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Background This integrative single-case study investigated the 12 h-to-12 h cause-effect relations between 55 kD soluble tumor necrosis factor receptor type 1 (sTNF-R55) and specific and unspecific symptoms in a 52-year-old Caucasian woman with mild systemic lupus erythematosus (SLE) disease activity. Methods The patient collected her entire urine for 56 days in 12 h-intervals to determine sTNF-R55/creatinine...
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