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Irreversible electroporation (IRE) is a biophysical process in which electric fields applied across a cell cause extensive or permanent permeabilization of the cell membrane, which eventually leads to cell death. It has shown significant advantages in ablating prostatic tissue, such as rapid lesion creation, rapid lesion resolution, sparing of structures such as vessels, nerves and urethra for treating...
A continuous label-free cell separation chip has been presented based on dielectrophoresis (DEP) utilizing the electrical properties of cells. The proposed microfluidic chip consists of three planar electrodes, where the positive DEP cells/particles were moved away from the central streamline while the negative DEP cell remained in the central streamline. DEP response were tested on polystyrene beads...
Binding reaction is a natural characteristic that is applied to design biosensors. In this study we simulate the binding reaction kinetics between the immobilized antibody and the targeted antigen in a reaction chamber (microchannel) of a biosensor under AC applied electric field. The diffusion boundary layer on the sensitive area of the biosensor would hinder the binding reaction from association...
We present a semi-automated event identification method for collecting the dielectrophoretic signatures of cells flowing through a dieletrophoretic cytometer. The marker free dielectrophoresis (DEP) cytometer presented in this study is capable of detecting electronic signatures of cells which identifies Claussius-Mossotti factor (CMF). The CMF can in turn be used to determine properties of the cell...
Particle separation is a challenge by highly miniaturized channel systems. Due to very low Reynolds number of buffer fluid, microseparators based on travelling wave dielectrophoresis effect have a good sufficiency in such applications. In this paper a microchannel technique based on surface micromachining is modified to a microseparator. Due to fabrication process the electrodes made of highly doped...
The design and fabrication of a broadband microwave microfluidic device are presented together with our preliminary measurement results on water dielectric saturation effects. Heavily-doped silicon is used to form microstrip lines and 250 nm deep planar microfluidic channels. The atomically smooth surfaces enable ∼ 0.9 MV/cm dc electric fields across the channel without breakdown issues. High frequency...
The main purpose of the present study was to investigate the feasibility of applying the technique of contactless dielectrophoresis (cDEP) on an insulator-based dielectrophoretic (iDEP) microdevice with effective focusing of particles. The particles were introduced into the microchannel and pre-confined hydrodynamically by the funnel-shaped insulating structures close to the inlet. The particles were,...
For medical applications of cell sorting, counting or flow cytometry, focusing of biological cells in microdevices is a prerequisite. Hydrodynamic focusing by sheath flow has been a widely used method for particle focusing, however, additional buffer inlets and precise flow control were needed. An insulator-based dielectrophoretic microdevice of four insulating structures forming X-pattern with effective...
MEMS, electromagnetic field is a way to manipulate droplets, beads or cells without direct contact. In particular, dielectrophoresis is often used in bioMEMS applications, for cell handling operations such as moving, sorting, trapping or deforming cells. In this paper, a 3D focusing geometry for the electrical field is proposed, that permit the trapping of single cell, or cells pair, thanks to positive...
This paper presents a microfluidic chip with arc-shape electrodes array (ASEA) for separation of different-size particles/Cells based on negative dielectrophoresis (nDEP). The purpose of ASEA is to generate the dielectrophoretic force perpendicular to the microchannel direction within the gap between each pairs of arc-shape electrodes. The DEP chip consisted of two regions of ASEA; first ASEA was...
Advances in microfabrication have introduced new possibilities for automated, high-throughput biomedical investigations and analyses. Physical effects such as dielectrophoresis and electroporation can be used to manipulate particles in solution to coordinate a sequence of bioanalytical processing steps. Dielectrophoresis is accomplished with non-uniform electric fields that can polarize particles...
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