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article

Investigation of the interaction between five alkaloids and human hemoglobin by fluorescence spectroscopy and molecular modeling

Wu He, Huanjing Dou, Zhigang Li, Xiaogai Wang, more

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy > 2014 > 123 > Complete > 176-186

This work studied the interaction of human hemoglobin (HHb) with aminophylline, acefylline, caffeine, theophylline and diprophylline systematically by UV–vis absorption spectroscopy and fluorescence spectroscopy in combination with molecular modeling. Five alkaloids caused the fluorescence quenching of HHb by the formation of alkaloids-HHb complex. The binding constants and thermodynamic parameters...

article

Effect of delayed harvesting and pre-treatment methods on the antinutritional contents of trifoliate yam flour

Olufunmilola Adunni Abiodun, Rahman Akinoso, O.A. Abiodun, R. Akinoso

Food Chemistry > 2014 > 146 > Complete > 515-520

Effects of delayed harvesting and pre-treatment methods on the anti-nutritional contents of trifoliate yam flour were examined. Trifoliate yam tubers were washed, peeled, sliced and subjected to pre-treatment methods, such as soaking, pre-cooking and blanching/soaking. The phenols, phytate, oxalate, tannin and alkaloid profiles of the flours were evaluated and the values of phenols, tannin, oxalate...

article

Botany, traditional uses, phytochemistry and pharmacology of Waltheria indica L. (syn. Waltheria americana): A review

F. Zongo, C. Ribuot, A. Boumendjel, I. Guissou, more

Journal of Ethnopharmacology > 2013 > 148 > 1 > 14-26

Ethnopharmacological relevance: Waltheria indica L. (syn. Waltheria americana) is commonly used in traditional medicine in Africa, South America and Hawaii, mainly against pain, inflammation, conditions of inflammation, diarrhea, dysentery, conjunctivitis, wounds, abscess, epilepsy, convulsions, anemia, erectile dysfunctions, bladder ailments and asthma. Aim of the review to provide an up-to-date...

article

Hepatoprotective and antioxidant activity of a mangrove plant Lumnitzera racemosa

Sundaram Ravikumar, Murugesan Gnanadesigan

Asian Pacific Journal of Tropical Biomedicine > 2011 > 1 > 5 > 348-352

To identify the hepatoprotective and in vitro antioxidant activity of Lumnitzera racemosa (L. racemosa) leaf extract. Animals in Group 1 served as vehicle control, Group 2 served as hepatotoxin (CCL ₄ treated) group, Group 3 served as positive control (Silymarin) group, and Group 4, 5 and 6 served as (75, 150 and 300 mg/kg bw p.o.) L. racemosa leaf extract treated groups. Moreover, in vitro...

article

Root elongation test on seeds of Sinapis alba reveals toxicity of extracts from thirteen colour forms of the Asian multi‐coloured ladybird, Harmonia axyridis

Samane Sakaki, Oldřich Nedvěd

Entomologia Experimentalis et Applicata > 171 > 3 > 186 - 195

Ladybirds (Coleoptera: Coccinellidae) use toxic compounds such as alkaloids in their hemolymph to defend against predators and pathogens. Direct measurement of their toxicity to predators is unavailable as predators show various avoidance reactions without eating the beetles. Because inhibition by harmonine – the alkaloid of the alien invasive ladybird Harmonia axyridis (Pallas) – was observed in...

article

Progress towards the Total Syntheses of Amaryllidaceae Alkaloids γ‐Lycorane

Jie Xiao, Guang‐Hua Zhou, An‐Xi Zhou, Cong‐Bin Ji

Chemistry & Biodiversity > 19 > 9 > n/a - n/a

γ‐Lycorane, a degradation product of the Aromaticaceae alkaloid lycorine, is one of the most attractive molecules in the Aromaticaceae family. It remains a popular target for synthesis due to its pentacyclic structure, which presents a vehicle for demonstrating the utility of new synthetic strategies. Various synthetic methods have been developed by synthetic chemists since the first synthesis of...

article

A General Electro‐Synthesis Approach to Amaryllidaceae Alkaloids

Dennis Pollok, Luca M. Großmann, Torsten Behrendt, Till Opatz, more

Chemistry – A European Journal > 28 > 50 > n/a - n/a

Amaryllidaceae alkaloids appeal to organic chemists with their attractive structures and their impressive antitumor and acetylcholinesterase inhibitory properties. We demonstrate a highly versatile access to this family of natural products. A general protocol with high yields in a sustainable electro‐organic key transformation on a metal‐free anode to spirodienones facilitates functionalization to...

article

Structural Elucidation and Total Synthesis of Trichodermotin A, A Natural α‐Glucosidase Inhibitor from Trichoderma asperellum

Muyuan Yu, Fengqing Wang, Si Yao, Yi Zang, more

Chinese Journal of Chemistry > 40 > 18 > 2219 - 2225

A pair of alkaloid enantiomers possessing a novel 1‐oxaspiro[4.4]non‐3‐ene‐2,7‐dione skeleton, trichodermotin A (1), was obtained from the fungus Trichoderma asperellum. Spectroscopic data, X‐ray diffraction, and ECD calculations were used to establish its structure and absolute configuration. (−)‐1 showed significant α‐glucosidase inhibitory activity (IC₅₀ = 10.1 μmol/L vs. 60.1 μmol/L of positive...

article

The terminal enzymatic step in piperine biosynthesis is co‐localized with the product piperine in specialized cells of black pepper (Piper nigrum L.)

Luise Jäckel, Arianne Schnabel, Hagen Stellmach, Ulrike Klauß, more

The Plant Journal > 111 > 3 > 731 - 747

Piperine (1‐piperoyl piperidine) is responsible for the pungent perception of dried black pepper (Piper nigrum) fruits and essentially contributes to the aromatic properties of this spice in combination with a blend of terpenoids. The final step in piperine biosynthesis involves piperine synthase (PS), which catalyzes the reaction of piperoyl CoA and piperidine to the biologically active and pungent...

article

Intramolecular (4+3) Cycloadditions of Oxidopyridinium Ions: Towards Daphnicyclidin A

Jianzhuo Tu, Rawshan A. Ripa, Steven P. Kelley, Michael Harmata

Chemistry – A European Journal > 28 > 41 > n/a - n/a

N‐alkylation of 5‐hydroxynicotinic acid esters with electrophiles containing diene functionality produces salts that undergo intramolecular (4+3) cycloaddition reactions upon heating in the presence of base. Initial studies used a three‐carbon tether to join the pyridinium ion and diene, revealing some aspects of the inherent selectivity of the reaction with such substrates. Much more challenging...

article

Natural alkaloid as a non‐toxic, environmentally friendly corrosion inhibitor

Jun H. Ng, Tariq Almubarak, Hisham Nasr‐El‐Din

The Canadian Journal of Chemical Engineering > 100 > 6 > 1214 - 1225

Acid treatments are commonly used in various oilfield treatments in order to remove inorganic scale or to stimulate formations. When applied in high temperature wells, these acids become very corrosive and can cause severe damage to tubulars as well as downhole equipment. Therefore, corrosion inhibitors are a necessary additive in these stimulation treatments. Commercial corrosion inhibitors used...

article

Pharmacokinetics of glaucine after intravenous and oral administrations and detection of systemic aporphine alkaloids after ingestion of tulip poplar shavings in horses

Joanne E. Haughan, Jaclyn R. Missanelli, Youwen You, Darko Stefanovski, more

Journal of Veterinary Pharmacology and Therapeutics > 45 > 3 > 273 - 282

Glaucine, an aporphine alkaloid with anti‐tussive, anti‐inflammatory, and anti‐nociceptive properties, has been identified in post‐race samples from racehorses. To investigate pharmacokinetics of glaucine in horses, a three‐way crossover study of intravenous and oral glaucine (0.1 mg/kg) and orally administered tulip poplar shavings (50 g shavings = 0.001 mg/kg glaucine) was performed in six horses...

article

Total Syntheses of the Imidazo[1,2‐f]phenanthridine‐Containing Alkaloid Zephycandidine A

Bingbing Sheng, Cuicui Zeng, Jing Chen, Wen‐Cai Ye, more

European Journal of Organic Chemistry > 2022 > 9 > n/a - n/a

Two distinct and concise syntheses of zephycandidine A (1) from readily available starting materials are reported. In the first, the imidazole derived from piperonal (7 a) was subjected to reaction with o‐bromoiodobenzene or the corresponding di‐iodide in the presence of Pd[0] and thereby forming, via Buchwald–Hartwig and Heck reactions, a mixture of target 1 and regio‐isomer 10. These products could...

article

Review on marine sponge alkaloid, aaptamine: A potential antibacterial and anticancer drug

Vinita Manimaran Nadar, Selvambigai Manivannan, Rajasekar Chinnaiyan, Muthusamy Govarthanan, more

Chemical Biology & Drug Design > 99 > 1 > 103 - 110

In recent years, biological macromolecules have piqued the interest of researchers owing to their vast variety of biological uses. As a result, the marine sponge is a multicellular heterotrophic parazoan with chemicals for defence against predator assaults, biofouling and microbial diseases. These priceless molecules are known as secondary metabolites, and they are essential for survival in a highly...

article

An ultrasound assisted extraction–solid‐phase extraction–ultra‐performance liquid chromatography combined strategy for atropine determination in Atropa belladonna leaves

Mariana Koetz, Luiz C. Klein‐Junior, Marí C. Santos, Thamires A. Silva, more

Biomedical Chromatography > 35 > 5 > n/a - n/a

Atropine is an antimuscarinic alkaloid identified in Atropa belladonna. In pharmacopeias, percolation is standardized as an extraction method for A. belladonna leaves, along with liquid–liquid extraction as a cleanup procedure and titration as an analytical method for assaying the atropine in the leaves. In this study, a faster, solvent‐saving, and more reliable method for quality control of A. belladonna...

article

Intramolecular Heck Reaction in Total Synthesis of Natural Products: An Update

Debobrata Paul, Subhendu Das, Sanu Saha, Himangshu Sharma, more

European Journal of Organic Chemistry > 2021 > 14 > 2057 - 2076

This review highlights the application of intramolecular Heck reaction in total synthesis of natural products which were successfully synthesized in recent years (2013 to 2019). Heck cyclization was used as one of the strategic steps for constructions of wide variety of cyclic scaffolds essential for preparation of different natural products.

article

Whole‐genome assembly and resequencing reveal genomic imprint and key genes of rapid domestication in narrow‐leafed lupin

Penghao Wang, Gaofeng Zhou, Jianbo Jian, Huaan Yang, more

The Plant Journal > 105 > 5 > 1192 - 1210

Shifting from a livestock‐based protein diet to a plant‐based protein diet has been proposed as an essential requirement to maintain global food sustainability, which requires the increased production of protein‐rich crops for direct human consumption. Meanwhile, the lack of sufficient genetic diversity in crop varieties is an increasing concern for sustainable food supplies. Countering this concern...

article

Toxin or medication? Immunotherapeutic effects of nicotine on a specialist caterpillar

Michael Garvey, Justin Bredlau, Karen Kester, Curtis Creighton, more

Functional Ecology > 35 > 3 > 614 - 626

A core tenant in the field of ecological immunology is that immune responses trade off with other physiological functions due to resource allocation costs. Caterpillars, for example, tend to exhibit reduced immune responses when reared on more toxic food plants due to a cost from detoxifying or sequestering secondary metabolites, also known as the ‘vulnerable host hypothesis’. However, support...

article

Traditional Chinese medicine may be further explored as candidate drugs for pancreatic cancer: A review

Yue Gao, Shiyu Chen, Jiayi Sun, Siyu Su, more

Phytotherapy Research > 35 > 2 > 603 - 628

Pancreatic cancer is a disease with a high mortality rate. Although survival rates for different types of cancers have improved in recent years, the five‐year survival rate of pancreatic cancer stands at 8%. Moreover, the current first‐line therapy, gemcitabine, results in low remission rates and is associated with drug resistance problems. Alternative treatments for pancreatic cancer such as surgery,...

article

Total Synthesis of (−)‐Lepadin F based on a Stereoselective Diels–Alder Reaction Controlled by a Ketolactone‐type Dienophile

He Gu, Yue Hu, Yuanliang Jia, Qin Zhou, more

Chemistry – A European Journal > 27 > 12 > 4141 - 4149

An efficient approach to the type III lepadin alkaloids (lepadins F and G) has been developed through a key Diels–Alder reaction, in which a novel ketolactone‐type dienophile with chiral diol unit is employed to generate the desirable all‐cis‐trisubstituted cyclohexene with excellent regio‐ and stereoselectivity control. The subsequent selective sulfonylation of the diol unit followed by S_N2 cyclization...

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Search results

Investigation of the interaction between five alkaloids and human hemoglobin by fluorescence spectroscopy and molecular modeling

Effect of delayed harvesting and pre-treatment methods on the antinutritional contents of trifoliate yam flour

Botany, traditional uses, phytochemistry and pharmacology of Waltheria indica L. (syn. Waltheria americana): A review

Hepatoprotective and antioxidant activity of a mangrove plant Lumnitzera racemosa

Root elongation test on seeds of Sinapis alba reveals toxicity of extracts from thirteen colour forms of the Asian multi‐coloured ladybird, Harmonia axyridis

Progress towards the Total Syntheses of Amaryllidaceae Alkaloids γ‐Lycorane

A General Electro‐Synthesis Approach to Amaryllidaceae Alkaloids

Structural Elucidation and Total Synthesis of Trichodermotin A, A Natural α‐Glucosidase Inhibitor from Trichoderma asperellum

The terminal enzymatic step in piperine biosynthesis is co‐localized with the product piperine in specialized cells of black pepper (Piper nigrum L.)

Intramolecular (4+3) Cycloadditions of Oxidopyridinium Ions: Towards Daphnicyclidin A

Natural alkaloid as a non‐toxic, environmentally friendly corrosion inhibitor

Pharmacokinetics of glaucine after intravenous and oral administrations and detection of systemic aporphine alkaloids after ingestion of tulip poplar shavings in horses

Total Syntheses of the Imidazo[1,2‐f]phenanthridine‐Containing Alkaloid Zephycandidine A

Review on marine sponge alkaloid, aaptamine: A potential antibacterial and anticancer drug

An ultrasound assisted extraction–solid‐phase extraction–ultra‐performance liquid chromatography combined strategy for atropine determination in Atropa belladonna leaves

Intramolecular Heck Reaction in Total Synthesis of Natural Products: An Update

Whole‐genome assembly and resequencing reveal genomic imprint and key genes of rapid domestication in narrow‐leafed lupin

Toxin or medication? Immunotherapeutic effects of nicotine on a specialist caterpillar

Traditional Chinese medicine may be further explored as candidate drugs for pancreatic cancer: A review

Total Synthesis of (−)‐Lepadin F based on a Stereoselective Diels–Alder Reaction Controlled by a Ketolactone‐type Dienophile

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