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We advance herein the hypothesis that aging and its consequences, including cardiac hypertrophy, result from actions of Angiotensin II (AII). Experimental findings indicate that hypertension and aging have similar effects on the structure and function of blood vessels, the heart, and, presumably, the kidney.
Cardiovascular diseases are the leading causes of death in the western world. The fact that cardiovascular mortality and morbidity rates increase exponentially in the elderly suggests that age per se is a major risk factor for cardiovascular diseases. Data from the Framingham Heart study and the Baltimore Longitudinal Study on Aging showed an age-dependent increase in left ventricular hypertrophy,...
Mitochondrion is one of the master players in both apoptosis and necrosis. However, most previous articles report that mitochondrial DNA-depleted cells without oxidative phosphorylation underwent apoptosis by several apoptotic effectors as efficiently as their parental cells, suggesting that intact mitochondrial function is dispensable for the progression of apoptosis. We studied the role of mitochondrial...
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