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In the medical practice, there are several methods to administer anti-cancer drugs. A commonly used method is the intermittent bolus doses (BD) administration when the patient receives drug on given days and the therapy has rest periods between the injections. The amount of bolus doses can be the maximum tolerated dose (MTD) or less. Anti-cancer drug can be administered in low doses over prolonged...
This paper deals with designing a feedback control strategy for drug release in treatment of solid tumors. The dynamical model comprises three coupled reaction diffusion equations governing the spatio-temporal dynamics of tumor cells, normal tissues and drug concentration. The control input is the rate of drug injection. By combining the merits of nonlinear dynamic inversion and variational optimization,...
In chemotherapy treatment of cancers, drug delivery has a significant impact on the therapeutic value of medication. Transdermal drug delivery uses microneedles to penetrate easily into the tumor by creating holes in the epidermis & providing a painless drug delivery. Microneedles are safer alternative to hypodermic needle injections in delivery of drugs. They could also be used for targeting...
The most effective cancer treatments are the ones that prolong patients’ lives while offering a reasonable quality of life during and after treatment. The treatments must also carry out their actions rapidly and with high efficiency such that a very large percentage of tumor cells die or shift into a state where they stop proliferating. Due to biological and microenvironmental variabilities within...
The most effective cancer treatments are the ones that prolong patients' lives while offering a reasonable quality of life during and after treatment. The treatments must also carry out their actions rapidly and with high efficiency such that a very large percentage of tumor cells die or shift into a state where they stop proliferating. Due to biological and micro-environmental variabilities within...
In literature it has been mentioned that several factors are responsible for the successful accomplishment of cancer therapy. Moreover, during the course of treatment patients has undergone different physiological states. In recent time several analytical models are developed to address these issue and further progresses are in the process. This actually prompted us to develop a multi-modal reasoning...
Solid tumors must recruit new blood vessels for growth and maintenance. Discovering drugs that block this tumor-induced development of new blood vessels (angiogenesis) is an important approach in cancer treatment. However, the complexity of angiogenesis and the difficulty in implementing and evaluating rationally-designed treatments prevent the discovery of effective new therapies. This paper presents...
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