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The forkhead transcription factor Foxp3 is essential for the development and function of CD4 + CD25 + regulatory T (Treg) cells, which act to maintain immune tolerance and prevent autoimmunity. Lysine acetylation that is regulated by lysine acetyltransferases and lysine deacetylases plays an important role in gene transcription and protein function. Lysine deacetylase inhibitor trichostatin...
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