To examine the association between current leukemia diagnosis and in‐hospital clinical outcomes in patients undergoing percutaneous coronary intervention (PCI) in the United States.
Leukemia is the most common hematological malignancy and is associated with an increased risk of thrombotic and bleeding complications in patients undergoing PCI. There are limited data around...
We wished to undertake a reconstructed individual patient data meta‐analysis of randomized clinical trials comparing transcatheter aortic valve replacement (TAVR) and surgery for patients with severe symptomatic aortic stenosis.
TAVR and surgery are both well‐established methods for treating patients with symptomatic severe aortic stenosis who are at low, intermediate, and...
Marfan syndrome is a connective tissue disorder caused by mutations in the fibrillar FBN‐1 gene. Aortic dissection and rupture are major causes of morbidity and mortality and are of special concern during pregnancy.
Materials and Methods
The authors report four cases of aortic root repair with preservation of the native aortic valve that have has created a discussion between cardiothoracic...
Studies have shown the cytoskeleton disorganization produced by diabetes and quantified F‐actin fluorescence in the striated muscles of diabetic animals. However, at present, there are no studies that have quantified F‐actin spatial organization (F‐actin‐SO). Through our research, we analyzed the effect of diabetes on F‐actin‐SO in the cardiac and skeletal muscles of a mouse model. The muscle samples...
Empowering parents as health promoters may contribute to decrease the costs associated with prematurity. In Portugal, 8% and 1% of the births occurring in 2018 were preterm and very preterm, respectively. This study aimed to assess prematurity‐related knowledge with regard to its prevalence, causes and consequences, according to sociodemographic, obstetric and offspring's characteristics,...
Aims and Objectives
To assess the impact of orientation programmes on new graduate nurses’ transition periods.
The transition of graduate nurses from students to the practising professional nurse is often found to be stressful.
The study has employed a descriptive correlational design.
The data were collected from 95 participants who were working as registered nurses...
Aim and Objectives
This study aimed to explore the effects of person‐centred care on their job productivity, job satisfaction and organisational commitment among employees in long‐term care facilities.
Person‐centred care has been regarded as the best caregiving model for long‐term care facilities. Few studies tested the impact of person‐centred care on employee performance.
Aims and Objectives
To explore mentorship pairing practices for new graduate nurses in a tertiary care hospital.
Many organisations have implemented mentorship transition programmes to decrease new nursing graduate turnover in the first two years of practice. Little is known about mentorship pairing processes.
An interpretive descriptive qualitative study was conducted in a...
Aims and objectives
The aim of this study was to explore nurse navigators and consumers’ experience of partnership.
The nurse navigator has recently emerged as an advanced practice role in the care of persons with complex and chronic disease states. Self‐care is an important principle in chronic disease models of care, requiring healthcare practitioners to partner with clients in their...
Most expression systems are tailored for model organisms rather than nonmodel organisms. However, heterologous gene expression in model organisms constrains the innate advantages of original strain carrying gene of interest. In this study, T7 expression system was developed in nonmodel bacterium Klebsiella pneumoniae for production of chemicals. First, we engineered a recombinant K. pneumoniae strain...
The Chinese hamster genome serves as a reference genome for the study of Chinese hamster ovary (CHO) cells, the preferred host system for biopharmaceutical production. Recent re‐sequencing of the Chinese hamster genome resulted in the RefSeq PICR meta‐assembly, a set of highly accurate scaffolds that filled over 95% of the gaps in previous assembly versions. However, these scaffolds did not reach...
There is a paucity of clinical data on critically ill patients with COVID‐19 requiring extracorporeal life support.
A statewide multi‐institutional collaborative for COVID‐19 patients was utilized to obtain clinical data on the first 10 critically ill COVID‐19 patients who required extracorporeal membrane oxygenation (ECMO).
Of the first 10 patients that required ECMO...
Background and Aim
Acute type A aortic dissection (AAAD) is a life‐threatening condition. The emergency operation usually results in 20% perioperative mortality. If preoperative cardiopulmonary resuscitation (CPR) is necessary, there is an increase in the rate of mortality. The aim of the present study was to report the outcomes of AAAD surgery in patients requiring preoperative CPR in a high‐volume...
Three‐dimensional (3D) cancer tumor models are becoming vital approaches for high‐throughput drug screening, drug targeting, development of novel theranostic systems, and personalized medicine. Yet, it is becoming more evident that the tumor progression and metastasis is fueled by a subpopulation of stem‐like cells within the tumor that are also called cancer stem cells (CSCs). This study aimed to...
The bacterium Escherichia coli is among the most popular hosts for recombinant protein production, including that of membrane proteins (MPs). We have recently generated the specialized MP‐producing E. coli strain SuptoxD, which upon co‐expression of the effector gene djlA, is capable of alleviating two major bottlenecks in bacterial recombinant MP production: it suppresses the toxicity that frequently...
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