polluted air samples. For this, two common brands of stick incense (A and B) and cigarettes (A and B) were harvested, and various types of incense...

article

Mutagenicity of the Danube River: The contribution of liquid phase and particulate suspended matter

Daniel A. Morales, Riccardo Massei, Tobias Schulze, Martin Krauss, more

Environmental and Molecular Mutagenesis > 63 > 3 > 162 - 168

Bioassays have been used to complement the chemical characterization of aquatic mutagenicity, but the tests sometimes are done only with water liquid phase (LP). Particle‐bound mutagens are important because they can be ingested by filtering organisms. Our objective was to evaluate the mutagenicity of organic extracts of the LP and the water suspended particulate matter (SPM) from 13 sites along Danube...

article

Assessment of the mutagenicity of two common indoor air pollutants, formaldehyde and toluene

Po‐Wen Chen, Tai‐Chen Kuo, Zhen‐Shu Liu, Hung‐Fu Lu

Indoor Air > 31 > 5 > 1353 - 1363

Traditionally, direct‐reading instruments have been used to directly determine the concentrations of indoor air pollutants that may exceed the regulation limits. However, these instruments cannot directly assess the potential health hazards of these pollutants to humans. In this study, we developed and improved a bacterial reverse mutation assay (Ames test) by using a direct gas exposure module to...

article

The release of contaminants from steel slags and natural aggregates: Evaluation of toxicity and genotoxicity

Carlotta Alias, Donatella Feretti, Laura Benassi, Alessandro Abbà, more

Environmental and Molecular Mutagenesis > 62 > 1 > 66 - 77

Steel slags (SS) are the major waste produced by iron and steel industry. Slags may be reused as recycled materials, instead of natural aggregates (NA), to reduce the final disposal in a landfill and the exploitation of raw materials. However, the reuse of SS may generate a potential release of toxic compounds for the environment and humans. The purpose of this study was to evaluate the toxicity and...

article

(Q)SAR tools for the prediction of mutagenic properties: Are they ready for application in pesticide regulation?

Kristin Herrmann, Andrea Holzwarth, Soyub Rime, Benjamin C Fischer, more

Pest Management Science > 76 > 10 > 3316 - 3325

The assessment of human health risks resulting from the presence of metabolites in groundwater and food residues has become an important element in pesticide authorisation. In this context, the evaluation of mutagenicity is of particular interest and a paradigm shift from exposure‐triggered testing to in silico‐based screening has been recommended in the European Food Safety Authority (EFSA) Guidance on the establishment of the residue definition for dietary risk assessment...

article

EVALUATION OF MUTAGENIC PROPERTIES OF 2(C6H15N2O2)+2I3-H2O IODINE COORDINATION COMPLEX IN BACTERIAL REVERSE MUTATION TEST

Ardak B. Jumagaziyeva, Zhanar A. Iskakbayeva, Auyes N. Myrzabayeva, Natalya A. Suldina, more

Acta Poloniae Pharmaceutica - Drug Research > 2020 > 77 > 3 > 465-473

Objective: 2(C6H15N2O2)+ 2I3-H2O iodine coordination complex is a new pharmaceutical substance that have high antibacterial activity against both sensitive and multidrug resistant strains of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa. Methods: Mutagenicity of 2(C6H15N2O2)+2I3-H2O iodine coordination complex was assessed using Salmonella/microsome (Ames) test. Tester strains used...

article

Mutagenic, genotoxic and cytotoxic studies of invasive corals Tubastraea coccinea and Tubastraea tagusensis

Raphael de Mello Carpes, Matteus de Assis Alves, Joel Christopher Creed, Carla Amaral Silva, more

Journal of Applied Toxicology > 40 > 3 > 373 - 387

The high diversity of species in the marine environment gives rise to compounds with unique structural patterns not found as natural products in other systems and with great potential for pharmacological, cosmetic and nutritional use. The genus Tubastraea (Class Anthozoa, Order Scleractinia, Family Dendrophylliidae) is characterized as a hard coral without the presence of zooxanthellae. In species...

article

Mutagenicity as a parameter in surface water monitoring programs—opportunity for water quality improvement

Deborah A. Roubicek, Célia M. Rech, Gisela A. Umbuzeiro

Environmental and Molecular Mutagenesis > 61 > 1 > 200 - 211

Effect‐based analyses are being recognized as excellent tools to a comprehensive and reliable water quality evaluation to complement physical and chemical parameters. The Salmonella/microsome mutagenicity test was introduced in the São Paulo State water quality‐monitoring program in 1999 and waters from 104 sites used to the production of drinking water were analyzed. Samples were tested after organic...

article

Synthesis and mode of action studies of novel {2‐(3‐R‐1H‐1,2,4‐triazol‐5‐yl)phenyl}amines to combat pathogenic fungi

Lyudmyla Antypenko, Zhanar Sadykova, Kostiantyn Shabelnyk, Fatuma Meyer, more

Archiv der Pharmazie > 352 > 10 > n/a - n/a

Due to their high specificity and efficacy, triazoles have become versatile antifungals to treat fungal infections in human healthcare and to control phytopathogenic fungi in agriculture. However, azole resistance is an emerging problem affecting human health as well as food security. Here we describe the synthesis of 10 novel {2‐(3‐R‐1H‐1,2,4‐triazol‐5‐yl)phenyl}amines. Their structure was ascertained...

article

Critical review of styrene genotoxicity focused on the mutagenicity/clastogenicity literature and using current organization of economic cooperation and development guidance

Martha M. Moore, Lynn H. Pottenger, Tamara House‐Knight

Environmental and Molecular Mutagenesis > 60 > 7 > 624 - 663

Styrene is an important high production volume chemical used to manufacture polymeric products. In 2018, International Agency for Research on Cancer classified styrene as probably carcinogenic to humans; National Toxicology Program lists styrene as reasonably anticipated to be a human carcinogen. The genotoxicity literature for styrene and its primary metabolite, styrene 7,8‐oxide (SO), begins in...

article

The effect of silver nanoparticles on the mutagenic and the genotoxic properties of the urban wastewater liquid sludges

Messaouda Khallef, Djamel Eddine Benouareth, Muhsin Konuk, Recep Liman, more

Environmental Science and Pollution Research > 2019 > 26 > 18 > 18403- 18410

Nanoparticles are very effective compounds to transform and detoxicate common environmental contaminants. For this reason, crude urban liquid wastewater sludges were treated by silver nanoparticles (Ag-NPs, 100 nm) for 24 h. Both Ag-NPs’ treated and untreated sludges were examined for the evaluation if there are possible mutagenic/anti-mutagenic, cytotoxic, and genotoxic/anti-genotoxic effects by...

article

Evaluation of Kagocel Genotoxicity

A. K. Zhanataev, T. G. Borovskaya, B. S. Shcherbakova, B. A. Rudoi, more

Bulletin of Experimental Biology and Medicine > 2019 > 166 > 6 > 731-734

Antiviral drug Kagocel in concentrations of 0.0008, 0.004, 0.02, 0.1, 0.5, and 2.5 mg/ml with or without metabolic activation does not induce gene mutations in S. typhimurium strains ТА98, ТА100, ТА1535, and ТА1537 and in a combination of E. coli strains pKM101 and uvrA. A single intragastric administration of Kagocel in a daily therapeutic dose and a 10-fold daily therapeutic dose to male mice or...

article

In vitro genotoxicity assessment of an oxidized dextrin‐based hydrogel for biomedical applications

Isabel Pereira, Sónia Fraga, Susana Silva, João Paulo Teixeira, more

Journal of Applied Toxicology > 39 > 4 > 639 - 649

Hydrogels are three‐dimensional, crosslinked networks of hydrophilic polymers swollen with a large amount of water or biological fluids, without dissolving. Dextrin, a low‐molecular‐weight carbohydrate composed by glucose residues, has been used to develop an injectable hydrogel for biomedical applications. Dextrin was first oxidized to introduce aldehyde groups, which then reticulate with adipic...

article

An oral toxicity test in rats and a genotoxicity study of extracts from the stems of Opuntia ficus-indica var. saboten

Eun Hye Han, Mi Kyung Lim, Sang Ho Lee, Md. Mahbubur Rahman, more

BMC Complementary and Alternative Medicine > 2019 > 19 > 1 > 1-10

Background Opuntia ficus-indica var. saboten (OFIS) is used widely in Korea to treat constipation due to its diuretic effects and its enhancement of bowel function and appetite. However, its safety has not yet been established. The aim of this study was to evaluate the repeated oral toxicity and genotoxicity of OFIS extract (OE). Methods White female and male Sprague Dawley rats (n = 6) were divided...

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Mutagenicity assessment of high‐power 1.6‐THz pulse laser radiation

Safety assessment of a solid lipid curcumin particle preparation: In vitro and in vivo genotoxicity studies

Determination of a positive response in the Ames Salmonella mutagenicity assay

Tools for monitoring toxicological and genotoxicological changes in a drinking water treatment plant in Northeast Italy

In vitro and in vivo assessments of the genotoxic potential of 3‐chloroallyl alcohol

Toxicity evaluation of main zopiclone impurities based on quantitative structure–activity relationship models and in vitro tests

Development and application of the Ames test using a direct‐exposure module: The assessment of mutagenicity of incense and sidestream cigarette smoke

Mutagenicity of the Danube River: The contribution of liquid phase and particulate suspended matter

Assessment of the mutagenicity of two common indoor air pollutants, formaldehyde and toluene

The release of contaminants from steel slags and natural aggregates: Evaluation of toxicity and genotoxicity

(Q)SAR tools for the prediction of mutagenic properties: Are they ready for application in pesticide regulation?

EVALUATION OF MUTAGENIC PROPERTIES OF 2(C6H15N2O2)+2I3-H2O IODINE COORDINATION COMPLEX IN BACTERIAL REVERSE MUTATION TEST

Mutagenic, genotoxic and cytotoxic studies of invasive corals Tubastraea coccinea and Tubastraea tagusensis

Mutagenicity as a parameter in surface water monitoring programs—opportunity for water quality improvement

Synthesis and mode of action studies of novel {2‐(3‐R‐1H‐1,2,4‐triazol‐5‐yl)phenyl}amines to combat pathogenic fungi

Critical review of styrene genotoxicity focused on the mutagenicity/clastogenicity literature and using current organization of economic cooperation and development guidance

The effect of silver nanoparticles on the mutagenic and the genotoxic properties of the urban wastewater liquid sludges

Evaluation of Kagocel Genotoxicity

In vitro genotoxicity assessment of an oxidized dextrin‐based hydrogel for biomedical applications

An oral toxicity test in rats and a genotoxicity study of extracts from the stems of Opuntia ficus-indica var. saboten

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