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Osteonecrosis, also known as aseptic necrosis, is a pathological process that has been associated with numerous conditions. The pathogenesis of osteonecrosis and especially the treatment both remain an area of controversy. In this article we review the etiology and pathogenesis of osteonecrosis as well as the main therapeutic options.
Recent studies show that bisphosphonates can decrease the development of femoral head deformity following ischemic osteonecrosis by inhibiting osteoclast-mediated bone resorption. Given the potential new indication, improved understanding of pharmacokinetics of bisphosphonates as it applies to the infarcted head would be beneficial. The purpose of this study was to investigate the local bioavailability...
Osteonecrosis of the hip is the final common pathway for a group of disorders that results in ischemia of the femoral head. Etiologies include disruption of vessels, external vascular occlusion, embolization, thrombosis, cytotoxicity, and idiopathic causes. As a result of the ischemia cell death occurs and the bone is weakened leading to collapse and eventual degenerative changes to the hip. Early...
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