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The collaborations of the diseases might be the key to understand the mechanism of the diseases since it is difficult to detect the role of complex genes and micro RNA in diseases. With the rapid development of technology, several metabolites of many kinds of diseases could be obtained by the advanced machines. Some diseases are related to several metabolites, and some metabolites have strong relationship...
Discovering similar diseases is very helpful for revealing the pathogenesis of diseases and making direction in drug use. And related diseases are often triggered by disease-related genes. Therefore, function interaction networks structured by disease-related genes are suitable for measurement of disease similarity, and some methods have utilized the advantage of function interaction of disease-related...
A significant part of our knowledge is relationships between two terms. However, most of these information is documented as unstructured text in various forms, like books, online articles and webpages. Extract those information and store them in a structured database could help people utilize these information more conveniently. In this study, we proposed a novel approach to extract the relationships...
Electronic medical record (EMR) system has become increasingly more important in developed countries due to its convenience and efficiency in medical information storage, management and analysis. However, one of the main limitations of EMR lies in that the clinical data for patients cannot be exchanged among different medical institutions. Recently, the cloud-based clinic system, featuring in lower...
Network pharmacology which is based on bioinformatics and system biology knowledge has been employed into the field of Traditional Chinese Medicine (TCM) researches in recent years. In order to summarize current available bioinformatics databases, especially those can be used for TCM formulae study; a systematic search of Chinese literature by May 2017 was conducted. Results showed that research methods...
Cataract is a cloudiness of eye lens and studies have reported many risk factors for the development of cataract. However, the cumulative effect of multiple factors along with clinical and systemic disease conditions have not been adequately tested due to a limitation in methodology. The collection of a large volume of Electronic Health Records (EHR) offers an opportunity to apply computational tools...
The dysregulations of long intergenic non-coding RNAs (lincRNAs) have shown to be linked with a wide variety of human diseases over the past few years. However, there are only a few lincRNA-disease association inference tools available with most of them relying on very specific type of prior knowledge about the lincRNAs and the diseases. They fall short in generalized association predictions when...
Gene (microRNA) identification is a key step in understanding the cellular mechanisms. Compared with biological experiments, computational prediction of disease genes is cheaper and more effortless. In this study, we analyzed the properties of tumor-associated microRNA in mouse and found that tumor-associated genes display 8distinguishingfeatures when compared with genes not yet known to be involved...
Recent advances in sequencing allow the study of all identified human genes (≈ 22,000 protein encoding genes), which have differential expression between tissues. However, current knowledge on gene interactions lags behind, especially when one of the elements encodes a mitochondrial protein (≈ 1500). Mitochondrial proteins are encoded either by mitochondrial DNA (mtDNA; 13 proteins) or by nuclear...
Recent studies show that drug-disease associations provide important information for drug discovery and drug repositioning. Wet experimental identification of drug-disease associations is time-consuming and labor-intensive. Therefore, the development of computational methods that predict drug-disease associations is an urgent task. In this paper, we propose a novel computational method named NTSIM,...
The availability of cost effective and fast genome sequencing techniques has paved the way for a personalized medical practice. The new sequencing technology produces huge datasets with different characteristics and the analysis has evolved from a single program to a workflow of tens of analytical steps, starting from the analysis of raw data until generating clinical reports. The mix between big...
Objective: This research focused on intrinsic biological distinctions between qi deficiency pattern and qi stagnation pattern with genes related to NEI. Methods: Using the keywords related to a disease to search literature in Pubmed. Collection and download literature related to a disease. Obtain compositions of characteristic NEI-related genes of qi deficiency pattern and qi stagnation pattern by...
This study extracted differentially expressed genes (DEG) from a RNA-Seq gene expression experiment of human red blood cells for both case and control. A protein interaction network (PIN) for the DEG at the red blood stage was extracted from protein interaction database. From the protein interaction network built, we identified 64 protein complexes using the molecular complex detection (MCODE) algorithm...
Clinical research registries need to be driven by data quality to improve the outcome of clinical trials and to provide the possibility to facilitate new research initiatives. The International Niemann-Pick Disease Registry (INPDR) is one such example of a clinical research registry. Unlike other registries where data quality is largely based around best effort manual data entry, the INPDR registry...
Timely and robust diagnosis of plant diseases and nutrient deficiencies play a major role in management of crop yield. Automation is a low cost alternative to human experts and can help to detect early onset of crop diseases which aids faster decision making and in giving recommendations to farmers to curb yield loss. We have developed a smart-phone based participatory sensing application for agriculture...
Migraine is a common disease throughout the world. Not only does it affect the life of people tremendously, but it also leads to high costs, e.g. due to inability to work or various required drug-taking cycles for finding the best drug for a patient. Solving the latter aspect could help to improve the life of patients and decrease the impact of the other consequences. Therefore, in this paper, we...
In recent years, personal genomic data can be quickly generated in an affordable price. Abundant research results on genetic diseases have also been published in the past two decade. Therefore, it is desired to utilize updated genetic disease research results into personal genomic data analysis and apply them into genomics-based personalized healthcare. However, this is a challenging task for current...
Expert system refers to a system that is trying to adopt human knowledge into a computer. Expert system contains certain knowledge so that everyone can use it to solve specific problems. The expert system by utilizing the forward chaining method starts from selecting the initial symptoms to find information in accordance with the rules of the rule. This study aimed to build an expert system application...
The Cardiovascular disease (CVD) is one of the most serious diseases in the world. To monitor cardiac condition and diagnose cardiovascular disease conveniently, a mobile intelligent Electrocardiogram (ECG) monitoring system is developed. The system is consisted of signal acquisition module, Bluetooth transmission module, signal processing module and intelligent diagnosis module. The ECG signals collected...
Off-label drug use is quite common in clinical practice and inevitable to some extent. Such uses might deliver effective treatment and suggest clinical innovation sometimes, however, they have the unknown risk to cause serious outcomes due to lacking scientific support. As gaining information about off-label drug use could present a clue to the stakeholders such as healthcare professionals and medication...
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