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Sclerotinia Sclerotiorum (White Mold): Cytotoxic, Mutagenic, and Antimalarial Effects In Vivo and In Vitro

Carolina Girotto Pressete, Laila Santos Vieira Giannini, Daniela Aparecida Chagas Paula, Mariana Araújo Vieira do Carmo, more

Journal of Food Science > 84 > 12 > 3866 - 3875

This work aimed includes performing the sclerotia chemical profile and evaluates their biological effects on mutagenesis, oxidative stress, cancer, and malaria. A chemical profile was determined by ultraperformance liquid chromatography mass spectrometry (UHPLC–HRMS) analysis dereplicating norditerpenoid dilactone, sclerolide, and other compounds. The GI₅₀ values to cancer cells (19.8 to 277.6 µg/mL)...

article

Higher glutathione demand may be necessary for assisting haemodialysis patients to cope with increased oxidative stress

En‐Ling Yeh, Cheng‐Hsu Chen, Shih‐Chien Huang, Yi‐Chia Huang

Nephrology > 25 > 1 > 90 - 95

Aim The removal of cysteine during a dialysis procedure may affect glutathione (GSH) concentration, allowing haemodialysis (HD) patients to become more susceptible to oxidative damage. This study was performed to determine whether the change of GSH/glutathione disulfide (GSSG) redox state and GSH redox potential were linked with the change of cysteine or oxidative stress in patients receiving HD...

article

Sexual dimorphic expression and release of transcription factors in bovine embryos exposed to oxidative stress

Mohamed O. Taqi, Mohammed Saeed‐Zidane, Samuel Gebremedhn, Dessie Salilew‐Wondim, more

Molecular Reproduction and Development > 86 > 12 > 2005 - 2019

Sexually dimorphic differences in genome activity, which is orchestrated by transcription factors (TFs), could explain the differential response of male and female embryos to environmental stressors. To proof this hypothesis, the expression of cellular and extracellular TFs was investigated in male and female bovine embryos in vitro cultured either under low (5%) or high (20%) oxygen levels. The intracellular...

article

Vitamin D3 treatment regulates apoptosis, antioxidant defense system, and DNA integrity in the epididymal sperm of an aged rat model

Malsawmhriatzuala Jeremy, Guruswami Gurusubramanian, Vikas Kumar Roy

Molecular Reproduction and Development > 86 > 12 > 1951 - 1962

The present study aimed to investigate the effects of vitamin D3 in the epididymal sperm cells of D‐gal‐induced aged rats. It is well known that during aging sperm quality and quantity declines and leads to age‐related infertility problems in males. The results of the present study showed that there were elevated levels of oxidative stress and poor DNA integrity of sperm of aged rats. The expression...

article

Artesunate suppresses inflammation and oxidative stress in a rat model of colorectal cancer

Vijay L. Kumar, Sneh Verma, Prasenjit Das

Drug Development Research > 80 > 8 > 1089 - 1097

Anti‐inflammatory drugs are well known to reduce the risk of colon cancer and prophylactic use of such agents is gaining acceptance as a cancer prevention therapy. As artesunate, an antimalarial drug, has been shown to exhibit chemopreventive properties, the present study was carried out to evaluate its inhibitory effect on oxidative stress and inflammation in a rat model of colon carcinogenesis....

article

Anlotinib attenuated bleomycin‐induced pulmonary fibrosis via the TGF‐β1 signalling pathway

Hao Ruan, Ziwei Lv, Shuaishuai Liu, Liang Zhang, more

Journal of Pharmacy and Pharmacology > 72 > 1 > 44 - 55

Objectives Anlotinib hydrochloride (AL3818) is a novel multitarget tyrosine kinase inhibitor which has the same targets as nintedanib, an effective drug has been approved for the treatment of idiopathic pulmonary fibrosis. Here, we examined whether anlotinib could also attenuate bleomycin‐induced pulmonary fibrosis in mice and explored the antifibrosis mechanism. Methods We have evaluated the effect...

article

Nrf2–Keap1 pathway–mediated effects of resveratrol on oxidative stress and apoptosis in hydrogen peroxide–treated rheumatoid arthritis fibroblast‐like synoviocytes

Ye Zhang, Gaoyuan Wang, Taorong Wang, Wei Cao, more

Annals of the New York Academy of Sciences > 1457 > 1 > 166 - 178

Resveratrol (Res) is a polyphenolic compound that has a variety of biological functions and activities. This study aimed to explore the mechanisms of the antioxidant and proapoptotic effects of Res in H₂O₂‐treated rheumatoid arthritis fibroblast‐like synoviocytes (RA‐FLSs) by the Nrf2–Keap1 signaling pathway. We found that 5 µM H₂O₂ promoted cell proliferation and increased intracellular reactive...

article

Dietary profile of n‐3 series LC‐PUFAs in rainbow trout under regular stripping condition: Semen production and quality, hepato‐somatic index, haemato‐immunologic values, oxidative stress and fatty acid composition of liver, muscle and semen

Serpil Mişe Yonar, Kenan Köprücü, Sinan Özcan

Aquaculture Research > 51 > 1 > 370 - 378

In this study, the semen production and quality, hepato‐somatic index, haemato‐immunologic values, oxidative stress and the fatty acid contents in liver, muscle and semen of rainbow trout fed diets supplemented n‐3 series long‐chain polyunsaturated fatty acids (LC‐PUFAs) under regular stripping condition were investigated. For this aim, three diets (Control, D1 and D2) were prepared. These diets were...

article

Quantitation of in vivo brain glutathione conformers in cingulate cortex among age‐matched control, MCI, and AD patients using MEGA‐PRESS

Deepika Shukla, Pravat Kumar Mandal, Manjari Tripathi, Gayatri Vishwakarma, more

Human Brain Mapping > 41 > 1 > 194 - 217

Oxidative stress (OS) plays an important role in Alzheimer's disease (AD) and glutathione (GSH) mitigates this effect by maintaining redox‐imbalance and free‐radical neutralization. Quantified brain GSH concentration provides distinct information about OS among age‐matched normal control (NC), mild cognitive impairment (MCI) and AD patients. We report alterations of in vivo GSH conformers, along with...

article

The extent to which lipopolysaccharide modulates oxidative stress response in Mugil cephalus juveniles

Afaf D. Abdel‐Mageid, Abeer Gamal Zaki, Yakout A. El Senosi, Amel M. El Asely, more

Aquaculture Research > 51 > 1 > 426 - 431

article

Physiological regulation of reactive oxygen species in organisms based on their physicochemical properties

Mei‐Zhou Huang, Jian‐Yong Li

Acta Physiologica > 228 > 1 > n/a - n/a

Oxidative stress is recognized as free radical dyshomeostasis, which has damaging effects on proteins, lipids and DNA. However, during cell differentiation and proliferation and other normal physiological processes, free radicals play a pivotal role in message transmission and are considered important messengers. Organisms maintain free radical homeostasis through a sophisticated regulatory system...

article

Melatonin long‐lasting beneficial effects on pulmonary vascular reactivity and redox balance in chronic hypoxic ovine neonates

Alejandro Gonzaléz‐Candia, Alejandro A. Candia, Esteban G. Figueroa, Elisenda Feixes, more

Journal of Pineal Research > 68 > 1 > n/a - n/a

Pulmonary arterial hypertension of the neonate (PAHN) is a pathophysiological condition characterized by maladaptive pulmonary vascular remodeling and abnormal contractile reactivity. This is a multifactorial syndrome with chronic hypoxia and oxidative stress as main etiological drivers, and with limited effectiveness in therapeutic approaches. Melatonin is a neurohormone with antioxidant and vasodilator...

article

Placental mitochondria and reactive oxygen species in the physiology and pathophysiology of pregnancy

Joshua J. Fisher, Lucy A. Bartho, Anthony V. Perkins, Olivia J. Holland

Clinical and Experimental Pharmacology and Physiology > 47 > 1 > 176 - 184

Mitochondria are central to cell function. The placenta forms the interface between maternal and fetal systems, and placental mitochondria have critical roles in maintaining pregnancy. The placenta is unusual in having two adjacent cell layers (cytotrophoblasts and the syncytiotrophoblast) with vastly different mitochondria that have distinct functions in health and disease. Mitochondria both produce...

article

The effects of lycopene supplement on the spermatogram and seminal oxidative stress in infertile men: A randomized, double‐blind, placebo‐controlled clinical trial

Mehran Nouri, Reza Amani, Mohammadhossein Nasr‐Esfahani, Mohammad Javad Tarrahi

Phytotherapy Research > 33 > 12 > 3203 - 3211

Infertility is a major, worldwide problem that is affected, and mediated, by several factors, in particular, oxidative stress. Thus, the aim of this study was to evaluate the effect of lycopene supplementation on spermatogram and seminal oxidative stress. In this randomized, double‐blind, placebo‐controlled trial study, 44 infertile men with oligozoospermia were randomly divided into two groups: The...

article

Effects of silymarin on growth performance, antioxidant capacity and immune response in turbot (Scophthalmus maximus L.)

Jingyu Wang, Huihui Zhou, Xuan Wang, Kangsen Mai, more

Journal of the World Aquaculture Society > 50 > 6 > 1168 - 1181

A 9‐week feeding trial was conducted using triplicate groups of turbot (6.50 ± 0.01 g) to explore the potential effects of silymarin. Three concentrations of silymarin (100, 200, and 400 mg/kg) were added to the plant protein‐based diet. Fish were randomly distributed into fiberglass tanks (30 fish per tank). The results showed that adding 100 mg/kg silymarin significantly improved the growth performance,...

article

Modulation of autophagy in traumatic brain injury

Zhiqing Zeng, Yao Zhang, Weiping Jiang, Lu He, more

Journal of Cellular Physiology > 235 > 3 > 1973 - 1985

Traumatic brain injury (TBI) is defined as a traumatically induced structural injury or physiological disruption of brain function as a result of external forces, leading to adult disability and death. A growing body of evidence reveals that alterations in autophagy‐related proteins exist extensively in both experimentally and clinically after TBI. Of note, the autophagy pathway plays an essential...

article

miR125a attenuates BMSCs apoptosis via the MAPK‐ERK pathways in the setting of craniofacial defect reconstruction

Longkun Fan, Jingxian Wang, Chao Ma

Journal of Cellular Physiology > 235 > 3 > 2857 - 2865

Bone mesenchymal stem cell (BMSC)‐based regenerative therapy is critical for the craniofacial defect reconstruction. However, oxidative stress microenvironment after transplantation limits the therapeutic efficiency of BMSC. The miR‐181c has been found to be associated with cell survival and proliferation. Herein, we investigated whether prior miR‐181c treatment promoted BMSC proliferation and survival...

article

Withaferin A reverses bile duct ligation‐induced liver fibrosis by modulating extracellular matrix deposition: Role of LOXL2/Snail1, vimentin, and NFκB signaling

Nilofer Sayed, Amit Khurana, Mohd Aslam Saifi, Mandip Singh, more

BioFactors > 45 > 6 > 959 - 974

Herein, we studied the effect of Withaferin A (WFA) in reversing bile duct ligation (BDL)‐induced liver fibrosis. BDL was performed on C57BL/6J mice and 2 days later, WFA (1 and 3 mg/kg) was administered for 12 days. Estimation of liver enzymes and assays for lipid peroxidation, reduced glutathione, and nitrite levels were performed. Picrosirius red, Masson's trichrome, and H&E staining were performed...

article

Docosahexaenoic acid and hydroxytyrosol co‐administration fully prevents liver steatosis and related parameters in mice subjected to high‐fat diet: A molecular approach

Sandra A. Soto‐Alarcón, Macarena Ortiz, Paula Orellana, Francisca Echeverría, more

BioFactors > 45 > 6 > 930 - 943

Attenuation of high‐fat diet (HFD)‐induced liver steatosis is accomplished by different nutritional interventions. Considering that the n‐3 PUFA docosahexaenoic acid (DHA) modulates lipid metabolism and the antioxidant hydroxytyrosol (HT) diminishes oxidative stress underlying fatty liver, it is hypothesized that HFD‐induced steatosis is suppressed by DHA and HT co‐administration. Male C57BL/6J mice...

article

Tri‐ortho‐cresyl phosphate (TOCP)‐induced reproductive toxicity involved in placental apoptosis, autophagy and oxidative stress in pregnant mice

Bei Yang, Xinlu Wang, Yilin Ma, Lei Yan, more

Environmental Toxicology > 35 > 1 > 97 - 107

Tri‐ortho‐cresyl phosphate (TOCP) has been widely used as plasticizers, and reported causing reproductive toxicity in mammals. However, little is known about the toxic effect on the placenta. In this study, dams were orally administered different doses of TOCP to explore the effect of TOCP on placental development. Results showed that TOCP exposure significantly reduced numbers of implanted embryo,...

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Search results

Sclerotinia Sclerotiorum (White Mold): Cytotoxic, Mutagenic, and Antimalarial Effects In Vivo and In Vitro

Higher glutathione demand may be necessary for assisting haemodialysis patients to cope with increased oxidative stress

Sexual dimorphic expression and release of transcription factors in bovine embryos exposed to oxidative stress

Vitamin D3 treatment regulates apoptosis, antioxidant defense system, and DNA integrity in the epididymal sperm of an aged rat model

Artesunate suppresses inflammation and oxidative stress in a rat model of colorectal cancer

Anlotinib attenuated bleomycin‐induced pulmonary fibrosis via the TGF‐β1 signalling pathway

Nrf2–Keap1 pathway–mediated effects of resveratrol on oxidative stress and apoptosis in hydrogen peroxide–treated rheumatoid arthritis fibroblast‐like synoviocytes

Dietary profile of n‐3 series LC‐PUFAs in rainbow trout under regular stripping condition: Semen production and quality, hepato‐somatic index, haemato‐immunologic values, oxidative stress and fatty acid composition of liver, muscle and semen

Quantitation of in vivo brain glutathione conformers in cingulate cortex among age‐matched control, MCI, and AD patients using MEGA‐PRESS

The extent to which lipopolysaccharide modulates oxidative stress response in Mugil cephalus juveniles

Physiological regulation of reactive oxygen species in organisms based on their physicochemical properties

Melatonin long‐lasting beneficial effects on pulmonary vascular reactivity and redox balance in chronic hypoxic ovine neonates

Placental mitochondria and reactive oxygen species in the physiology and pathophysiology of pregnancy

The effects of lycopene supplement on the spermatogram and seminal oxidative stress in infertile men: A randomized, double‐blind, placebo‐controlled clinical trial

Effects of silymarin on growth performance, antioxidant capacity and immune response in turbot (Scophthalmus maximus L.)

Modulation of autophagy in traumatic brain injury

miR125a attenuates BMSCs apoptosis via the MAPK‐ERK pathways in the setting of craniofacial defect reconstruction

Withaferin A reverses bile duct ligation‐induced liver fibrosis by modulating extracellular matrix deposition: Role of LOXL2/Snail1, vimentin, and NFκB signaling

Docosahexaenoic acid and hydroxytyrosol co‐administration fully prevents liver steatosis and related parameters in mice subjected to high‐fat diet: A molecular approach

Tri‐ortho‐cresyl phosphate (TOCP)‐induced reproductive toxicity involved in placental apoptosis, autophagy and oxidative stress in pregnant mice

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