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In the present study, we examined the development of environment-independent and environment-dependent tolerance to ethanol-induced analgesia (EIA) and cross-tolerance with morphine-induced analgesia (MIA). To examine the development of environment-independent tolerance, male Long-Evans rats were given increasing amounts of ethanol (5 days each of 5% (v/v), 10% (v/v), and 15% (v/v)) added to their...
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