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Human pluripotent stem cell (hPSC) density is an important factor in self‐renewal and differentiation fates; however, the mechanisms through which hPSCs sense cell density and process this information in making cell fate decisions remain to be fully understood. One particular pathway that may prove important in density‐dependent signaling in hPSCs is the Hippo pathway, which is regulated by cell‐cell...
Mouse embryonic stem (ES) cells can be differentiated into neural lineage cells, but the differentiation efficiency remains low. This study revealed two important factors that influence the neural differentiation efficiency of mouse ES cells: the first is the quality of embryonic bodies (EBs); good quality of EBs consistently originated from a suspension culture of 1×10 5 EScells/ml serum-free...
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