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Carbon nanotubes (CNTs) have been widely investigated as one of the most promising nanomaterials in biomedical applications. Functionalization of CNTs with poly(ethylene glycol) diamine (PEG) is a recognized methodology with good solubility and biocompatibility. In this study, PEG conjugated (PEGylated) multi-walled CNTs (MWCNTs) were prepared and labeled with fluorophore FITC. Using fluorophore-conjugated...
Protein-protein interactions (PPI) play an important role in cellular processes and metabolic processes within a cell. An important task is to determine the existence of interactions among proteins. Unfortunately, existing biological experimental techniques are expensive, time-consuming and labor-intensive. The network structures of many such networks are sparse, incomplete and noisy, containing many...
A novel laminar stream-based microfluidic chip that can serve as the high efficient technique for human sperm motility sorting through the use of flow cytometry was proposed in this study. Recently, the selection of good sperms in semen plays an important role in the reproductive medicine. However, the traditional sorting methods are normally expensive and time consuming. This modified microfluidic...
One of the most considerations in the field of chromosome analysis is the segmentation and determination of the centromere detection and karyotying of the chromosomes. Previously depend upon centromere position and its angle with the p-arm and q-arm positions, bond comparisons as made the classification of chromosomes and the pairing possibilities of the chromosomes. Such that in this paper as describe...
microDoR Human is a web server tool based on machine learning algorithm to predict Human miRNA-mediated gene silencing: mRNA degradation or translational repression. For a miRNA-mRNA interaction, microDoR Human identifies whether the target mRNA is cleaved or translationally inhibite. microDoR Human is expected to serve as a useful tool for understanding of miRNA-mediated gene regulation. The microDoR...
Construction and analysis of molecular networks for each cancer patient is a promising strategy for making individual risk predictions and treatment decisions in cancer therapy. Systems biology enables us to reconstruct a gene network within a cell from gene expression data. However, from a collection of gene expression data for clinical samples, traditional methods including Bayesian networks can...
Assays of micronucleus are extensively used in genotoxicity testing and in monitoring of human exposure to genotoxic materials. As nuclear buds could be a new source of micronuclei formed in interphase, the assay of contents of nuclear bud in normal and comparison group is needed. In this paper, we proposed a new automatic nuclear buds detection algorithm based on ellipse fitting. Experimental results...
Most loci discovered through genome-wide association analyses are predicted to affect gene expression, the integrative approach of genome-wide analysis with gene expression data is becoming essential procedure for discovering genetic effect of disease development. Many studies have been performed to discover significant SNP-gene associations, but most of them are limited to consider only cis-associations...
Background: Although clinical significance of serum p53 Abs (s-p53 Abs) in cancer patients has been studied during the past few years, how to detect it effectively is a crucial issue. Methods: wild-type p53 protein (wt p53) and phage-displayed peptide were prepared. Three types of enzymelinked immunosorbent assays (ELISA) methods were constructed and a hybrid antigen-ELISA approach was attempted....
We formulate the control problem in gene regulatory networks as an inverse perturbation problem, which provides the feasible set of perturbations that force the network to transition from an undesirable steady-state distribution to a desirable one. We derive a general characterization of such perturbations in an appropriate basis representation. We subsequently consider the optimal perturbation, which...
Mammalian adipose tissue derived stem cells have a tremendous potential in regenerative medicine for tissue engineering and somatic nuclear transfer (SNT). The isolation methods of human and bovine adipose tissue derived stem cells are compared in this paper to determine the feasibility and optimum method of isolation. The optimum isolation method will reduce the processing time, efforts and money...
Protein-Protein Interactions (PPIs) play a very important role in many cellular processes and a variety of experimental approaches have been developed for their identification. These approaches however suffer from high error rates. Recently, computational methods have been employed to assist for the prediction. A common problem with the applied computational methods is that they either result in low...
This study aimed at the biocompatibility evaluation of bioglass nanoparticles to chondrocyte cells using isothermal micro/nano calorimetry (IMNC), which is a new method to study cell/biomaterial interactions. For this purpose, 63S bioglass nanoparticles were made via sol-gel method and primary characterization was carried out on the particles. XRD analysis showed the amorphous structure of the glass...
Considering the latest researches on the significant between mitochondrial disorders and human diseases, mainly on the nervous system, we propose a novel solution concerning the enriching of healthy mitochondrial population into cells. It is a totally theoretical proposal and refers mostly to mitochondrial encephalomyopathies which involve to brain disorders, like Alzheimer's disease.
In this article, the goal is to design an Atomic Force Microscopy (AFM) based nano-telemanipulation system for indenting on a human chromosome. The existence of unmodeled/uncertain parameters in robot dynamics weakens the stability robustness and performance of the system, therefore by designing an impedance-based sliding mode controller on the slave side, the master-slave position coordination despite...
Electroporation is an elegant technique used for proliferation control in Cancer cells. This budding mode of therapy called electrochemotherapy uses electrical pulses and chemodrugs to trigger cell death in cancerous cells. The efficacy of this technique depends on a variety of factors including electric field intensity, pulse duration and the number of pulses. In this study, Human cervical (ME180),...
An automated segmentation method is proposed for low contrast endothelial cell images. Morphological reconstruction and histogram equalization are used to remove the uneven background and enhance the contrast. Conventional thresholding and morphological filtering follow up to perform the coarse segmentation. Finally the watershed transform with markers obtained from the coarse segmentation is adopted...
Intrusion detection systems (IDS) usually trigger a great number of alarm messages that frequently overwhelm their human operators. Hierarchically clustering technique is able to help IDS operators to get meaningful overviews from the great number of alarms. A dilemma is encountered when the clusters are generated. If the clusters are obtained one by one, they cannot be prevented from overlapping...
Raman microspectroscopy of human sperm cells and nearfield infrared microscopy of nanoscale biomaterials like nanografted DNA have been performed. A newly developed station for the ANKA-IR2 beamline combines several techniques to study the same sample at the same position.
Purpose To investigate the expression of small G protein R-Ras in breast cancer and to explore the significance of R-Ras, expression in the carcinogensis and development of breast carcinoma, and we also analysed the correlation of R-Ras expressions with ER, PR. Methods Real time quantitative reverse transcription polymerase chain reaction (RQ-RT-PCR) technique was applied for detecting R-Ras expression...
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