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Using conventionalin vitroextracellular field potential recordings we have investigated both short- and long-term synaptic plasticity in the hippocampal CA1 area of mice infected with ME7 scrapie. In agreement with earlier studies, no changes were seen in the properties of the Schäffer collateral-evoked field excitatory postsynaptic potential during the early stages of the disease (up to 160 days,...
Conventional electrophysiological intracellular recording techniques were used to test the hypothesis that enhanced calcium entry via voltage-gated calcium channels or theN-methyl-d-aspartate (NMDA) subtype of glutamate receptor–channel complex may be a primary pathological mechanism triggering neurodegeneration in scrapie and related diseases. This study was carried out at a time when cell loss is...
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