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Poly(lactic acid)-poly(ethylene oxide)-poly(lactic acid) (PLA-PEO-PLA) triblock copolymer hydrogels are a promising biomaterial, with applications to drug delivery and cell scaffolds for tissue engineering. Using L-lactic acid gives PLLA-PEO-PLLA, which has stereoregular end blocks. The resulting system forms lamellae with hydrophobic semi crystalline domains of PLLA with hydrophilic domains of PEO...
Various silk based drug delivery systems were designed to exploit silk's novel material properties in order to attain slow, sustained, controlled release. Using the small molecule model drug adenosine, release profiles from various silk delivery systems were characterized in vitro. The therapeutic potential of the implants was validated in a dose response study in the rat model of kindling epileptogenesis...
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