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Cancer in adolescents and young adults is associated with an increased risk for suicidal ideation (SI). There are no reported pediatric oncology cases describing management of SI during end of life. We present the case of a 14‐year‐old male with relapsed, high‐risk, B‐cell acute lymphoblastic leukemia who received a haploidentical stem cell transplant and was suicidal at various points in his treatment...
Children with sickle cell disease (SCD) are at risk of complications from viral infections, including SARS‐CoV‐2. We present the clinical characteristics and outcomes of pediatric patients with SCD from the Pediatric COVID‐19 United States Registry who developed acute COVID‐19 due to SARS‐CoV‐2 infection (n = 259) or multisystem inflammatory syndrome in children (MIS‐C; n = 4). Nearly half of hospitalized...
Objective
The objective of this study was to examine the prevalence of overweight/obesity and excessive gestational weight gain (GWG) among military beneficiaries and to assess associations of these risk factors with maternal/neonatal complications and substantial postpartum weight retention (PPWR).
Methods
We obtained data for 48,391 TRICARE beneficiaries who gave birth in 2018 or 2019 in the...
Objective
The objective of this study was to investigate body composition changes with weight cycling (WC) among adult C57BL/6J mice with diet‐induced obesity.
Methods
A total of 555 single‐housed mice were fed a high‐fat diet ad libitum (AL) from 8 to 43 weeks of age. The 200 heaviest mice of each sex were randomized to the following four groups: ever obese (EO, continued AL feeding); obese weight...
Objective
We investigated how changes in 24‐h respiratory exchange ratio (RER) and substrate oxidation during fasting versus an energy balance condition influence subsequent ad libitum food intake.
Methods
Forty‐four healthy, weight‐stable volunteers (30 male and 14 female; mean [SD], age 39.3 [11.0] years; BMI 31.7 [8.3] kg/m2) underwent 24‐h energy expenditure measurements in a respiratory chamber...
Objective
This study explores the impact of maternal pre‐pregnancy BMI on infant neurodevelopment at 24 months in low‐income Latino families. It also investigates whether infant diet mediates this relationship.
Methods
Latino mother‐infant pairs (n = 163) were enrolled at 1 month post partum and were followed for 2 years, with assessments at 6‐month intervals. Maternal pre‐pregnancy anthropometrics...
Objective
The objective of this study is to determine whether in utero exposure to SARS‐CoV‐2 is associated with increased risk for a cardiometabolic diagnosis by 18 months of age.
Methods
This retrospective electronic health record (EHR)‐based cohort study included the live‐born offspring of all individuals who delivered during the COVID‐19 pandemic (April 1, 2020–December 31, 2021) at eight hospitals...
Objective
The incidence of metabolic dysfunction‐associated steatotic liver disease (MASLD) is rapidly ramping up due to the spread of obesity, which is characterized by expanded and dysfunctional visceral adipose tissue (VAT). Previous studies have investigated the hepatic transcriptome across MASLD, whereas few studies have focused on VAT.
Methods
We performed RNA sequencing in 167 hepatic samples...
Objective
This study examines the plasma proteomic profile of abdominal obesity in older adults.
Methods
The association of abdominal obesity (waist circumference [WC]) with 4265 plasma proteins identified using the SomaScan Assay was examined in 969 Ashkenazi Jewish participants (LonGenity cohort), aged 65 years and older (mean [SD] age 75.7 [6.7] years, 55.4% women), using regression models....
Objective
The study objective was to investigate whether changes in metabolic phenotype affect the risk of cardiovascular events.
Methods
All 117,589 participants were included in this retrospective cohort study. The metabolic phenotypes of the participants were assessed at two points (the second evaluation was set 2 years after the first evaluation), and the incidence rate of cardiovascular events...
Objective
Reduced myocardial mechano‐energetic efficiency (MEE) was associated with BMI. Subgroups of individuals with increased BMI but favorable cardiovascular risk profile were identified as individuals with “metabolically healthy overweight” (MHOW) and “metabolically healthy obesity” (MHO), respectively. We aim to investigate whether those with MHOW/MHO, defined as those having none of the components...
Objective
High BMI, which poorly represents specific fat depots, is linked to poorer cognition and higher dementia risk, with different associations between sexes. This study examined associations of abdominal fat depots with cognition and brain volumes and whether sex modifies this association.
Methods
A total of 204 healthy middle‐aged offspring of Alzheimer's dementia patients (mean age = 59...
Objective
This network meta‐analysis evaluates the efficacy and safety of tirzepatide compared to glucagon‐like peptide‐1 receptor agonists (GLP‐1 RA) and other weight loss drugs in the treatment of overweight and obesity.
Methods
MEDLINE, Embase, and Cochrane CENTRAL were searched for randomized controlled trials on tirzepatide, GLP‐1 RA, and weight loss drugs approved by the US Food and Drug...
Objective
The objective of this study was to determine the role of body fat percentage (BFP) changes in diabetes remission (DR) and the association between baseline body composition and its changes after bariatric surgery.
Methods
We analyzed 203 patients with type 2 diabetes who underwent Roux‐en‐Y gastric bypass. Body composition was measured using a gold‐standard‐derived predictive equation...
Objective
Dichlorodiphenyldichloroethylene (DDE), an obesogen accumulating in adipose tissue, is released into circulation with weight loss, although its impact is underexplored among adolescents. We tested the association using an integrative translational approach of epidemiological analysis among adolescents with obesity and in vitro measures exploring the impact of DDE on adipogenesis via preadipocytes...
Objective
The objective of this study was to examine associations between umbilical cord mitochondrial DNA copy number (mtDNAcn) and adiposity across childhood.
Methods
In a prospective birth cohort of Dominican and African American children from New York City, New York (1998–2006), mtDNAcn was measured in cord blood. Children (N = 336) were evaluated for their height, weight, and bioimpedance...
Objective
This study aimed to investigate the efficacy and safety of repeated photodynamic therapy (PDT) with a chlorin e6 (Ce6)‐embedded intragastric satiety‐inducing device (ISD) to maintain therapeutic effects of obesity in a juvenile pig.
Methods
The Ce6‐embedded ISD was fabricated with a dipping method. Twelve pigs were divided into four groups of three and were administered control, single,...
Objective
Big Data are increasingly used in obesity and nutrition research to gain new insights and derive personalized guidance; however, this data in raw form are often not usable. Substantial preprocessing, which requires machine learning (ML), human judgment, and specialized software, is required to transform Big Data into artificial intelligence (AI)‐ and ML‐ready data. These preprocessing steps...
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