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article

Living 3,4‐(Co)Polymerization of Isoprene/Myrcene and One‐Pot Synthesis of a Polyisoprene Blend Catalyzed by Binuclear Rare‐Earth Metal Amidinate Complexes

Xiaying Yu, Meng Li, Jianquan Hong, Xigeng Zhou, more

Chemistry – A European Journal > 25 > 10 > 2569 - 2576

Mononuclear amidinate yttrium complex C₄H₉C(NR)₂Y(o‐CH₂C₆H₄NMe₂)₂ (R=2,6‐iPr₂C₆H₃) and a series of binuclear rare‐earth metal complexes bearing a bridged amidinate ligand [(RN)₂C(CH₂)₄C(NR)₂][RE{CH₂C₆H₄(o‐NMe₂)}₂]₂ (R=2,6‐iPr₂C₆H₃, RE=Y, Lu, Sc) were synthesized and fully characterized. The catalytic behavior of these complexes for (co)polymerization of conjugated dienes such as isoprene and myrcene...

article

Domain knowledge specification for energy tuning

Madhura Kumaraswamy, Anamika Chowdhury, Michael Gerndt, Zakaria Bendifallah, more

Concurrency and Computation: Practice and Experience > 31 > 6 > n/a - n/a

To overcome the challenges of energy consumption of HPC systems, the European Union Horizon 2020 READEX (Runtime Exploitation of Application Dynamism for Energy‐efficient Exascale computing) project uses an online auto‐tuning approach to improve energy efficiency of HPC applications. The READEX methodology pre‐computes optimal system configurations at design‐time, such as the CPU frequency, for instances...

article

21‐hydroxylase autoantibodies are more prevalent in Turner syndrome but without an association to the autoimmune polyendocrine syndrome type I

A. Berglund, L. Cleemann, B. E. Oftedal, K. Holm, more

Clinical & Experimental Immunology > 195 > 3 > 364 - 368

Turner syndrome (TS) is associated with an increased frequency of autoimmunity. Frequently observed autoimmune diseases in TS are also seen in the autoimmune polyendocrine syndrome type I (APS I), of which Addison disease is a key component. An overlapping antibody profile between TS and APS I could be considered. The aim of this work was to study women with TS regarding 21‐hydroxylase (21‐OH) antibodies...

article

Behçet’s syndrome as a tool to dissect the mechanisms of thrombo‐inflammation: clinical and pathogenetic aspects

M. Becatti, G. Emmi, A. Bettiol, E. Silvestri, more

Clinical & Experimental Immunology > 195 > 3 > 322 - 333

Behçet’s syndrome (BS) is a complex disease with different organ involvement. The vascular one is the most intriguing, considering the existence of a specific group of patients suffering from recurrent vascular events involving the venous and, more rarely, the arterial vessels. Several clinical clues suggest the inflammatory nature of thrombosis in BS, especially of the venous involvement, thus BS...

article

Particle size and gastrointestinal absorption influence tiotropium pharmacokinetics: a pilot bioequivalence study of PUR0200 and Spiriva HandiHaler

Jason Perry, Brian Trautman, Joe Takher‐Smith, Steve Kramer, more

British Journal of Clinical Pharmacology > 85 > 3 > 580 - 589

Aims Plasma pharmacokinetics permit the assessment of efficacy and safety of inhaled drugs, and possibly their bioequivalence to other inhaled products. Correlating drug product attributes to lung deposited dose is important to achieving equivalence. PUR0200 is a spray‐dried formulation of tiotropium that enables more efficient lung delivery than Spiriva^® HandiHaler^® (HH). The ratio of tiotropium...

article

Thermal and Photophysical Properties of Highly Quadrupolar Liquid‐Crystalline Derivatives of the [closo‐B₁₂H₁₂]²⁻ Anion

Muhammad O. Ali, John C. Lasseter, Remigiusz Żurawiński, Anna Pietrzak, more

Chemistry – A European Journal > 25 > 10 > 2616 - 2630

Two series of 1,12‐bis‐zwitterionic derivatives of the [closo‐B₁₂H₁₂]²⁻ anion (B), containing either two 4‐alkoxypyridinium groups (1B[n]‐p) or one 4‐alkoxypyridinium and one 4‐pentylthianium groups (2B[n]‐p), were prepared and their structural (XRD, DFT), thermal, and photophysical properties were compared with those of the analogous derivatives of the [closo‐B₁₀H₁₀]²⁻ anion (1A[n]‐p and 2A[n]‐p)...

article

(Li₆Si₅)_2–5: The Smallest Cluster‐Assembled Materials Based on Aromatic Si₅⁶⁻ Rings

Osvaldo Yañez, Victor Garcia, Jorge Garza, Walter Orellana, more

Chemistry – A European Journal > 25 > 10 > 2467 - 2471

Extensive explorations of their potential energy surfaces, combined with high‐level quantum chemical computations, strikingly show that the lowest energy structures of the (Li₆Si₅)_2–5 systems consist of 2–5 Si₅⁶⁻ aromatic units, surrounded by Li⁺ counterions, respectively. These viable gas‐phase compounds are the pioneering reported cases of oligomers made by planar aromatic silicon rings. Based on...

article

Haemophilia and ageing

Susan Shapiro, Mike Makris

British Journal of Haematology > 184 > 5 > 712 - 720

Advances in the development of effective and safe treatments for haemophilia over the last 50 years have resulted in a significant increase in the life expectancy of persons with haemophilia (PWH). The management of this new cohort of middle‐aged and elderly PWH is challenging because of the opposing risks of haemophilia and age‐related cardiovascular disease and malignancy. Furthermore, this cohort...

article

Safety profile of human papilloma virus vaccines: an analysis of the US Vaccine Adverse Event Reporting System from 2007 to 2017

Giulia Bonaldo, Alberto Vaccheri, Ottavio D'Annibali, Domenico Motola

British Journal of Clinical Pharmacology > 85 > 3 > 634 - 643

Aims Human papilloma virus (HPV) is the cause of different types of carcinoma. Despite the remarkable effectiveness of the HPV vaccines, there have been many complaints about their risk–benefit profile due to adverse events following immunization (AEFI). The purpose of this study is to analyse the safety profile of the HPV vaccine basing on real‐life data derived from reports of suspected AEFIs collected...

article

Issue highlights

British Journal of Clinical Pharmacology > 85 > 3 > 465 - 466

article

Glecaprevir/Pibrentasvir in patients with chronic HCV genotype 3 infection: An integrated phase 2/3 analysis

Steven Flamm, David Mutimer, Armen Asatryan, Stanley Wang, more

Journal of Viral Hepatitis > 26 > 3 > 337 - 349

Glecaprevir coformulated with pibrentasvir (G/P) is approved to treat hepatitis C virus (HCV) infection and was highly efficacious in phase 2 and 3 studies. Treating HCV genotype (GT) 3 infection remains a priority, as these patients are harder to cure and at a greater risk for liver steatosis, fibrosis progression and hepatocellular carcinoma. Data were pooled from five phase 2 or 3 trials that evaluated...

article

Population pharmacokinetics of oral ivermectin in venous plasma and dried blood spots in healthy volunteers

Urs Duthaler, Claudia Suenderhauf, Mats O. Karlsson, Janine Hussner, more

British Journal of Clinical Pharmacology > 85 > 3 > 626 - 633

Aims The anthelminthic ivermectin is receiving new attention as it is being repurposed for new indications such as mass drug administrations for the treatment of scabies or in malaria vector control. As its pharmacokinetics are still poorly understood, we aimed to characterize the population pharmacokinetics of ivermectin in plasma and dried blood spots (DBS), a sampling method better suited to field...

article

Tributaries as biodiversity preserves: An ichthyoplankton perspective from the severely impounded Upper Paraná River

Patricia Sarai Silva, Leandro Esteban Miranda, Sergio Makrakis, Lucileine Assumpção, more

Aquatic Conservation: Marine and Freshwater Ecosystems > 29 > 2 > 258 - 269

Conservation of fish assemblages in severely impounded rivers has often focused on providing longitudinal and lateral connectivity along the main stem. Less attention has been given to tributaries, some of which remain unimpounded. This study shows that the biodiversity of ichthyoplankton in tributaries to the largest reservoir in the Paraná River, Brazil, is similar to that of tributaries of the...

article

Characterization of VWF gene conversions causing von Willebrand disease

Firdos Ahmad, Meganathan Kannan, Tobias Obser, Ulrich Budde, more

British Journal of Haematology > 184 > 5 > 817 - 825

We previously reported that von Willebrand Factor gene (VWF) conversions are a relatively frequent cause of von Willebrand disease (VWD), however, their molecular pathomechanisms resulting in variant phenotypes is largely unknown. Here, we characterized VWF conversions harbouring missense and synonymous mutations, through generating a series of mutant constructs followed by transient expression in...

article

Cover Picture

Journal of Mass Spectrometry > 54 > 2 > i - i

article

Successful mechanical eradication of spotted bass (Micropterus punctulatus (Rafinesque, 1819)) from a South African river

Johannes A. Walt, Sean M. Marr, Marius J. Wheeler, N. Dean Impson, more

Aquatic Conservation: Marine and Freshwater Ecosystems > 29 > 2 > 303 - 311

Following the discovery in 2007 of non‐native spotted bass (Micropterus punctulatus (Rafinesque, 1819)) in the Thee River, Olifants‐Doring River system, Western Cape Province, South Africa, a mechanical removal project was initiated in 2010 to eradicate them to protect the unique native fish assemblage in the river. A temporary gabion barrier was constructed to halt spotted bass invasion into upstream...

article

Lenalidomide‐based response‐adapted therapy for older adults without high risk myeloma

Rachid Baz, Syeda Mahrukh Hussnain Naqvi, Jae‐Hoon Lee, Jason Brayer, more

British Journal of Haematology > 184 > 5 > 735 - 743

Combined lenalidomide and dexamethasone is a standard‐of‐care therapy for the treatment of older adults with multiple myeloma. Lenalidomide monotherapy has not been evaluated in newly diagnosed myeloma patients. We conducted a phase II study, evaluating a response‐adapted therapy for older adults newly diagnosed with multiple myeloma without high‐risk features who were ineligible for high‐dose therapy...

article

Visible‐Light Photoredox Catalysis Enables the Biomimetic Synthesis of Nyingchinoids A, B, and D, and Rasumatranin D

Jacob D. Hart, Laura Burchill, Aaron J. Day, Christopher G. Newton, more

Angewandte Chemie International Edition > 58 > 9 > 2791 - 2794

The total synthesis of nyingchinoids A and B has been achieved through successive rearrangements of a 1,2‐dioxane intermediate that was assembled using a visible‐light photoredox‐catalysed aerobic [2+2+2] cycloaddition. Nyingchinoid D was synthesised with a competing [2+2] cycloaddition. Based on NMR data and biosynthetic speculation, we proposed a structure revision of the related natural product...

article

Somatic growth contributes to population variation in marine fishes

Christine C. Stawitz, Timothy E. Essington, Lesley Lancaster

Journal of Animal Ecology > 88 > 2 > 315 - 329

Understanding population fluctuations is a major goal of population ecology. In unpredictable marine environments, population variation is thought to be caused primarily by varying survival rates through a critical early life‐history stage. However, there is increasing evidence that somatic growth variation is common and causes population fluctuations. We examine the relative effects of empirically...

article

A certain invariance property of BLUE in a whole‐genome regression context

Daniel Gianola, Rohan L. Fernando, Dorian J. Garrick

Journal of Animal Breeding and Genetics > 136 > 2 > 113 - 117

A curious result from mixed linear models applied to genome‐wide association studies was expanded. In particular, a model in which one or more markers are considered as fixed but are allowed to contribute to the covariance structure by treating such markers as random as well was examined. The best linear unbiased estimator of marker effects is invariant with respect to whether those markers are employed...

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Living 3,4‐(Co)Polymerization of Isoprene/Myrcene and One‐Pot Synthesis of a Polyisoprene Blend Catalyzed by Binuclear Rare‐Earth Metal Amidinate Complexes

Domain knowledge specification for energy tuning

21‐hydroxylase autoantibodies are more prevalent in Turner syndrome but without an association to the autoimmune polyendocrine syndrome type I

Behçet’s syndrome as a tool to dissect the mechanisms of thrombo‐inflammation: clinical and pathogenetic aspects

Particle size and gastrointestinal absorption influence tiotropium pharmacokinetics: a pilot bioequivalence study of PUR0200 and Spiriva HandiHaler

Thermal and Photophysical Properties of Highly Quadrupolar Liquid‐Crystalline Derivatives of the [closo‐B₁₂H₁₂]²⁻ Anion

(Li₆Si₅)_2–5: The Smallest Cluster‐Assembled Materials Based on Aromatic Si₅⁶⁻ Rings

Haemophilia and ageing

Safety profile of human papilloma virus vaccines: an analysis of the US Vaccine Adverse Event Reporting System from 2007 to 2017

Issue highlights

Glecaprevir/Pibrentasvir in patients with chronic HCV genotype 3 infection: An integrated phase 2/3 analysis

Population pharmacokinetics of oral ivermectin in venous plasma and dried blood spots in healthy volunteers

Tributaries as biodiversity preserves: An ichthyoplankton perspective from the severely impounded Upper Paraná River

Characterization of VWF gene conversions causing von Willebrand disease

Cover Picture

Successful mechanical eradication of spotted bass (Micropterus punctulatus (Rafinesque, 1819)) from a South African river

Lenalidomide‐based response‐adapted therapy for older adults without high risk myeloma

Visible‐Light Photoredox Catalysis Enables the Biomimetic Synthesis of Nyingchinoids A, B, and D, and Rasumatranin D

Somatic growth contributes to population variation in marine fishes

A certain invariance property of BLUE in a whole‐genome regression context

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