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Background & AimsNonsteroidal anti‐inflammatory drugs (NSAIDs) are commonly used and have been associated with hepatotoxicity. Studies of liver injury from NSAIDs have been retrospective and prospective data are lacking. The aim was to report the features and outcomes of the subjects with severe drug‐induced liver injury from NSAIDS.
MethodsThe U.S. Drug Induced Liver Injury Network is a prospective...
ObjectivesParenteral diclofenac is frequently used for analgesia following minor orthopedic interventions. Currently available diclofenac formulations are for intramuscular (IM) or intravenous injection. A new 1 mL volume formulation of diclofenac containing hydroxypropyl‐β‐cyclodextrin (HPβCD) allows both SC and IM administration. The objective of this open‐label, randomized, parallel group, active‐controlled...
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