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Cellular decision making in differentiation, proliferation or cell death is mediated by molecular signalling processes, which control the regulation and expression of genes. Vice versa, the expression of genes can trigger the activity of signalling pathways. We introduce and describe a statistical method called dynamic nested effects model (D-NEM) for analyzing the temporal interplay of cell signalling...
The objective of this study is to investigate the relationship between caspase-3 expression and apoptosis in the gastric adenocarcinoma cell line SGC-7901 transfected with the adenovirus-mediated FasL gene. The human gastric adenocarcinoma cell line SGC-7901 was transfected with the adenovirus-mediated FasL gene. The expression of caspase-3 and apoptotic morphological changes were measured by flow...
Cardiomyocyte death is a critical risk factor in a variety of cardiovascular diseases. At the level of individual cardiomyocyte, cell adhesion alters at the early phase of ongoing death. In the previous study, we developed the impedance-sensing technique for real-time monitoring cardiomyocyte adhesion. In this work, we demonstrated the application of our impedance-sensing technique in regulating cell...
Traumatic brain injury (TBI) is caused by in response to mechanical loading of the head. An extended biological cascade is initiated by the deformation and results in delayed cell death and dysfunction. Using an in vitro model of TBI based on organotypic brain slice cultures, we have quantitatively studied the relationship between tissue deformation and outcome. In the current study, we asked the...
Cell death in hepatocellular carcinoma (HCC) cells as well as in other cell types is driven by a complex signaling transduction network comprised of several different pathways. In this study, we measured cell death of the HCC cell line C3A and we quantify the contribution of several signaling pathways using a reverse approach; namely instead of measuring the activity of the intracellular signal, we...
Summary form only given. Over the last several years pulse power technology has developed into a novel and innovative time domain nanotechnology as a new modality to treat cancer. The technology treats cancer in the absence of drugs by generating non-ionizing radiation with nanosecond pulsed electric fields (nsPEFs or nanopulses) that are high in power (gigawatts) and low in energy (millijoules)....
We for the first time used fluorescence technology to study and find the taxol-induced caspases-independent cytoplasm vacuolization and cell death resembling paraptosis in through ER and mitochondria swelling at single living ASTC-a-1 cell level.
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