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Hot-melt extrusion is a popular process in the field of industrial product manufacturing. In this work, a simple distributed parameter model consisting in partial differential equations derived from mass balances, well-adapted to the design of a control strategy, is expressed. Parameter identification is applied to a specific device with a complex screw geometry and provides a good representation...
Improper disposal of unwanted medications can be very costly and harmful to the environment and people's health. To facilitate safe disposal and remove excessive household storage of medicines, this paper proposes an integrated reverse supply chain (RSC) model with a pharmaceutical company, a recycler, retailers, customers and government. We investigates the impact of different categories of unwanted...
Supplier selection/evaluation is considered as a critical activity for establishing an effective supply chain. This is particularly relevant to situations where a large number of global suppliers are involved, as is in the case of a pharmaceutical set-up. The current study focuses on a multi-criteria decision making problem which includes both qualitative and quantitative criteria relevant to supplier...
Integrated continuous manufacturing offers ample opportunities for efficient and cost-effective pharmaceutical processes. Plant-wide control is required for meeting the stringent regulatory requirements on quality attributes of products in continuous pharmaceutical manufacturing processes. This paper investigates plant-wide model predictive control (MPC) of an end-to-end continuous pharmaceutical...
Tubular reactors, which are often assumed to behave as plug-flow reactors, have many applications in chemical reaction engineering, because of their narrow residence time distribution and ease of scaling-up. In the pharmaceutical industries, the requirements of fast development and scalable design have also made the tubular crystallizer a promising platform for continuous manufacturing and crystallization...
It has been widely known that employees pose insider threats to the information and technology resources of an organization. In this paper, we develop a model to explain insiders' intentional violation of the requirements of an information security policy. We propose sunk cost as a mediating factor. We test our research model on data collected from three information-intensive organizations in banking...
The objective of this paper aims to optimally schedule and dispatch production plan of pharmaceutical products. The production of this product is deemed complex and must rigidly comply with regulations such as GMP, PIC/S (Pharmaceutical Inspection Co-operation Scheme) and so on. Thus, certain procedures such as setup and clean up when changing production are inevitable in order to avoid contamination...
Medical supply chain is an extremely complicated process. On basis of the perishable inventory theory, the paper mainly focuses on the optimal ordering policy of multi-pharmaceutical for the large public hospitals. The paper develops a mathematical model with constraints on space where the shortage are allowed and has a lead-time, in order to maximum the total profit of the inventory system. Then,...
The mechanisms involved for compaction of pharmaceutical powders have become a crucial step in the development cycle for tablet design. Compressibility and compactibility are two important properties which define the ability of loose powder to transform into a compact. The compacted powder, also known as tablet, needs to be strong enough in order to handle different types of stress due to packaging...
Many industries, such as chemical, mining, food, pharmaceutical and agriculture require mixing as part of the production process. Several industries such as pharmaceutical and mining, mixing is a critical process that plays a significant role towards the quality of the final product. The mixing process, therefore, must be scrutinized to ensure homogeneity of mixtures. The characteristics of a mixing...
This paper studies the relationship between corporate governance characteristics and corporate social responsibility information revelation (abbreviated as CSRIR) by using index analysis. The results show :1) there are significant negative relationships between board size, board independence and CEO duality and CSRIR; 2) there are significant positive relationships between management salary, the proportion...
Based on the background of the cross framework of the university medical insurance system, this paper tries to analyze the medical insurance in the universities from the sight of market segmentation, here, the cross framework indicates that a system which is combined with the commercial medical insurance and the social insurance. Starts from the viewpoint of market segmentation, the analysis treats...
The control of pH process has a vast range of applications in wastewater treatment, biochemical and electrochemical processes, the paper and pulp industry and many other areas. Tight control of pH is also critical in the production of pharmaceuticals. However, the dynamics of pH process is highly nonlinear, time varying with change in gain of several orders. It is very difficult to investigate the...
The use of RFID technology for anti-counterfeiting involves complex event processing, which exceeds the current state of the art of product tracking and tracing implementations. The use of RFID requires storing good related events for anti-counterfeiting in a distributed way by each handling party individually. We define a formal approach for modeling of data entities, events, and operations that...
Schisandra Chinensis is a traditional Chinese medicine. The effects of dried schisandra impact the medicinal value and economic benefit of schisandra directly. Presently, studies on the characteristics and uses of schisandra chinensis are reported frequently in China. However, the studies of factors on the influencing drying effect of schisanda chinensis have not been reported. In this paper, the...
This paper takes soft capsule dropping pills pharmaceutical production process as the research object. In order to improve the yield of soft capsule dropping pills and its stability of product quality, the modeling and optimizing control are studied based on intelligent control, data-driven modeling and intelligent optimizing algorithms. Firstly, the soft capsule dropping pills pharmaceutical production...
In today's global and ecological business environment, supplier selection has increasingly been regarded as one of the most important strategies of eco enterprises to obtain competitive advantage. This paper is aimed to present a model to evaluate the performance of buyer-supplier relationship between the eco enterprises and its supplier by applying the analytic network process. Firstly, the analysis...
Based on the pharmacokinetic model of conventional agents, through introduction of sustained-release effect factor, we build a pharmacokinetic model of sustained-release agents so as to provide a new model of agents for clinical application. We discuss the properties of the new model and make a comparison with the conventional ones. By theoretical analysis and clinical data validation of metformin...
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is performed by obtaining sequential MRI images, before, during, and after the injection of a contrast agent. T1 weighted MR imaging is used to observe the exchange of contrast agent between the vascular space and extravascular extracellular space (EES), providing information about blood volume and microvascular permeability. Signal intensity...
For most biotech start-ups' financing, the fundraising from the venture capital and capital market is not enough. Strategic partnership with the big pharmaceutical or biotech companies is also necessary. At the uncertain projects in the biopharmaceuticals, the flexibility of decision making is valuable against irreversibility. On the other hand, the strategic flexibility tends to become the trade-off...
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