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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a potent inducer of cell death, producing reactive oxygen species (ROS) and causing apoptosis in PC12h cells at 1 mM [Shimoke et al., J. Neurosci. Res. 63 (2001) 402-409]. We showed here that MPTP also had a weak proliferative effect on PC12h at 500 μM when treated for 24 h. The proliferative effect was additive within 24 h cells when nerve growth...
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