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Stroke and Alzheimer’s disease (AD) are leading causes of dementia in developed countries. Up until now, both diseases, vascular dementia (VaD) and AD were considered as completely different entities with their own physiopathology. The former due to a brain circulation impairment, and the latter due to a primary brain degenerative disorder. However recent epidemiological studies as well as neuropathological...
Although the cell cycle machinery is essentially linked to cellular proliferation, recent findings suggest that neuronal cell death is frequently concurrent with the aberrant expression of cell cycle proteins in post-mitotic neurons. The present work reviews the evidence of cell cycle reentry and expression of cell cycle-associated proteins as a complex response of neurons to insults in the adult...
Functional magnetic resonance imaging (fMRI) is being widely used to study recovery of function in patients with several neurological conditions, including multiple sclerosis, stroke and Alzheimer’s disease. The application of this MR technique has shown that plastic cortical changes do occur after central nervous system (CNS) injury of different aetiology, that such changes are related to the extent...
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