To characterize patient‐reported ideas and concerns about cluster headache, treatment options, and management strategies.
Cluster headache patients experience severe pain and often suffer additional consequences from their disease. Patients have identified methods to cope with and combat cluster headache that are not widely known.
Secondary analysis was performed...
Patients are not well informed about sexual dysfunction after rectal cancer surgery and often turn to the Internet for information. The purpose of this study was to assess online information for patients on sexual dysfunction after rectal cancer surgery.
An online search of Google, Yahoo and Bing was performed using specific (e.g., rectal cancer surgery and vaginal pain) and general...
Our aim was to study the implementation of the low anterior resection syndrome (LARS) score in a clinical setting and to evaluate a nurse‐led standardized intervention for bowel dysfunction following rectal cancer surgery.
All patients who underwent curatively intended, restorative rectal cancer resection in a single centre between 2012 and 2016 were screened using the LARS score. At...
The purpose of this study was to evaluate the subsequent health resource utilization (HRU) between patients with migraine who received opioid medications at their emergency department (ED) visits (“opioid recipients”) versus patients with migraine who did not receive opioid medications at their ED visits (“non‐recipients”).
Previous studies have found that opioid use is common...
To empirically address how thunderclap headache (TCH) is described in a relevant real‐world setting.
TCH refers to a highly recognizable description of a severe headache that reaches maximum severity within 1 minute and endures for at least 5 minutes. The use of a numerical rating scale (NRS) to appraise TCH severity, as well as assessment of TCH progression in patients with...
Clinical trials have demonstrated magnesium supplements to be effective for prophylactic treatment of migraine. Dietary magnesium intake of many Americans is known to be below nutritional recommendations, but typical magnesium intake from dietary sources in adults with migraine has not previously been evaluated.
This study aimed to quantify dietary and total (diet + supplement)...
Cyclic vomiting syndrome (CVS) is a disabling disorder of gut–brain interaction manifested by stereotypical and severe episodes of nausea and vomiting. Prevalence data indicate that CVS affects 1–2% of children and there has been a recent dramatic rise in diagnosed adults.
This narrative review summarizes relevant literature pertaining to pediatric and adult CVS and...
To report a case of arachnoiditis as a complication of epidural blood patch procedures and to systematically review the diagnostic workup, clinical outcomes, and treatment modalities reported in the literature.
Epidural blood patching is an effective treatment for low‐pressure headache secondary to spontaneous cerebrospinal fluid leak or iatrogenic post‐dural puncture. Spontaneous...
Over the last six decades (earliest included publication from 1959), clinical trials of migraine preventive treatments have led to the regulatory approval of many medications and devices. Despite similar clinical goals, the outcomes and endpoints used in these trials are broad and not well standardized.
To describe results from a systematic literature review focused on outcomes...
Local, traditional, or indigenous knowledge play an important role in disaster risk reduction (DRR), and many policy recommendations now call for the integration of local and expert views. While these attempts at integration are indeed promising, they are often built on assumptions that local knowledge is inherently separate from, or even subordinate to, expert perspectives. This article presents...
The recent proliferation of resilience discourses invited critical inquiries into the concept and its ability to construct policy narratives of “certainty.” Critical works have deconstructed and debated the instrumentalist notions of resilience as overly simplified, raised to the forefront questions of power, emphasised the linkages of the concept to dominant political and economic regimes, and underscored...
In Maarten Hajer and his colleagues' insightful papers (Hajer & Pelzer, 2018, Energy Research and Social Science, 44, 222; Hajer & Versteeg, 2019, Territory, Politics, Governance, 7, 122) and the following sharp commentaries, we confirmed that critical scholars in the field of urban studies and energy research recognise that “the future is now” for imagining post‐fossil cities and dismantling...
Background and Purpose
The metabolic activity of cytochrome P450 (CYP) 2D6 is highly variable and CYP2D6 genotypes insufficiently explain the extensive and intermediate metabolic phenotypes, limiting the prediction of drug response plus adverse drug reactions. Since CYP2D6 prototypic substrates are positively charged, the aim of this study was to evaluate the organic cation transporters (OCTs) and...
Amyotrophic lateral sclerosis (ALS) is an adult onset disorder characterized by progressive neuromuscular junction (NMJ) dismantling and degeneration of motor neurons leading to atrophy and paralysis of voluntary muscles responsible for motion and breathing. Except for a minority of patients harbouring genetic mutations, the origin of most ALS cases remains elusive. Peripheral tissues, and particularly...
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