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article

Different patterns of brain activation in normal aging and Alzheimer's disease from cognitional sight: meta analysis using activation likelihood estimation

Saeed Sadigh-Eteghad, Alireza Majdi, Mehdi Farhoudi, Mahnaz Talebi, more

Journal of the Neurological Sciences > 2014 > 343 > 1-2 > 159-166

Alzheimer disease (AD) is a chronic neurological disease, frequently affecting cognitional functions. Recently, a large body of neuro-imaging studies have aimed at finding reliable biomarkers of AD for early diagnosis of disease in contrast with healthy elderlies. We intended to have a meta-analytical study on recent functional neuroimaging studies to find the relationship between cognition in AD...

article

Tau protein, beta-amyloid1–42 and clusterin CSF levels in the differential diagnosis of Parkinsonian syndrome with dementia

Hana Přikrylová Vranová, Eva Hényková, Michaela Kaiserová, Kateřina Menšíková, more

Journal of the Neurological Sciences > 2014 > 343 > 1-2 > 120-124

Background: Parkinson's disease (PD), PD with dementia (PDD) and Lewy body dementia (DLB) are synucleinopathies. PDD and DLB are sometimes considered a transition between PD and Alzheimer dementia (AD). Finding in vivo markers or their combination could help in the differential diagnosis of these neurodegenerative (ND) diseases. Objective: The aim of this study was to assess cerebrospinal fluid (CSF)...

article

Vision function abnormalities in Alzheimer disease

Radouil Tzekov, Michael Mullan, R. Tzekov, M. Mullan

Survey of Ophthalmology > 2014 > 59 > 4 > 414-433

Alzheimer disease (AD) is a progressive, age-related debilitating condition that is a growing public health problem in the developed world. Visual system abnormalities in AD were recognized in the early 1970s, but were initially considered to be of strictly cortical origin. Studies in the past 20 years reveal that all parts of the visual system may be affected, including the optic nerve and the retina...

article

Different modes of synaptic and extrasynaptic NMDA receptor alteration in the hippocampus of P301S tau transgenic mice

Rocío Alfaro‐Ruiz, Carolina Aguado, Alejandro Martín‐Belmonte, Ana Esther Moreno‐Martínez, more

Brain Pathology > 33 > 1 > n/a - n/a

N‐methyl‐d‐aspartate receptors (NMDARs) are pivotal players in the synaptic transmission and synaptic plasticity underlying learning and memory. Accordingly, dysfunction of NMDARs has been implicated in the pathophysiology of Alzheimer disease (AD). Here, we used histoblot and sodium dodecylsulphate‐digested freeze‐fracture replica labelling (SDS‐FRL) techniques to investigate the expression and subcellular...

article

AP2S1 regulates APP degradation through late endosome–lysosome fusion in cells and APP/PS1 mice

Qi‐Xin Wen, Biao Luo, Xiao‐Yong Xie, Gui‐Feng Zhou, more

Traffic > 24 > 1 > 20 - 33

AP2S1 is the sigma 2 subunit of adaptor protein 2 (AP2) that is essential for endocytosis. In this study, we investigated the potential role of AP2S1 in intracellular processing of amyloid precursor protein (APP), which contributes to the pathogenesis of Alzheimer disease (AD) by generating the toxic β‐amyloid peptide (Aβ). We found that knockdown or overexpression of AP2S1 decreased or increased...

article

Psychotropic medication prescribing in assisted living and nursing home residents with dementia after the National Partnership

Antoinette B. Coe, Tingting Zhang, Andrew R. Zullo, Lauren B. Gerlach, more

Journal of the American Geriatrics Society > 70 > 12 > 3513 - 3525

Background The Centers for Medicare & Medicaid Services implemented the National Partnership to Improve Dementia Care in Nursing Homes (the Partnership) to decrease antipsychotic use and improve care for nursing home (NH) residents with dementia. We determined whether the extent of antipsychotic and other psychotropic medication prescribing in AL residents with dementia mirrored that of long‐stay...

article

Dementia risk in patients with bipolar disorder

Tomoyuki Kawada

International Journal of Geriatric Psychiatry > 38 > 1 > n/a - n/a

article

Towards an understanding of the pathological basis of senile depression and incident dementia: Implications for treatment

Ito Kawakami, Jun‐ichi Iga, Sho Takahashi, Yi‐Ting Lin, more

Psychiatry and Clinical Neurosciences > 76 > 12 > 620 - 632

Senile depression (SD) is a heterogeneous syndrome. Several clinical profiles are more likely to appear in SD than in early‐life depression, but it remains unclear whether the pathophysiology is different. The prevalence of dementia increases with aging, and the underlying pathophysiological processes in the preclinical phase begin even before cognitive deficits or neurological signs appear. SD may...

article

Associations between cerebrospinal fluid markers and cognition in ageing and dementia: A systematic review

Tyler S. Saunders, Danni A. Gadd, Tara L. Spires‐Jones, Declan King, more

European Journal of Neuroscience > 56 > 9 > 5650 - 5713

A biomarker associated with cognition in neurodegenerative dementias would aid in the early detection of disease progression, complement clinical staging and act as a surrogate endpoint in clinical trials. The current systematic review evaluates the association between cerebrospinal fluid protein markers of synapse loss and neuronal injury and cognition. We performed a systematic search which revealed...

article

Associations of sleep timing and time in bed with dementia and cognitive decline among Chinese older adults: A cohort study

Rui Liu, Yifei Ren, Tingting Hou, Xiaoyan Liang, more

Journal of the American Geriatrics Society > 70 > 11 > 3138 - 3151

Background The longitudinal associations of sleep timing and time in bed (TIB) with dementia and cognitive decline in older adults are unclear. Methods This population‐based cohort study used data from 1982 participants who were aged ≥60 years, free of dementia, and living in rural communities in western Shandong, China. At the baseline (2014) and follow‐up (2018) examinations, sleep parameters...

article

Dual‐Functional, Multi‐Targeting GNNQQNY‐AIE Conjugates as Amyloid Probes and Amyloid Modulators via Amyloid Cross‐Seeding Principle

Yijing Tang, Dong Zhang, Xiong Gong, Jie Zheng

Advanced Functional Materials > 32 > 45 > n/a - n/a

Amyloid protein aggregation is associated with many neurodegenerative diseases, including amyloid‐β (Aβ) in Alzheimer disease, human islet amyloid polypeptide (hIAPP) in type II diabetes, and human calcitonin (hCT) in medullary thyroid carcinoma. Significant efforts have been made to develop different diagnostic and prevention strategies for the early detection and intervention of these disease‐causative...

article

Dual‐Functional, Multi‐Targeting GNNQQNY‐AIE Conjugates as Amyloid Probes and Amyloid Modulators via Amyloid Cross‐Seeding Principle (Adv. Funct. Mater. 45/2022)

Yijing Tang, Dong Zhang, Xiong Gong, Jie Zheng

Advanced Functional Materials > 32 > 45 > n/a - n/a

Enhanced Oxygen‐Evolution Photoanodes In article number 2208022, Zheng and co‐workers design “dual‐functional and multi‐targeting” amyloid‐aggregation‐induced emission conjugates of GNNQQNY‐triphenylvinyl benzoic acid as amyloid probes and modulators for monitoring, detecting, and altering amyloid aggregation of different amyloid proteins.

article

Calcium inhibits penetration of Alzheimer's Aβ₁–₄₂ monomers into the membrane

Subramanian Boopathi, Ramón Garduño‐Juárez

Proteins: Structure, Function, and Bioinformatics > 90 > 12 > 2124 - 2143

Calcium ion regulation plays a crucial role in maintaining neuronal functions such as neurotransmitter release and synaptic plasticity. Copper (Cu²⁺) coordination to amyloid‐β (Aβ) has accelerated Aβ_1–42 aggregation that can trigger calcium dysregulation by enhancing the influx of calcium ions by extensive perturbing integrity of the membranes. Aβ_1–42 aggregation, calcium dysregulation, and membrane...

article

Mental health and periodontal and peri‐implant diseases

Jake Ball, Ivan Darby

Periodontology 02000 > 90 > 1 > 106 - 124

Mental health disorders, particularly depression and anxiety, affect a significant number of the global population. Several pathophysiological pathways for these disorders have been identified, including the hypothalamic‐pituitary‐adrenal axis, autonomic nervous system, and the immune system. In addition, life events, environmental factors, and lifestyle affect the onset, progression, and recurrence...

article

Factors associated with social participation in Brazilian older adults with Alzheimer’s disease: A correlational, cross‐sectional study

Marcos Paulo Braz de Oliveira, Paula Regina Mendes da Silva Serrão, Jéssica Bianca Aily, Julimara Gomes dos Santos, more

Health & Social Care in the Community > 30 > 5 > e3000 - e3008

The occurrence of Alzheimer's disease (AD) can exert a negative impact in social participation in affected older adults. The purpose of this study was to investigate whether social participation in older adults with AD is associated with disease stage and cognitive function as well as the quality of life and depressive symptoms in their caregivers. A correlational, cross‐sectional study was conducted...

article

The clinical and mechanistic roles of bile acids in depression, Alzheimer's disease, and stroke

Wu Lirong, Zhao Mingliang, Li Mengci, Guo Qihao, more

PROTEOMICS > 22 > 15-16 > n/a - n/a

The burden of neurological and neuropsychiatric disorders continues to grow with significant impacts on human health and social economy worldwide. Increasing clinical and preclinical evidences have implicated that bile acids (BAs) are involved in the onset and progression of neurological and neuropsychiatric diseases. Here, we summarized recent studies of BAs in three types of highly prevalent brain...

article

A Time‐to‐Event Exposure‐Response Model for Amyloid‐Related Imaging Abnormalities Following Administration of Aducanumab to Subjects With Early Alzheimer Disease

Kumar Kandadi Muralidharan, Sravan Karumanchi, Kenneth G. Kowalski, Patrick Burkett, more

The Journal of Clinical Pharmacology > 62 > 8 > 1030 - 1046

Amyloid‐related imaging abnormalities with edema (ARIA‐E) have been reported in patients with early Alzheimer disease treated with aducanumab. ARIA‐E incidence has been observed to be dependent on both dose and apolipoprotein E4 carrier status. A time‐to‐event (TTE) approach applying data from 2 phase 3 studies (studies 301 and 302) was used to describe the effect of aducanumab serum exposure on the...

article

A novel approach to type 3 diabetes mechanism: The interplay between noncoding RNAs and insulin signaling pathway in Alzheimer's disease

Kiana Moayedi, Shirin Orandi, Reyhane Ebrahimi, Maryam Tanhapour, more

Journal of Cellular Physiology > 237 > 7 > 2838 - 2861

Today, growing evidence indicates that patients with type 2 diabetes (T2D) are at a higher risk of developing Alzheimer's disease (AD). Indeed, AD as one of the main causes of dementia in people aged more than 65 years can be aggravated by insulin resistance (IR) and other metabolic risk factors related to T2D which are also linked to the function of the brain. Remarkably, a new term called “type...

article

Association between nutritional and functional status indicators with caregivers' burden in Alzheimer's disease

Odete Vicente de Sousa, Joana Mendes, Teresa F. Amaral

Nutrition & Dietetics > 79 > 3 > 380 - 389

Aim To investigate the association between nutritional and functional status of Alzheimer's disease patients and caregivers' burden. Methods A cross‐sectional study was conducted among 79 community‐dwelling Alzheimer's disease patients living with their caregivers. Caregivers' burden was assessed using the Zarit Burden‐Interview. Multinomial logistic regressions were carried out using caregivers'...

article

Hippocampal calcification and its effects on cognitive function and symptoms in dementia

Shunsuke Takagi, Katsumi Yamashiro, Genichi Sugihara, Masato Matsuura, more

Psychogeriatrics > 22 > 4 > 427 - 432

Background Hippocampal calcification (HC), highly prevalent in older people, has not attracted attention until recently. Despite its potential effects on cognition and behaviour, and its possible impact on the diagnosis and severity of dementia, it has not been investigated. This study aimed to evaluate the prevalence of HC and its influence on cognition and behavioural symptoms in patients with...

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Search results

Different patterns of brain activation in normal aging and Alzheimer's disease from cognitional sight: meta analysis using activation likelihood estimation

Tau protein, beta-amyloid1–42 and clusterin CSF levels in the differential diagnosis of Parkinsonian syndrome with dementia

Vision function abnormalities in Alzheimer disease

Different modes of synaptic and extrasynaptic NMDA receptor alteration in the hippocampus of P301S tau transgenic mice

AP2S1 regulates APP degradation through late endosome–lysosome fusion in cells and APP/PS1 mice

Psychotropic medication prescribing in assisted living and nursing home residents with dementia after the National Partnership

Dementia risk in patients with bipolar disorder

Towards an understanding of the pathological basis of senile depression and incident dementia: Implications for treatment

Associations between cerebrospinal fluid markers and cognition in ageing and dementia: A systematic review

Associations of sleep timing and time in bed with dementia and cognitive decline among Chinese older adults: A cohort study

Dual‐Functional, Multi‐Targeting GNNQQNY‐AIE Conjugates as Amyloid Probes and Amyloid Modulators via Amyloid Cross‐Seeding Principle

Dual‐Functional, Multi‐Targeting GNNQQNY‐AIE Conjugates as Amyloid Probes and Amyloid Modulators via Amyloid Cross‐Seeding Principle (Adv. Funct. Mater. 45/2022)

Calcium inhibits penetration of Alzheimer's Aβ₁–₄₂ monomers into the membrane

Mental health and periodontal and peri‐implant diseases

Factors associated with social participation in Brazilian older adults with Alzheimer’s disease: A correlational, cross‐sectional study

The clinical and mechanistic roles of bile acids in depression, Alzheimer's disease, and stroke

A Time‐to‐Event Exposure‐Response Model for Amyloid‐Related Imaging Abnormalities Following Administration of Aducanumab to Subjects With Early Alzheimer Disease

A novel approach to type 3 diabetes mechanism: The interplay between noncoding RNAs and insulin signaling pathway in Alzheimer's disease

Association between nutritional and functional status indicators with caregivers' burden in Alzheimer's disease

Hippocampal calcification and its effects on cognitive function and symptoms in dementia

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