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article

CT negative subarachnoid hemorrhage in emergency department

Jacek Szypenbejl, Mariusz Siemiński, Edyta Szurowska, Tomasz Szmuda, more

European Journal of Translational and Clinical Medicine > 2020 > 3 > 1 > 43-48

Background Subarachnoid hemorrhage (SAH) is rare but potentially life-threatening cause of acute headache. First diagnostic test performed in the Emergency Department (ED) for acute “thunderclap” headache is computed tomography of the head (CT) without contrast enhancement. Negative non-contrast head CT may be erroneously interpreted as an exclusion of SAH and lead to ED discharge. The consequences...

article

Anthropometric measurements, nutritional status and body composition in children with cystic fibrosis – the prospective study

Katarzyna N. Kaźmierska, Aleksandra Lemanowicz-Kustra, Agnieszka Jankowska, Agnieszka Szlagatys-Sidorkiewicz, more

European Journal of Translational and Clinical Medicine > 2020 > 3 > 1 > 34-42

Background Cystic fibrosis(CF),despite much progress in therapy, remains the disease which affects nutrition. Nutrition is an important prognostic factor of the outcome of the disease. We want to evaluate physical development, nutrition and body composition in CF children. Material and methods 75 children diagnosed with CF (9 months to 18 years old) were included into the study. 33 healthy children...

article

How to deal with patients with atrial fibrillation during the COVID-19 epidemic?

Anna Tomaszuk-Kazberuk

European Journal of Translational and Clinical Medicine > 2020 > 3 > 1 > 53-59

Patients with atrial fibrillation (AF) due to old age and comorbidities are at a higher risk of SARS-CoV-2 infection. These patients should protect themselves by limiting contact with other people to an absolute minimum and they should be educated about hygiene, including careful hand washing. In general, the principles of antiarrhythmic drug treatment of quarantined, infected and asymptomatic individuals...

article

It didn’t have to happen this way – what COVID-19 tells us about translational medicine

Tomasz Smiatacz

European Journal of Translational and Clinical Medicine > 2020 > 3 > 1 > 7-10

article

Risk factors of acute respiratory distress syndrome after on-pump cardiac surgery in the INFLACOR cohort study

Maciej M. Kowalik, Romuald Lango, Andrzej Łoś, Magdalena Chmara, more

European Journal of Translational and Clinical Medicine > 2020 > 3 > 1 > 24-33

Background Acute respiratory distress syndrome (ARDS) is a serious complication after cardiac surgery with a variety of clinical risk factors. It was hypothesized that genome variants predispose these patients to it. Material and methods A cohort of 509 adult Caucasians undergoing on-pump cardiac surgery were observed for postoperative ARDS defined by the Berlin definition. Clinical variables and...

article

How to write a scientific paper? Lessons from a distinguished scientist and editor

Shan Ali, Tomasz Szmuda, Zbigniew Wszołek

European Journal of Translational and Clinical Medicine > 2020 > 3 > 1 > 74-78

Background This editorial is an instructive guide on how to write and publish a scientific paper. It was inspired by a lecture given at the Medical University of Gdańsk by a distinguished professor. To further advance science, particularly in the currently emerging era of individualized medicine, the collaboration of researchers with a varied level of experience, and from different areas of expertise...

article

Sciatica: Internet Search Trends

Tomasz Szmuda, Shan Ali, Marcin Czyz, Paweł Słoniewski

European Journal of Translational and Clinical Medicine > 2020 > 3 > 1 > 49-52

Background Sciatica carries a significant health burden in the world as the lifetime incidence of sciatica estimated between 13% to 40%. We used modern scientific tools to assess the online health interest of sciatica and lower back pain. Material and methods Google Trends, Wikipedia statistics and PubMed data were used to gauge the online public interest in sciatica and lower back pain. Results Over...

article

Effect of a bicarbonate-buffered peritoneal dialysis solution on clinical and laboratory indices of dialysis adequacy

Michał Chmielewski, Dorota Bielińska-Ogrodnik, Piotr Jagodziński, Monika Lichodziejewska-Niemierko

European Journal of Translational and Clinical Medicine > 2020 > 3 > 1 > 11-15

Background Biocompatible fluids were introduced to improve dialysis and patient outcome in end-stage renal disease. However, being buffered with lactate, they may insufficiently correct metabolic acidosis, and lead to changes in peritoneum structure. Bicarbonate buffered fluids might mitigate these complications. The aim of the study was to evaluate the influence of a bicarbonate dialysis fluid on...

article

The role of interdisciplinary cooperation in the prevention of medication-related osteonecrosis of the jaw (MRONJ)

Monika Teślak, Izabela Chlebus, Iwona Ordyniec-Kwaśnica

European Journal of Translational and Clinical Medicine > 2020 > 3 > 1 > 60-65

Medication-related osteonecrosis of the jaw (MRONJ) is considered one of the most severe complications of treatment with antiresorptive drugs. The number of patients with MRONJ has significantly increased due to the broadening of the indication to treat with bisphosphonates and other antiresorptive drugs (e.g. denosumab). Because MRONJ has a significant impact on the patients’ quality of life, it...

article

Thoracic trauma – principals of surgical management

Jerzy Lasek, Eugeniusz Jadczuk

European Journal of Translational and Clinical Medicine > 2020 > 3 > 1 > 66-73

Thoracic trauma continues to be a significant surgical problem. It is estimated that 25% of trauma-related deaths are due to penetrating and blunt thoracic injuries. Principals of surgical management of specific thoracic injuries (tension pneumothorax, open pneumothorax, massive haemothorax, flail chest, cardiac injuries, ruptures of the aorta, tracheobronchial tree lesions, oesophageal and diaphragmatic...

article

Toxicological evaluation of xanthan gum based hydrogel formulation in Wistar rats using single dose study

Nadia S. Malik, Mahmood Ahmad, Muhammad U. Minhas, Ruqia Tulain, more

Acta Poloniae Pharmaceutica - Drug Research > 2020 > 77 > 2 > 353-360

Xanthan gum-based hydrogel formulation FXG3 was prepared by a free radical polymerization technique. To assess safety of FXG3 hydrogel for potential application as new drug delivery system, a single oral dose toxicity study was conducted according to OECD guidelines. Female adult rats of Wistar strain were divided into group A and group B. Group A served as the control and was given 1mL/100 g body...

article

The radiolytic studies of panipenem in the solid state

Przemysław Zalewski, Natalia Rosiak, Karolina Kilińska, Robert Skibiński, more

Acta Poloniae Pharmaceutica - Drug Research > 2020 > 77 > 2 > 241-250

The influence of ionizing radiation on the physicochemical properties of panipenem in solid state was studied. In the first part of our studies, we evaluated the possibility of applying radiosterilization to obtain sterile panipenem. Spectroscopic (FT-IR, Raman), chromatography (HPLC and HPLC-MS) and X-ray powder diffraction (XRPD) studies have shown that irradiation of ertapenem with the 25 kGy,...

article

Low doses of fenofibrate and bezafibrate stimulate renal 2-oxoglutarate dehydrogenase (2-OGDH) in protein-restricted rats

Malgorzata E. Knapik-Czajka, Jagoda M. Drag, Anna Gawedzka

Acta Poloniae Pharmaceutica - Drug Research > 2020 > 77 > 2 > 281-288

2-oxoglutarate dehydrogenase (2-OGDH) is the key regulatory enzyme of cell metabolism. It has been previously demonstrated that in rats subjected to protein restriction low, clinically relevant doses of fibrates up-regulate liver 2-OGDH and promote 2-oxoglutarate catabolism. The aim of the present study was to evaluate the effect of low doses of fenofibrate and bezafibrate on renal 2-OGDH complex...

article

ENCAPSULATION OF ROXITHROMYCIN INTO GELLAN GUM MATRICES AND THE IMPACT OF OTHER NATURAL POLYMERS ON DRUG RELEASE

Piotr Gadziński, Anna Froelich, Urszula Kowalska, Marcin Soból, more

Acta Poloniae Pharmaceutica - Drug Research > 2020 > 77 > 2 > 319-330

The aim of the work was to investigate the properties of polysaccharide matrices loaded with roxithromycin (ROX), made on the basis of low-acyl gellan and its blends with sodium alginate, pectin, karaya gum, methycellulose and κ-carageenan. The obtained formulations were investigated as potential oral dosage forms with the ability to protect it from the acidic conditions of the stomach. Another desired...

article

Biological Medicinal Therapy in terms of Respecting Patients’ Rights – Assessment of the Present Legal Status in Poland

Agnieszka E. Zimmermann, Natalia Susłowska

Acta Poloniae Pharmaceutica - Drug Research > 2020 > 77 > 2 > 373-379

Introduction: Patients’ rights must be respected at every stage of therapy, including during biological drug therapy. For clinicians, it is key to be involved in the decision-making process with regard to the choices of medication and possible drug substitution. In Poland, the law encourages automatic drug substitution and does not recognise disparities in biological drugs. Aim: The main aim of the...

article

COMPARISON OF ARTIFICIAL HYDROPHILIC AND LIPOPHILIC MEMBRANES AND HUMAN SKIN TO EVALUATE NIACINAMIDE PENETRATION IN VITRO

Anna Nowak, Martin K. Church, Wiktoria Duchnik, Monika Różewicka-Czabańska, more

Acta Poloniae Pharmaceutica - Drug Research > 2020 > 77 > 2 > 271-279

The evaluation of skin penetration of active substances from topical preparations is a pre-clinical requirement in the pharmaceutical industry. While in vitro preparations of human or animal skin are frequently used the development of artificial lipophilic and hydrophilic membranes with similar properties to human or animal skin need to be developed. This preliminary study compared the in vitro permeation...

article

ANTI-INFLAMMATORY ACTIVITY AND CYTOTOXICITY OF DIOSGENIN ON LIPOPOLYSACCHARIDES INDUCED RAW 264.7 CELLS

jing ning, yu chang, ruxia wang, zhiwei lan, more

Acta Poloniae Pharmaceutica - Drug Research > 2020 > 77 > 2 > 313-317

Diosgenin is a steroidal sapogenin compound, and possesses multiple biological activities including anti-inflammatory, anticancer, immunological regulation, and anti-aging. The current study focused on its anti-inflammatory activities and cytotoxicity by analysis of NO production, phagocytosis activity, secretion of TNF-α and IL-6 and cell viability in LPS-induced RAW 264.7 cells. An IC50 value of...

article

ANALYSIS OF IRON CONTENT IN FOOD SUPPLEMENTS IN RELATION TO THE SAFETY OF THEIR USE

Joanna M. Surowiecka, Pawel Olczyk, Diana Ivanova, Yoana Kiselova-Kaneva:, more

Acta Poloniae Pharmaceutica - Drug Research > 2020 > 77 > 2 > 229-239

Objective of the study was to test dietary supplements available on the European market with regard to their iron content. Twenty-nine vitamin and mineral supplements were investigated, with additional assessment of their mass homogeneity. Iron was determined by means of the AAS1 method following microwave mineralization of particular samples. Findings were compared to iron contents declared by producers...

article

Novel Aryl/Alkyl Azole Derivates as an anti-nociceptive and anti-inflammatory drug candidates

Yesim Kaya-Yasar, Elif N. Barut, Seckin Engin, Inci S. Dogan, more

Acta Poloniae Pharmaceutica - Drug Research > 2020 > 77 > 2 > 289-294

Novel aryl/alkyl azole derivative compounds C1 and C2 were screened for in vivo anti-nociceptive and anti-inflammatory activities by using the hot plate test and formalin-induced hind paw edema test, respectively. Ability of these compounds to inhibit cyclooxygenase-1/2 (COX-1/2) and 5/15-lipoxygenase (5/15-LOX) were evaluated in vitro by using a colorimetric method. C1 (30 and 50 mg/kg, i.p.) and...

article

COMPARISON OF PERSONALIZED AND STANDARD PROPHYLAXIS BASED ON OCTOCOG ALFA IN PEDIATRIC PATIENTS WITH HEMOPHILIA A

Tomasz Tatara, Marta Dąbrowska-Bender, Aneta Duda-Zalewska, Anna Staniszewska, more

Acta Poloniae Pharmaceutica - Drug Research > 2020 > 77 > 2 > 221-218

Comparison of personalized and standard prophylaxis prevention therapies based on octocog alfa in pediatric patients with hemophilia A. Studies on a general population (adults and children) demonstrate a statistically significant advantage of personalized prevention therapy over standard prophylaxis prevention therapy in terms of annual bleeding rate (ABR) and annual joint bleeding rate (AJBR) while...

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Search results

CT negative subarachnoid hemorrhage in emergency department

Anthropometric measurements, nutritional status and body composition in children with cystic fibrosis – the prospective study

How to deal with patients with atrial fibrillation during the COVID-19 epidemic?

It didn’t have to happen this way – what COVID-19 tells us about translational medicine

Risk factors of acute respiratory distress syndrome after on-pump cardiac surgery in the INFLACOR cohort study

How to write a scientific paper? Lessons from a distinguished scientist and editor

Sciatica: Internet Search Trends

Effect of a bicarbonate-buffered peritoneal dialysis solution on clinical and laboratory indices of dialysis adequacy

The role of interdisciplinary cooperation in the prevention of medication-related osteonecrosis of the jaw (MRONJ)

Thoracic trauma – principals of surgical management

Toxicological evaluation of xanthan gum based hydrogel formulation in Wistar rats using single dose study

The radiolytic studies of panipenem in the solid state

Low doses of fenofibrate and bezafibrate stimulate renal 2-oxoglutarate dehydrogenase (2-OGDH) in protein-restricted rats

ENCAPSULATION OF ROXITHROMYCIN INTO GELLAN GUM MATRICES AND THE IMPACT OF OTHER NATURAL POLYMERS ON DRUG RELEASE

Biological Medicinal Therapy in terms of Respecting Patients’ Rights – Assessment of the Present Legal Status in Poland

COMPARISON OF ARTIFICIAL HYDROPHILIC AND LIPOPHILIC MEMBRANES AND HUMAN SKIN TO EVALUATE NIACINAMIDE PENETRATION IN VITRO

ANTI-INFLAMMATORY ACTIVITY AND CYTOTOXICITY OF DIOSGENIN ON LIPOPOLYSACCHARIDES INDUCED RAW 264.7 CELLS

ANALYSIS OF IRON CONTENT IN FOOD SUPPLEMENTS IN RELATION TO THE SAFETY OF THEIR USE

Novel Aryl/Alkyl Azole Derivates as an anti-nociceptive and anti-inflammatory drug candidates

COMPARISON OF PERSONALIZED AND STANDARD PROPHYLAXIS BASED ON OCTOCOG ALFA IN PEDIATRIC PATIENTS WITH HEMOPHILIA A

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