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We had reported the results of application that the terahertz wave irradiation to an experimental transplanted prostate cancer model mouse using the gyrotron. We irradiated the 107 or 203 GHz wave (22.56W/cm2×20 min=27,180 J/cm2), resepectively, against the tumor model BALB-c-nu/nu strain, mail, 12 week old mouse at 43 degree C, which to rising time for 10 min and to keeping the temperature at 43...
To investigate the structural mechanisms by which light/dye treatment induces microvascular hyperpermeability and thrombosis, we quantified thrombus initiation time, thrombus growth rate, and microvessel occlusion time in post-capillary venule of rat mesentery. We also measured the microvessel hydraulic conductivity (Lp) under the same light/dye treatment. With the light intensity of 0.37 mW/mm2,...
The purpose of this study is to investigate transient process of the charring at the laser catheter-tip in blood during therapeutic laser irradiation by the back scattering light measurement to detect precursor state of the charring. We took account of using photodynamic therapy for arrhythmia in blood through the laser catheter. We observed the influence of the red laser irradiation (λ=663 nm) upon...
The authors studied the application of photosensitization-reaction-induced cytotoxicity to establish electrical blockade of myocardial tissue. This photosensitization-reaction-induced cytotoxicity, i.e., photodynamic therapy (PDT) was performed with chlorine photosensitizer, talaporfin sodium, and a red (670 nm) diode laser. The cytotoxicity on rat cardiac myocytes and the electrical blockade by PDT...
Mid-infrared (MIR) laser with a specific wavelength can excite the corresponding biomolecular site to regulate chemical, thermal and mechanical interactions to biological molecules and tissues. In laser surgery and medicine, tunable MIR laser irradiation can realize the safety regulation of therapeutic effect, less-invasive treatments and the special diagnosis by vibrational spectroscopic information...
The port-wine stains photodynamic therapy binocular surveillance system is used as an assistant surveillance of photodynamic therapy to improve therapy efficiency. The image segmentation in this system should meet some special requirements. This paper summarizes these requirements and designs an image segmentation algorithm that combines the threshold segmentation and connected component labeling...
The dynamics of clinical and hormonal statuses is studied at patients with SPCO on a background of the low-intensive laser therapy and through 3 and 6 months after stopping of treatment. Analysis of the got results, proved high efficiency of the low-intensive laser therapy of patients with SPCO in the initial stage of disease. Positive clinical effect exposed by us, is confirmed by the indexes of...
Photodynamic therapy (PDT) is a clinical approach that uses light-activated drugs for the treatment of different kind of tumor tissues. HeLa tumor cells, as an experimental model for studying the new biomedical concept of associated PDT with 5, 10, 15, 20 -sulphonato-phenyl-porphyrin (TSPP) and an antitumor agent - cisplatin (CisPt), yielded to an enhanced effect on the suppression of tumor cells...
In traditional acupuncture, reinforcement and reduction are conducted to stimulate the channel Qi by puncturing or heating the points with specific manners so as to regulate the functional activities of the internal organs. Reinforcement and reduction manners played an important role in clinical practice of traditional Chinese medicine, especially in disease curing. And the non-invasive nature of...
Laser spectroscopy techniques can be used for tumour detection as well as for localised therapy of malignancies. Laser-induced fluorescence with or without exogenously administered tumour seeking agents is a promising technique for real-time detection of atypical cells and dysplasia before the diseased areas can be visualised by the naked eye. Tumour borders can also be delineated towards normal non-affected...
Photothermal therapy by the strategy of adding Au nanoparticles (NPs), UV-absorbed around near IR range of 800-1000 nm, had been studied and used as a novel tool to eliminate and kill cancer cells. However, we had successfully developed the bacteria of E. Coli. as a new template for growing and self-assembling Au NPs even nano-shell on E. Coli. surface and treated cells for photothermal therapy studies...
Photodynamic therapy (PDT) is an alternative treatment for cancer that involves the administration of a photosensitizing agent, which will be activated by light at a specific wavelength. In order to compare different photosensitisers for their cytotoxic activity, photophysical parameters provide good indicators. These parameters are generally estimated one by one from in vitro dedicated experiments,...
In this report the results of laser-induced tissue oxygenation for elimination of tissue hypoxia in solid tumors are presented. It is predicted that the efficiency of PDT as well as radiation and chemotherapeutic methods could be significantly increased due to extra supply of tumor tissue by free molecular oxygen. The results of mathematical modeling the kinetic of oxygen distribution into tissue...
Photobiomodulation (PBM) is a modulation of monochromatic light or laser irradiation (LI) on biosystems, which stimulates or inhibits biological functions but does not result in irreducible damage. As photonic methods that could potentially initiate regeneration or cell proliferation in articular disease, the PBM of low intensity LI (LIL), ~10 mW/cm2, moderate intensity LI (MIL), 102~3 mW/cm2, and...
The presentation covers fundamental operating principles of some of the most widely used methods of low-level laser therapy (LLLT). It includes also recently developed LLLT technologies and medical devices such as LLLT cardiovascular and brain therapy, tissue regeneration and pain relive. The mechanism of LLLT involving interaction with mitochondria. The effects of LLLT are wavelength specific upon...
This paper discusses advances in photonics/biophotonics that are integral to the continuing development of photodynamic therapy as a novel clinical modality. Challenges posed by new PDT paradigms are highlighted
Born corn is regenerative born formation with all specific elements and histological structure of born tissue. It has been developed after fracture in born regenerative region. The influence of pulse solid state laser radiation to human fibroblasts in vitro and to animals in vivo has been studied. At the result we concluded that power pulse laser radiation decreases of proliferative and biosynthetic...
Laser acupuncture is defined as the stimulation of traditional acupuncture points with low-intensity, non-thermal laser irradiation. It has been well applied in clinic since the 1970s; however, some traditional acupuncture manipulating methods still cannot be implemented in the design of this kind of instruments, such as lifting and thrusting manipulating method, and twisting and twirling manipulating...
Laser acupuncture is defined as the stimulation of traditional acupuncture points with low-intensity, non-thermal laser irradiation. It has been well applied in clinic since the 1970s; however, some traditional acupuncture manipulating methods still cannot be implemented in the design of this kind of instruments, such as lifting and thrusting manipulating method, and twisting and twirling manipulating...
The modeling and control of laser-irradiated tissue is a challenging problem due to the non-linear behavior of the tissue when heated. This is compounded by the fact that in-vivo tissue parameters are not well known. In order to properly model and design control methods for LITT, it is necessary to quantify the uncertainties in the model parameters and their effect on the variability of the final...
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