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The decision tree to determine whether the P‐glycoprotein (P‐gp)/multidrug resistance protein 1 (MDR1)‐mediated drug–drug interaction (DDI) study is recommended has been proposed by the International Transporter Consortium. We, therefore, designed an in vitro P‐gp inhibition assay and determined the appropriate risk criteria for P‐gp‐mediated DDI at the drug discovery stage. Effects of P‐gp inhibitors...
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