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dl-Gylcerol monoester of pivalic acid was synthesized by alcoholysis reaction of pivalyl chloride with acetone ketal of glycerine. The effect of molar ratio, reaction time, reaction temperature and catalyst dosage on the yield was investigated. The product structure was characterized by IR and 1HNMR. Results indicated that yield of dl-gylcerol monoester of pivalic acid reached 75.5% at 25°C and 6h...
Radio Frequency Identification (RFID) is a very promising wireless technology able to trace and track individual objects. The pharmaceutical supply chain is a challenging scenario, where an item-level traceability is crucial to guarantee transparency and safety in the drug flow. Unfortunately, there are still some barriers limiting the large-scale deployment of these innovative technologies. In order...
A detailed intracellular (IC) model describing the pharmacokinetics (PK) of gemcitabine (2',2'-difluoro-2'-deoxycytidine, dFdC) was developed and linked to a systemic plasma dFdC PK model. Based on in vivo PK, pharmacodynamic (PD) effect predictions were made using a simplified cell-cycle model (CCM). A reduced-order compartmental model describing the IC metabolism of dFdC was fit to in vitro data...
Key to inducing adaptive immune responses is TCR recognition of HLA/peptide complexes, following HLA binding of the antigenic peptides. Numerous sequence-and structure-based predictors have been devised with regard to the recognition and the binding problem. The structure-based ones, however, are often not suited for high-throughput screenings of the greatly polymorphic immunogenic repertoire. It...
Chinese medicinal insects were added into the media to investigate their effects on the mycelial growth and polysaccharide formation by Ganoderma lucidum SCIM 0819. The experiments were carried out in submerged fermentation using shake flasks. The results show that addition of C. molossus at 5.0 g/L lead to significant increase in intracellular polysaccharides (IPS) concentration from 1.48 ± 0.12...
Aim: To get the IR spectrums of Agrimonia Pilosa Ledeb (APL) from china and korea areas, and to find out the characters of IR spectrums through the content of different chemical constituents, provide a fast and effective analysis method monitor the inherent qualities of traditional Chinese medicine-APL. Method: Fourier transform infrared spectroscopy (FT-IR) was applied to detect sample of APL from...
Jiangcan, Bombyx batryticatus, was extracted by five solvents with increasing polarity, named chloroform, ethyl acetate, acetone, methanol and deionized water to investigate the potential antioxidant activities. Four in vitro assays were employed, including scavenging activity on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, the reducing power, the chelating ability on ferrous ions and inhibiting...
Alkaline (NaOH) hydrolysis and aqueous extraction method were comparatively studied in polysaccharides extraction from mycelia of Grifola frondosa obtained with submerged-culture. The results show that the polysaccharide content and the total extract rate from alkaline extraction method were obviously higher than those from the aqueous extraction method. The conditions of alkaline extraction were...
Red toon leaves have been consumed as herbal medicine and vegetable. In this study, the antioxidant and cytotoxic activities of its ethanol extract were investigated. The results showed that the extract was an effective scavenger in quenching hydroxyl radicals with IC50 of 10.57 mg/mL. A linear correlation between concentration of the extract and reducing power was observed with a coefficient of r2...
We have investigated the organic solid-state chemical reaction of selected organic materials using THz time-domain spectroscopy technique. The THz spectra of the resultant materials show a new absorption peaks in the spectral range from 0.5 to 4.0 THz.
Due to its inherent sensitivity to both subtle changes in crystal structure and the hydrogen bonding network of organic molecular crystals and moisture, terahertz time-domain spectroscopy (THz-TDS) is a very promising technique to study physico-chemical changes during stability testing of pharmaceutical dosage forms. Using a variable temperature and humidity chamber the effects of moisture and temperature...
At present, to search fluorescent compounds or to increase the native fluorescence is an active research line specially and not only with analytical purposes. On some analytical areas and from the early times of applications of fluorescence (mid-fifties) the fluorimeter was defined as the suitable detector for determination of pharmaceuticals and subsequently, this detection mode has been widely applied...
The multispectral imaging method is presented to test the relative content of berberine of cortex phellodendri chinensis (CP) in vivo. It is the first time that the method is applied to testing the traditional Chinese medicines. The testing system is the liquid crystal multispectral imaging system designed by ourselves. The samples coming from eight different producing areas are tested. As a comparison,...
The inclusion complex formation of irisquinone with hydroxypropyl-beta-cyclodextrin(HP-beta-CD) and the physico- chemical properties were studied. Complex of host molecules with irisquinoe was studied by x-ray diffraction (XRD) and differential scanning calorimetry(DSC). The quantitative analysis with uv-vis indicated that HP-beta-CD could increase the solubility of irisquinone, where the best results...
A sensitive and specific high-performance liquid chromatography (HPLC)-UV method has been developed for the simultaneous determination of five water-soluble components, Danshensu (DSS), protocatechuic acid (PAC), protocatechuic aldehyde (PAL), salvianolic acid B (SAB) and salvianolic acid A (SAA) of Danshen Injection in rabbits. After liquid-liquid extraction with ethyl acetate, plasma sample was...
Objective: To find the antitumor compounds from Rabdosia Serra (Maxim) Hara, phytochemical isolation procedures were performed by bioassay-guided fractionation. Methods: The ethanol extract of Rabdosia serra (Maxim) Hara was fractionated by organic solvents-petroleum ether, benzene, ethyl acetate and butanol in sequence. The in vitro antitumor activity against human hepatoma cell line HepG2 and human...
Abstracted by Tris-HCl buffer,pH8.5, treated by n-butanol, and fractioned by (NH4)2SO4 (60%) ,the alkaline phosphatase( AKP) from guts of Hypophthalmichthys molitrix Cuv.et Val was separated through DEAE-Sepharose and Sephacryl S-200. The purification folds was 150.08,while the specific activity was 4031.15 U/mg.The properties research suggested that the optimal pH and temperature were pH10.2 and...
The optimal conditions for extraction, isolation and determination of chemical components of Gastrodia tuber with HPLC (High-performance liquid chromatography) were established. Using these conditions the chemical fingerprints and Gastrodin content of Gastrodia tuber samples from 6 different provinces or regions were determined. The results show that the chemical fingerprints of all tested Gastrodia...
Bamboo has been used to heal some diseases in the Chinese Folk for a long time. In order to explore widely the potential as the biomedicine utilization, the determination of the chemical components from the five-year-old Dinochloa puberula McClure in South China was carried out by means of Py- GC/MS. The results indicated that the main chemical components in Dinochloa puberula were carbon dioxide(46...
[18F]FDG has been the most widely used as the PET tracer for detecting brain and systemic tumors, however, [18F]FDG uptake in adjacent normal brain tissue is so strong that [18F]FDG-PET imaging could not give an effect for brain functional imaging. In order to develop new PET radiopharmaceuticals to complement [18F]FDG, a simple method for automatic synthesis of ethyl [18F]fluoroacetate which can...
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