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Rationale and objectives The effects of low thyroid hormone level during embryogenesis on MRI of the brain and social behaviors of hatchlings were examined using “fertilized hen's egg–embryo–chick” system. Methods and results Control and hatchlings treated with methimazole (20 μmol/egg), which hatched 3 days later than controls were examined. The results are as follows: 1. The MRI examination...
Rationale and objectives To evaluate direct exposure to sodium valproate (VPA) during embryogenesis, we administered VPA to chick embryos and examined their social behaviors after hatching. Methods and results Embryos treated with VPA (35 μmol/egg) on day 14 were similar to controls for hatching date (day 21) and hatchlings' abilities, such as motor, imprinting, and surface righting. However, these...
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