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Protein kinases are key actors of signaling networks and important drug targets. They cycle between active and inactive conformations, distinguished by a few elements within the catalytic domain. One is the activation loop, whose conserved DFG motif can occupy DFG‐in, DFG‐out, and some rarer conformations. Annotation and classification of the structural kinome are important, as different conformations...
One of the most important role of economic variables in today's world countries are the price and the change of the price of crude oil. Changes in the price of crude oil have a very critical role in terms of treasury and budget, both in company and state planning. For example, one may choose one of the energy or natural gas indexed energy production plans based on the trend of the crude oil price,...
Data mining approach can be used to discover knowledge by analyzing the patterns or correlations among of fields in large databases. Data mining approach was used to find the patterns of the data from Tanzania Ministry of Water. It is used to predict current and future status of water pumps in Tanzania. The data mining method proposed is XGBoost (eXtreme Gradient Boosting). XGBoost implement the concept...
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