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Items from 1 to 20 out of 15,692 results

article

Hydrogen‐deuterium exchange mass spectrometry highlights conformational changes induced by factor XI activation and binding of factor IX to factor XIa

Awital Bar Barroeta, Josse Galen, Ingrid Stroo, J. Arnoud Marquart, more

Journal of Thrombosis and Haemostasis > 17 > 12 > 2047 - 2055

Background Factor XI (FXI) is a zymogen in the coagulation pathway that, once activated, promotes haemostasis by activating factor IX (FIX). Substitution studies using apple domains of the homologous protein prekallikrein have identified that FIX binds to the apple 3 domain of FXI. However, the molecular changes upon activation of FXI or binding of FIX to FXIa have remained largely unresolved. ...

article

Quantification of the Charge Consuming Phenomena under High‐Voltage Hold of Carbon/Carbon Supercapacitors by Coupling Operando and Post‐Mortem Analyses

Patryk Przygocki, Paula Ratajczak, François Béguin

Angewandte Chemie International Edition > 58 > 50 > 17969 - 17977

Enhancing the operating voltage of supercapacitors (SCs), hence their specific energy, is important. However, long‐term hold at high voltage entails loss of capacitance, increase of resistance and internal pressure. Such detrimental effects could be reduced by obtaining quantitative information on the relative impact of the various mechanisms leading to the worsening of the SCs performance. Now, for...

article

Extraction and characterization of collagens from yak rumen smooth muscle

Shengsheng Li, Qunli Yu

Animal Science Journal > 90 > 12 > 1581 - 1589

This study reports an effective method using enzymatic methods to extract collagen from yak rumen smooth muscle. The enzymatic extraction methods were optimized by response surface methodology. Additionally, the properties of the extracted collagen were analyzed by Fourier transform infrared (FT‐IR) spectroscopy and mass spectrometry (MS). The results showed that the optimal conditions were as follows:...

article

Ion‐Mobility Spectrometry Can Assign Exact Fucosyl Positions in Glycans and Prevent Misinterpretation of Mass‐Spectrometry Data After Gas‐Phase Rearrangement

Javier Sastre Toraño, Ivan A. Gagarinov, Gaël M. Vos, Frederik Broszeit, more

Angewandte Chemie International Edition > 58 > 49 > 17616 - 17620

The fucosylation of glycans leads to diverse structures and is associated with many biological and disease processes. The exact determination of fucoside positions by tandem mass spectrometry (MS/MS) is complicated because rearrangements in the gas phase lead to erroneous structural assignments. Here, we demonstrate that the combined use of ion‐mobility MS and well‐defined synthetic glycan standards...

article

Analysis of dihydroindole‐type alkaloids in Strychnos nux‐vomica unprocessed and processed seeds by high‐performance liquid chromatography coupled with diode array detection and mass spectrometry

Xin Jiang, Ji‐Xin Tian, Min Wang, Yuan Tian, more

Journal of Separation Science > 42 > 22 > 3395 - 3402

The ripened seeds of Strychnos nux‐vomica L. have been extensively used as herbal medicines in Asian countries. Dihydroindole‐type alkaloids are not only the active constituents but also the toxicants in Strychnos. However, the simultaneous determination of these alkaloids in both crude and processed Semen Strychni is still lacking. The present study represents the first quantitation and relative...

article

Characterization of chemical constituents and absorbed components, screening the active components of gelanxinning capsule and an evaluation of therapeutic effects by ultra‐high performance liquid chromatography with quadrupole time of flight mass spectrometry

Xin Gao, Xiaohu Hu, Qiong Zhang, Xijing Wang, more

Journal of Separation Science > 42 > 22 > 3439 - 3450

We revealed the potential biomarker and pathway of gelanxinning capsule on rat model with coronary heart disease, which aims to clarify holistic therapeutic effect and predict quality‐markers of gelanxinning capsule. Ultra‐high performance liquid chromatography coupled with mass spectrometry based on metabolomics technique was used to find the biomarkers and related metabolic pathways of coronary...

article

An approach to analysis of primary amines by a combination of thin‐layer chromatography and matrix‐assisted laser desorption ionization mass spectrometry in conjunction with post‐chromatographic derivatization

Roman Borisov, Cesar Esparza, Nikolai Polovkov, Artyom Topolyan, more

Journal of Separation Science > 42 > 22 > 3470 - 3478

On‐spot derivatization has been suggested for the modification of primary amine containing compounds for their analysis by thin‐layer chromatography hyphenated with matrix‐assisted laser desorption ionization mass spectrometry. The proposed approach was based on post‐chromatographic treatment of separated analytes inside the chromatographic zones on the thin‐layer chromatography plates by tris(2,6‐dimethoxyphenyl)methilium...

article

Verification of cheeses authenticity by mass spectrometry

Stepanka Kuckova, Kristyna Zitkova, Ondrej Novotny, Tatiana Smirnova

Journal of Separation Science > 42 > 22 > 3487 - 3496

Cheeses are a group of fermented dairy products that are produced all over the world in various forms and flavours. Milk, especially sheep or goat milk, is still regarded as an expensive raw material in the world, which makes milk and milk products highly attractive as a fraud target. Most often, such fraud includes partial or complete substitution with cheaper sorts of milk (e.g. bovine milk). The...

article

Immunopeptidomics of colorectal cancer organoids reveals a sparse HLA class I neoantigen landscape and no increase in neoantigens with interferon or MEK-inhibitor treatment

Alice Newey, Beatrice Griffiths, Justine Michaux, Hui Song Pak, more

Journal for ImmunoTherapy of Cancer > 2019 > 7 > 1 > 1-15

Background Patient derived organoids (PDOs) can be established from colorectal cancers (CRCs) as in vitro models to interrogate cancer biology and its clinical relevance. We applied mass spectrometry (MS) immunopeptidomics to investigate neoantigen presentation and whether this can be augmented through interferon gamma (IFNγ) or MEK-inhibitor treatment. Methods Four microsatellite stable PDOs from...

article

Direct Conversion of Methane with Carbon Dioxide Mediated by RhVO₃⁻ Cluster Anions

Yuan Yang, Bin Yang, Yan‐Xia Zhao, Li‐Xue Jiang, more

Angewandte Chemie International Edition > 58 > 48 > 17287 - 17292

Direct conversion of methane with carbon dioxide to value‐added chemicals is attractive but extremely challenging because of the thermodynamic stability and kinetic inertness of both molecules. Herein, the first dinuclear cluster species, RhVO₃⁻, has been designed to mediate the co‐conversion of CH₄ and CO₂ to oxygenated products, CH₃OH and CH₂O, in the temperature range of 393–600 K. The resulting...

article

Synthesis of Polycyclic Aromatic Hydrocarbons by Phenyl Addition–Dehydrocyclization: The Third Way

Long Zhao, Matthew B. Prendergast, Ralf I. Kaiser, Bo Xu, more

Angewandte Chemie International Edition > 58 > 48 > 17442 - 17450

Polycyclic aromatic hydrocarbons (PAHs) represent the link between resonance‐stabilized free radicals and carbonaceous nanoparticles generated in incomplete combustion processes and in circumstellar envelopes of carbon rich asymptotic giant branch (AGB) stars. Although these PAHs resemble building blocks of complex carbonaceous nanostructures, their fundamental formation mechanisms have remained elusive...

article

Management of Tamm–Horsfall Protein for Reliable Urinary Analytics

Xiaomeng Xu, Karina Barreiro, Luca Musante, Oliver Kretz, more

PROTEOMICS – Clinical Applications > 13 > 6 > n/a - n/a

Purpose Urinary extracellular vesicles (uEVs) are a novel source of biomarkers. However, urinary Tamm–Horsfall Protein (THP; uromodulin) interferes with all vesicle isolation attempts, precipitates with normal urinary proteins, thus, representing an unwanted “contaminant” in urinary assays. Thus, the aim is to develop a simple method to manage THP efficiently. Experimental design The uEVs are isolated...

article

Untargeted metabolomics of strawberry (Fragaria x ananassa ‘Camarosa’) fruit from plants grown under osmotic stress conditions

Ana CN Antunes, Tanize dos S Acunha, Ellen C Perin, Cesar V Rombaldi, more

Journal of the Science of Food and Agriculture > 99 > 15 > 6973 - 6980

BACKGROUND Plants activate defense mechanisms to cope with adverse environmental conditions, leading to the accumulation and / or depletion of general and specialized metabolites. In this study, a multiplatform untargeted metabolomics strategy was employed to evaluate metabolic changes in strawberry fruit of cv. Camarosa grown under osmotic stress conditions. Liquid chromatography‐mass spectrometry...

article

Determination of ring-substituted amphetamines through automated online hollow fiber liquid-phase microextraction-liquid chromatography

Luis Felipe Rodríguez Cabal, Deyber Arley Vargas Medina, Jose Luiz Costa, Fernando Mauro Lanças, more

Analytical and Bioanalytical Chemistry > 2019 > 411 > 29 > 7889-7897

The present paper describes an original method for the online preconcentration and analysis of ring-substituted amphetamines in urine samples, used on the integration of robot-assisted hollow fiber liquid-phase microextraction (HF-LPME), high-performance liquid chromatography (HPLC), and fluorescence detection (FLD). A lab-made autosampler, actuating a 100-μL syringe and equipped with a three-way...

article

A validated LC-MSMS method for the simultaneous quantification of meropenem and vaborbactam in human plasma and renal replacement therapy effluent and its application to a pharmacokinetic study

Suzanne L. Parker, Saurabh Pandey, Fekade B. Sime, Jeffrey Lipman, more

Analytical and Bioanalytical Chemistry > 2019 > 411 > 29 > 7831-7840

A simple method for the simultaneous quantification of meropenem and the recently approved β-lactamase inhibitor, vaborbactam, in human plasma and renal replacement therapy effluent (RRTE) was developed and validated. This antibiotic combination protects a primary β-lactam, meropenem, with a new β-lactamase inhibitor, and expands the limited options for treatment of multidrug-resistant Gram-negative...

article

Chemometric study of kosmotropic and chaotropic ion properties related to Hofmeister effects

Anna Jakubowska, Tomasz Kozik

Journal of Chemometrics > 33 > 11 > n/a - n/a

The ion specificity is ubiquitous in biological and colloidal phenomena. In this study, the Hofmeister effects have been observed in binding of univalent cations with the surfactant dimers. Chemometric analysis has also revealed that the ion specificity observed is mainly related to the effect of ions on the water structure, ie, to their kosmotropic and chaotropic properties. These ion properties,...

article

Mass spectrometry: A platform for biomarker discovery and validation for Alzheimer's and Parkinson's diseases

Eugene M. Cilento, Lorrain Jin, Tessandra Stewart, Min Shi, more

Journal of Neurochemistry > 151 > 4 > 397 - 416

Accurate, reliable, and objective biomarkers for Alzheimer's disease (AD), Parkinson's disease (PD), and related age‐associated neurodegenerative disorders are urgently needed to assist in both diagnosis, particularly at early stages, and monitoring of disease progression. Technological advancements in protein detection platforms over the last few decades have resulted in a plethora of reported molecular...

article

Development of a CE‐MS method for the study of riociguat and metabolite M1 in pharmaceutical analysis

Martin Štícha, Tomáš Hložek, Miroslava Bursová, Radomír Čabala, more

ELECTROPHORESIS > 40 > 22 > 2936 - 2945

Riociguat is a novel antihypertensive drug for the treatment of pulmonary hypertension. We present electrophoretic characterization, i.e. migration behavior of riociguat and metabolite M1 as support for optimized CZE/MS assay. Fundamental separation parameters, such as peak width, symmetry, and resolution are studied in a series of ammonium formate buffers within pH range 2.60–5.61. The narrow region...

article

Challenges and Opportunities in Cancer Metabolomics

Ashish Kumar, Biswapriya B. Misra

PROTEOMICS > 19 > 21-22 > n/a - n/a

Challenges in metabolomics for a given spectrum of disease are more or less comparable, ranging from the accurate measurement of metabolite abundance, compound annotation, identification of unknown constituents, and interpretation of untargeted and analysis of high throughput targeted metabolomics data leading to the identification of biomarkers. However, metabolomics approaches in cancer studies...

article

Tissue Proteome Signatures Associated with Five Grades of Prostate Cancer and Benign Prostatic Hyperplasia

Rebeca Kawahara, Saulo Recuero, Fabio C. S. Nogueira, Gilberto B. Domont, more

PROTEOMICS > 19 > 21-22 > n/a - n/a

The histology‐based Gleason score (GS) of prostate cancer (PCa) tissue biopsy is the most accurate predictor of disease aggressiveness and an important measure to guide treatment strategies and patient management. The variability associated with PCa tumor sampling and the subjective determination of the GS are challenges that limit accurate diagnostication and prognostication. Thus, novel molecular...

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Search results

Hydrogen‐deuterium exchange mass spectrometry highlights conformational changes induced by factor XI activation and binding of factor IX to factor XIa

Quantification of the Charge Consuming Phenomena under High‐Voltage Hold of Carbon/Carbon Supercapacitors by Coupling Operando and Post‐Mortem Analyses

Extraction and characterization of collagens from yak rumen smooth muscle

Ion‐Mobility Spectrometry Can Assign Exact Fucosyl Positions in Glycans and Prevent Misinterpretation of Mass‐Spectrometry Data After Gas‐Phase Rearrangement

Analysis of dihydroindole‐type alkaloids in Strychnos nux‐vomica unprocessed and processed seeds by high‐performance liquid chromatography coupled with diode array detection and mass spectrometry

Characterization of chemical constituents and absorbed components, screening the active components of gelanxinning capsule and an evaluation of therapeutic effects by ultra‐high performance liquid chromatography with quadrupole time of flight mass spectrometry

An approach to analysis of primary amines by a combination of thin‐layer chromatography and matrix‐assisted laser desorption ionization mass spectrometry in conjunction with post‐chromatographic derivatization

Verification of cheeses authenticity by mass spectrometry

Immunopeptidomics of colorectal cancer organoids reveals a sparse HLA class I neoantigen landscape and no increase in neoantigens with interferon or MEK-inhibitor treatment

Direct Conversion of Methane with Carbon Dioxide Mediated by RhVO₃⁻ Cluster Anions

Synthesis of Polycyclic Aromatic Hydrocarbons by Phenyl Addition–Dehydrocyclization: The Third Way

Management of Tamm–Horsfall Protein for Reliable Urinary Analytics

Untargeted metabolomics of strawberry (Fragaria x ananassa ‘Camarosa’) fruit from plants grown under osmotic stress conditions

Determination of ring-substituted amphetamines through automated online hollow fiber liquid-phase microextraction-liquid chromatography

A validated LC-MSMS method for the simultaneous quantification of meropenem and vaborbactam in human plasma and renal replacement therapy effluent and its application to a pharmacokinetic study

Chemometric study of kosmotropic and chaotropic ion properties related to Hofmeister effects

Mass spectrometry: A platform for biomarker discovery and validation for Alzheimer's and Parkinson's diseases

Development of a CE‐MS method for the study of riociguat and metabolite M1 in pharmaceutical analysis

Challenges and Opportunities in Cancer Metabolomics

Tissue Proteome Signatures Associated with Five Grades of Prostate Cancer and Benign Prostatic Hyperplasia

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